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Fusion Protein:NUDCD3-CAMK2B |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: NUDCD3-CAMK2B | FusionPDB ID: 60806 | FusionGDB2.0 ID: 60806 | Hgene | Tgene | Gene symbol | NUDCD3 | CAMK2B | Gene ID | 23386 | 816 |
| Gene name | NudC domain containing 3 | calcium/calmodulin dependent protein kinase II beta | |
| Synonyms | NudCL | CAM2|CAMK2|CAMKB|CaMKIIbeta|MRD54 | |
| Cytomap | 7p13 | 7p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nudC domain-containing protein 3NudC-like protein | calcium/calmodulin-dependent protein kinase type II subunit betaCaM kinase II beta subunitCaM-kinase II beta chaincaMK-II subunit betaproline rich calmodulin-dependent protein kinase | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q13554 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000355451, ENST00000460110, | ENST00000258682, ENST00000346990, ENST00000347193, ENST00000353625, ENST00000358707, ENST00000395747, ENST00000440254, ENST00000502837, ENST00000489429, ENST00000350811, ENST00000395749, ENST00000457475, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 9 X 4=288 | 4 X 4 X 5=80 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/80*10)=-0.192645077942396 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: NUDCD3 [Title/Abstract] AND CAMK2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NUDCD3(44444039)-CAMK2B(44323824), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | NUDCD3-CAMK2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NUDCD3-CAMK2B seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CAMK2B | GO:0046777 | protein autophosphorylation | 18817731 |
| Fusion gene breakpoints across NUDCD3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CAMK2B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-02-2485-01A | NUDCD3 | chr7 | 44444039 | - | CAMK2B | chr7 | 44323824 | - |
| ChimerDB4 | GBM | TCGA-02-2486-01A | NUDCD3 | chr7 | 44444039 | - | CAMK2B | chr7 | 44323824 | - |
| ChimerDB4 | GBM | TCGA-41-2571-01A | NUDCD3 | chr7 | 44431896 | - | CAMK2B | chr7 | 44302663 | - |
| ChimerDB4 | LGG | TCGA-E1-A7YJ | NUDCD3 | chr7 | 44431896 | - | CAMK2B | chr7 | 44323824 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000355451 | NUDCD3 | chr7 | 44444039 | - | ENST00000350811 | CAMK2B | chr7 | 44323824 | - | 3218 | 1066 | 974 | 2629 | 551 |
| ENST00000355451 | NUDCD3 | chr7 | 44444039 | - | ENST00000457475 | CAMK2B | chr7 | 44323824 | - | 4933 | 1066 | 974 | 2557 | 527 |
| ENST00000355451 | NUDCD3 | chr7 | 44444039 | - | ENST00000395749 | CAMK2B | chr7 | 44323824 | - | 5371 | 1066 | 974 | 3001 | 675 |
| ENST00000355451 | NUDCD3 | chr7 | 44431896 | - | ENST00000350811 | CAMK2B | chr7 | 44323824 | - | 3407 | 1255 | 1133 | 2818 | 561 |
| ENST00000355451 | NUDCD3 | chr7 | 44431896 | - | ENST00000457475 | CAMK2B | chr7 | 44323824 | - | 5122 | 1255 | 1133 | 2746 | 537 |
| ENST00000355451 | NUDCD3 | chr7 | 44431896 | - | ENST00000395749 | CAMK2B | chr7 | 44323824 | - | 5560 | 1255 | 1133 | 3190 | 685 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000355451 | ENST00000350811 | NUDCD3 | chr7 | 44444039 | - | CAMK2B | chr7 | 44323824 | - | 0.010554681 | 0.98944527 |
| ENST00000355451 | ENST00000457475 | NUDCD3 | chr7 | 44444039 | - | CAMK2B | chr7 | 44323824 | - | 0.004297996 | 0.99570197 |
| ENST00000355451 | ENST00000395749 | NUDCD3 | chr7 | 44444039 | - | CAMK2B | chr7 | 44323824 | - | 0.009960268 | 0.99003977 |
| ENST00000355451 | ENST00000350811 | NUDCD3 | chr7 | 44431896 | - | CAMK2B | chr7 | 44323824 | - | 0.012829986 | 0.98717 |
| ENST00000355451 | ENST00000457475 | NUDCD3 | chr7 | 44431896 | - | CAMK2B | chr7 | 44323824 | - | 0.005242692 | 0.9947573 |
| ENST00000355451 | ENST00000395749 | NUDCD3 | chr7 | 44431896 | - | CAMK2B | chr7 | 44323824 | - | 0.01646105 | 0.983539 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >60806_60806_1_NUDCD3-CAMK2B_NUDCD3_chr7_44431896_ENST00000355451_CAMK2B_chr7_44323824_ENST00000350811_length(amino acids)=561AA_BP=1 MTRSTRSAPWPPWMRRNRRCWTGLPLTTTRSCRASHRAMSWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA IEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQA KSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFE AYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHR -------------------------------------------------------------- >60806_60806_2_NUDCD3-CAMK2B_NUDCD3_chr7_44431896_ENST00000355451_CAMK2B_chr7_44323824_ENST00000395749_length(amino acids)=685AA_BP=440 MTRSTRSAPWPPWMRRNRRCWTGLPLTTTRSCRASHRAMSWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA IEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQA KSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGP LPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCP SPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIG -------------------------------------------------------------- >60806_60806_3_NUDCD3-CAMK2B_NUDCD3_chr7_44431896_ENST00000355451_CAMK2B_chr7_44323824_ENST00000457475_length(amino acids)=537AA_BP=1 MTRSTRSAPWPPWMRRNRRCWTGLPLTTTRSCRASHRAMSWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA IEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAA TSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEG -------------------------------------------------------------- >60806_60806_4_NUDCD3-CAMK2B_NUDCD3_chr7_44444039_ENST00000355451_CAMK2B_chr7_44323824_ENST00000350811_length(amino acids)=551AA_BP=0 MGSASSWKGSSPTRSTLRVLSGVSSPGSAFWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSIS EEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW FGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI TAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADG VKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGL TSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHF -------------------------------------------------------------- >60806_60806_5_NUDCD3-CAMK2B_NUDCD3_chr7_44444039_ENST00000355451_CAMK2B_chr7_44323824_ENST00000395749_length(amino acids)=675AA_BP=430 MGSASSWKGSSPTRSTLRVLSGVSSPGSAFWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSIS EEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW FGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI TAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADG VKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFS PLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPT PSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIR -------------------------------------------------------------- >60806_60806_6_NUDCD3-CAMK2B_NUDCD3_chr7_44444039_ENST00000355451_CAMK2B_chr7_44323824_ENST00000457475_length(amino acids)=527AA_BP=0 MGSASSWKGSSPTRSTLRVLSGVSSPGSAFWGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSIS EEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW FGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI TAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPA ALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFEN -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:44444039/chr7:44323824) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CAMK2B |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NUDCD3 | chr7:44431896 | chr7:44323824 | ENST00000355451 | - | 5 | 6 | 185_277 | 325.0 | 362.0 | Domain | CS |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000258682 | 0 | 20 | 20_28 | 21.666666666666668 | 573.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000346990 | 0 | 16 | 20_28 | 21.666666666666668 | 505.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000347193 | 0 | 20 | 20_28 | 21.666666666666668 | 548.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000350811 | 0 | 21 | 20_28 | 21.666666666666668 | 738.3333333333334 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000353625 | 0 | 18 | 20_28 | 21.666666666666668 | 559.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000358707 | 0 | 19 | 20_28 | 21.666666666666668 | 520.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395747 | 0 | 19 | 20_28 | 21.666666666666668 | 519.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395749 | 0 | 24 | 20_28 | 21.666666666666668 | 1455.3333333333333 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000440254 | 0 | 21 | 20_28 | 21.666666666666668 | 566.6666666666666 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000457475 | 0 | 20 | 20_28 | 21.666666666666668 | 1265.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000258682 | 0 | 20 | 20_28 | 21.666666666666668 | 573.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000346990 | 0 | 16 | 20_28 | 21.666666666666668 | 505.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000347193 | 0 | 20 | 20_28 | 21.666666666666668 | 548.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000350811 | 0 | 21 | 20_28 | 21.666666666666668 | 738.3333333333334 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000353625 | 0 | 18 | 20_28 | 21.666666666666668 | 559.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000358707 | 0 | 19 | 20_28 | 21.666666666666668 | 520.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395747 | 0 | 19 | 20_28 | 21.666666666666668 | 519.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395749 | 0 | 24 | 20_28 | 21.666666666666668 | 1455.3333333333333 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000440254 | 0 | 21 | 20_28 | 21.666666666666668 | 566.6666666666666 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000457475 | 0 | 20 | 20_28 | 21.666666666666668 | 1265.0 | Nucleotide binding | ATP | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000258682 | 0 | 20 | 283_292 | 21.666666666666668 | 573.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000258682 | 0 | 20 | 291_301 | 21.666666666666668 | 573.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000346990 | 0 | 16 | 283_292 | 21.666666666666668 | 505.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000346990 | 0 | 16 | 291_301 | 21.666666666666668 | 505.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000347193 | 0 | 20 | 283_292 | 21.666666666666668 | 548.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000347193 | 0 | 20 | 291_301 | 21.666666666666668 | 548.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000350811 | 0 | 21 | 283_292 | 21.666666666666668 | 738.3333333333334 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000350811 | 0 | 21 | 291_301 | 21.666666666666668 | 738.3333333333334 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000353625 | 0 | 18 | 283_292 | 21.666666666666668 | 559.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000353625 | 0 | 18 | 291_301 | 21.666666666666668 | 559.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000358707 | 0 | 19 | 283_292 | 21.666666666666668 | 520.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000358707 | 0 | 19 | 291_301 | 21.666666666666668 | 520.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395747 | 0 | 19 | 283_292 | 21.666666666666668 | 519.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395747 | 0 | 19 | 291_301 | 21.666666666666668 | 519.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395749 | 0 | 24 | 283_292 | 21.666666666666668 | 1455.3333333333333 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395749 | 0 | 24 | 291_301 | 21.666666666666668 | 1455.3333333333333 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000440254 | 0 | 21 | 283_292 | 21.666666666666668 | 566.6666666666666 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000440254 | 0 | 21 | 291_301 | 21.666666666666668 | 566.6666666666666 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000457475 | 0 | 20 | 283_292 | 21.666666666666668 | 1265.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000457475 | 0 | 20 | 291_301 | 21.666666666666668 | 1265.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000258682 | 0 | 20 | 283_292 | 21.666666666666668 | 573.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000258682 | 0 | 20 | 291_301 | 21.666666666666668 | 573.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000346990 | 0 | 16 | 283_292 | 21.666666666666668 | 505.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000346990 | 0 | 16 | 291_301 | 21.666666666666668 | 505.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000347193 | 0 | 20 | 283_292 | 21.666666666666668 | 548.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000347193 | 0 | 20 | 291_301 | 21.666666666666668 | 548.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000350811 | 0 | 21 | 283_292 | 21.666666666666668 | 738.3333333333334 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000350811 | 0 | 21 | 291_301 | 21.666666666666668 | 738.3333333333334 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000353625 | 0 | 18 | 283_292 | 21.666666666666668 | 559.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000353625 | 0 | 18 | 291_301 | 21.666666666666668 | 559.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000358707 | 0 | 19 | 283_292 | 21.666666666666668 | 520.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000358707 | 0 | 19 | 291_301 | 21.666666666666668 | 520.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395747 | 0 | 19 | 283_292 | 21.666666666666668 | 519.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395747 | 0 | 19 | 291_301 | 21.666666666666668 | 519.0 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395749 | 0 | 24 | 283_292 | 21.666666666666668 | 1455.3333333333333 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395749 | 0 | 24 | 291_301 | 21.666666666666668 | 1455.3333333333333 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000440254 | 0 | 21 | 283_292 | 21.666666666666668 | 566.6666666666666 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000440254 | 0 | 21 | 291_301 | 21.666666666666668 | 566.6666666666666 | Region | Note=Calmodulin-binding | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000457475 | 0 | 20 | 283_292 | 21.666666666666668 | 1265.0 | Region | Autoinhibitory domain | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000457475 | 0 | 20 | 291_301 | 21.666666666666668 | 1265.0 | Region | Note=Calmodulin-binding |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NUDCD3 | chr7:44444039 | chr7:44323824 | ENST00000355451 | - | 4 | 6 | 185_277 | 262.0 | 362.0 | Domain | CS |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000258682 | 0 | 20 | 14_272 | 21.666666666666668 | 573.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000346990 | 0 | 16 | 14_272 | 21.666666666666668 | 505.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000347193 | 0 | 20 | 14_272 | 21.666666666666668 | 548.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000350811 | 0 | 21 | 14_272 | 21.666666666666668 | 738.3333333333334 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000353625 | 0 | 18 | 14_272 | 21.666666666666668 | 559.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000358707 | 0 | 19 | 14_272 | 21.666666666666668 | 520.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395747 | 0 | 19 | 14_272 | 21.666666666666668 | 519.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000395749 | 0 | 24 | 14_272 | 21.666666666666668 | 1455.3333333333333 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000440254 | 0 | 21 | 14_272 | 21.666666666666668 | 566.6666666666666 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44431896 | chr7:44323824 | ENST00000457475 | 0 | 20 | 14_272 | 21.666666666666668 | 1265.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000258682 | 0 | 20 | 14_272 | 21.666666666666668 | 573.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000346990 | 0 | 16 | 14_272 | 21.666666666666668 | 505.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000347193 | 0 | 20 | 14_272 | 21.666666666666668 | 548.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000350811 | 0 | 21 | 14_272 | 21.666666666666668 | 738.3333333333334 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000353625 | 0 | 18 | 14_272 | 21.666666666666668 | 559.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000358707 | 0 | 19 | 14_272 | 21.666666666666668 | 520.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395747 | 0 | 19 | 14_272 | 21.666666666666668 | 519.0 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000395749 | 0 | 24 | 14_272 | 21.666666666666668 | 1455.3333333333333 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000440254 | 0 | 21 | 14_272 | 21.666666666666668 | 566.6666666666666 | Domain | Protein kinase | |
| Tgene | CAMK2B | chr7:44444039 | chr7:44323824 | ENST00000457475 | 0 | 20 | 14_272 | 21.666666666666668 | 1265.0 | Domain | Protein kinase |
Top |
Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
Top |
pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
NUDCD3_pLDDT.png  |
CAMK2B_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
Top |
Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| NUDCD3 | |
| CAMK2B |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to NUDCD3-CAMK2B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to NUDCD3-CAMK2B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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