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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AP2A2-PSMD13

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AP2A2-PSMD13
FusionPDB ID: 5230
FusionGDB2.0 ID: 5230
HgeneTgene
Gene symbol

AP2A2

PSMD13

Gene ID

161

5719

Gene nameadaptor related protein complex 2 subunit alpha 2proteasome 26S subunit, non-ATPase 13
SynonymsADTAB|CLAPA2|HIP-9|HIP9|HYPJHSPC027|Rpn9|S11|p40.5
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin as26S proteasome non-ATPase regulatory subunit 1326S proteasome regulatory subunit RPN926S proteasome regulatory subunit S1126S proteasome regulatory subunit p40.526S proteasome subunit p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
Modification date2020031320200313
UniProtAcc

O94973

.
Ensembl transtripts involved in fusion geneENST idsENST00000332231, ENST00000448903, 
ENST00000534328, ENST00000525891, 
ENST00000532025, ENST00000352303, 
ENST00000532097, ENST00000431206, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 12=15608 X 11 X 5=440
# samples 229
** MAII scorelog2(22/1560*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/440*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AP2A2 [Title/Abstract] AND PSMD13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AP2A2(977224)-PSMD13(252505), # samples:3
Anticipated loss of major functional domain due to fusion event.AP2A2-PSMD13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AP2A2-PSMD13 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2A2

GO:0072583

clathrin-dependent endocytosis

23676497


check buttonFusion gene breakpoints across AP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2758-01AAP2A2chr11

977224

-PSMD13chr11

252505

+
ChimerDB4LUSCTCGA-66-2758-01AAP2A2chr11

977224

+PSMD13chr11

252505

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

251545

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

251546

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

251819

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

251820

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

252504

+
ChimerDB4LUSCTCGA-66-2758AP2A2chr11

977224

+PSMD13chr11

252505

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11252505+1222745142840232
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11252505+1221744141839232
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11252505+1221744141839232
ENST00000534328AP2A2chr11977224+ENST00000532097PSMD13chr11251545+13957451421038298
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11251545+14207451421038298
ENST00000332231AP2A2chr11977224+ENST00000532097PSMD13chr11251545+13947441411037298
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11251545+14197441411037298
ENST00000448903AP2A2chr11977224+ENST00000532097PSMD13chr11251545+13947441411037298
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11251545+14197441411037298
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11252504+1222745142840232
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11252504+1221744141839232
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11252504+1221744141839232
ENST00000534328AP2A2chr11977224+ENST00000532097PSMD13chr11251819+1314745142957271
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11251819+1339745142957271
ENST00000534328AP2A2chr11977224+ENST00000352303PSMD13chr11251819+1311745142957271
ENST00000332231AP2A2chr11977224+ENST00000532097PSMD13chr11251819+1313744141956271
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11251819+1338744141956271
ENST00000332231AP2A2chr11977224+ENST00000352303PSMD13chr11251819+1310744141956271
ENST00000448903AP2A2chr11977224+ENST00000532097PSMD13chr11251819+1313744141956271
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11251819+1338744141956271
ENST00000448903AP2A2chr11977224+ENST00000352303PSMD13chr11251819+1310744141956271
ENST00000534328AP2A2chr11977224+ENST00000532097PSMD13chr11251546+13957451421038298
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11251546+14207451421038298
ENST00000332231AP2A2chr11977224+ENST00000532097PSMD13chr11251546+13947441411037298
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11251546+14197441411037298
ENST00000448903AP2A2chr11977224+ENST00000532097PSMD13chr11251546+13947441411037298
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11251546+14197441411037298
ENST00000534328AP2A2chr11977224+ENST00000532097PSMD13chr11251820+1314745142957271
ENST00000534328AP2A2chr11977224+ENST00000431206PSMD13chr11251820+1339745142957271
ENST00000534328AP2A2chr11977224+ENST00000352303PSMD13chr11251820+1311745142957271
ENST00000332231AP2A2chr11977224+ENST00000532097PSMD13chr11251820+1313744141956271
ENST00000332231AP2A2chr11977224+ENST00000431206PSMD13chr11251820+1338744141956271
ENST00000332231AP2A2chr11977224+ENST00000352303PSMD13chr11251820+1310744141956271
ENST00000448903AP2A2chr11977224+ENST00000532097PSMD13chr11251820+1313744141956271
ENST00000448903AP2A2chr11977224+ENST00000431206PSMD13chr11251820+1338744141956271
ENST00000448903AP2A2chr11977224+ENST00000352303PSMD13chr11251820+1310744141956271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11252505+0.0016074910.9983925
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11252505+0.00154310.99845695
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11252505+0.00154310.99845695
ENST00000534328ENST00000532097AP2A2chr11977224+PSMD13chr11251545+0.0018545620.99814546
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11251545+0.0020083240.9979917
ENST00000332231ENST00000532097AP2A2chr11977224+PSMD13chr11251545+0.0017904260.9982096
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11251545+0.0019369420.998063
ENST00000448903ENST00000532097AP2A2chr11977224+PSMD13chr11251545+0.0017904260.9982096
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11251545+0.0019369420.998063
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11252504+0.0016074910.9983925
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11252504+0.00154310.99845695
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11252504+0.00154310.99845695
ENST00000534328ENST00000532097AP2A2chr11977224+PSMD13chr11251819+0.0018376050.99816245
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11251819+0.0019454610.9980545
ENST00000534328ENST00000352303AP2A2chr11977224+PSMD13chr11251819+0.0018294070.9981706
ENST00000332231ENST00000532097AP2A2chr11977224+PSMD13chr11251819+0.0017390690.9982609
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11251819+0.0018446190.9981554
ENST00000332231ENST00000352303AP2A2chr11977224+PSMD13chr11251819+0.0017314930.9982685
ENST00000448903ENST00000532097AP2A2chr11977224+PSMD13chr11251819+0.0017390690.9982609
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11251819+0.0018446190.9981554
ENST00000448903ENST00000352303AP2A2chr11977224+PSMD13chr11251819+0.0017314930.9982685
ENST00000534328ENST00000532097AP2A2chr11977224+PSMD13chr11251546+0.0018545620.99814546
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11251546+0.0020083240.9979917
ENST00000332231ENST00000532097AP2A2chr11977224+PSMD13chr11251546+0.0017904260.9982096
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11251546+0.0019369420.998063
ENST00000448903ENST00000532097AP2A2chr11977224+PSMD13chr11251546+0.0017904260.9982096
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11251546+0.0019369420.998063
ENST00000534328ENST00000532097AP2A2chr11977224+PSMD13chr11251820+0.0018376050.99816245
ENST00000534328ENST00000431206AP2A2chr11977224+PSMD13chr11251820+0.0019454610.9980545
ENST00000534328ENST00000352303AP2A2chr11977224+PSMD13chr11251820+0.0018294070.9981706
ENST00000332231ENST00000532097AP2A2chr11977224+PSMD13chr11251820+0.0017390690.9982609
ENST00000332231ENST00000431206AP2A2chr11977224+PSMD13chr11251820+0.0018446190.9981554
ENST00000332231ENST00000352303AP2A2chr11977224+PSMD13chr11251820+0.0017314930.9982685
ENST00000448903ENST00000532097AP2A2chr11977224+PSMD13chr11251820+0.0017390690.9982609
ENST00000448903ENST00000431206AP2A2chr11977224+PSMD13chr11251820+0.0018446190.9981554
ENST00000448903ENST00000352303AP2A2chr11977224+PSMD13chr11251820+0.0017314930.9982685

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5230_5230_1_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251545_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_2_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251545_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_3_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251546_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_4_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251546_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_5_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251819_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_6_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251819_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_7_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251819_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_8_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251820_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_9_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251820_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_10_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_251820_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_11_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_252504_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

>5230_5230_12_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000332231_PSMD13_chr11_252505_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

>5230_5230_13_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251545_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_14_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251545_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_15_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251546_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_16_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251546_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_17_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251819_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_18_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251819_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_19_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251819_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_20_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251820_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_21_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251820_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_22_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_251820_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_23_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_252504_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

>5230_5230_24_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000448903_PSMD13_chr11_252505_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

>5230_5230_25_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251545_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_26_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251545_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_27_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251546_ENST00000431206_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_28_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251546_ENST00000532097_length(amino acids)=298AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKG

--------------------------------------------------------------

>5230_5230_29_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251819_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_30_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251819_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_31_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251819_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_32_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251820_ENST00000352303_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_33_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251820_ENST00000431206_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_34_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_251820_ENST00000532097_length(amino acids)=271AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDIL

--------------------------------------------------------------

>5230_5230_35_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_252504_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

>5230_5230_36_AP2A2-PSMD13_AP2A2_chr11_977224_ENST00000534328_PSMD13_chr11_252505_ENST00000431206_length(amino acids)=232AA_BP=169
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:977224/chr11:252505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP2A2

O94973

.
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:977224chr11:251545ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251545ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251545ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251545ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251545ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251545ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251546ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251546ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251546ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251546ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251546ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251546ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251819ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251819ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251819ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251819ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251819ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251819ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251820ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251820ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251820ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:251820ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251820ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:251820ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:252504ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252504ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252504ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:252504ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252504ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252504ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:252505ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252505ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252505ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:252505ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252505ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:252505ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePSMD13chr11:977224chr11:251545ENST00000431206711171_338281.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:251545ENST00000532097913171_338279.0377.0DomainPCI
TgenePSMD13chr11:977224chr11:251546ENST00000431206711171_338281.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:251546ENST00000532097913171_338279.0377.0DomainPCI
TgenePSMD13chr11:977224chr11:251819ENST00000431206811171_338308.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:251819ENST000005320971013171_338306.0377.0DomainPCI
TgenePSMD13chr11:977224chr11:251820ENST00000431206811171_338308.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:251820ENST000005320971013171_338306.0377.0DomainPCI
TgenePSMD13chr11:977224chr11:252504ENST00000431206911171_338347.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:252504ENST000005320971113171_338345.0377.0DomainPCI
TgenePSMD13chr11:977224chr11:252505ENST00000431206911171_338347.0379.0DomainPCI
TgenePSMD13chr11:977224chr11:252505ENST000005320971113171_338345.0377.0DomainPCI


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>356_AP2A2_977224_PSMD13_252505_ranked_0.pdbAP2A2977224977224ENST00000352303PSMD13chr11252505+
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
232


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
AP2A2_pLDDT.png
all structure
all structure
PSMD13_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AP2A2
PSMD13


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AP2A2-PSMD13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AP2A2-PSMD13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource