UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MLLT10-PICALM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MLLT10-PICALM
FusionPDB ID: 54266
FusionGDB2.0 ID: 54266
HgeneTgene
Gene symbol

MLLT10

PICALM

Gene ID

8028

8301

Gene nameMLLT10 histone lysine methyltransferase DOT1L cofactorphosphatidylinositol binding clathrin assembly protein
SynonymsAF10CALM|CLTH|LAP
Cytomap

10p12.31

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 protphosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc

P55197

Q13492

Ensembl transtripts involved in fusion geneENST idsENST00000495130, ENST00000307729, 
ENST00000377059, ENST00000377072, 
ENST00000377091, ENST00000377100, 
ENST00000446906, 		ENST00000356360, 
ENST00000393346, ENST00000526033, 
ENST00000528398, ENST00000532317, 
ENST00000528411, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 15 X 10=270035 X 26 X 12=10920
# samples 2444
** MAII scorelog2(24/2700*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MLLT10 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MLLT10(21906136)-PICALM(85670103), # samples:6
PICALM(85685751)-MLLT10(21940602), # samples:6
Anticipated loss of major functional domain due to fusion event.MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MLLT10-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MLLT10-PICALM seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
MLLT10-PICALM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PICALM-MLLT10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029

TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across MLLT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2849-03AMLLT10chr10

21906136

-PICALMchr11

85670103

-
ChimerDB4LAMLTCGA-AB-2849_61660AAXX_5MLLT10chr10

21906136

+PICALMchr11

85670103

-
ChimerDB4LAMLTCGA-AB-2849_6166WAAXX_5MLLT10chr10

21906136

+PICALMchr11

85670103

-
ChimerDB4LAMLTCGA-AB-2849MLLT10chr10

21906136

+PICALMchr11

85670103

-
ChimerDB4LAMLTCGA-AB-2855-03AMLLT10chr10

21906136

-PICALMchr11

85670103

-
ChimerDB4LAMLTCGA-AB-2855_700H2AAXX_7MLLT10chr10

21906136

+PICALMchr11

85670103

-
ChiTaRS5.0N/AAF060927MLLT10chr10

21827841

+PICALMchr11

85670104

-
ChiTaRS5.0N/AAF060928MLLT10chr10

21823733

+PICALMchr11

85670105

-
ChiTaRS5.0N/AAF060929MLLT10chr10

21860955

+PICALMchr11

85685857

-
ChiTaRS5.0N/AAF060930MLLT10chr10

21827842

+PICALMchr11

85687726

-
ChiTaRS5.0N/AAF060931MLLT10chr10

21827841

+PICALMchr11

85685856

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000446906MLLT10chr1021906136+ENST00000532317PICALMchr1185670103-242410473301061243
ENST00000446906MLLT10chr1021906136+ENST00000356360PICALMchr1185670103-112110473301061243
ENST00000377072MLLT10chr1021906136+ENST00000532317PICALMchr1185670103-242410473301061243
ENST00000377072MLLT10chr1021906136+ENST00000356360PICALMchr1185670103-112110473301061243
ENST00000307729MLLT10chr1021906136+ENST00000532317PICALMchr1185670103-2254877160891243
ENST00000307729MLLT10chr1021906136+ENST00000356360PICALMchr1185670103-951877160891243
ENST00000377059MLLT10chr1021906136+ENST00000532317PICALMchr1185670103-20766990713237
ENST00000377059MLLT10chr1021906136+ENST00000356360PICALMchr1185670103-7736990713237
ENST00000446906MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-196558833060290
ENST00000446906MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-66258833060290
ENST00000377072MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-196558833060290
ENST00000377072MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-66258833060290
ENST00000307729MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-179541816043290
ENST00000307729MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-49241816043290
ENST00000377059MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-1617240025484
ENST00000377059MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-314240025484
ENST00000377100MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-197359633861090
ENST00000377100MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-67059633861090
ENST00000377091MLLT10chr1021827841+ENST00000532317PICALMchr1185670104-179341615843090
ENST00000377091MLLT10chr1021827841+ENST00000356360PICALMchr1185670104-49041615843090
ENST00000446906MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-188150841965578
ENST00000446906MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-75550841965578
ENST00000377072MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-188150841965578
ENST00000377072MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-75550841965578
ENST00000307729MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-171133824948578
ENST00000307729MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-58533824948578
ENST00000377059MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-15331607130778
ENST00000377059MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-4071607130778
ENST00000377100MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-188951642766378
ENST00000377100MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-76351642766378
ENST00000377091MLLT10chr1021823733+ENST00000526033PICALMchr1185670105-170933624748378
ENST00000377091MLLT10chr1021823733+ENST00000393346PICALMchr1185670105-58333624748378
ENST00000446906MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-2130588330767145
ENST00000446906MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-2126588330767145
ENST00000446906MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-1000588330767145
ENST00000446906MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-975588330767145
ENST00000377072MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-2130588330767145
ENST00000377072MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-2126588330767145
ENST00000377072MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-1000588330767145
ENST00000377072MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-975588330767145
ENST00000307729MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-1960418160597145
ENST00000307729MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-1956418160597145
ENST00000307729MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-830418160597145
ENST00000307729MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-805418160597145
ENST00000377059MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-17822400419139
ENST00000377059MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-17782400419139
ENST00000377059MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-6522400419139
ENST00000377059MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-6272400419139
ENST00000377100MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-2138596338775145
ENST00000377100MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-2134596338775145
ENST00000377100MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-1008596338775145
ENST00000377100MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-983596338775145
ENST00000377091MLLT10chr1021827842+ENST00000532317PICALMchr1185687726-1958416158595145
ENST00000377091MLLT10chr1021827842+ENST00000526033PICALMchr1185687726-1954416158595145
ENST00000377091MLLT10chr1021827842+ENST00000393346PICALMchr1185687726-828416158595145
ENST00000377091MLLT10chr1021827842+ENST00000528398PICALMchr1185687726-803416158595145
ENST00000446906MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-2070588330707125
ENST00000446906MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-2066588330707125
ENST00000446906MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-940588330707125
ENST00000446906MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-915588330707125
ENST00000446906MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-767588330707125
ENST00000377072MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-2070588330707125
ENST00000377072MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-2066588330707125
ENST00000377072MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-940588330707125
ENST00000377072MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-915588330707125
ENST00000377072MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-767588330707125
ENST00000307729MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-1900418160537125
ENST00000307729MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-1896418160537125
ENST00000307729MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-770418160537125
ENST00000307729MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-745418160537125
ENST00000307729MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-597418160537125
ENST00000377059MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-17222400359119
ENST00000377059MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-17182400359119
ENST00000377059MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-5922400359119
ENST00000377059MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-5672400359119
ENST00000377059MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-4192400359119
ENST00000377100MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-2078596338715125
ENST00000377100MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-2074596338715125
ENST00000377100MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-948596338715125
ENST00000377100MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-923596338715125
ENST00000377100MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-775596338715125
ENST00000377091MLLT10chr1021827841+ENST00000532317PICALMchr1185685856-1898416158535125
ENST00000377091MLLT10chr1021827841+ENST00000526033PICALMchr1185685856-1894416158535125
ENST00000377091MLLT10chr1021827841+ENST00000393346PICALMchr1185685856-768416158535125
ENST00000377091MLLT10chr1021827841+ENST00000528398PICALMchr1185685856-743416158535125
ENST00000377091MLLT10chr1021827841+ENST00000356360PICALMchr1185685856-595416158535125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000446906ENST00000532317MLLT10chr1021906136+PICALMchr1185670103-0.0004515480.9995484
ENST00000446906ENST00000356360MLLT10chr1021906136+PICALMchr1185670103-0.0016027610.9983972
ENST00000377072ENST00000532317MLLT10chr1021906136+PICALMchr1185670103-0.0004515480.9995484
ENST00000377072ENST00000356360MLLT10chr1021906136+PICALMchr1185670103-0.0016027610.9983972
ENST00000307729ENST00000532317MLLT10chr1021906136+PICALMchr1185670103-0.0003328260.99966717
ENST00000307729ENST00000356360MLLT10chr1021906136+PICALMchr1185670103-0.0008479070.99915206
ENST00000377059ENST00000532317MLLT10chr1021906136+PICALMchr1185670103-0.0003059240.9996941
ENST00000377059ENST00000356360MLLT10chr1021906136+PICALMchr1185670103-0.0007765180.9992235
ENST00000446906ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.34241940.6575806
ENST00000446906ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.088960010.91103995
ENST00000377072ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.34241940.6575806
ENST00000377072ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.088960010.91103995
ENST00000307729ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.107155740.8928443
ENST00000307729ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.0431739840.956826
ENST00000377059ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.0842909140.91570914
ENST00000377059ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.088256560.91174346
ENST00000377100ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.53860340.4613966
ENST00000377100ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.0949626340.9050374
ENST00000377091ENST00000532317MLLT10chr1021827841+PICALMchr1185670104-0.102419480.8975805
ENST00000377091ENST00000356360MLLT10chr1021827841+PICALMchr1185670104-0.0463275240.95367247
ENST00000446906ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.77574680.22425313
ENST00000446906ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.21403620.7859638
ENST00000377072ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.77574680.22425313
ENST00000377072ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.21403620.7859638
ENST00000307729ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.34967730.6503227
ENST00000307729ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.049371830.95062816
ENST00000377059ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.56939310.43060684
ENST00000377059ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.188116770.8118832
ENST00000377100ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.82938910.1706109
ENST00000377100ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.238624720.7613753
ENST00000377091ENST00000526033MLLT10chr1021823733+PICALMchr1185670105-0.307497320.6925027
ENST00000377091ENST00000393346MLLT10chr1021823733+PICALMchr1185670105-0.05139490.9486051
ENST00000446906ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.01362350.98637646
ENST00000446906ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0147843040.98521566
ENST00000446906ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.038262970.96173704
ENST00000446906ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.038567270.9614327
ENST00000377072ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.01362350.98637646
ENST00000377072ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0147843040.98521566
ENST00000377072ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.038262970.96173704
ENST00000377072ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.038567270.9614327
ENST00000307729ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.0082678080.9917321
ENST00000307729ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0080173930.99198264
ENST00000307729ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.0131140240.986886
ENST00000307729ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.0138187460.9861813
ENST00000377059ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.008271880.9917282
ENST00000377059ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0087780590.9912219
ENST00000377059ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.020528190.9794718
ENST00000377059ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.0216424670.97835755
ENST00000377100ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.0207859930.979214
ENST00000377100ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0205539020.97944605
ENST00000377100ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.046609540.9533905
ENST00000377100ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.049184260.95081574
ENST00000377091ENST00000532317MLLT10chr1021827842+PICALMchr1185687726-0.0078933030.9921067
ENST00000377091ENST00000526033MLLT10chr1021827842+PICALMchr1185687726-0.0076345580.9923654
ENST00000377091ENST00000393346MLLT10chr1021827842+PICALMchr1185687726-0.0142853720.9857146
ENST00000377091ENST00000528398MLLT10chr1021827842+PICALMchr1185687726-0.0148676440.9851324
ENST00000446906ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.032294420.96770555
ENST00000446906ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.032257690.9677423
ENST00000446906ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.080427320.9195727
ENST00000446906ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.072956110.9270439
ENST00000446906ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.0567824580.9432175
ENST00000377072ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.032294420.96770555
ENST00000377072ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.032257690.9677423
ENST00000377072ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.080427320.9195727
ENST00000377072ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.072956110.9270439
ENST00000377072ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.0567824580.9432175
ENST00000307729ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.0104779530.98952204
ENST00000307729ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.0101041510.9898958
ENST00000307729ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.0318160.96818405
ENST00000307729ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.0310526660.9689473
ENST00000307729ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.0189202930.9810797
ENST00000377059ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.0162287190.9837713
ENST00000377059ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.017433310.98256665
ENST00000377059ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.03639550.9636045
ENST00000377059ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.0378447360.9621552
ENST00000377059ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.0536527560.9463472
ENST00000377100ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.0448422880.95515776
ENST00000377100ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.0452462360.95475376
ENST00000377100ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.087552150.91244787
ENST00000377100ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.089504790.9104952
ENST00000377100ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.060169080.9398309
ENST00000377091ENST00000532317MLLT10chr1021827841+PICALMchr1185685856-0.0146196470.98538035
ENST00000377091ENST00000526033MLLT10chr1021827841+PICALMchr1185685856-0.0145292910.9854708
ENST00000377091ENST00000393346MLLT10chr1021827841+PICALMchr1185685856-0.037600740.9623993
ENST00000377091ENST00000528398MLLT10chr1021827841+PICALMchr1185685856-0.0359125770.9640875
ENST00000377091ENST00000356360MLLT10chr1021827841+PICALMchr1185685856-0.0241055360.97589445

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>54266_54266_1_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000307729_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_2_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000307729_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_3_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377059_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_4_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377059_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_5_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377072_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_6_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377072_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_7_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377091_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_8_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377091_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_9_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377100_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_10_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000377100_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_11_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000446906_PICALM_chr11_85670105_ENST00000393346_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_12_MLLT10-PICALM_MLLT10_chr10_21823733_ENST00000446906_PICALM_chr11_85670105_ENST00000526033_length(amino acids)=78AA_BP=28

--------------------------------------------------------------

>54266_54266_13_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_14_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_15_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_16_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_17_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_18_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_19_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000307729_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_20_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=84AA_BP=

--------------------------------------------------------------

>54266_54266_21_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=84AA_BP=

--------------------------------------------------------------

>54266_54266_22_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=119AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQMGSVPVM

--------------------------------------------------------------

>54266_54266_23_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=119AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQMGSVPVM

--------------------------------------------------------------

>54266_54266_24_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=119AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQMGSVPVM

--------------------------------------------------------------

>54266_54266_25_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=119AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQMGSVPVM

--------------------------------------------------------------

>54266_54266_26_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377059_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=119AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQMGSVPVM

--------------------------------------------------------------

>54266_54266_27_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_28_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_29_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_30_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_31_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_32_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_33_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377072_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_34_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_35_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_36_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_37_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_38_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_39_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_40_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377091_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_41_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_42_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_43_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_44_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_45_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_46_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_47_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000377100_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_48_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85670104_ENST00000356360_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_49_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85670104_ENST00000532317_length(amino acids)=90AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVIQFM

--------------------------------------------------------------

>54266_54266_50_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85685856_ENST00000356360_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_51_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85685856_ENST00000393346_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_52_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85685856_ENST00000526033_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_53_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85685856_ENST00000528398_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_54_MLLT10-PICALM_MLLT10_chr10_21827841_ENST00000446906_PICALM_chr11_85685856_ENST00000532317_length(amino acids)=125AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVPPQM

--------------------------------------------------------------

>54266_54266_55_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000307729_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_56_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000307729_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_57_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000307729_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_58_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000307729_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_59_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377059_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=139AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPVMAYPAT

--------------------------------------------------------------

>54266_54266_60_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377059_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=139AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPVMAYPAT

--------------------------------------------------------------

>54266_54266_61_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377059_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=139AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPVMAYPAT

--------------------------------------------------------------

>54266_54266_62_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377059_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=139AA_BP=80
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPVMAYPAT

--------------------------------------------------------------

>54266_54266_63_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377072_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_64_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377072_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_65_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377072_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_66_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377072_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_67_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377091_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_68_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377091_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_69_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377091_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_70_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377091_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_71_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377100_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_72_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377100_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_73_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377100_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_74_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000377100_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_75_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000446906_PICALM_chr11_85687726_ENST00000393346_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_76_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000446906_PICALM_chr11_85687726_ENST00000526033_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_77_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000446906_PICALM_chr11_85687726_ENST00000528398_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_78_MLLT10-PICALM_MLLT10_chr10_21827842_ENST00000446906_PICALM_chr11_85687726_ENST00000532317_length(amino acids)=145AA_BP=86
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVAPPV

--------------------------------------------------------------

>54266_54266_79_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000307729_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

>54266_54266_80_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000307729_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

>54266_54266_81_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000377059_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=237AA_BP=
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDG
ALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEE

--------------------------------------------------------------

>54266_54266_82_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000377059_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=237AA_BP=
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDG
ALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEE

--------------------------------------------------------------

>54266_54266_83_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000377072_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

>54266_54266_84_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000377072_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

>54266_54266_85_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000446906_PICALM_chr11_85670103_ENST00000356360_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

>54266_54266_86_MLLT10-PICALM_MLLT10_chr10_21906136_ENST00000446906_PICALM_chr11_85670103_ENST00000532317_length(amino acids)=243AA_BP=
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:21906136/chr11:85670103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT10

P55197

PICALM

Q13492

FUNCTION: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302). {ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+32322_7480.01069.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+32422_7480.01476.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+3522_7480.0127.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+3422_7480.0180.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+32322_7480.01069.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+32422_7480.01476.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+3522_7480.0127.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+3422_7480.0180.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+32322_7480.01069.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+32422_7480.01476.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+3522_7480.0127.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+3422_7480.0180.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+823135_198233.01069.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+82322_74233.01069.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+82379_112233.01069.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+824135_198233.01476.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+82422_74233.01476.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+82479_112233.01476.0Zinc fingerC2HC pre-PHD-type
TgenePICALMchr10:21827842chr11:85687726ENST0000035636001914_1450.0633.0DomainENTH

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223229_24053.3333333333333361069.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224229_24053.3333333333333361476.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25229_24053.333333333333336127.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24229_24053.333333333333336180.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323229_24080.01069.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324229_24080.01476.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35229_24080.0127.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34229_24080.0180.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323229_24080.01069.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324229_24080.01476.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35229_24080.0127.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34229_24080.0180.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323229_24080.01069.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324229_24080.01476.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35229_24080.0127.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34229_24080.0180.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+823229_240233.01069.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+824229_240233.01476.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15229_2400127.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14229_2400180.0Compositional biasNote=Glu/Lys-rich
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223311_67453.3333333333333361069.0RegionNote=DNA-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223703_78453.3333333333333361069.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223750_77853.3333333333333361069.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+22380_28753.3333333333333361069.0RegionNote=Self-association
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224311_67453.3333333333333361476.0RegionNote=DNA-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224703_78453.3333333333333361476.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224750_77853.3333333333333361476.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+22480_28753.3333333333333361476.0RegionNote=Self-association
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25311_67453.333333333333336127.0RegionNote=DNA-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25703_78453.333333333333336127.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25750_77853.333333333333336127.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+2580_28753.333333333333336127.0RegionNote=Self-association
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24311_67453.333333333333336180.0RegionNote=DNA-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24703_78453.333333333333336180.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24750_77853.333333333333336180.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+2480_28753.333333333333336180.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323311_67480.01069.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323703_78480.01069.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323750_77880.01069.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+32380_28780.01069.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324311_67480.01476.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324703_78480.01476.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324750_77880.01476.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+32480_28780.01476.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35311_67480.0127.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35703_78480.0127.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35750_77880.0127.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+3580_28780.0127.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34311_67480.0180.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34703_78480.0180.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34750_77880.0180.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+3480_28780.0180.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323311_67480.01069.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323703_78480.01069.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323750_77880.01069.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+32380_28780.01069.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324311_67480.01476.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324703_78480.01476.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324750_77880.01476.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+32480_28780.01476.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35311_67480.0127.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35703_78480.0127.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35750_77880.0127.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+3580_28780.0127.0RegionNote=Self-association
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34311_67480.0180.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34703_78480.0180.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34750_77880.0180.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+3480_28780.0180.0RegionNote=Self-association
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323311_67480.01069.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323703_78480.01069.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323750_77880.01069.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+32380_28780.01069.0RegionNote=Self-association
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324311_67480.01476.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324703_78480.01476.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324750_77880.01476.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+32480_28780.01476.0RegionNote=Self-association
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35311_67480.0127.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35703_78480.0127.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35750_77880.0127.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+3580_28780.0127.0RegionNote=Self-association
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34311_67480.0180.0RegionNote=DNA-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34703_78480.0180.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34750_77880.0180.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+3480_28780.0180.0RegionNote=Self-association
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+823311_674233.01069.0RegionNote=DNA-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+823703_784233.01069.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+823750_778233.01069.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21906136chr11:85670103ENST00000307729+82380_287233.01069.0RegionNote=Self-association
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+824311_674233.01476.0RegionNote=DNA-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+824703_784233.01476.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+824750_778233.01476.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377072+82480_287233.01476.0RegionNote=Self-association
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15311_6740127.0RegionNote=DNA-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15703_7840127.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15750_7780127.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+1580_2870127.0RegionNote=Self-association
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14311_6740180.0RegionNote=DNA-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14703_7840180.0RegionNote=Transactivation domain%3B required for DOT1L-binding
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14750_7780180.0RegionNote=Leucine-zipper
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+1480_2870180.0RegionNote=Self-association
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223135_19853.3333333333333361069.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+22322_7453.3333333333333361069.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+22379_11253.3333333333333361069.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224135_19853.3333333333333361476.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+22422_7453.3333333333333361476.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+22479_11253.3333333333333361476.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25135_19853.333333333333336127.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+2522_7453.333333333333336127.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+2579_11253.333333333333336127.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24135_19853.333333333333336180.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+2422_7453.333333333333336180.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+2479_11253.333333333333336180.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323135_19880.01069.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+32379_11280.01069.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324135_19880.01476.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+32479_11280.01476.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35135_19880.0127.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+3579_11280.0127.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34135_19880.0180.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+3479_11280.0180.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323135_19880.01069.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+32379_11280.01069.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324135_19880.01476.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+32479_11280.01476.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35135_19880.0127.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+3579_11280.0127.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34135_19880.0180.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+3479_11280.0180.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323135_19880.01069.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+32379_11280.01069.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324135_19880.01476.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+32479_11280.01476.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35135_19880.0127.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+3579_11280.0127.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34135_19880.0180.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+3479_11280.0180.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15135_1980127.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+1522_740127.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+1579_1120127.0Zinc fingerC2HC pre-PHD-type
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14135_1980180.0Zinc fingerPHD-type 2
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+1422_740180.0Zinc fingerPHD-type 1
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+1479_1120180.0Zinc fingerC2HC pre-PHD-type
TgenePICALMchr10:21823733chr11:85670105ENST00000356360171914_145628.0633.0DomainENTH
TgenePICALMchr10:21823733chr11:85670105ENST00000393346182014_145648.0653.0DomainENTH
TgenePICALMchr10:21823733chr11:85670105ENST00000526033182014_145641.0646.0DomainENTH
TgenePICALMchr10:21823733chr11:85670105ENST00000528398171914_145547.0552.0DomainENTH
TgenePICALMchr10:21823733chr11:85670105ENST00000532317182014_145606.0611.0DomainENTH
TgenePICALMchr10:21827841chr11:85670104ENST00000356360171914_145628.0633.0DomainENTH
TgenePICALMchr10:21827841chr11:85670104ENST00000393346182014_145648.0653.0DomainENTH
TgenePICALMchr10:21827841chr11:85670104ENST00000526033182014_145641.0646.0DomainENTH
TgenePICALMchr10:21827841chr11:85670104ENST00000528398171914_145547.0552.0DomainENTH
TgenePICALMchr10:21827841chr11:85670104ENST00000532317182014_145606.0611.0DomainENTH
TgenePICALMchr10:21827841chr11:85685856ENST00000356360161914_145593.0633.0DomainENTH
TgenePICALMchr10:21827841chr11:85685856ENST00000393346172014_145613.0653.0DomainENTH
TgenePICALMchr10:21827841chr11:85685856ENST00000526033172014_145606.0646.0DomainENTH
TgenePICALMchr10:21827841chr11:85685856ENST00000528398161914_145512.0552.0DomainENTH
TgenePICALMchr10:21827841chr11:85685856ENST00000532317172014_145571.0611.0DomainENTH
TgenePICALMchr10:21827842chr11:85687726ENST00000393346162014_145593.0653.0DomainENTH
TgenePICALMchr10:21827842chr11:85687726ENST00000526033162014_145586.0646.0DomainENTH
TgenePICALMchr10:21827842chr11:85687726ENST00000528398151914_145492.0552.0DomainENTH
TgenePICALMchr10:21827842chr11:85687726ENST00000532317162014_145551.0611.0DomainENTH
TgenePICALMchr10:21906136chr11:85670103ENST00000356360171914_145628.0633.0DomainENTH
TgenePICALMchr10:21906136chr11:85670103ENST00000393346182014_145648.0653.0DomainENTH
TgenePICALMchr10:21906136chr11:85670103ENST00000526033182014_145641.0646.0DomainENTH
TgenePICALMchr10:21906136chr11:85670103ENST00000528398171914_145547.0552.0DomainENTH
TgenePICALMchr10:21906136chr11:85670103ENST00000532317182014_145606.0611.0DomainENTH


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>391_MLLT10_21906136_PICALM_85670103_ranked_0.pdbMLLT102182784121906136ENST00000356360PICALMchr1185670103-
MSGKARMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCEL
CPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFA
243


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MLLT10_pLDDT.png
all structure
all structure
PICALM_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PICALMPLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MLLT10all structure
PICALMall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMLLT10chr10:21823733chr11:85670105ENST00000307729+223141_23353.3333333333333361069.0FSTL3
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377072+224141_23353.3333333333333361476.0FSTL3
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377091+25141_23353.333333333333336127.0FSTL3
HgeneMLLT10chr10:21823733chr11:85670105ENST00000377100+24141_23353.333333333333336180.0FSTL3
HgeneMLLT10chr10:21827841chr11:85670104ENST00000307729+323141_23380.01069.0FSTL3
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377072+324141_23380.01476.0FSTL3
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377091+35141_23380.0127.0FSTL3
HgeneMLLT10chr10:21827841chr11:85670104ENST00000377100+34141_23380.0180.0FSTL3
HgeneMLLT10chr10:21827841chr11:85685856ENST00000307729+323141_23380.01069.0FSTL3
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377072+324141_23380.01476.0FSTL3
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377091+35141_23380.0127.0FSTL3
HgeneMLLT10chr10:21827841chr11:85685856ENST00000377100+34141_23380.0180.0FSTL3
HgeneMLLT10chr10:21827842chr11:85687726ENST00000307729+323141_23380.01069.0FSTL3
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377072+324141_23380.01476.0FSTL3
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377091+35141_23380.0127.0FSTL3
HgeneMLLT10chr10:21827842chr11:85687726ENST00000377100+34141_23380.0180.0FSTL3
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377091+15141_2330127.0FSTL3
HgeneMLLT10chr10:21906136chr11:85670103ENST00000377100+14141_2330180.0FSTL3
TgenePICALMchr10:21823733chr11:85670105ENST000003563601719221_294628.0633.0PIMREG
TgenePICALMchr10:21823733chr11:85670105ENST000003933461820221_294648.0653.0PIMREG
TgenePICALMchr10:21823733chr11:85670105ENST000005260331820221_294641.0646.0PIMREG
TgenePICALMchr10:21823733chr11:85670105ENST000005283981719221_294547.0552.0PIMREG
TgenePICALMchr10:21823733chr11:85670105ENST000005323171820221_294606.0611.0PIMREG
TgenePICALMchr10:21827841chr11:85670104ENST000003563601719221_294628.0633.0PIMREG
TgenePICALMchr10:21827841chr11:85670104ENST000003933461820221_294648.0653.0PIMREG
TgenePICALMchr10:21827841chr11:85670104ENST000005260331820221_294641.0646.0PIMREG
TgenePICALMchr10:21827841chr11:85670104ENST000005283981719221_294547.0552.0PIMREG
TgenePICALMchr10:21827841chr11:85670104ENST000005323171820221_294606.0611.0PIMREG
TgenePICALMchr10:21827841chr11:85685856ENST000003563601619221_294593.0633.0PIMREG
TgenePICALMchr10:21827841chr11:85685856ENST000003933461720221_294613.0653.0PIMREG
TgenePICALMchr10:21827841chr11:85685856ENST000005260331720221_294606.0646.0PIMREG
TgenePICALMchr10:21827841chr11:85685856ENST000005283981619221_294512.0552.0PIMREG
TgenePICALMchr10:21827841chr11:85685856ENST000005323171720221_294571.0611.0PIMREG
TgenePICALMchr10:21827842chr11:85687726ENST000003933461620221_294593.0653.0PIMREG
TgenePICALMchr10:21827842chr11:85687726ENST000005260331620221_294586.0646.0PIMREG
TgenePICALMchr10:21827842chr11:85687726ENST000005283981519221_294492.0552.0PIMREG
TgenePICALMchr10:21827842chr11:85687726ENST000005323171620221_294551.0611.0PIMREG
TgenePICALMchr10:21906136chr11:85670103ENST000003563601719221_294628.0633.0PIMREG
TgenePICALMchr10:21906136chr11:85670103ENST000003933461820221_294648.0653.0PIMREG
TgenePICALMchr10:21906136chr11:85670103ENST000005260331820221_294641.0646.0PIMREG
TgenePICALMchr10:21906136chr11:85670103ENST000005283981719221_294547.0552.0PIMREG
TgenePICALMchr10:21906136chr11:85670103ENST000005323171820221_294606.0611.0PIMREG


Top

Related Drugs to MLLT10-PICALM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MLLT10-PICALM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0025202melanoma1CTD_human
HgeneMLLT10C0025286Meningioma1CTD_human
HgeneMLLT10C0205834Meningiomas, Multiple1CTD_human
HgeneMLLT10C0259785Malignant Meningioma1CTD_human
HgeneMLLT10C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0281784Benign Meningioma1CTD_human
HgeneMLLT10C0334605Meningothelial meningioma1CTD_human
HgeneMLLT10C0334606Fibrous Meningioma1CTD_human
HgeneMLLT10C0334607Psammomatous Meningioma1CTD_human
HgeneMLLT10C0334608Angiomatous Meningioma1CTD_human
HgeneMLLT10C0334609Hemangioblastic Meningioma1CTD_human
HgeneMLLT10C0334610Hemangiopericytic Meningioma1CTD_human
HgeneMLLT10C0334611Transitional Meningioma1CTD_human
HgeneMLLT10C0347515Spinal Meningioma1CTD_human
HgeneMLLT10C0349604Intracranial Meningioma1CTD_human
HgeneMLLT10C0431121Clear Cell Meningioma1CTD_human
HgeneMLLT10C0457190Xanthomatous Meningioma1CTD_human
HgeneMLLT10C0751303Cerebral Convexity Meningioma1CTD_human
HgeneMLLT10C0751304Parasagittal Meningioma1CTD_human
HgeneMLLT10C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneMLLT10C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneMLLT10C1334261Intraorbital Meningioma1CTD_human
HgeneMLLT10C1334271Intraventricular Meningioma1CTD_human
HgeneMLLT10C1335107Olfactory Groove Meningioma1CTD_human
HgeneMLLT10C1384406Secretory meningioma1CTD_human
HgeneMLLT10C1384408Microcystic meningioma1CTD_human
HgeneMLLT10C1527197Angioblastic Meningioma1CTD_human
HgeneMLLT10C1565950Posterior Fossa Meningioma1CTD_human
HgeneMLLT10C1565951Sphenoid Wing Meningioma1CTD_human
HgeneMLLT10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET
HgeneMLLT10C3163622Papillary Meningioma1CTD_human
TgenePICALMC0002395Alzheimer's Disease2CTD_human
TgenePICALMC0011265Presenile dementia2CTD_human
TgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
TgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
TgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
TgenePICALMC0234985Mental deterioration1CTD_human
TgenePICALMC0338656Impaired cognition1CTD_human
TgenePICALMC1270972Mild cognitive disorder1CTD_human