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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIF13A-CCHCR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIF13A-CCHCR1
FusionPDB ID: 42528
FusionGDB2.0 ID: 42528
HgeneTgene
Gene symbol

KIF13A

CCHCR1

Gene ID

63971

54535

Gene namekinesin family member 13Acoiled-coil alpha-helical rod protein 1
SynonymsRBKIN|bA500C11.2C6orf18|HCR|SBP|pg8
Cytomap

6p22.3

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF13Ahomolog of mouse KIF13A mannose-6-phosphate receptor transporterkinesin-like protein RBKINcoiled-coil alpha-helical rod protein 1HCR (a-helix coiled-coil rod homologue)StAR-binding proteinalpha-helical coiled-coil rod proteinputative gene 8 protein
Modification date2020031320200327
UniProtAcc

Q9H1H9

Q8TD31

Ensembl transtripts involved in fusion geneENST idsENST00000259711, ENST00000378814, 
ENST00000378816, ENST00000378826, 
ENST00000378843, ENST00000502704, 
ENST00000503342, 		ENST00000383341, 
ENST00000383527, ENST00000396263, 
ENST00000400351, ENST00000400352, 
ENST00000400406, ENST00000400412, 
ENST00000414614, ENST00000416163, 
ENST00000416392, ENST00000419528, 
ENST00000425620, ENST00000428677, 
ENST00000433804, ENST00000447252, 
ENST00000451521, ENST00000452333, 
ENST00000466904, ENST00000467461, 
ENST00000470755, ENST00000474554, 
ENST00000480060, ENST00000481855, 
ENST00000376266, ENST00000396268, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 9=15122 X 2 X 2=8
# samples 173
** MAII scorelog2(17/1512*10)=-3.15285148808337
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIF13A [Title/Abstract] AND CCHCR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIF13A(17849608)-CCHCR1(31113585), # samples:3
Anticipated loss of major functional domain due to fusion event.KIF13A-CCHCR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF13A-CCHCR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF13A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCHCR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-8138-01AKIF13Achr6

17849608

-CCHCR1chr6

31113585

-
ChimerDB4LUSCTCGA-77-8138KIF13Achr6

17849607

-CCHCR1chr6

31113585

-
ChimerDB4LUSCTCGA-77-8138KIF13Achr6

17849608

-CCHCR1chr6

31113585

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378814KIF13Achr617849608-ENST00000396268CCHCR1chr631113585-201983001865621
ENST00000378814KIF13Achr617849608-ENST00000376266CCHCR1chr631113585-201983001865621
ENST00000259711KIF13Achr617849608-ENST00000396268CCHCR1chr631113585-21259361061971621
ENST00000259711KIF13Achr617849608-ENST00000376266CCHCR1chr631113585-21259361061971621
ENST00000378843KIF13Achr617849608-ENST00000396268CCHCR1chr631113585-2037848181883621
ENST00000378843KIF13Achr617849608-ENST00000376266CCHCR1chr631113585-2037848181883621
ENST00000378826KIF13Achr617849608-ENST00000396268CCHCR1chr631113585-2038849191884621
ENST00000378826KIF13Achr617849608-ENST00000376266CCHCR1chr631113585-2038849191884621
ENST00000378816KIF13Achr617849608-ENST00000396268CCHCR1chr631113585-21249351051970621
ENST00000378816KIF13Achr617849608-ENST00000376266CCHCR1chr631113585-21249351051970621
ENST00000378814KIF13Achr617849607-ENST00000396268CCHCR1chr631113585-201983001865621
ENST00000378814KIF13Achr617849607-ENST00000376266CCHCR1chr631113585-201983001865621
ENST00000259711KIF13Achr617849607-ENST00000396268CCHCR1chr631113585-21259361061971621
ENST00000259711KIF13Achr617849607-ENST00000376266CCHCR1chr631113585-21259361061971621
ENST00000378843KIF13Achr617849607-ENST00000396268CCHCR1chr631113585-2037848181883621
ENST00000378843KIF13Achr617849607-ENST00000376266CCHCR1chr631113585-2037848181883621
ENST00000378826KIF13Achr617849607-ENST00000396268CCHCR1chr631113585-2038849191884621
ENST00000378826KIF13Achr617849607-ENST00000376266CCHCR1chr631113585-2038849191884621
ENST00000378816KIF13Achr617849607-ENST00000396268CCHCR1chr631113585-21249351051970621
ENST00000378816KIF13Achr617849607-ENST00000376266CCHCR1chr631113585-21249351051970621

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378814ENST00000396268KIF13Achr617849608-CCHCR1chr631113585-0.0206843110.97931576
ENST00000378814ENST00000376266KIF13Achr617849608-CCHCR1chr631113585-0.0206843110.97931576
ENST00000259711ENST00000396268KIF13Achr617849608-CCHCR1chr631113585-0.0208467880.97915316
ENST00000259711ENST00000376266KIF13Achr617849608-CCHCR1chr631113585-0.0208467880.97915316
ENST00000378843ENST00000396268KIF13Achr617849608-CCHCR1chr631113585-0.020872470.9791276
ENST00000378843ENST00000376266KIF13Achr617849608-CCHCR1chr631113585-0.020872470.9791276
ENST00000378826ENST00000396268KIF13Achr617849608-CCHCR1chr631113585-0.020722130.9792779
ENST00000378826ENST00000376266KIF13Achr617849608-CCHCR1chr631113585-0.020722130.9792779
ENST00000378816ENST00000396268KIF13Achr617849608-CCHCR1chr631113585-0.0223331250.9776669
ENST00000378816ENST00000376266KIF13Achr617849608-CCHCR1chr631113585-0.0223331250.9776669
ENST00000378814ENST00000396268KIF13Achr617849607-CCHCR1chr631113585-0.0206843110.97931576
ENST00000378814ENST00000376266KIF13Achr617849607-CCHCR1chr631113585-0.0206843110.97931576
ENST00000259711ENST00000396268KIF13Achr617849607-CCHCR1chr631113585-0.0208467880.97915316
ENST00000259711ENST00000376266KIF13Achr617849607-CCHCR1chr631113585-0.0208467880.97915316
ENST00000378843ENST00000396268KIF13Achr617849607-CCHCR1chr631113585-0.020872470.9791276
ENST00000378843ENST00000376266KIF13Achr617849607-CCHCR1chr631113585-0.020872470.9791276
ENST00000378826ENST00000396268KIF13Achr617849607-CCHCR1chr631113585-0.020722130.9792779
ENST00000378826ENST00000376266KIF13Achr617849607-CCHCR1chr631113585-0.020722130.9792779
ENST00000378816ENST00000396268KIF13Achr617849607-CCHCR1chr631113585-0.0223331250.9776669
ENST00000378816ENST00000376266KIF13Achr617849607-CCHCR1chr631113585-0.0223331250.9776669

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42528_42528_1_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000259711_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_2_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000259711_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_3_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378814_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_4_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378814_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_5_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378816_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERRPSQVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_6_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378816_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERRPSQVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_7_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378826_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_8_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378826_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_9_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378843_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_10_KIF13A-CCHCR1_KIF13A_chr6_17849607_ENST00000378843_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_11_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000259711_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_12_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000259711_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_13_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378814_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_14_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378814_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_15_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378816_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERRPSQVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_16_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378816_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERRPSQVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_17_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378826_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_18_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378826_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_19_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378843_CCHCR1_chr6_31113585_ENST00000376266_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

>42528_42528_20_KIF13A-CCHCR1_KIF13A_chr6_17849608_ENST00000378843_CCHCR1_chr6_31113585_ENST00000396268_length(amino acids)=621AA_BP=277
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:17849608/chr6:31113585)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF13A

Q9H1H9

CCHCR1

Q8TD31

FUNCTION: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. {ECO:0000269|PubMed:19841138, ECO:0000269|PubMed:20208530}.FUNCTION: May be a regulator of keratinocyte proliferation or differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-939102_109276.66666666666671806.0Nucleotide bindingATP
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-938102_109276.66666666666671750.0Nucleotide bindingATP
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-938102_109276.66666666666671771.0Nucleotide bindingATP
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-937102_109276.66666666666671758.0Nucleotide bindingATP
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-939102_109276.66666666666671806.0Nucleotide bindingATP
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-938102_109276.66666666666671750.0Nucleotide bindingATP
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-938102_109276.66666666666671771.0Nucleotide bindingATP
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-937102_109276.66666666666671758.0Nucleotide bindingATP
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000376266918498_691437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383341018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383341018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383341018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383527018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383527018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000383527018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400352018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400352018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400352018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400412018111_3030872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400412018344_4370872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000400412018498_6910872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000416163018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000416163018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000416163018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000425620018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000425620018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000425620018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000451521918498_691490.6666666666667836.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000376266918498_691437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383341018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383341018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383341018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383527018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383527018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000383527018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400352018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400352018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400352018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400412018111_3030872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400412018344_4370872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000400412018498_6910872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000416163018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000416163018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000416163018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000425620018111_3030783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000425620018344_4370783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000425620018498_6910783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000451521918498_691490.6666666666667836.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-9391100_1138276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-9391518_1547276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-939359_436276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-939602_775276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-9381100_1138276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-9381518_1547276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-938359_436276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-938602_775276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-9381100_1138276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-9381518_1547276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-938359_436276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-938602_775276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-9371100_1138276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-9371518_1547276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-937359_436276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-937602_775276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-131100_1138071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-131518_1547071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-13359_436071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-13602_775071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-9391100_1138276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-9391518_1547276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-939359_436276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-939602_775276.66666666666671806.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-9381100_1138276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-9381518_1547276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-938359_436276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-938602_775276.66666666666671750.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-9381100_1138276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-9381518_1547276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-938359_436276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-938602_775276.66666666666671771.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-9371100_1138276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-9371518_1547276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-937359_436276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-937602_775276.66666666666671758.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-131100_1138071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-131518_1547071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-13359_436071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-13602_775071.0Coiled coilOntology_term=ECO:0000255
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-939469_519276.66666666666671806.0DomainNote=FHA
HgeneKIF13Achr6:17849607chr6:31113585ENST00000259711-9395_352276.66666666666671806.0DomainKinesin motor
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-938469_519276.66666666666671750.0DomainNote=FHA
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378814-9385_352276.66666666666671750.0DomainKinesin motor
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-938469_519276.66666666666671771.0DomainNote=FHA
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378826-9385_352276.66666666666671771.0DomainKinesin motor
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-937469_519276.66666666666671758.0DomainNote=FHA
HgeneKIF13Achr6:17849607chr6:31113585ENST00000378843-9375_352276.66666666666671758.0DomainKinesin motor
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-13469_519071.0DomainNote=FHA
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-135_352071.0DomainKinesin motor
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-939469_519276.66666666666671806.0DomainNote=FHA
HgeneKIF13Achr6:17849608chr6:31113585ENST00000259711-9395_352276.66666666666671806.0DomainKinesin motor
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-938469_519276.66666666666671750.0DomainNote=FHA
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378814-9385_352276.66666666666671750.0DomainKinesin motor
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-938469_519276.66666666666671771.0DomainNote=FHA
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378826-9385_352276.66666666666671771.0DomainKinesin motor
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-937469_519276.66666666666671758.0DomainNote=FHA
HgeneKIF13Achr6:17849608chr6:31113585ENST00000378843-9375_352276.66666666666671758.0DomainKinesin motor
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-13469_519071.0DomainNote=FHA
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-135_352071.0DomainKinesin motor
HgeneKIF13Achr6:17849607chr6:31113585ENST00000502704-13102_109071.0Nucleotide bindingATP
HgeneKIF13Achr6:17849608chr6:31113585ENST00000502704-13102_109071.0Nucleotide bindingATP
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000376266918111_303437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000376266918344_437437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000396268918111_303526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000396268918344_437526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000396268918498_691526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000451521918111_303490.6666666666667836.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849607chr6:31113585ENST00000451521918344_437490.6666666666667836.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000376266918111_303437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000376266918344_437437.6666666666667783.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000396268918111_303526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000396268918344_437526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000396268918498_691526.6666666666666872.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000451521918111_303490.6666666666667836.0Coiled coilOntology_term=ECO:0000255
TgeneCCHCR1chr6:17849608chr6:31113585ENST00000451521918344_437490.6666666666667836.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1307_KIF13A_17849608_CCHCR1_31113585_1307_KIF13A_17849608_CCHCR1_31113585_ranked_0.pdbKIF13A1784960717849608ENST00000376266CCHCR1chr631113585-
MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMDESNTTKYAGQEVVFKCLGEGILEKA
FQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGP
YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLK
EGSNINNSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQL
SARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR
LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL
621


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KIF13A_pLDDT.png
all structure
all structure
CCHCR1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIF13A
CCHCR1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIF13A-CCHCR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIF13A-CCHCR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource