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Fusion Protein:MANF-SETD2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MANF-SETD2 | FusionPDB ID: 51136 | FusionGDB2.0 ID: 51136 | Hgene | Tgene | Gene symbol | MANF | SETD2 | Gene ID | 7873 | 29072 |
| Gene name | mesencephalic astrocyte derived neurotrophic factor | SET domain containing 2, histone lysine methyltransferase | |
| Synonyms | ARMET|ARP | HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP | |
| Cytomap | 3p21.2 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mesencephalic astrocyte-derived neurotrophic factorarginine-rich, mutated in early stage tumors | histone-lysine N-methyltransferase SETD2SET domain containing 2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | P55145 | Q9BYW2 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000470900, ENST00000528157, | ENST00000409792, ENST00000492397, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 2 X 2 X 2=8 | 14 X 12 X 8=1344 |
| # samples | 2 | 17 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(17/1344*10)=-2.98292648664106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MANF [Title/Abstract] AND SETD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MANF(51423766)-SETD2(47108608), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | MANF-SETD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MANF-SETD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MANF-SETD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MANF-SETD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SETD2 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 24843002 |
| Tgene | SETD2 | GO:0018023 | peptidyl-lysine trimethylation | 27518565 |
| Tgene | SETD2 | GO:0018026 | peptidyl-lysine monomethylation | 28753426 |
| Tgene | SETD2 | GO:0032465 | regulation of cytokinesis | 27518565 |
| Tgene | SETD2 | GO:0032727 | positive regulation of interferon-alpha production | 28753426 |
| Tgene | SETD2 | GO:0034340 | response to type I interferon | 28753426 |
| Tgene | SETD2 | GO:0051607 | defense response to virus | 28753426 |
| Tgene | SETD2 | GO:0097198 | histone H3-K36 trimethylation | 23043551|24843002|26002201|27474439|28753426 |
| Tgene | SETD2 | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
| Tgene | SETD2 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 27518565 |
| Tgene | SETD2 | GO:1905634 | regulation of protein localization to chromatin | 24843002 |
| Fusion gene breakpoints across MANF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SETD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A3KC-01A | MANF | chr3 | 51423766 | - | SETD2 | chr3 | 47108608 | - |
| ChimerDB4 | BRCA | TCGA-A2-A3KC-01A | MANF | chr3 | 51423766 | + | SETD2 | chr3 | 47108608 | - |
| ChimerDB4 | BRCA | TCGA-A2-A3KC | MANF | chr3 | 51423766 | + | SETD2 | chr3 | 47108608 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000528157 | MANF | chr3 | 51423766 | + | ENST00000409792 | SETD2 | chr3 | 47108608 | - | 2557 | 518 | 140 | 2152 | 670 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000528157 | ENST00000409792 | MANF | chr3 | 51423766 | + | SETD2 | chr3 | 47108608 | - | 0.002286048 | 0.9977139 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >51136_51136_1_MANF-SETD2_MANF_chr3_51423766_ENST00000528157_SETD2_chr3_47108608_ENST00000409792_length(amino acids)=670AA_BP=126 MGKWHVGGRRGAPRQWGATARGRDLEAVRRGGCGSVGRRRQRRRRRRRRRRRMRRMWATQGLAVALALSVLPGSRALRPGDCEVCISYLG RFYQDLKDRDVTFSPATIENELIKFCREARGKENRLEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEK RKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPF AGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSV AVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGV VVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHE AEMDLGTPTYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYC -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:51423766/chr3:47108608) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MANF | SETD2 |
| FUNCTION: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057). {ECO:0000250|UniProtKB:P0C5H9, ECO:0000269|PubMed:12794311, ECO:0000269|PubMed:18561914, ECO:0000269|PubMed:22637475, ECO:0000269|PubMed:29497057}. | FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 2117_2146 | 2020.0 | 2565.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 2149_2232 | 2020.0 | 2565.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 2266_2365 | 2020.0 | 2565.0 | Compositional bias | Note=Gln-rich | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 2389_2422 | 2020.0 | 2565.0 | Domain | WW | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 2137_2366 | 2020.0 | 2565.0 | Region | Low charge region |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 166_247 | 2020.0 | 2565.0 | Compositional bias | Note=Pro-rich | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 385_456 | 2020.0 | 2565.0 | Compositional bias | Note=Arg-rich | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1494_1548 | 2020.0 | 2565.0 | Domain | AWS | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1550_1667 | 2020.0 | 2565.0 | Domain | SET | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1674_1690 | 2020.0 | 2565.0 | Domain | Post-SET | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1560_1562 | 2020.0 | 2565.0 | Region | S-adenosyl-L-methionine binding | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1603_1605 | 2020.0 | 2565.0 | Region | S-adenosyl-L-methionine binding | |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1628_1629 | 2020.0 | 2565.0 | Region | S-adenosyl-L-methionine binding |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
MANF_pLDDT.png  |
SETD2_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| SETD2 | HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, HCVgp1, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, Ttll7, Soga1, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25, SPOP, PCGF1, ESR2, FGFR2, MDC1, KIAA1429, RPA1, RAD51, HIST1H4A, DCAF4, CUL7, nsp9ab, nsp9, NPM1, CENPF, ORF14, ESR1, MYCN, RNGTT, AURKB, BRPF3, CECR2, SP110, TRIM66, C12orf49, BRD4, DDX58, APEX1, DDX23, DHX40, DHX8, TERF2IP, ARX, SHANK3, NAA40, SCRIB, PSD2, STK11, CTCFL, KIAA0408, ABTB2, ARAF, RNF145, RNPS1, ZBTB44, RNH1, OR10H1, SRSF6, C2CD4B, CCDC96, COQ3, SLC35G1, FGF12, RAMP1, FTSJ3, VDR, SAP18, CCDC71, LRRTM4, ZNF10, CSNK2B, PIGF, SRPK2, FGF11, SLU7, CXCL6, NFKBIL1, SLFN11, SIRT6, ATRX, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MANF | |
| SETD2 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SETD2 | chr3:51423766 | chr3:47108608 | ENST00000409792 | 11 | 21 | 1418_1714 | 2020.0 | 2565.0 | TUBA1A |
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Related Drugs to MANF-SETD2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MANF-SETD2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SETD2 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 6 | CGI;CTD_human;UNIPROT |
| Tgene | SETD2 | C4085873 | LUSCAN-LUMISH SYNDROME | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | SETD2 | C0007134 | Renal Cell Carcinoma | 2 | CTD_human |
| Tgene | SETD2 | C0023467 | Leukemia, Myelocytic, Acute | 2 | UNIPROT |
| Tgene | SETD2 | C1266042 | Chromophobe Renal Cell Carcinoma | 2 | CTD_human |
| Tgene | SETD2 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 2 | CTD_human |
| Tgene | SETD2 | C1266044 | Collecting Duct Carcinoma of the Kidney | 2 | CTD_human |
| Tgene | SETD2 | C1306837 | Papillary Renal Cell Carcinoma | 2 | CTD_human |
| Tgene | SETD2 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | UNIPROT |
| Tgene | SETD2 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Tgene | SETD2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | SETD2 | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| Tgene | SETD2 | C0023418 | leukemia | 1 | CTD_human |
| Tgene | SETD2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | SETD2 | C0175695 | Sotos' syndrome | 1 | ORPHANET |
| Tgene | SETD2 | C0206656 | Embryonal Rhabdomyosarcoma | 1 | CTD_human |
| Tgene | SETD2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | SETD2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Tgene | SETD2 | C0600066 | Malignant Cystosarcoma Phyllodes | 1 | CTD_human |
| Tgene | SETD2 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Tgene | SETD2 | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | SETD2 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Tgene | SETD2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | SETD2 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| Tgene | SETD2 | C1721098 | Replication Error Phenotype | 1 | CTD_human |
| Tgene | SETD2 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Tgene | SETD2 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
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