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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAP4-NME6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP4-NME6
FusionPDB ID: 51445
FusionGDB2.0 ID: 51445
HgeneTgene
Gene symbol

MAP4

NME6

Gene ID

4134

10201

Gene namemicrotubule associated protein 4NME/NM23 nucleoside diphosphate kinase 6
Synonyms-IPIA-ALPHA|NDK 6|NM23-H6
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4nucleoside diphosphate kinase 6NDP kinase 6inhibitor of p53-induced apoptosis-alphanon-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
Modification date2020031320200313
UniProtAcc

Q9Y4K4

O75414

Ensembl transtripts involved in fusion geneENST idsENST00000360240, ENST00000383737, 
ENST00000395734, ENST00000426837, 
ENST00000434267, ENST00000439356, 
ENST00000264724, ENST00000420772, 
ENST00000441748, ENST00000462206, 
ENST00000435684, ENST00000447314, 
ENST00000451657, ENST00000415053, 
ENST00000415644, ENST00000442597, 
ENST00000444069, ENST00000452211, 
ENST00000421967, ENST00000426689, 
ENST00000426723, ENST00000450160, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score43 X 31 X 16=213282 X 3 X 3=18
# samples 613
** MAII scorelog2(61/21328*10)=-5.12779563263872
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAP4 [Title/Abstract] AND NME6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP4(48019355)-NME6(48338319), # samples:3
Anticipated loss of major functional domain due to fusion event.MAP4-NME6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4-NME6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4-NME6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MAP4-NME6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAP4-NME6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNME6

GO:0030308

negative regulation of cell growth

10618642

TgeneNME6

GO:0045839

negative regulation of mitotic nuclear division

10618642


check buttonFusion gene breakpoints across MAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NME6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA7Q-01AMAP4chr3

48130263

-NME6chr3

48342124

-
ChimerDB4TGCTTCGA-2G-AAH8-01AMAP4chr3

48019355

-NME6chr3

48338319

-
ChimerDB4TGCTTCGA-2G-AAH8MAP4chr3

48019355

-NME6chr3

48338319

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383737MAP4chr348019355-ENST00000421967NME6chr348338319-2662818340918192
ENST00000383737MAP4chr348019355-ENST00000426689NME6chr348338319-1929818340918192
ENST00000383737MAP4chr348019355-ENST00000452211NME6chr348338319-1843818340918192
ENST00000383737MAP4chr348019355-ENST00000450160NME6chr348338319-1785818340918192
ENST00000383737MAP4chr348019355-ENST00000426723NME6chr348338319-1624818340918192
ENST00000395734MAP4chr348019355-ENST00000421967NME6chr348338319-222237838478146
ENST00000395734MAP4chr348019355-ENST00000426689NME6chr348338319-148937838478146
ENST00000395734MAP4chr348019355-ENST00000452211NME6chr348338319-140337838478146
ENST00000395734MAP4chr348019355-ENST00000450160NME6chr348338319-134537838478146
ENST00000395734MAP4chr348019355-ENST00000426723NME6chr348338319-118437838478146
ENST00000426837MAP4chr348019355-ENST00000421967NME6chr348338319-227543140531163
ENST00000426837MAP4chr348019355-ENST00000426689NME6chr348338319-154243140531163
ENST00000426837MAP4chr348019355-ENST00000452211NME6chr348338319-145643140531163
ENST00000426837MAP4chr348019355-ENST00000450160NME6chr348338319-139843140531163
ENST00000426837MAP4chr348019355-ENST00000426723NME6chr348338319-123743140531163
ENST00000360240MAP4chr348019355-ENST00000421967NME6chr348338319-2655811333911192
ENST00000360240MAP4chr348019355-ENST00000426689NME6chr348338319-1922811333911192
ENST00000360240MAP4chr348019355-ENST00000452211NME6chr348338319-1836811333911192
ENST00000360240MAP4chr348019355-ENST00000450160NME6chr348338319-1778811333911192
ENST00000360240MAP4chr348019355-ENST00000426723NME6chr348338319-1617811333911192
ENST00000439356MAP4chr348019355-ENST00000421967NME6chr348338319-220736323463146
ENST00000439356MAP4chr348019355-ENST00000426689NME6chr348338319-147436323463146
ENST00000439356MAP4chr348019355-ENST00000452211NME6chr348338319-138836323463146
ENST00000439356MAP4chr348019355-ENST00000450160NME6chr348338319-133036323463146
ENST00000439356MAP4chr348019355-ENST00000426723NME6chr348338319-116936323463146

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383737ENST00000421967MAP4chr348019355-NME6chr348338319-0.054757290.94524264
ENST00000383737ENST00000426689MAP4chr348019355-NME6chr348338319-0.026158590.9738415
ENST00000383737ENST00000452211MAP4chr348019355-NME6chr348338319-0.018439320.9815607
ENST00000383737ENST00000450160MAP4chr348019355-NME6chr348338319-0.0040443460.9959557
ENST00000383737ENST00000426723MAP4chr348019355-NME6chr348338319-0.0012719260.9987281
ENST00000395734ENST00000421967MAP4chr348019355-NME6chr348338319-0.045785930.95421404
ENST00000395734ENST00000426689MAP4chr348019355-NME6chr348338319-0.0163743160.9836257
ENST00000395734ENST00000452211MAP4chr348019355-NME6chr348338319-0.0157805630.9842195
ENST00000395734ENST00000450160MAP4chr348019355-NME6chr348338319-0.0020415970.9979584
ENST00000395734ENST00000426723MAP4chr348019355-NME6chr348338319-0.0024192140.99758077
ENST00000426837ENST00000421967MAP4chr348019355-NME6chr348338319-0.0046647510.9953353
ENST00000426837ENST00000426689MAP4chr348019355-NME6chr348338319-0.0026787710.9973212
ENST00000426837ENST00000452211MAP4chr348019355-NME6chr348338319-0.0028925020.99710757
ENST00000426837ENST00000450160MAP4chr348019355-NME6chr348338319-0.002435020.99756503
ENST00000426837ENST00000426723MAP4chr348019355-NME6chr348338319-0.0027186180.9972813
ENST00000360240ENST00000421967MAP4chr348019355-NME6chr348338319-0.066685730.93331426
ENST00000360240ENST00000426689MAP4chr348019355-NME6chr348338319-0.02779110.97220886
ENST00000360240ENST00000452211MAP4chr348019355-NME6chr348338319-0.0197417620.9802582
ENST00000360240ENST00000450160MAP4chr348019355-NME6chr348338319-0.0029683420.9970317
ENST00000360240ENST00000426723MAP4chr348019355-NME6chr348338319-0.0018484470.9981515
ENST00000439356ENST00000421967MAP4chr348019355-NME6chr348338319-0.063018470.9369815
ENST00000439356ENST00000426689MAP4chr348019355-NME6chr348338319-0.026541020.973459
ENST00000439356ENST00000452211MAP4chr348019355-NME6chr348338319-0.0218506530.97814935
ENST00000439356ENST00000450160MAP4chr348019355-NME6chr348338319-0.003084070.99691594
ENST00000439356ENST00000426723MAP4chr348019355-NME6chr348338319-0.0041571220.9958429

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51445_51445_1_MAP4-NME6_MAP4_chr3_48019355_ENST00000360240_NME6_chr3_48338319_ENST00000421967_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_2_MAP4-NME6_MAP4_chr3_48019355_ENST00000360240_NME6_chr3_48338319_ENST00000426689_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_3_MAP4-NME6_MAP4_chr3_48019355_ENST00000360240_NME6_chr3_48338319_ENST00000426723_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_4_MAP4-NME6_MAP4_chr3_48019355_ENST00000360240_NME6_chr3_48338319_ENST00000450160_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_5_MAP4-NME6_MAP4_chr3_48019355_ENST00000360240_NME6_chr3_48338319_ENST00000452211_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_6_MAP4-NME6_MAP4_chr3_48019355_ENST00000383737_NME6_chr3_48338319_ENST00000421967_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_7_MAP4-NME6_MAP4_chr3_48019355_ENST00000383737_NME6_chr3_48338319_ENST00000426689_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_8_MAP4-NME6_MAP4_chr3_48019355_ENST00000383737_NME6_chr3_48338319_ENST00000426723_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_9_MAP4-NME6_MAP4_chr3_48019355_ENST00000383737_NME6_chr3_48338319_ENST00000450160_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_10_MAP4-NME6_MAP4_chr3_48019355_ENST00000383737_NME6_chr3_48338319_ENST00000452211_length(amino acids)=192AA_BP=159
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV

--------------------------------------------------------------

>51445_51445_11_MAP4-NME6_MAP4_chr3_48019355_ENST00000395734_NME6_chr3_48338319_ENST00000421967_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_12_MAP4-NME6_MAP4_chr3_48019355_ENST00000395734_NME6_chr3_48338319_ENST00000426689_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_13_MAP4-NME6_MAP4_chr3_48019355_ENST00000395734_NME6_chr3_48338319_ENST00000426723_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_14_MAP4-NME6_MAP4_chr3_48019355_ENST00000395734_NME6_chr3_48338319_ENST00000450160_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_15_MAP4-NME6_MAP4_chr3_48019355_ENST00000395734_NME6_chr3_48338319_ENST00000452211_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_16_MAP4-NME6_MAP4_chr3_48019355_ENST00000426837_NME6_chr3_48338319_ENST00000421967_length(amino acids)=163AA_BP=130
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_17_MAP4-NME6_MAP4_chr3_48019355_ENST00000426837_NME6_chr3_48338319_ENST00000426689_length(amino acids)=163AA_BP=130
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_18_MAP4-NME6_MAP4_chr3_48019355_ENST00000426837_NME6_chr3_48338319_ENST00000426723_length(amino acids)=163AA_BP=130
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_19_MAP4-NME6_MAP4_chr3_48019355_ENST00000426837_NME6_chr3_48338319_ENST00000450160_length(amino acids)=163AA_BP=130
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_20_MAP4-NME6_MAP4_chr3_48019355_ENST00000426837_NME6_chr3_48338319_ENST00000452211_length(amino acids)=163AA_BP=130
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_21_MAP4-NME6_MAP4_chr3_48019355_ENST00000439356_NME6_chr3_48338319_ENST00000421967_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_22_MAP4-NME6_MAP4_chr3_48019355_ENST00000439356_NME6_chr3_48338319_ENST00000426689_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_23_MAP4-NME6_MAP4_chr3_48019355_ENST00000439356_NME6_chr3_48338319_ENST00000426723_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_24_MAP4-NME6_MAP4_chr3_48019355_ENST00000439356_NME6_chr3_48338319_ENST00000450160_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

>51445_51445_25_MAP4-NME6_MAP4_chr3_48019355_ENST00000439356_NME6_chr3_48338319_ENST00000452211_length(amino acids)=146AA_BP=113
MPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48019355/chr3:48338319)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4

Q9Y4K4

NME6

O75414

FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}.FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319248_54597.333333333333331153.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318248_54597.333333333333331136.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34248_54597.33333333333333100.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34248_54597.33333333333333100.0RegionNote=17 X 14 AA tandem repeats
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-3191023_105397.333333333333331153.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-3191054_108597.333333333333331153.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319248_26197.333333333333331153.0RepeatNote=1
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319262_27597.333333333333331153.0RepeatNote=2
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319276_28997.333333333333331153.0RepeatNote=3
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319290_30397.333333333333331153.0RepeatNote=4
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319304_31797.333333333333331153.0RepeatNote=5
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319318_33197.333333333333331153.0RepeatNote=6
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319332_34597.333333333333331153.0RepeatNote=7
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319346_35197.333333333333331153.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319352_37797.333333333333331153.0RepeatNote=26 residues 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319378_40397.333333333333331153.0RepeatNote=26 residues 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319408_42197.333333333333331153.0RepeatNote=9
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319422_43397.333333333333331153.0RepeatNote=10
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319434_44797.333333333333331153.0RepeatNote=11
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319448_46197.333333333333331153.0RepeatNote=12
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319462_47597.333333333333331153.0RepeatNote=13
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319476_48997.333333333333331153.0RepeatNote=14
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319490_50397.333333333333331153.0RepeatNote=15
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319504_51797.333333333333331153.0RepeatNote=16
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319532_54597.333333333333331153.0RepeatNote=17
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319923_95397.333333333333331153.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000360240-319992_102297.333333333333331153.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-3181023_105397.333333333333331136.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-3181054_108597.333333333333331136.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318248_26197.333333333333331136.0RepeatNote=1
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318262_27597.333333333333331136.0RepeatNote=2
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318276_28997.333333333333331136.0RepeatNote=3
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318290_30397.333333333333331136.0RepeatNote=4
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318304_31797.333333333333331136.0RepeatNote=5
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318318_33197.333333333333331136.0RepeatNote=6
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318332_34597.333333333333331136.0RepeatNote=7
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318346_35197.333333333333331136.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318352_37797.333333333333331136.0RepeatNote=26 residues 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318378_40397.333333333333331136.0RepeatNote=26 residues 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318408_42197.333333333333331136.0RepeatNote=9
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318422_43397.333333333333331136.0RepeatNote=10
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318434_44797.333333333333331136.0RepeatNote=11
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318448_46197.333333333333331136.0RepeatNote=12
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318462_47597.333333333333331136.0RepeatNote=13
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318476_48997.333333333333331136.0RepeatNote=14
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318490_50397.333333333333331136.0RepeatNote=15
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318504_51797.333333333333331136.0RepeatNote=16
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318532_54597.333333333333331136.0RepeatNote=17
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318923_95397.333333333333331136.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000395734-318992_102297.333333333333331136.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-341023_105397.33333333333333100.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-341054_108597.33333333333333100.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34248_26197.33333333333333100.0RepeatNote=1
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34262_27597.33333333333333100.0RepeatNote=2
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34276_28997.33333333333333100.0RepeatNote=3
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34290_30397.33333333333333100.0RepeatNote=4
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34304_31797.33333333333333100.0RepeatNote=5
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34318_33197.33333333333333100.0RepeatNote=6
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34332_34597.33333333333333100.0RepeatNote=7
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34346_35197.33333333333333100.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34352_37797.33333333333333100.0RepeatNote=26 residues 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34378_40397.33333333333333100.0RepeatNote=26 residues 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34408_42197.33333333333333100.0RepeatNote=9
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34422_43397.33333333333333100.0RepeatNote=10
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34434_44797.33333333333333100.0RepeatNote=11
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34448_46197.33333333333333100.0RepeatNote=12
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34462_47597.33333333333333100.0RepeatNote=13
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34476_48997.33333333333333100.0RepeatNote=14
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34490_50397.33333333333333100.0RepeatNote=15
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34504_51797.33333333333333100.0RepeatNote=16
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34532_54597.33333333333333100.0RepeatNote=17
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34923_95397.33333333333333100.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000434267-34992_102297.33333333333333100.0RepeatNote=Tau/MAP 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-341023_105397.33333333333333100.0RepeatNote=Tau/MAP 3
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-341054_108597.33333333333333100.0RepeatNote=Tau/MAP 4
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34248_26197.33333333333333100.0RepeatNote=1
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34262_27597.33333333333333100.0RepeatNote=2
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34276_28997.33333333333333100.0RepeatNote=3
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34290_30397.33333333333333100.0RepeatNote=4
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34304_31797.33333333333333100.0RepeatNote=5
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34318_33197.33333333333333100.0RepeatNote=6
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34332_34597.33333333333333100.0RepeatNote=7
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34346_35197.33333333333333100.0RepeatNote=8%3B truncated
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34352_37797.33333333333333100.0RepeatNote=26 residues 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34378_40397.33333333333333100.0RepeatNote=26 residues 2
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34408_42197.33333333333333100.0RepeatNote=9
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34422_43397.33333333333333100.0RepeatNote=10
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34434_44797.33333333333333100.0RepeatNote=11
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34448_46197.33333333333333100.0RepeatNote=12
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34462_47597.33333333333333100.0RepeatNote=13
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34476_48997.33333333333333100.0RepeatNote=14
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34490_50397.33333333333333100.0RepeatNote=15
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34504_51797.33333333333333100.0RepeatNote=16
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34532_54597.33333333333333100.0RepeatNote=17
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34923_95397.33333333333333100.0RepeatNote=Tau/MAP 1
HgeneMAP4chr3:48019355chr3:48338319ENST00000439356-34992_102297.33333333333333100.0RepeatNote=Tau/MAP 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>237_MAP4_48019355_NME6_48338319_ranked_0.pdbMAP44801935548019355ENST00000426723NME6chr348338319-
MRRPSRGDEEAAASLRPAPPASSLAPGSSRRLLPPHGSSRRSPGSLLPQLRLGGGGQLQWCRMADLSLADALTEPSPDIEGEIKRDFIAT
LEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGCSSADSKQQVPDCTNERTTV
192


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MAP4_pLDDT.png
all structure
all structure
NME6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAP4
NME6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MAP4-NME6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAP4-NME6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource