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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAX-ACTN1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAX-ACTN1
	FusionPDB ID: 51935
	FusionGDB2.0 ID: 51935
		Hgene	Tgene
	Gene symbol	MAX	ACTN1
	Gene ID	4149	87
	Gene name	MYC associated factor X	actinin alpha 1
	Synonyms	bHLHd4	BDPLT15
	Cytomap	14q23.3	14q24.1\|14q22-q24
	Type of gene	protein-coding	protein-coding
	Description	protein maxclass D basic helix-loop-helix protein 4	alpha-actinin-1F-actin cross-linking proteinactinin 1 smooth musclealpha-actinin cytoskeletal isoformepididymis secretory sperm binding proteinnon-muscle alpha-actinin-1
	Modification date	20200313	20200327
	UniProtAcc	P61244	P12814
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000246163, ENST00000284165, ENST00000341653, ENST00000358402, ENST00000358664, ENST00000555667, ENST00000556443, ENST00000556979, ENST00000557746, ENST00000557277, ENST00000555419, ENST00000555932,	ENST00000376839, ENST00000538545, ENST00000554508, ENST00000193403, ENST00000394419, ENST00000438964,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 4 X 6=144	17 X 18 X 5=1530
	# samples	6	20
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1530*10)=-2.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAX [Title/Abstract] AND ACTN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAX(65560426)-ACTN1(69392389), # samples:3
Anticipated loss of major functional domain due to fusion event.	MAX-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAX-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAX-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAX-ACTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAX	GO:0000122	negative regulation of transcription by RNA polymerase II	8521822

Fusion gene breakpoints across MAX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-AB2O-01A	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-
ChimerDB4	SARC	TCGA-DX-AB2V-01A	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341653	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3509	219	48	2792	914
ENST00000341653	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3395	219	48	2858	936
ENST00000341653	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	2951	219	48	2777	909
ENST00000358402	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3599	309	165	2882	905
ENST00000358402	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3485	309	165	2948	927
ENST00000358402	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3041	309	165	2867	900
ENST00000284165	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3610	320	149	2893	914
ENST00000284165	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3496	320	149	2959	936
ENST00000284165	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3052	320	149	2878	909
ENST00000358664	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3592	302	131	2875	914
ENST00000358664	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3478	302	131	2941	936
ENST00000358664	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3034	302	131	2860	909
ENST00000556979	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3639	349	178	2922	914
ENST00000556979	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3525	349	178	2988	936
ENST00000556979	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3081	349	178	2907	909
ENST00000555667	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3612	322	178	2895	905
ENST00000555667	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3498	322	178	2961	927
ENST00000555667	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3054	322	178	2880	900
ENST00000557746	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3612	322	178	2895	905
ENST00000557746	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3498	322	178	2961	927
ENST00000557746	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3054	322	178	2880	900
ENST00000556443	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3612	322	178	2895	905
ENST00000556443	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3498	322	178	2961	927
ENST00000556443	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3054	322	178	2880	900
ENST00000246163	MAX	chr14	65560426	-	ENST00000193403	ACTN1	chr14	69392389	-	3631	341	170	2914	914
ENST00000246163	MAX	chr14	65560426	-	ENST00000394419	ACTN1	chr14	69392389	-	3517	341	170	2980	936
ENST00000246163	MAX	chr14	65560426	-	ENST00000438964	ACTN1	chr14	69392389	-	3073	341	170	2899	909

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341653	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006363981	0.993636
ENST00000341653	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006575983	0.99342406
ENST00000341653	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.008871456	0.99112856
ENST00000358402	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005968844	0.99403113
ENST00000358402	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006550793	0.9934493
ENST00000358402	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.01052047	0.9894796
ENST00000284165	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005731512	0.9942684
ENST00000284165	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006426751	0.99357325
ENST00000284165	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.010016983	0.98998296
ENST00000358664	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006100181	0.9938998
ENST00000358664	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006607059	0.9933929
ENST00000358664	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.009770183	0.9902298
ENST00000556979	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005352402	0.99464756
ENST00000556979	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006104496	0.9938955
ENST00000556979	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.009766401	0.99023354
ENST00000555667	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005757724	0.99424225
ENST00000555667	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006375026	0.9936249
ENST00000555667	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.010472733	0.98952734
ENST00000557746	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005757724	0.99424225
ENST00000557746	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006375026	0.9936249
ENST00000557746	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.010472733	0.98952734
ENST00000556443	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005757724	0.99424225
ENST00000556443	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006375026	0.9936249
ENST00000556443	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.010472733	0.98952734
ENST00000246163	ENST00000193403	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.005413469	0.99458647
ENST00000246163	ENST00000394419	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.006145095	0.9938548
ENST00000246163	ENST00000438964	MAX	chr14	65560426	-	ACTN1	chr14	69392389	-	0.009747972	0.990252

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51935_51935_1_MAX-ACTN1_MAX_chr14_65560426_ENST00000246163_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=914AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQG
EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD

--------------------------------------------------------------

>51935_51935_2_MAX-ACTN1_MAX_chr14_65560426_ENST00000246163_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=936AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK
KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ

--------------------------------------------------------------

>51935_51935_3_MAX-ACTN1_MAX_chr14_65560426_ENST00000246163_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=909AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFA
RIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFS

--------------------------------------------------------------

>51935_51935_4_MAX-ACTN1_MAX_chr14_65560426_ENST00000284165_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=914AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQG
EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD

--------------------------------------------------------------

>51935_51935_5_MAX-ACTN1_MAX_chr14_65560426_ENST00000284165_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=936AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK
KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ

--------------------------------------------------------------

>51935_51935_6_MAX-ACTN1_MAX_chr14_65560426_ENST00000284165_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=909AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFA
RIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFS

--------------------------------------------------------------

>51935_51935_7_MAX-ACTN1_MAX_chr14_65560426_ENST00000341653_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=914AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQG
EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD

--------------------------------------------------------------

>51935_51935_8_MAX-ACTN1_MAX_chr14_65560426_ENST00000341653_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=936AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK
KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ

--------------------------------------------------------------

>51935_51935_9_MAX-ACTN1_MAX_chr14_65560426_ENST00000341653_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=909AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFA
RIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFS

--------------------------------------------------------------

>51935_51935_10_MAX-ACTN1_MAX_chr14_65560426_ENST00000358402_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=905AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMS
IVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALY

--------------------------------------------------------------

>51935_51935_11_MAX-ACTN1_MAX_chr14_65560426_ENST00000358402_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=927AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDD
FRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMA

--------------------------------------------------------------

>51935_51935_12_MAX-ACTN1_MAX_chr14_65560426_ENST00000358402_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=900AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPN
RLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL

--------------------------------------------------------------

>51935_51935_13_MAX-ACTN1_MAX_chr14_65560426_ENST00000358664_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=914AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQG
EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD

--------------------------------------------------------------

>51935_51935_14_MAX-ACTN1_MAX_chr14_65560426_ENST00000358664_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=936AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK
KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ

--------------------------------------------------------------

>51935_51935_15_MAX-ACTN1_MAX_chr14_65560426_ENST00000358664_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=909AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFA
RIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFS

--------------------------------------------------------------

>51935_51935_16_MAX-ACTN1_MAX_chr14_65560426_ENST00000555667_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=905AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMS
IVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALY

--------------------------------------------------------------

>51935_51935_17_MAX-ACTN1_MAX_chr14_65560426_ENST00000555667_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=927AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDD
FRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMA

--------------------------------------------------------------

>51935_51935_18_MAX-ACTN1_MAX_chr14_65560426_ENST00000555667_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=900AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPN
RLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL

--------------------------------------------------------------

>51935_51935_19_MAX-ACTN1_MAX_chr14_65560426_ENST00000556443_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=905AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMS
IVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALY

--------------------------------------------------------------

>51935_51935_20_MAX-ACTN1_MAX_chr14_65560426_ENST00000556443_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=927AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDD
FRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMA

--------------------------------------------------------------

>51935_51935_21_MAX-ACTN1_MAX_chr14_65560426_ENST00000556443_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=900AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPN
RLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL

--------------------------------------------------------------

>51935_51935_22_MAX-ACTN1_MAX_chr14_65560426_ENST00000556979_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=914AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQG
EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALD

--------------------------------------------------------------

>51935_51935_23_MAX-ACTN1_MAX_chr14_65560426_ENST00000556979_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=936AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK
KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ

--------------------------------------------------------------

>51935_51935_24_MAX-ACTN1_MAX_chr14_65560426_ENST00000556979_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=909AA_BP=57
MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL
LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT
APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA
FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF
NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS
EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA
APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR
QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA
LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFA
RIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFS

--------------------------------------------------------------

>51935_51935_25_MAX-ACTN1_MAX_chr14_65560426_ENST00000557746_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=905AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMS
IVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALY

--------------------------------------------------------------

>51935_51935_26_MAX-ACTN1_MAX_chr14_65560426_ENST00000557746_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=927AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDD
FRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMA

--------------------------------------------------------------

>51935_51935_27_MAX-ACTN1_MAX_chr14_65560426_ENST00000557746_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=900AA_BP=48
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERL
AKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQ
NFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAET
AANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRL
SNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKH
EAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEG
AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA
LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTN
YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPN
RLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:65560426/chr14:69392389)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAX P61244	ACTN1 P12814
FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269\|PubMed:26070438}.	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

759_770

35.0

893.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

800_811

35.0

893.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

759_770

35.0

915.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

800_811

35.0

915.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

759_770

35.0

888.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

800_811

35.0

888.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

759_770

35.0

931.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

800_811

35.0

931.0

Calcium binding

Ontology_term=ECO:0000255

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

144_250

35.0

893.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

746_781

35.0

893.0

Domain

EF-hand 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

787_822

35.0

893.0

Domain

EF-hand 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

144_250

35.0

915.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

746_781

35.0

915.0

Domain

EF-hand 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

787_822

35.0

915.0

Domain

EF-hand 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

144_250

35.0

888.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

746_781

35.0

888.0

Domain

EF-hand 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

787_822

35.0

888.0

Domain

EF-hand 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

144_250

35.0

931.0

Domain

Calponin-homology (CH) 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

746_781

35.0

931.0

Domain

EF-hand 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

787_822

35.0

931.0

Domain

EF-hand 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

274_384

35.0

893.0

Repeat

Note=Spectrin 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

394_499

35.0

893.0

Repeat

Note=Spectrin 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

509_620

35.0

893.0

Repeat

Note=Spectrin 3

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

630_733

35.0

893.0

Repeat

Note=Spectrin 4

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

274_384

35.0

915.0

Repeat

Note=Spectrin 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

394_499

35.0

915.0

Repeat

Note=Spectrin 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

509_620

35.0

915.0

Repeat

Note=Spectrin 3

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

630_733

35.0

915.0

Repeat

Note=Spectrin 4

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

274_384

35.0

888.0

Repeat

Note=Spectrin 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

394_499

35.0

888.0

Repeat

Note=Spectrin 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

509_620

35.0

888.0

Repeat

Note=Spectrin 3

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

630_733

35.0

888.0

Repeat

Note=Spectrin 4

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

274_384

35.0

931.0

Repeat

Note=Spectrin 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

394_499

35.0

931.0

Repeat

Note=Spectrin 2

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

509_620

35.0

931.0

Repeat

Note=Spectrin 3

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

630_733

35.0

931.0

Repeat

Note=Spectrin 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000246163

23_74

57.0

97.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000284165

23_74

57.0

135.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000341653

23_74

57.0

84.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358402

23_74

48.0

152.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358664

23_74

57.0

161.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000556979

23_74

57.0

104.0

Domain

bHLH

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000246163

152_156

57.0

97.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000284165

152_156

57.0

135.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000341653

152_156

57.0

84.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358402

152_156

48.0

152.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358664

152_156

57.0

161.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000556979

152_156

57.0

104.0

Motif

Note=Nuclear localization signal

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000246163

81_102

57.0

97.0

Region

Note=Leucine-zipper

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000284165

81_102

57.0

135.0

Region

Note=Leucine-zipper

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000341653

81_102

57.0

84.0

Region

Note=Leucine-zipper

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358402

81_102

48.0

152.0

Region

Note=Leucine-zipper

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000358664

81_102

57.0

161.0

Region

Note=Leucine-zipper

Hgene

MAX

chr14:65560426

chr14:69392389

ENST00000556979

81_102

57.0

104.0

Region

Note=Leucine-zipper

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

31_135

35.0

893.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

31_135

35.0

915.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

31_135

35.0

888.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

31_135

35.0

931.0

Domain

Calponin-homology (CH) 1

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000193403

1_247

35.0

893.0

Region

Note=Actin-binding

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000394419

1_247

35.0

915.0

Region

Note=Actin-binding

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000438964

1_247

35.0

888.0

Region

Note=Actin-binding

Tgene

ACTN1

chr14:65560426

chr14:69392389

ENST00000538545

1_247

35.0

931.0

Region

Note=Actin-binding

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1728_MAX_65560426_ACTN1_69392389_ranked_0.pdb	MAX	65560426	65560426	ENST00000438964	ACTN1	chr14	69392389	-	MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLL LEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKT APYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHA FSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINF NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLS EIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVR QLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEA LIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQK KTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ	936

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAX_pLDDT.png

ACTN1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAX
ACTN1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAX-ACTN1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAX-ACTN1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source