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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIRREL-PYHIN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIRREL-PYHIN1
FusionPDB ID: 42791
FusionGDB2.0 ID: 42791
HgeneTgene
Gene symbol

KIRREL

PYHIN1

Gene ID

55243

149628

Gene namekirre like nephrin family adhesion molecule 1pyrin and HIN domain family member 1
SynonymsKIRREL|NEPH1IFIX
Cytomap

1q23.1

1q23.1

Type of geneprotein-codingprotein-coding
Descriptionkin of IRRE-like protein 1kin of IRRE likekin of irregular chiasm-like protein 1nephrin relatednephrin-like protein 1pyrin and HIN domain-containing protein 1interferon-inducible protein X
Modification date2020031320200313
UniProtAcc

Q8IZU9

.
Ensembl transtripts involved in fusion geneENST idsENST00000359209, ENST00000360089, 
ENST00000368172, ENST00000368173, 
ENST00000392272, ENST00000416935, 
ENST00000368135, ENST00000485134, 
ENST00000368138, ENST00000368140, 
ENST00000392252, ENST00000392254, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 5 X 6=3303 X 3 X 3=27
# samples 133
** MAII scorelog2(13/330*10)=-1.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIRREL [Title/Abstract] AND PYHIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIRREL(158063552)-PYHIN1(158911767), # samples:2
Anticipated loss of major functional domain due to fusion event.KIRREL-PYHIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIRREL-PYHIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIRREL-PYHIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIRREL-PYHIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePYHIN1

GO:0043388

positive regulation of DNA binding

16479015

TgenePYHIN1

GO:0045893

positive regulation of transcription, DNA-templated

16479015|18247378

TgenePYHIN1

GO:1900182

positive regulation of protein localization to nucleus

16479015

TgenePYHIN1

GO:1902164

positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

16479015

TgenePYHIN1

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

18247378


check buttonFusion gene breakpoints across KIRREL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PYHIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-7223-01AKIRRELchr1

158063552

+PYHIN1chr1

158911767

+
ChimerDB4LUSCTCGA-56-7223KIRRELchr1

158063552

+PYHIN1chr1

158911767

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392272KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+307318144042713769
ENST00000392272KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+274718144042713769
ENST00000392272KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+262218144042620738
ENST00000392272KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+262218144042620738
ENST00000368173KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+343021714043070888
ENST00000368173KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+310421714043070888
ENST00000368173KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+297921714042977857
ENST00000368173KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+297921714042977857
ENST00000360089KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+307718185372717726
ENST00000360089KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+275118185372717726
ENST00000360089KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+262618185372624695
ENST00000360089KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+262618185372624695
ENST00000359209KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+30451786672685872
ENST00000359209KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+27191786672685872
ENST00000359209KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+25941786672592842
ENST00000359209KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+25941786672592842
ENST00000416935KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+27101451322350772
ENST00000416935KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+23841451322350772
ENST00000416935KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+22591451322257741
ENST00000416935KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+22591451322257741
ENST00000368172KIRRELchr1158063552+ENST00000368140PYHIN1chr1158911767+24321173122072686
ENST00000368172KIRRELchr1158063552+ENST00000368138PYHIN1chr1158911767+21061173122072686
ENST00000368172KIRRELchr1158063552+ENST00000392254PYHIN1chr1158911767+19811173121979655
ENST00000368172KIRRELchr1158063552+ENST00000392252PYHIN1chr1158911767+19811173121979655

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392272ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.0010650620.9989349
ENST00000392272ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0019569730.99804306
ENST00000392272ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0021048790.9978951
ENST00000392272ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0021048790.9978951
ENST00000368173ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.0010781630.9989219
ENST00000368173ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0017586670.9982413
ENST00000368173ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0019545350.99804544
ENST00000368173ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0019545350.99804544
ENST00000360089ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.0014115440.9985884
ENST00000360089ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0025730850.9974269
ENST00000360089ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0026780140.997322
ENST00000360089ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0026780140.997322
ENST00000359209ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.0015075910.99849236
ENST00000359209ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0025701080.9974299
ENST00000359209ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0029807710.9970193
ENST00000359209ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0029807710.9970193
ENST00000416935ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.002342680.9976573
ENST00000416935ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0040172810.99598277
ENST00000416935ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0043956850.9956044
ENST00000416935ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0043956850.9956044
ENST00000368172ENST00000368140KIRRELchr1158063552+PYHIN1chr1158911767+0.0023027180.9976973
ENST00000368172ENST00000368138KIRRELchr1158063552+PYHIN1chr1158911767+0.0041912980.9958087
ENST00000368172ENST00000392254KIRRELchr1158063552+PYHIN1chr1158911767+0.0041406740.9958593
ENST00000368172ENST00000392252KIRRELchr1158063552+PYHIN1chr1158911767+0.0041406740.9958593

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42791_42791_1_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000359209_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=872AA_BP=527
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS
GVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV
ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFF
HVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRK
TTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTT

--------------------------------------------------------------

>42791_42791_2_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000359209_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=872AA_BP=527
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS
GVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV
ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFF
HVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRK
TTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTT

--------------------------------------------------------------

>42791_42791_3_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000359209_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=842AA_BP=527
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS
GVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV
ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFF
HVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRK
TTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTT

--------------------------------------------------------------

>42791_42791_4_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000359209_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=842AA_BP=527
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS
GVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV
ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFF
HVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRK
TTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTT

--------------------------------------------------------------

>42791_42791_5_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000360089_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=726AA_BP=381
MLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQE
GERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVT
LTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIG
STPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS
ILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPII
AMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIR
RAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFI
QIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRITSPTVAPPLSSDTSTN

--------------------------------------------------------------

>42791_42791_6_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000360089_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=726AA_BP=381
MLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQE
GERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVT
LTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIG
STPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS
ILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPII
AMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIR
RAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFI
QIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPPTTPSSSSFTKKDETHPGAQSSPANFRITSPTVAPPLSSDTSTN

--------------------------------------------------------------

>42791_42791_7_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000360089_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=695AA_BP=381
MLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQE
GERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVT
LTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIG
STPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS
ILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPII
AMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIR
RAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFI

--------------------------------------------------------------

>42791_42791_8_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000360089_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=695AA_BP=381
MLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQE
GERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVT
LTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIG
STPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS
ILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPII
AMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIR
RAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFI

--------------------------------------------------------------

>42791_42791_9_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368172_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=686AA_BP=341
MNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNK
VGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADA
GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTL
TINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE
PLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLN
INLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEI
QDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHL

--------------------------------------------------------------

>42791_42791_10_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368172_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=686AA_BP=341
MNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNK
VGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADA
GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTL
TINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE
PLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLN
INLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEI
QDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHL

--------------------------------------------------------------

>42791_42791_11_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368172_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=655AA_BP=341
MNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNK
VGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADA
GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTL
TINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE
PLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLN
INLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEI
QDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHL

--------------------------------------------------------------

>42791_42791_12_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368172_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=655AA_BP=341
MNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNK
VGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADA
GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTL
TINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE
PLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLN
INLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEI
QDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHL

--------------------------------------------------------------

>42791_42791_13_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368173_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=888AA_BP=543
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA
LSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE
VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR
KGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENE
QRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGY
IVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMAL

--------------------------------------------------------------

>42791_42791_14_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368173_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=888AA_BP=543
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA
LSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE
VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR
KGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENE
QRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGY
IVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMAL

--------------------------------------------------------------

>42791_42791_15_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368173_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=857AA_BP=543
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA
LSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE
VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR
KGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENE
QRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGY
IVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMAL

--------------------------------------------------------------

>42791_42791_16_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000368173_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=857AA_BP=543
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA
LSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE
VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR
KGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENE
QRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGY
IVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMAL

--------------------------------------------------------------

>42791_42791_17_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000392272_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=769AA_BP=424
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTE
PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRA
IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME
ADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSD
REDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKF
IKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSM
AVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPP

--------------------------------------------------------------

>42791_42791_18_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000392272_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=769AA_BP=424
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTE
PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRA
IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME
ADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSD
REDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKF
IKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSM
AVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPP

--------------------------------------------------------------

>42791_42791_19_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000392272_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=738AA_BP=424
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTE
PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRA
IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME
ADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSD
REDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKF
IKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSM
AVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPP

--------------------------------------------------------------

>42791_42791_20_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000392272_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=738AA_BP=424
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLNPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTE
PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRA
IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME
ADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSD
REDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLKRKF
IKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKTGSM
AVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQMPP

--------------------------------------------------------------

>42791_42791_21_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000416935_PYHIN1_chr1_158911767_ENST00000368138_length(amino acids)=772AA_BP=427
MLSLLVWILTLSDTFSQVPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPT
DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSF
FTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYT
CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN
VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTM
HSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLK
RKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKT
GSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQ

--------------------------------------------------------------

>42791_42791_22_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000416935_PYHIN1_chr1_158911767_ENST00000368140_length(amino acids)=772AA_BP=427
MLSLLVWILTLSDTFSQVPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPT
DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSF
FTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYT
CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN
VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTM
HSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLK
RKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKT
GSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQ

--------------------------------------------------------------

>42791_42791_23_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000416935_PYHIN1_chr1_158911767_ENST00000392252_length(amino acids)=741AA_BP=427
MLSLLVWILTLSDTFSQVPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPT
DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSF
FTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYT
CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN
VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTM
HSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLK
RKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKT
GSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQ

--------------------------------------------------------------

>42791_42791_24_KIRREL-PYHIN1_KIRREL_chr1_158063552_ENST00000416935_PYHIN1_chr1_158911767_ENST00000392254_length(amino acids)=741AA_BP=427
MLSLLVWILTLSDTFSQVPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPT
DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSF
FTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYT
CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINN
VMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTM
HSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENEQRRMFHATVATQTQFFHVKVLNINLK
RKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGYIVYGLFMLHTKIVNRKTTIYEIQDKT
GSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMALPQEQSQHPKPSEASTTLPESHLKTPQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:158063552/chr1:158911767)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIRREL

Q8IZU9

.
FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250|UniProtKB:Q8BR86}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315120_216573.0758.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+131521_115573.0758.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315223_299573.0758.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315308_387573.0758.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315392_488573.0758.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315120_216589.0774.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+131521_115589.0774.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315223_299589.0774.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315308_387589.0774.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315392_488589.0774.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113120_216470.0655.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+111321_115470.0655.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113223_299470.0655.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113308_387470.0655.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315405_407573.0758.0MotifCell attachment site
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315405_407589.0774.0MotifCell attachment site
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113405_407470.0655.0MotifCell attachment site
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+131517_499573.0758.0Topological domainExtracellular
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+131517_499589.0774.0Topological domainExtracellular
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315500_520573.0758.0TransmembraneHelical
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315500_520589.0774.0TransmembraneHelical
TgenePYHIN1chr1:158063552chr1:158911767ENST0000036813505199_3990246.0DomainHIN-200
TgenePYHIN1chr1:158063552chr1:158911767ENST00000368135051_880246.0DomainPyrin
TgenePYHIN1chr1:158063552chr1:158911767ENST0000036813839199_399184.0420.6666666666667DomainHIN-200
TgenePYHIN1chr1:158063552chr1:158911767ENST0000036814039199_399193.0536.0DomainHIN-200
TgenePYHIN1chr1:158063552chr1:158911767ENST0000039225238199_399184.0453.0DomainHIN-200
TgenePYHIN1chr1:158063552chr1:158911767ENST0000039225438199_399193.0462.0DomainHIN-200

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113392_488470.0655.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:158063552chr1:158911767ENST00000359209+1315521_757573.0758.0Topological domainCytoplasmic
HgeneKIRRELchr1:158063552chr1:158911767ENST00000368173+1315521_757589.0774.0Topological domainCytoplasmic
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+111317_499470.0655.0Topological domainExtracellular
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113521_757470.0655.0Topological domainCytoplasmic
HgeneKIRRELchr1:158063552chr1:158911767ENST00000392272+1113500_520470.0655.0TransmembraneHelical
TgenePYHIN1chr1:158063552chr1:158911767ENST00000368138391_88184.0420.6666666666667DomainPyrin
TgenePYHIN1chr1:158063552chr1:158911767ENST00000368140391_88193.0536.0DomainPyrin
TgenePYHIN1chr1:158063552chr1:158911767ENST00000392252381_88184.0453.0DomainPyrin
TgenePYHIN1chr1:158063552chr1:158911767ENST00000392254381_88193.0462.0DomainPyrin


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1681_KIRREL_158063552_PYHIN1_158911767_ranked_0.pdbKIRREL158063552158063552ENST00000392252PYHIN1chr1158911767+
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA
ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHES
RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA
LSAQVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE
VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRR
KGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSLKPLANRHATASKNIFREDPIIAMVLNATKVFKYESSENE
QRRMFHATVATQTQFFHVKVLNINLKRKFIKKRIIIISNYSKRNSLLEVNEASSVSEAGPDQTFEVPKDIIRRAKKIPKINILHKQTSGY
IVYGLFMLHTKIVNRKTTIYEIQDKTGSMAVVGKGECHNIPCEKGDKLRLFCFRLRKRENMSKLMSEMHSFIQIQKNTNQRSHDSRSMAL
888


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
PYHIN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIRREL
PYHIN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIRREL-PYHIN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIRREL-PYHIN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource