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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NUP107-LGR5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NUP107-LGR5
FusionPDB ID: 60958
FusionGDB2.0 ID: 60958
HgeneTgene
Gene symbol

NUP107

LGR5

Gene ID

57122

8549

Gene namenucleoporin 107leucine rich repeat containing G protein-coupled receptor 5
SynonymsNPHS11|NUP84|ODG6|ODG6; GAMOS7FEX|GPR49|GPR67|GRP49|HG38
Cytomap

12q15

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear pore complex protein Nup107nucleoporin 107kDaleucine-rich repeat-containing G-protein coupled receptor 5G-protein coupled receptor 49G-protein coupled receptor 67G-protein coupled receptor HG38orphan G protein-coupled receptor HG38
Modification date2020031320200329
UniProtAcc

P57740

O75473

Ensembl transtripts involved in fusion geneENST idsENST00000378905, ENST00000229179, 
ENST00000401003, ENST00000539906, 
ENST00000266674, ENST00000536515, 
ENST00000540815, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 6=33613 X 15 X 9=1755
# samples 920
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1755*10)=-3.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NUP107 [Title/Abstract] AND LGR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUP107

GO:0006406

mRNA export from nucleus

11684705

TgeneLGR5

GO:0090263

positive regulation of canonical Wnt signaling pathway

21693646|22815884


check buttonFusion gene breakpoints across NUP107 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LGR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..NUP107chr12

69080853

+LGR5chr12

71965293

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229179NUP107chr1269080853+ENST00000266674LGR5chr1271965293+35703403081993561
ENST00000229179NUP107chr1269080853+ENST00000536515LGR5chr1271965293+21023403081993561
ENST00000229179NUP107chr1269080853+ENST00000540815LGR5chr1271965293+20963403081993561

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>60958_60958_1_NUP107-LGR5_NUP107_chr12_69080853_ENST00000229179_LGR5_chr12_71965293_ENST00000266674_length(amino acids)=561AA_BP=10
MCVEKALAMDRDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS
FPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFL
LDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGV
DAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY
GASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFI
SPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVP

--------------------------------------------------------------

>60958_60958_2_NUP107-LGR5_NUP107_chr12_69080853_ENST00000229179_LGR5_chr12_71965293_ENST00000536515_length(amino acids)=561AA_BP=10
MCVEKALAMDRDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS
FPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFL
LDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGV
DAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY
GASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFI
SPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVP

--------------------------------------------------------------

>60958_60958_3_NUP107-LGR5_NUP107_chr12_69080853_ENST00000229179_LGR5_chr12_71965293_ENST00000540815_length(amino acids)=561AA_BP=10
MCVEKALAMDRDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS
FPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFL
LDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGV
DAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKY
GASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFI
SPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr12:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUP107

P57740

LGR5

O75473

FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (411) >>>411.pdbFusion protein BP residue: 10
CIF file (411) >>>411.cif		NUP107chr1269080853+LGR5chr1271965293+
MCVEKALAMDRDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQ
LLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLT
HLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWN
KGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPG
PFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLI
GVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIF
ASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMA
AVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTK
LYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFI
SPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKH
PSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESC
561
3D view using mol* of 411 (AA BP:10)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NUP107_pLDDT.png
all structure
all structure
LGR5_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NUP107_LGR5_411_pLDDT.png (AA BP:10)
all structure
NUP107_LGR5_411_pLDDT_and_active_sites.png (AA BP:10)
all structure
NUP107_LGR5_411_violinplot.png (AA BP:10)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NUP107_LGR5_411.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
4111.2251971.263312.4730.3040.9581.222.1490.7722.7841.091Chain A: 218,253,257,260,263,264,267,298,299,301,3
02,303,305,306,309,367,368,370,380,383,384,387,391
,429,432,433,436,439,440,459,460,462,463,464,466,4
67,470

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
411ZINC000006716957DB04868Nilotinib-7.69311-7.83271
411ZINC000000034157DB06707Levonordefrin-7.59526-7.61276
411ZINC000000057624DB00368Norepinephrine-7.49454-7.51204
411ZINC000000000469DB00816Orciprenaline-7.4601-7.4745
411NetarsudilDB00816-7.38207-7.39317
411ZINC000000002273DB00816Orciprenaline-7.26314-7.27754
411ZINC000072318121DB12001Abemaciclib-6.43464-7.25304
411ZINC000000025958DB12332Rucaparib-7.23353-7.24853
411ZINC000000007601DB01001Salbutamol-7.23034-7.23034
411ZINC000000000746DB00871Terbutaline-7.2035-7.2178
411ZINC000028639340DB01263Posaconazole-5.12332-7.21192
411ZINC000000002281DB00871Terbutaline-7.19493-7.20923
411ZINC000150338819DB09027Ledipasvir-6.43991-7.19771
411ZINC000000056652DB01064Isoprenaline-7.1767-7.1767
411ZINC000053084692DB06654Safinamide-6.35224-7.13034
411ZINC000242437514DB00798Gentamicin-6.93995-7.12385
411ZINC000049637509DB06636Isavuconazonium-5.15075-7.05545
411ZINC000000039089DB00668Epinephrine-7.03374-7.04514
411ZINC000035801098DB05039Indacaterol-6.95579-6.99799
411ZINC000001550477DB01259Lapatinib-5.8154-6.9838

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000006716957DB04868NilotinibSmall moleculeCC1=CN(C=N1)C1=CC(NC(=O)C2=CC=C(C)C(NC3=NC=CC(=N3)C3=CN=CC=C3)=C2)=CC(=C1)C(F)(F)FApproved|Investigational
ZINC000000034157DB06707LevonordefrinSmall moleculeC[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000000057624DB00368NorepinephrineSmall moleculeNC[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000000000469DB00816OrciprenalineSmall moleculeCC(C)NCC(O)C1=CC(O)=CC(O)=C1Approved
ZINC000072318121DB12001AbemaciclibSmall moleculeCCN1CCN(CC2=CC=C(NC3=NC=C(F)C(=N3)C3=CC(F)=C4N=C(C)N(C(C)C)C4=C3)N=C2)CC1Approved|Investigational
ZINC000000025958DB12332RucaparibSmall moleculeCNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3Approved|Investigational
ZINC000000002281DB00871TerbutalineSmall moleculeCC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1Approved
ZINC000150338819DB09027LedipasvirSmall moleculeCOC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1C1=NC(=CN1)C1=CC=C2C3=CC=C(C=C3C(F)(F)C2=C1)C1=CC=C2NC(=NC2=C1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)CApproved
ZINC000053084692DB06654SafinamideSmall moleculeC[C@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C(N)=OApproved|Investigational
ZINC000049637509DB06636IsavuconazoniumSmall molecule[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1Approved|Investigational
ZINC000000039089DB00668EpinephrineSmall moleculeCNC[C@H](O)C1=CC(O)=C(O)C=C1Approved|Vet_approved
ZINC000035801098DB05039IndacaterolSmall moleculeCCC1=C(CC)C=C2CC(CC2=C1)NC[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1Approved
ZINC000001550477DB01259LapatinibSmall moleculeCS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1Approved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000006716957529.5239.347869.837176.991116.445458.887117.5141566.646288.756186.60922
ZINC000006716957529.5239.13916.303177.777139.994481.329117.2021619.513288.76183.65222
ZINC000000034157183.2071.584399.847106.772186.848106.2270646.19954.28.948252.10900
ZINC000000034157183.2072.284398.836105.841186.106106.8890643.15454.28.781252.1900
ZINC000000057624169.183.43375.22557.715204.72112.790592.16854.28.952246.79100
ZINC000000057624169.182.409366.47858.999201.357106.1220584.36954.28.77247.30600
ZINC000000000469211.262.192479.658212.457159.848107.3530782.09444.79.205261.39100
ZINC000000000469211.263.668477.852212.113158.053107.6850779.05944.78.929261.6900
ZINC000000002273211.263.006479.657212.456159.848107.3530782.1444.79.145261.39200
ZINC000000002273211.264.606477.851212.113158.053107.6850779.10844.78.94261.6900
ZINC000072318121506.65.724882.072501.54476.304232.91871.3061606.256198.587377.35410
ZINC000072318121506.64.405874.4504.04395.396202.46872.4931597.94198.614272.86310
ZINC000072318121506.66.174880.624501.36894.423212.29972.5351602.968198.63273.30910
ZINC000072318121506.66.931894.874510.75681.694230.15272.2731611.93198.605376.40211
ZINC000000025958323.3699.363601.398214.232112.926227.81946.4211032.273348.52385.06400
ZINC000000025958323.3699.466597.964212.386112.007227.15246.4191026.229348.513385.03900
ZINC000000007601239.3143.133507.069275.176145.07586.8170875.64345.159.068266.52200
ZINC000000000746225.2873.599496.174234.367155.26106.5470827.34444.29.067261.8700
ZINC000000000746225.2871.595496.002233.982154.54107.480824.98644.28.979261.98100
ZINC000028639340700.7877.4041124.08472.765117.692460.37673.2482110.438111.28.362185.02331
ZINC000028639340700.7879.0091124.607459.294130.195459.08576.0332100.905111.28.651182.08231
ZINC000000002281225.2871.825496.176234.368155.26106.5470827.34644.29.125261.8700
ZINC000000002281225.2871.72496.493234.237154.658107.5980825.34844.28.976261.96200
ZINC000150338819889.0124.3881369.588772.236205.681331.75859.9142637.5922.512.58.669166.60131
ZINC000150338819889.0128.2551369.279775.121203.738327.3763.052645.2712.512.58.582167.42631
ZINC000150338819889.0129.6191351.189790.212180.178319.4461.362612.5082.512.58.678171.81131
ZINC000150338819889.0123.7791408.248811.944183.707340.05872.5392660.5462.512.58.565173.19231
ZINC000150338819889.0129.4481400.543793.783195.881338.35672.5242661.7462.512.58.543170.18231
ZINC000150338819889.0124.8391395.432791.3195.813335.78172.5382661.1332.512.58.437170.20531
ZINC000150338819889.0127.521431.265780.081196.772394.6159.8022709.9662.512.58.583172.17231
ZINC000150338819889.0125.3721296.949757.843185.555289.1464.4112577.2052.512.58.658168.62631
ZINC000150338819889.01210.9691383.164796.537180.774333.32572.5282658.9422.512.58.466174.00331
ZINC000000056652211.263.507478.577212.52152.49113.5670781.05944.78.941263.0100
ZINC000053084692302.3486.36612.581156.033105.388304.28646.8741036.21834.759.083376.96100
ZINC000053084692302.3483.053603.233143.432120.534292.3746.8971022.59734.759.137372.68300
ZINC000242437514477.66.23754.999539.296215.703001462.851116.958.491022
ZINC000242437514477.66.136809.083575.464233.619001506.9791116.958.8311022
ZINC000242437514477.65.983810.649574.72235.929001510.5751116.958.8611022
ZINC000242437514477.63.325725.209510.111215.098001431.2661116.958.5231022
ZINC000242437514477.61.994731.573514.031217.542001438.5631116.958.6531022
ZINC000000039089183.2070.987415.609139.04163.719112.850664.11744.79.006256.40200
ZINC000000039089183.2071.06412.1135.076165.027111.9960658.64344.79.004256.18600
ZINC000035801098392.4976.567723.38351.978176.028195.37401302.33846.458.773273.75101
ZINC000035801098392.4973.839725.07357.079176.515191.47501297.13446.458.801273.41201
ZINC000035801098392.4976.636719.071347.003176.457195.6101289.86946.458.766273.21401
ZINC000001550477581.068.763984.429219.392136.563520.447108.0271738.43918.258.353175.11221
ZINC000001550477581.068.228914.704239.85389.107476.75108.9941676.88418.258.025182.62721


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000006716957Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn10.1808085090.281031049
ZINC000000034157C[C@H](N)[C@H](O)c1ccc(O)c(O)c10.1350791920.302260037
ZINC000000057624NC[C@H](O)c1ccc(O)c(O)c10.187147430.309816979
ZINC000000000469CC(C)NC[C@@H](O)c1cc(O)cc(O)c10.1702212550.19797014
ZINC000000002273CC(C)NC[C@H](O)c1cc(O)cc(O)c10.1702212550.19797014
ZINC000072318121CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC10.141041870.152770594
ZINC000000025958CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc10.2042597990.179994505
ZINC000000007601CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c10.1762384550.331044881
ZINC000000000746CC(C)(C)NC[C@H](O)c1cc(O)cc(O)c10.1598452130.248277396
ZINC000028639340CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O0.0317243810.429306683
ZINC000000002281CC(C)(C)NC[C@@H](O)c1cc(O)cc(O)c10.1598452130.248277396
ZINC000150338819COC(=O)N[C@H](C(=O)N1CC2(CC2)C[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc([C@@H]6[C@H]7CC[C@H](C7)N6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c5c4)ccc2-3)[nH]1)C(C)C0.0048310950.217274953
ZINC000000056652CC(C)NC[C@H](O)c1ccc(O)c(O)c10.2021505940.209218132
ZINC000053084692C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O0.2799554790.265373208
ZINC000242437514CN[C@H](C)[C@@H]1CC[C@H](N)[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@@H](N)C[C@H]2N)O10.0132652410.371016745
ZINC000049637509CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000000039089CNC[C@H](O)c1ccc(O)c(O)c10.1917482760.25662051
ZINC000035801098CCc1cc2c(cc1CC)CC(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C20.1052921910.180827637
ZINC000001550477CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o10.187595690.281219747


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP107SEH1L, NUP133, NUP85, NUP160, NUP43, NUP37, SEC13, TPR, NUP214, KPNB1, Nup107, Nup98, SIRT7, NUP98, WRNIP1, CUL3, CENPF, NUP153, TP53BP1, PNPT1, EIF4B, CORO1B, MYL1, C1QBP, CPSF6, VCP, PYCARD, CUL7, OBSL1, SUZ12, EED, PNKD, NTRK1, IFI16, SYNE1, APC, PRKDC, RRP1B, NALCN, CD1E, ACTBL2, HSP90AB1, XPO1, SENP1, SENP2, AHCTF1, RANGAP1, H2AFV, NUP50, RANBP2, B9D2, ACLY, RCC1, GLE1, ITPR2, KPNA4, NUP88, RAN, UBE2I, SUMO1, AAAS, RAE1, NUP155, NUP93, NUPL1, WDR1, NXF1, IPO7, NUPL2, NUP205, NUP210, NUP188, NUP62, NXT1, SEC61A1, NUP54, TMEM214, SMPD4, NDC1, KRAS, IP6K3, TMEM209, NUP35, RPUSD3, RGPD8, POM121C, Ranbp2, Ube2i, Rcc1, Kifc1, Nup155, Nup214, FOXA3, FOXI2, FOXK2, FOXL1, FOXP3, FOXQ1, CDC5L, ZNF746, DUSP13, SPAST, UXS1, SIGLECL1, CD70, RAF1, PDHA1, TRIM25, BRCA1, EGLN3, TGFB1, NKX2-1, RNF4, CDC34, BPLF1, EZH2, DCPS, MYC, CDK9, CANX, EZR, LMNA, TOMM20, MGST3, PTRH2, KIAA1429, HIST1H4A, Dppa3, BIRC3, LMBR1L, PLEKHA4, GAPDH, M, nsp16, nsp4, nsp6, ORF6, MAU2, LRRC31, CIT, KIF14, PRC1, TRIM66, FKBP8, PTPN1, RHOT2, SLC25A46, SUMO2, NUPR1, CIC, LGALS9, DYRK1A, BKRF1, DNAJC1, ANAPC2, COX8A, DERL1, EMD, KRT8, LMNB1, LRRC59, RPN1, SEC61B, STIM1, SYNE3, TMPO, NAA40, VPS33A, RGPD1, EFNA4, COMTD1, SLFN11, FBXW7, FBXO32, RCHY1, SIRT6, GLI3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NUP107all structure
LGR5all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NUP107-LGR5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NUP107-LGR5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNUP107C4225228NEPHROTIC SYNDROME, TYPE 112CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneNUP107C0018051Gonadal Dysgenesis1GENOMICS_ENGLAND
HgeneNUP107C0685837Pure Gonadal Dysgenesis, 46, XX1ORPHANET
HgeneNUP107C0795949Galloway Mowat syndrome1ORPHANET
HgeneNUP107C0949595Gonadal Dysgenesis, 46,XX1ORPHANET
HgeneNUP107C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
HgeneNUP107C4748084OVARIAN DYSGENESIS 61UNIPROT
TgeneLGR5C0007102Malignant tumor of colon1CTD_human
TgeneLGR5C0009375Colonic Neoplasms1CTD_human
TgeneLGR5C0009402Colorectal Carcinoma1CTD_human
TgeneLGR5C0009404Colorectal Neoplasms1CTD_human