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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MECOM-RPN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MECOM-RPN1
FusionPDB ID: 52515
FusionGDB2.0 ID: 52515
HgeneTgene
Gene symbol

MECOM

RPN1

Gene ID

2122

6184

Gene nameMDS1 and EVI1 complex locusribophorin I
SynonymsAML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2OST1|RBPH1
Cytomap

3q26.2

3q21.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1RPN-Idolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunitoligosaccharyltransferase 1 homologoligosaccharyltransferase complex subunit (non-catalytic)ribop
Modification date2020031320200327
UniProtAcc

Q03112

P04843

Ensembl transtripts involved in fusion geneENST idsENST00000494292, ENST00000485957, 
ENST00000264674, ENST00000392736, 
ENST00000433243, ENST00000460814, 
ENST00000464456, ENST00000468789, 
ENST00000472280, 		ENST00000497289, 
ENST00000490166, ENST00000296255, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 21 X 11=762311 X 7 X 7=539
# samples 4311
** MAII scorelog2(43/7623*10)=-4.14795031118505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MECOM [Title/Abstract] AND RPN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MECOM(169381124)-RPN1(128363826), # samples:4
RPN1(128369493)-MECOM(168849291), # samples:1
RPN1(128369383)-MECOM(168849321), # samples:1
Anticipated loss of major functional domain due to fusion event.MECOM-RPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-RPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

HgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

HgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across MECOM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2944-03AMECOMchr3

169381124

-RPN1chr3

128363826

-
ChimerDB4LAMLTCGA-AB-2944_703RKAAXX_7MECOMchr3

169381124

-RPN1chr3

128363826

-
ChimerDB4LAMLTCGA-AB-2944_7046WAAXX_2MECOMchr3

169381124

-RPN1chr3

128363826

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000494292MECOMchr3169381124-ENST00000296255RPN1chr3128363826-21351351651697510

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000494292ENST00000296255MECOMchr3169381124-RPN1chr3128363826-0.0008107280.9991893

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52515_52515_1_MECOM-RPN1_MECOM_chr3_169381124_ENST00000494292_RPN1_chr3_128363826_ENST00000296255_length(amino acids)=510AA_BP=
MEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTK
LGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSI
RSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDS
LTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYV
RLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169381124/chr3:128363826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MECOM

Q03112

RPN1

P04843

FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:E2RQ08, ECO:0000269|PubMed:31831667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPN1chr3:169381124chr3:128363826ENST00000296255010458_60787.0608.0Topological domainCytoplasmic
TgeneRPN1chr3:169381124chr3:128363826ENST00000296255010439_45787.0608.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-1171065_111601117.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-1171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-1151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-1161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-1161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-11778_19001117.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-11678_19001052.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-11778_19001053.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-11578_19001043.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-11678_19001052.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-11678_19001053.0DomainSET
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117609_62201117.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117741_74501117.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117772_77601117.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115609_62201043.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115741_74501043.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115772_77601043.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116609_62201052.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116741_74501052.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116772_77601052.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116609_62201053.0MotifNuclear localization signal
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116741_74501053.0MotifCTBP-binding motif 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116772_77601053.0MotifCTBP-binding motif 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117209_23601117.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117263_28501117.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117291_31301117.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117319_34201117.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117348_37001117.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117376_39801117.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117405_42701117.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117912_93401117.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117940_96301117.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117969_99101117.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117969_99101053.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115209_23601043.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115263_28501043.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115291_31301043.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115319_34201043.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115348_37001043.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115376_39801043.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115405_42701043.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115912_93401043.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115940_96301043.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115969_99101043.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116209_23601052.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116263_28501052.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116291_31301052.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116319_34201052.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116348_37001052.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116376_39801052.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116405_42701052.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116912_93401052.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116940_96301052.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116969_99101052.0Zinc fingerC2H2-type 10
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116209_23601053.0Zinc fingerC2H2-type 1
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116263_28501053.0Zinc fingerC2H2-type 2
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116291_31301053.0Zinc fingerC2H2-type 3
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116319_34201053.0Zinc fingerC2H2-type 4
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116348_37001053.0Zinc fingerC2H2-type 5
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116376_39801053.0Zinc fingerC2H2-type 6
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116405_42701053.0Zinc fingerC2H2-type 7%3B atypical
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116912_93401053.0Zinc fingerC2H2-type 8
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116940_96301053.0Zinc fingerC2H2-type 9
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116969_99101053.0Zinc fingerC2H2-type 10
TgeneRPN1chr3:169381124chr3:128363826ENST0000029625501024_43887.0608.0Topological domainLumenal


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1085_MECOM_169381124_RPN1_128363826_1085_MECOM_169381124_RPN1_128363826_ranked_0.pdbMECOM169381124169381124ENST00000296255RPN1chr3128363826-
MEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTK
LGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSI
RSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDS
LTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYV
RLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDR
510


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MECOM_pLDDT.png
all structure
all structure
RPN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RPN1GSTK1, USP49, SLX4IP, ERBB3, FOXRED2, SEL1L, RNF185, MYC, HDAC5, INSIG2, CDK9, NELFB, ELAVL1, OS9, FBXO25, CUL3, COPS5, UBQLN4, NHS, HSPA5, FBXO6, STT3B, RPN2, SSR3, RPSA, TECR, ILF3, SLC25A5, VDAC2, SYNCRIP, SND1, ESR1, ECT2, VCP, FN1, VCAM1, ATF2, UBL4A, env, MMS19, OST4, CLN3, CLN5, ADRB2, EGFR, ASB5, ASB11, LGR4, STAU1, SGTA, UBQLN1, EED, RNF2, BMI1, UBC, ILK, SCCPDH, RPS6KB2, ATP5C1, CANX, CCDC47, CLGN, CYC1, IDH3A, COX2, NDUFA12, NDUFB8, PC, PPIB, RAB2A, RPL35, ABCB7, ACADM, AFG3L2, ATAD3A, ATAD3B, ATP1A1, ATP5A1, ATP5L, ATP6V0D1, ATP6V1A, BCAP29, CCT3, CCT6A, CCT7, CCT8, CDC5L, CLTC, DDOST, DDX39A, DDX39B, EIF2S1, EIF3M, HNRNPU, HSD17B12, HSP90B1, IPO5, IPO9, KDSR, MTCH1, MTCH2, NDUFB9, NOMO1, NOMO2, PDIA6, PKM, PPP2R1A, PPP2R1B, PRPF19, PSMC1, PSMC2, PSMC3, PSMC5, RAB1A, RAB1B, RAB5A, RAB5B, RAB5C, RDH13, SCAMP2, SLC25A3, SSR2, SUCLG2, TCP1, TMCO1, UQCRC2, VDAC1, VDAC3, SSR1, SSR4, TUFM, NTRK1, SCARNA22, BAG6, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, TUBG1, TMEM63B, TUBA1C, Tmed2, Sacm1l, CRY2, MCM2, U2AF2, RC3H1, TMEM258, CDC73, DERL1, ZNF746, NCDN, COX15, DLST, PDHA1, SDHA, EDEM3, CFTR, MLEC, ZNF598, FBXO7, EGLN3, POLD1, SLC25A1, TMPO, PTPLA, PPEF1, PTPN5, TPTE, PHOSPHO1, PTPN23, PTCH1, FGFR1, HSPA8, CSNK1A1, TGFB1, UBE2M, RAD18, EFTUD2, AAR2, TNIP2, RNF4, CHD3, CHD4, SMARCB1, HEXIM1, MEPCE, TRIM11, RNF123, PPT1, SENP2, SNAI1, AGR2, WWOX, RECQL4, TXNIP, LAMP1, GRWD1, METTL14, KIAA1429, ATG16L1, PHB, TMEM41B, NR2C2, UCHL3, UBQLN2, HDAC2, CTCF, PRDM16, MECOM, AGRN, ATXN3, CYB5R3, GBAS, MGST1, CYB5A, TOMM40, CPT1A, HADHB, TOMM22, TOMM5, HIST1H4A, PSMD14, IFITM3, P2RY6, SLC15A3, UNC93B1, CA9, ITFG1, BIRC3, LMBR1L, NFX1, BRD7, FAM105A, CALR3, TEX101, CAMLG, KRTAP1-3, OBSL1, PLEKHA4, KCTD10, PINK1, YAP1, TFCP2, FANCD2, ZC3H18, CAV2, EMC1, EMC2, MMGT1, PPP1R12A, POLR3C, URAD, TDRD12, GCC2, KIAA1407, PANX2, PBX4, NTNG1, STT3A, PDIA5, ANKS1A, LMBRD1, STAB1, UTS2B, ANKRD55, E, M, nsp13, nsp4, nsp5, nsp6, ORF14, ORF3a, ORF6, ORF7a, ORF7b, ORF8, S, MAU2, ST7, NEK4, DUX4, CIT, ANLN, CHMP4C, KIF14, KIF23, PRC1, ARHGAP9, ARHGAP11B, ARHGAP36, DOCK8, PLEKHG4, ARHGAP27, Arhgap30, ARHGAP39, FAM13B, Ophn1, TIAM1, FKBP8, PTPN1, RHOT2, RMDN3, SLC25A46, ABCA3, ANO10, ANO6, APP, BET1, CLCN7, CLPTM1L, DHRS1, DNAJC16, ERGIC3, FRAS1, FZD6, HMGCR, ITPR2, LMF2, NBAS, NETO2, PIGU, RPN1, SLC30A9, SLC4A2, SLC9A1, SOAT1, SURF4, TMEM109, TMEM173, TRPM7, UBE2J1, WFS1, SIN3B, TOX4, JMJD1C, RPL23A, DNAJB12, LSR, Rnf183, C18orf8, CIC, Apc2, RBM39, FBP1, GRB7, USP10, FAM20C, RIN3, DNAJC22, DNAJC25, SEC63, DNAJC19, DNAJC30, DNAJB11, DNAJC10, DNAJC3, KDF1, BAG5, PARK2, UFL1, DDRGK1, TP53, AKAP1, ARF6, ATP2A1, B3GAT1, BCAP31, CALU, CD3EAP, CKAP4, COIL, CYP2C9, DHFRL1, EMD, ERGIC1, GJD3, HSD17B11, HSD3B7, KRAS, LAMP2, LAMP3, LMAN1, LMNB1, KIAA1715, LRRC59, MARCKS, METTL7A, NOP56, PDIA4, PEX3, PXMP2, RAB35, RAB9A, AAAS, ABCC1, ABHD12, ACBD3, ACBD5, ACSL3, ADCY9, AGPAT1, ALDH3A2, ALG9, ANKLE2, APOL2, ARF1, ARF5, ARHGAP1, ARL6IP5, ATAD1, ATF6, ATL1, ATP13A1, ATP2B1, ATP6AP2, AUP1, BRI3BP, BTN3A3, C16orf58, C2CD2L, CCPG1, CDK5RAP3, CDKAL1, CERS1, CERS6, CHML, CHMP7, CISD2, CLCC1, CLPTM1, CPD, CYB5B, DDX54, DHCR7, DHRS7, DNAJB14, DNAJC1, DOLPP1, DPY19L1, DSC2, EBP, EI24, EIF2AK3, ELOVL2, EMC7, EMC8, ESYT1, FADS2, FAF2, FDFT1, FNDC3A, GGT7, GJA1, GLUD2, GORASP2, AGPAT9, AGPAT6, GPR89A, GRAMD1A, HERPUD1, HIST1H2BD, HIST1H3F, HLA-C, HM13, HMOX2, HSPA1B, ICMT, IGF2R, IKBIP, INF2, ITGB1, ITM2C, ITPR1, ITPR3, JAG2, JAGN1, JPH1, KCNB2, KTN1, LBR, LEMD3, LMBR1, LMNA, LMNB2, LPCAT1, LRIG2, LRRC8D, TMEM57, MAGT1, MBOAT2, MBOAT7, MFSD10, MIA3, MOSPD2, MTDH, MXRA7, NDC1, NOTCH2, NPC1, NSDHL, NUP107, NUP160, NUP210, OCLN, OSBPL8, PBXIP1, PDE3B, PDZD8, PGRMC1, PGRMC2, PIGB, PIGK, PIGO, PIGT, PIGW, PKMYT1, PLD3, PLXNB2, POR, PRAF2, PREB, PTDSS1, PTPN2, RAB3GAP1, RAB3GAP2, RAB7A, RABL3, REEP4, FAM134B, RFT1, RRBP1, SCD, SCD5, SEC16A, SEC22B, SEC62, SLC12A2, SLC27A4, SLC29A1, SLC33A1, SLC38A2, SLC39A10, SLC39A7, SLC3A2, SLC41A3, SLC4A7, SLC6A15, SLC6A6, SLC6A8, SLC7A1, SMPD4, SNAP47, SNX19, SPCS2, SRPR, SRPRB, STBD1, STEAP3, STIM1, STIM2, STX18, STX5, SUCO, SUN1, SUN2, SV2A, SYNE2, SYVN1, TACC1, TAPT1, TEX264, TLCD2, TM9SF3, TMEM106C, TMEM131, KIAA0922, TMEM161A, TMEM199, TMEM201, TMEM209, TMEM214, TMEM230, TMEM245, ZMYM6NB, TMEM38B, TMEM39A, TMEM87A, TMEM9, TMEM97, TMX1, TMX4, TOR1AIP1, TOR1AIP2, TP53I11, TRIM13, TRPM4, TYW1, UBAC2, UBB, UBIAD1, UBXN4, UBXN8, UGT8, USE1, USP33, VANGL1, VANGL2, VAPA, VAPB, VEZT, VKORC1L1, VMP1, VPS13A, VRK2, WDR41, WLS, YIF1A, YKT6, ZC3HAV1, ZMPSTE24, CERS2, COPA, ESYT2, PTPLAD1, HLA-A, LSG1, NOC2L, NUBP2, PDCL, PSMC4, REEP5, RHBDD2, RTN3, RTN4, SEC61B, SLC7A5, SRBD1, SYAP1, TEX2, TMEM33, ZW10, SYNE3, TRIM37, USP11, VTCN1, WDR5, PAGE4, BGLT3, EDEM1, ZBTB2, EFNB2, ICAM2, LRRC32, SPRTN, EP300, RBFOX2, Htatsf1, TMPRSS2, TFRC, CTSL, CTSB, FURIN, ANPEP, CTSS, DPP4, BSG, TMPRSS11B, CLEC4D, ACE2, CLEC4E, N, nsp14, nsp16, nsp7, nsp3, ORF10, RCHY1, TMEM106B, CALCOCO2, CNR2, NR3C1, KLF16, RB1CC1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MECOMall structure
RPN1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMECOMchr3:169381124chr3:128363826ENST00000264674-117189_44001117.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:128363826ENST00000392736-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:128363826ENST00000433243-117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:128363826ENST00000464456-115189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:128363826ENST00000468789-116189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
HgeneMECOMchr3:169381124chr3:128363826ENST00000472280-116189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1


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Related Drugs to MECOM-RPN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MECOM-RPN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 23GENOMICS_ENGLAND;UNIPROT
HgeneMECOMC0006142Malignant neoplasm of breast1CTD_human
HgeneMECOMC0007102Malignant tumor of colon1CTD_human
HgeneMECOMC0009375Colonic Neoplasms1CTD_human
HgeneMECOMC0023448Lymphoid leukemia1CTD_human
HgeneMECOMC0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneMECOMC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneMECOMC0023470Myeloid Leukemia1CTD_human
HgeneMECOMC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneMECOMC0027022Myeloproliferative disease1CTD_human
HgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMECOMC0030312Pancytopenia1CTD_human
HgeneMECOMC0038002Splenomegaly1CTD_human
HgeneMECOMC0238301Cancer of Nasopharynx1CTD_human
HgeneMECOMC0678222Breast Carcinoma1CTD_human
HgeneMECOMC0919267ovarian neoplasm1CTD_human
HgeneMECOMC1140680Malignant neoplasm of ovary1CTD_human
HgeneMECOMC1257931Mammary Neoplasms, Human1CTD_human
HgeneMECOMC1458155Mammary Neoplasms1CTD_human
HgeneMECOMC1854273Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia1GENOMICS_ENGLAND;ORPHANET
HgeneMECOMC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneMECOMC2931456Prostate cancer, familial1CTD_human
HgeneMECOMC4704874Mammary Carcinoma, Human1CTD_human
HgeneMECOMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human