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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NEK11-BDH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NEK11-BDH1
FusionPDB ID: 58498
FusionGDB2.0 ID: 58498
HgeneTgene
Gene symbol

NEK11

BDH1

Gene ID

79858

622

Gene nameNIMA related kinase 113-hydroxybutyrate dehydrogenase 1
Synonyms-BDH|SDR9C1
Cytomap

3q22.1

3q29

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Nek11NIMA (never in mitosis gene a)- related kinase 11D-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1epididymis secretory sperm binding proteinshort chain dehydrogenase/red
Modification date2020031320200313
UniProtAcc

Q8NG66

Q02338

Ensembl transtripts involved in fusion geneENST idsENST00000356918, ENST00000383366, 
ENST00000412440, ENST00000429253, 
ENST00000507910, ENST00000508196, 
ENST00000510688, ENST00000510769, 
ENST00000511262, ENST00000426022, 
ENST00000476764, ENST00000358186, 
ENST00000392378, ENST00000392379, 
ENST00000441275, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 5=1008 X 8 X 8=512
# samples 514
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/512*10)=-1.87071698305503
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NEK11 [Title/Abstract] AND BDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NEK11(130889731)-BDH1(197241287), # samples:4
Anticipated loss of major functional domain due to fusion event.NEK11-BDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEK11-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEK11

GO:0006468

protein phosphorylation

15161910|19734889

HgeneNEK11

GO:0031573

intra-S DNA damage checkpoint

15161910

HgeneNEK11

GO:0035556

intracellular signal transduction

15161910


check buttonFusion gene breakpoints across NEK11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A5RA-01ANEK11chr3

130889731

-BDH1chr3

197241287

-
ChimerDB4LGGTCGA-HT-A5RA-01ANEK11chr3

130889731

+BDH1chr3

197241287

-
ChimerDB4LGGTCGA-HT-A5RANEK11chr3

130889731

+BDH1chr3

197241287

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356918NEK11chr3130889731+ENST00000392379BDH1chr3197241287-438716522412274677
ENST00000356918NEK11chr3130889731+ENST00000392378BDH1chr3197241287-438716522412274677
ENST00000356918NEK11chr3130889731+ENST00000358186BDH1chr3197241287-438716522412274677
ENST00000356918NEK11chr3130889731+ENST00000441275BDH1chr3197241287-257616522412274677
ENST00000510769NEK11chr3130889731+ENST00000392379BDH1chr3197241287-407213372411959572
ENST00000510769NEK11chr3130889731+ENST00000392378BDH1chr3197241287-407213372411959572
ENST00000510769NEK11chr3130889731+ENST00000358186BDH1chr3197241287-407213372411959572
ENST00000510769NEK11chr3130889731+ENST00000441275BDH1chr3197241287-226113372411959572
ENST00000429253NEK11chr3130889731+ENST00000392379BDH1chr3197241287-438716522412274677
ENST00000429253NEK11chr3130889731+ENST00000392378BDH1chr3197241287-438716522412274677
ENST00000429253NEK11chr3130889731+ENST00000358186BDH1chr3197241287-438716522412274677
ENST00000429253NEK11chr3130889731+ENST00000441275BDH1chr3197241287-257616522412274677
ENST00000510688NEK11chr3130889731+ENST00000392379BDH1chr3197241287-435816232122245677
ENST00000510688NEK11chr3130889731+ENST00000392378BDH1chr3197241287-435816232122245677
ENST00000510688NEK11chr3130889731+ENST00000358186BDH1chr3197241287-435816232122245677
ENST00000510688NEK11chr3130889731+ENST00000441275BDH1chr3197241287-254716232122245677
ENST00000511262NEK11chr3130889731+ENST00000392379BDH1chr3197241287-442716922812314677
ENST00000511262NEK11chr3130889731+ENST00000392378BDH1chr3197241287-442716922812314677
ENST00000511262NEK11chr3130889731+ENST00000358186BDH1chr3197241287-442716922812314677
ENST00000511262NEK11chr3130889731+ENST00000441275BDH1chr3197241287-261616922812314677
ENST00000383366NEK11chr3130889731+ENST00000392379BDH1chr3197241287-442716922812314677
ENST00000383366NEK11chr3130889731+ENST00000392378BDH1chr3197241287-442716922812314677
ENST00000383366NEK11chr3130889731+ENST00000358186BDH1chr3197241287-442716922812314677
ENST00000383366NEK11chr3130889731+ENST00000441275BDH1chr3197241287-261616922812314677
ENST00000412440NEK11chr3130889731+ENST00000392379BDH1chr3197241287-402812933471915522
ENST00000412440NEK11chr3130889731+ENST00000392378BDH1chr3197241287-402812933471915522
ENST00000412440NEK11chr3130889731+ENST00000358186BDH1chr3197241287-402812933471915522
ENST00000412440NEK11chr3130889731+ENST00000441275BDH1chr3197241287-221712933471915522
ENST00000507910NEK11chr3130889731+ENST00000392379BDH1chr3197241287-450417693582391677
ENST00000507910NEK11chr3130889731+ENST00000392378BDH1chr3197241287-450417693582391677
ENST00000507910NEK11chr3130889731+ENST00000358186BDH1chr3197241287-450417693582391677
ENST00000507910NEK11chr3130889731+ENST00000441275BDH1chr3197241287-269317693582391677
ENST00000508196NEK11chr3130889731+ENST00000392379BDH1chr3197241287-4134139902021673
ENST00000508196NEK11chr3130889731+ENST00000392378BDH1chr3197241287-4134139902021673
ENST00000508196NEK11chr3130889731+ENST00000358186BDH1chr3197241287-4134139902021673
ENST00000508196NEK11chr3130889731+ENST00000441275BDH1chr3197241287-2323139902021673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356918ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000356918ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000356918ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000356918ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.003532630.99646735
ENST00000510769ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0019597860.99804026
ENST00000510769ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0019597860.99804026
ENST00000510769ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0019597860.99804026
ENST00000510769ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0033870170.99661297
ENST00000429253ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000429253ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000429253ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0020769730.9979231
ENST00000429253ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.003532630.99646735
ENST00000510688ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0020067570.99799323
ENST00000510688ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0020067570.99799323
ENST00000510688ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0020067570.99799323
ENST00000510688ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0035224690.99647754
ENST00000511262ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000511262ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000511262ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000511262ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0036639330.9963361
ENST00000383366ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000383366ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000383366ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0019508470.99804914
ENST00000383366ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0036639330.9963361
ENST00000412440ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0018032540.9981968
ENST00000412440ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0018032540.9981968
ENST00000412440ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0018032540.9981968
ENST00000412440ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0026358860.9973641
ENST00000507910ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0018130260.998187
ENST00000507910ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0018130260.998187
ENST00000507910ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0018130260.998187
ENST00000507910ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0035514090.9964485
ENST00000508196ENST00000392379NEK11chr3130889731+BDH1chr3197241287-0.0022401810.9977598
ENST00000508196ENST00000392378NEK11chr3130889731+BDH1chr3197241287-0.0022401810.9977598
ENST00000508196ENST00000358186NEK11chr3130889731+BDH1chr3197241287-0.0022401810.9977598
ENST00000508196ENST00000441275NEK11chr3130889731+BDH1chr3197241287-0.0042092540.9957908

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>58498_58498_1_NEK11-BDH1_NEK11_chr3_130889731_ENST00000356918_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_2_NEK11-BDH1_NEK11_chr3_130889731_ENST00000356918_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_3_NEK11-BDH1_NEK11_chr3_130889731_ENST00000356918_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_4_NEK11-BDH1_NEK11_chr3_130889731_ENST00000356918_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_5_NEK11-BDH1_NEK11_chr3_130889731_ENST00000383366_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_6_NEK11-BDH1_NEK11_chr3_130889731_ENST00000383366_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_7_NEK11-BDH1_NEK11_chr3_130889731_ENST00000383366_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_8_NEK11-BDH1_NEK11_chr3_130889731_ENST00000383366_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_9_NEK11-BDH1_NEK11_chr3_130889731_ENST00000412440_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=522AA_BP=315
MDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK
HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLM
CRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQ
LSVDVLHESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP
LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKD

--------------------------------------------------------------

>58498_58498_10_NEK11-BDH1_NEK11_chr3_130889731_ENST00000412440_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=522AA_BP=315
MDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK
HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLM
CRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQ
LSVDVLHESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP
LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKD

--------------------------------------------------------------

>58498_58498_11_NEK11-BDH1_NEK11_chr3_130889731_ENST00000412440_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=522AA_BP=315
MDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK
HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLM
CRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQ
LSVDVLHESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP
LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKD

--------------------------------------------------------------

>58498_58498_12_NEK11-BDH1_NEK11_chr3_130889731_ENST00000412440_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=522AA_BP=315
MDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK
HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLM
CRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQ
LSVDVLHESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP
LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKD

--------------------------------------------------------------

>58498_58498_13_NEK11-BDH1_NEK11_chr3_130889731_ENST00000429253_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_14_NEK11-BDH1_NEK11_chr3_130889731_ENST00000429253_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_15_NEK11-BDH1_NEK11_chr3_130889731_ENST00000429253_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_16_NEK11-BDH1_NEK11_chr3_130889731_ENST00000429253_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_17_NEK11-BDH1_NEK11_chr3_130889731_ENST00000507910_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_18_NEK11-BDH1_NEK11_chr3_130889731_ENST00000507910_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_19_NEK11-BDH1_NEK11_chr3_130889731_ENST00000507910_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_20_NEK11-BDH1_NEK11_chr3_130889731_ENST00000507910_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_21_NEK11-BDH1_NEK11_chr3_130889731_ENST00000508196_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=673AA_BP=466
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPA
IVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNK
NPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLH
ELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCI
TKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID

--------------------------------------------------------------

>58498_58498_22_NEK11-BDH1_NEK11_chr3_130889731_ENST00000508196_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=673AA_BP=466
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPA
IVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNK
NPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLH
ELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCI
TKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID

--------------------------------------------------------------

>58498_58498_23_NEK11-BDH1_NEK11_chr3_130889731_ENST00000508196_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=673AA_BP=466
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPA
IVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNK
NPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLH
ELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCI
TKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID

--------------------------------------------------------------

>58498_58498_24_NEK11-BDH1_NEK11_chr3_130889731_ENST00000508196_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=673AA_BP=466
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPA
IVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSR
LLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNK
NPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKL
KKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLH
ELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCI
TKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID

--------------------------------------------------------------

>58498_58498_25_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510688_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_26_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510688_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_27_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510688_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_28_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510688_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_29_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510769_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=572AA_BP=365
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEEN
SKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATS
DLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC
LRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTP

--------------------------------------------------------------

>58498_58498_30_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510769_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=572AA_BP=365
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEEN
SKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATS
DLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC
LRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTP

--------------------------------------------------------------

>58498_58498_31_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510769_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=572AA_BP=365
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEEN
SKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATS
DLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC
LRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTP

--------------------------------------------------------------

>58498_58498_32_NEK11-BDH1_NEK11_chr3_130889731_ENST00000510769_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=572AA_BP=365
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEEN
SKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATS
DLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC
LRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTP

--------------------------------------------------------------

>58498_58498_33_NEK11-BDH1_NEK11_chr3_130889731_ENST00000511262_BDH1_chr3_197241287_ENST00000358186_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_34_NEK11-BDH1_NEK11_chr3_130889731_ENST00000511262_BDH1_chr3_197241287_ENST00000392378_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_35_NEK11-BDH1_NEK11_chr3_130889731_ENST00000511262_BDH1_chr3_197241287_ENST00000392379_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

>58498_58498_36_NEK11-BDH1_NEK11_chr3_130889731_ENST00000511262_BDH1_chr3_197241287_ENST00000441275_length(amino acids)=677AA_BP=470
MFGAMLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKL
DHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDF
GVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMES
MLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEK
ARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPS
MDLHELESIVEDATSDLGYHGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARS
PYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:130889731/chr3:197241287)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEK11

Q8NG66

BDH1

Q02338

FUNCTION: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEK11chr3:130889731chr3:197241287ENST00000356918+1314346_385466.3333333333333483.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000383366+1418346_385466.3333333333333646.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000429253+1317346_385466.3333333333333646.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000507910+1314346_385466.3333333333333483.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000508196+1216346_385466.3333333333333646.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000510688+1316346_385466.3333333333333600.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000511262+1415346_385466.3333333333333471.0Coiled coilOntology_term=ECO:0000250,ECO:0000255
HgeneNEK11chr3:130889731chr3:197241287ENST00000356918+131429_287466.3333333333333483.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000383366+141829_287466.3333333333333646.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000429253+131729_287466.3333333333333646.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000507910+131429_287466.3333333333333483.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000508196+121629_287466.3333333333333646.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000510688+131629_287466.3333333333333600.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000511262+141529_287466.3333333333333471.0DomainProtein kinase
HgeneNEK11chr3:130889731chr3:197241287ENST00000356918+131435_43466.3333333333333483.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000383366+141835_43466.3333333333333646.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000429253+131735_43466.3333333333333646.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000507910+131435_43466.3333333333333483.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000508196+121635_43466.3333333333333646.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000510688+131635_43466.3333333333333600.0Nucleotide bindingATP
HgeneNEK11chr3:130889731chr3:197241287ENST00000511262+141535_43466.3333333333333471.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBDH1chr3:130889731chr3:197241287ENST000003581864759_83136.33333333333334344.0Nucleotide bindingNAD
TgeneBDH1chr3:130889731chr3:197241287ENST000003923784759_83136.33333333333334344.0Nucleotide bindingNAD
TgeneBDH1chr3:130889731chr3:197241287ENST000003923795859_83136.33333333333334344.0Nucleotide bindingNAD


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NEK11_pLDDT.png
all structure
all structure
BDH1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NEK11
BDH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NEK11-BDH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NEK11-BDH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource