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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LAMA5-CLCN7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LAMA5-CLCN7
FusionPDB ID: 43901
FusionGDB2.0 ID: 43901
HgeneTgene
Gene symbol

LAMA5

CLCN7

Gene ID

3911

1186

Gene namelaminin subunit alpha 5chloride voltage-gated channel 7
Synonyms-CLC-7|CLC7|HOD|OPTA2|OPTB4|PPP1R63
Cytomap

20q13.33

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alphaH(+)/Cl(-) exchange transporter 7chloride channel 7 alpha subunitchloride channel protein 7chloride channel, voltage-sensitive 7protein phosphatase 1, regulatory subunit 63
Modification date2020031320200315
UniProtAcc

O15230

P51798

Ensembl transtripts involved in fusion geneENST idsENST00000252999, ENST00000370677, 
ENST00000370692, ENST00000492698, 
ENST00000566812, ENST00000262318, 
ENST00000382745, ENST00000448525, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 20 X 14=56008 X 5 X 6=240
# samples 288
** MAII scorelog2(28/5600*10)=-4.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LAMA5 [Title/Abstract] AND CLCN7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LAMA5(60900372)-CLCN7(1509188), # samples:3
Anticipated loss of major functional domain due to fusion event.LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA5-CLCN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLAMA5

GO:0016477

cell migration

11821406

HgeneLAMA5

GO:0034446

substrate adhesion-dependent cell spreading

16236823


check buttonFusion gene breakpoints across LAMA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLCN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6465-01ALAMA5chr20

60900372

-CLCN7chr16

1509188

-
ChimerDB4READTCGA-G5-6572-01ALAMA5chr20

60900372

-CLCN7chr16

1509188

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252999LAMA5chr2060900372-ENST00000448525CLCN7chr161509188-911755966774192450
ENST00000252999LAMA5chr2060900372-ENST00000382745CLCN7chr161509188-911655966774192450
ENST00000252999LAMA5chr2060900372-ENST00000262318CLCN7chr161509188-870855966777792570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252999ENST00000448525LAMA5chr2060900372-CLCN7chr161509188-0.0055944590.9944055
ENST00000252999ENST00000382745LAMA5chr2060900372-CLCN7chr161509188-0.0055996450.9944003
ENST00000252999ENST00000262318LAMA5chr2060900372-CLCN7chr161509188-0.0036187290.9963813

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43901_43901_1_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000262318_length(amino acids)=2570AA_BP=1842
MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA
GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR
TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL
GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN
CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR
PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP
CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ
ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC
EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS
CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN
FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV
LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL
SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE
ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP
AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA
LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC
HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC
SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA
NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG
TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS
QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG
KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST
FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA
TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI
PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH
IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE
RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQACVAPTGVQAVPGPGPAAPGGGGQPQSGCRVGDQE
GPRQVPPGKERLGGALAGPDVRPSPAHNGHWRWHPGPSAFPPGVTGFSAQTMLPSSGNGEHPAAGRAGGRRGTDPLAGLTLLWAVVSPLG

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>43901_43901_2_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000382745_length(amino acids)=2450AA_BP=1842
MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA
GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR
TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL
GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN
CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR
PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP
CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ
ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC
EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS
CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN
FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV
LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL
SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE
ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP
AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA
LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC
HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC
SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA
NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG
TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS
QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG
KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST
FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA
TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI
PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH
IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE
RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRK

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>43901_43901_3_LAMA5-CLCN7_LAMA5_chr20_60900372_ENST00000252999_CLCN7_chr16_1509188_ENST00000448525_length(amino acids)=2450AA_BP=1842
MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARIAASATCGEEAPARGSPRPTEDLYCKLVGGPVA
GGDPNQTIRGQYCDICTAANSNKAHPASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSMDFGR
TYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLL
GHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCN
CYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCR
PNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQP
CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQ
ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYC
EAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACAS
CKDGFFGLDQADYFGCRSCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFGFNPLEFEN
FSWRGYAQMAPVQPRIVARLNLTSPDLFWLVFRYVNRGAMSVSGRVSVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFV
LNPGTWALRVEAEGVLLDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCRQDNSLPRPCPTEQL
SPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGVAVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSE
ASVRLTAEQARFFLHGVTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGLPLTHAQDLTPAMSP
AGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGYQPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQA
LLDVTHSELTVTVRVPKGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGC
HEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNC
SGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAA
NPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGG
TLRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREELMMVLASLEQLQIRALFS
QISSAVFLRRVALEVASPAGQGALASNVELCLCPASYRGDSCQPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG
KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMIST
FTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA
TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFI
PSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMH
IQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVE
RSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60900372/chr16:1509188)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA5

O15230

CLCN7

P51798

FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801438_14831843.03696.0DomainLaminin EGF-like 12
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801484_15271843.03696.0DomainLaminin EGF-like 13
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801528_15761843.03696.0DomainLaminin EGF-like 14
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801577_16271843.03696.0DomainLaminin EGF-like 15
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801628_16371843.03696.0DomainLaminin EGF-like 16%3B first part
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801641_18301843.03696.0DomainLaminin IV type A
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180300_3581843.03696.0DomainLaminin EGF-like 1
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180359_4281843.03696.0DomainLaminin EGF-like 2
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-418041_2991843.03696.0DomainLaminin N-terminal
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180429_4741843.03696.0DomainLaminin EGF-like 3
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180494_5401843.03696.0DomainLaminin EGF-like 4
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180541_5861843.03696.0DomainLaminin EGF-like 5
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180587_6311843.03696.0DomainLaminin EGF-like 6
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180632_6761843.03696.0DomainLaminin EGF-like 7
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180677_7221843.03696.0DomainLaminin EGF-like 8
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180723_7751843.03696.0DomainLaminin EGF-like 9
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180776_8281843.03696.0DomainLaminin EGF-like 10
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180829_8501843.03696.0DomainLaminin EGF-like 11%3B truncated
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801722_17241843.03696.0MotifCell attachment site
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801838_18401843.03696.0MotifCell attachment site
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-4180851_14371843.03696.0RegionNote=Domain IV 1 (domain IV B)
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525631_695198.0806.0DomainCBS 1
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525741_799198.0806.0DomainCBS 2
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424631_695174.0782.0DomainCBS 1
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424741_799174.0782.0DomainCBS 2
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525206_213198.0806.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525288_300198.0806.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525304_312198.0806.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525545_559198.0806.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525560_562198.0806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525563_574198.0806.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525575_578198.0806.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424206_213174.0782.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424288_300174.0782.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424304_312174.0782.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424545_559174.0782.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424560_562174.0782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424563_574174.0782.0IntramembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424575_578174.0782.0IntramembraneNote%3DLoop between two helices
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525203_207198.0806.0MotifSelectivity filter part_1
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525245_249198.0806.0MotifSelectivity filter part_2
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525512_516198.0806.0MotifSelectivity filter part_3
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424203_207174.0782.0MotifSelectivity filter part_1
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424245_249174.0782.0MotifSelectivity filter part_2
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424512_516174.0782.0MotifSelectivity filter part_3
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525658_660198.0806.0Nucleotide bindingATP
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525783_786198.0806.0Nucleotide bindingATP
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424658_660174.0782.0Nucleotide bindingATP
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424783_786174.0782.0Nucleotide bindingATP
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525598_805198.0806.0Topological domainCytoplasmic
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424598_805174.0782.0Topological domainCytoplasmic
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525223_241198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525247_264198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525322_341198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525375_405198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525410_432198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525487_507198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525512_535198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525579_597198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424174_197174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424223_241174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424247_264174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424322_341174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424375_405174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424410_432174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424487_507174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424512_535174.0782.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424579_597174.0782.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802203_22211843.03696.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802335_24661843.03696.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802510_26701843.03696.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801831_18631843.03696.0DomainLaminin EGF-like 16%3B second part
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801864_19121843.03696.0DomainLaminin EGF-like 17
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801913_19681843.03696.0DomainLaminin EGF-like 18
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41801969_20221843.03696.0DomainLaminin EGF-like 19
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802023_20691843.03696.0DomainLaminin EGF-like 20
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802070_21161843.03696.0DomainLaminin EGF-like 21
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802117_21661843.03696.0DomainLaminin EGF-like 22
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802736_29291843.03696.0DomainLaminin G-like 1
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802941_31151843.03696.0DomainLaminin G-like 2
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41803124_32921843.03696.0DomainLaminin G-like 3
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41803340_35131843.03696.0DomainLaminin G-like 4
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41803520_36921843.03696.0DomainLaminin G-like 5
HgeneLAMA5chr20:60900372chr16:1509188ENST00000252999-41802167_27351843.03696.0RegionNote=Domain II and I
TgeneCLCN7chr20:60900372chr16:1509188ENST000003827455251_126198.0806.0Topological domainCytoplasmic
TgeneCLCN7chr20:60900372chr16:1509188ENST000004485254241_126174.0782.0Topological domainCytoplasmic
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525127_159198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000382745525174_197198.0806.0TransmembraneHelical
TgeneCLCN7chr20:60900372chr16:1509188ENST00000448525424127_159174.0782.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LAMA5_pLDDT.png
all structure
all structure
CLCN7_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LAMA5
CLCN7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LAMA5-CLCN7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LAMA5-CLCN7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource