UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PAK2-DLG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAK2-DLG1
FusionPDB ID: 62434
FusionGDB2.0 ID: 62434
HgeneTgene
Gene symbol

PAK2

DLG1

Gene ID

5586

1739

Gene nameprotein kinase N2discs large MAGUK scaffold protein 1
SynonymsPAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7DLGH1|SAP-97|SAP97|hdlg
Cytomap

1p22.2

3q29

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2disks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97
Modification date2020031320200327
UniProtAcc.

Q12959

Ensembl transtripts involved in fusion geneENST idsENST00000327134, ENST00000314062, 
ENST00000346964, ENST00000357674, 
ENST00000392382, ENST00000419354, 
ENST00000422288, ENST00000443183, 
ENST00000448528, ENST00000450955, 
ENST00000452595, ENST00000485409, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 11=88014 X 15 X 6=1260
# samples 1716
** MAII scorelog2(17/880*10)=-2.37196877738696
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAK2 [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLG1(197009550)-PAK2(196534653), # samples:3
PAK2(196532254)-DLG1(196876667), # samples:3
Anticipated loss of major functional domain due to fusion event.DLG1-PAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-PAK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAK2-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAK2-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAK2-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAK2-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePAK2

GO:0006468

protein phosphorylation

17332740

HgenePAK2

GO:0010631

epithelial cell migration

21754995

TgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

TgeneDLG1

GO:0007015

actin filament organization

14699157

TgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

TgeneDLG1

GO:0042391

regulation of membrane potential

12970345

TgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

TgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

TgeneDLG1

GO:0098609

cell-cell adhesion

14699157

TgeneDLG1

GO:1902473

regulation of protein localization to synapse

23676497

TgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345


check buttonFusion gene breakpoints across PAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DLG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6F8-01APAK2chr3

196467028

+DLG1chr3

196921460

-
ChimerDB4OVTCGA-25-1328-01APAK2chr3

196532254

+DLG1chr3

196869639

-
ChimerDB4OVTCGA-25-1328-01APAK2chr3

196532254

+DLG1chr3

196876667

-
ChimerDB4OVTCGA-25-1328-01APAK2chr3

196532254

-DLG1chr3

196888609

-
ChimerDB4OVTCGA-25-1328-01APAK2chr3

196532254

+DLG1chr3

196888609

-
ChimerDB4OVTCGA-25-1328PAK2chr3

196532254

+DLG1chr3

196876667

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327134PAK2chr3196532254+ENST00000357674DLG1chr3196876667-50527903222988888
ENST00000327134PAK2chr3196532254+ENST00000357674DLG1chr3196869639-49987903222934870
ENST00000327134PAK2chr3196532254+ENST00000314062DLG1chr3196869639-49327903222868848
ENST00000327134PAK2chr3196532254+ENST00000346964DLG1chr3196869639-49987903222934870
ENST00000327134PAK2chr3196532254+ENST00000419354DLG1chr3196869639-38617903222868848
ENST00000327134PAK2chr3196532254+ENST00000452595DLG1chr3196869639-32327903222868848
ENST00000327134PAK2chr3196532254+ENST00000422288DLG1chr3196869639-31617903222868848
ENST00000327134PAK2chr3196532254+ENST00000448528DLG1chr3196869639-29417903222868848
ENST00000327134PAK2chr3196532254+ENST00000443183DLG1chr3196869639-29687903222904860
ENST00000327134PAK2chr3196532254+ENST00000450955DLG1chr3196869639-29357903222934871
ENST00000327134PAK2chr3196532254+ENST00000392382DLG1chr3196869639-28697903222868849

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327134ENST00000357674PAK2chr3196532254+DLG1chr3196876667-0.0001486470.99985135
ENST00000327134ENST00000357674PAK2chr3196532254+DLG1chr3196869639-0.0002278230.99977213
ENST00000327134ENST00000314062PAK2chr3196532254+DLG1chr3196869639-0.0002134750.99978656
ENST00000327134ENST00000346964PAK2chr3196532254+DLG1chr3196869639-0.0002278230.99977213
ENST00000327134ENST00000419354PAK2chr3196532254+DLG1chr3196869639-0.0004139150.99958605
ENST00000327134ENST00000452595PAK2chr3196532254+DLG1chr3196869639-0.0010056930.9989943
ENST00000327134ENST00000422288PAK2chr3196532254+DLG1chr3196869639-0.0012194610.99878055
ENST00000327134ENST00000448528PAK2chr3196532254+DLG1chr3196869639-0.0015822680.99841774
ENST00000327134ENST00000443183PAK2chr3196532254+DLG1chr3196869639-0.0016202130.9983798
ENST00000327134ENST00000450955PAK2chr3196532254+DLG1chr3196869639-0.0016794570.9983205
ENST00000327134ENST00000392382PAK2chr3196532254+DLG1chr3196869639-0.0016458920.9983541

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62434_62434_1_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000314062_length(amino acids)=848AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_2_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000346964_length(amino acids)=870AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF
YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR

--------------------------------------------------------------

>62434_62434_3_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000357674_length(amino acids)=870AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF
YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR

--------------------------------------------------------------

>62434_62434_4_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000392382_length(amino acids)=849AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_5_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000419354_length(amino acids)=848AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_6_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000422288_length(amino acids)=848AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_7_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000443183_length(amino acids)=860AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYLILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVT
SREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTF

--------------------------------------------------------------

>62434_62434_8_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000448528_length(amino acids)=848AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_9_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000450955_length(amino acids)=871AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF
YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR

--------------------------------------------------------------

>62434_62434_10_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196869639_ENST00000452595_length(amino acids)=848AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNA
SDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH
KFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTE

--------------------------------------------------------------

>62434_62434_11_PAK2-DLG1_PAK2_chr3_196532254_ENST00000327134_DLG1_chr3_196876667_ENST00000357674_length(amino acids)=888AA_BP=156
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAANPPPVLVNTDSLETPTYVNGTDA
DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK
RRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV
YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG
IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRT
SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKG
QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP
DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPI

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:197009550/chr3:196534653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DLG1

Q12959

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+51574_87156.0525.0DomainCRIB
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51574_87156.0525.0DomainCRIB
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+51569_112156.0525.0RegionGTPase-binding
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+51569_137156.0525.0RegionAutoregulatory region
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51569_112156.0525.0RegionGTPase-binding
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+51569_137156.0525.0RegionAutoregulatory region
TgeneDLG1chr3:196532254chr3:196869639ENST00000314062424224_310161.0854.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000314062424319_405161.0854.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000314062424466_546161.0854.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000314062424581_651161.0854.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000314062424714_889161.0854.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626224_310212.0927.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626319_405212.0927.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626466_546212.0927.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626581_651212.0927.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626714_889212.0927.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525224_310179.0894.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525319_405179.0894.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525466_546179.0894.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525581_651179.0894.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525714_889179.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525224_310179.0872.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525319_405179.0872.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525466_546179.0872.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525581_651179.0872.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525714_889179.0872.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626224_310212.0905.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626319_405212.0905.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626466_546212.0905.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626581_651212.0905.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626714_889212.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000422288323224_310161.0854.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000422288323319_405161.0854.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000422288323466_546161.0854.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000422288323581_651161.0854.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000422288323714_889161.0854.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000443183122224_31096.0801.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000443183122319_40596.0801.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000443183122466_54696.0801.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000443183122581_65196.0801.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000443183122714_88996.0801.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626224_310212.0905.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626319_405212.0905.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626466_546212.0905.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626581_651212.0905.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626714_889212.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424224_310179.0894.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424319_405179.0894.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424466_546179.0894.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424581_651179.0894.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424714_889179.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196869639ENST00000452595121224_31096.0789.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196869639ENST00000452595121319_40596.0789.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196869639ENST00000452595121466_54696.0789.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196869639ENST00000452595121581_65196.0789.0DomainSH3
TgeneDLG1chr3:196532254chr3:196869639ENST00000452595121714_88996.0789.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062024224_3100854.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062024319_4050854.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062024466_5460854.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST000003140620244_640854.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062024581_6510854.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000314062024714_8890854.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526224_310194.0927.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526319_405194.0927.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526466_546194.0927.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526581_651194.0927.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526714_889194.0927.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674425224_310161.0894.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674425319_405161.0894.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674425466_546161.0894.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674425581_651161.0894.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000357674425714_889161.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382425224_310161.0872.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382425319_405161.0872.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382425466_546161.0872.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382425581_651161.0872.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000392382425714_889161.0872.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526224_310194.0905.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526319_405194.0905.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526466_546194.0905.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526581_651194.0905.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526714_889194.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288023224_3100.0854.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288023319_4050.0854.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288023466_5460.0854.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST000004222880234_640.0854.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288023581_6510.0854.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000422288023714_8890.0854.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183022224_31078.0801.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183022319_40578.0801.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183022466_54678.0801.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183022581_65178.0801.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000443183022714_88978.0801.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526224_310194.0905.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526319_405194.0905.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526466_546194.0905.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526581_651194.0905.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526714_889194.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955324224_310161.0894.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955324319_405161.0894.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955324466_546161.0894.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955324581_651161.0894.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000450955324714_889161.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595021224_31078.0789.0DomainPDZ 1
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595021319_40578.0789.0DomainPDZ 2
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595021466_54678.0789.0DomainPDZ 3
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595021581_65178.0789.0DomainSH3
TgeneDLG1chr3:196532254chr3:196876667ENST00000452595021714_88978.0789.0DomainGuanylate kinase-like

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+515249_499156.0525.0DomainProtein kinase
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515249_499156.0525.0DomainProtein kinase
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+515245_251156.0525.0MotifNote=Nuclear localization signal
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515245_251156.0525.0MotifNote=Nuclear localization signal
HgenePAK2chr3:196532254chr3:196869639ENST00000327134+515255_263156.0525.0Nucleotide bindingATP
HgenePAK2chr3:196532254chr3:196876667ENST00000327134+515255_263156.0525.0Nucleotide bindingATP
TgeneDLG1chr3:196532254chr3:196869639ENST000003140624244_64161.0854.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000003469646264_64212.0927.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000003576745254_64179.0894.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000003923825254_64179.0872.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004193546264_64212.0905.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004222883234_64161.0854.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004431831224_6496.0801.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004485286264_64212.0905.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004509554244_64179.0894.0DomainL27
TgeneDLG1chr3:196532254chr3:196869639ENST000004525951214_6496.0789.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000003469645264_64194.0927.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000003576744254_64161.0894.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000003923824254_64161.0872.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000004193545264_64194.0905.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000004431830224_6478.0801.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000004485285264_64194.0905.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000004509553244_64161.0894.0DomainL27
TgeneDLG1chr3:196532254chr3:196876667ENST000004525950214_6478.0789.0DomainL27


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1682_PAK2_196532254_DLG1_196876667_ranked_0.pdbPAK2196532254196532254ENST00000392382DLG1chr3196876667-
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAANPPPVLVNTDSLETPTYVNGTDA
DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK
RRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV
YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG
IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRT
SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKG
QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP
DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPI
888


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PAK2_pLDDT.png
all structure
all structure
DLG1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAK2
DLG1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDLG1chr3:196532254chr3:196869639ENST00000346964626162_212212.0927.0SH3 domains
TgeneDLG1chr3:196532254chr3:196869639ENST00000357674525162_212179.0894.0SH3 domains
TgeneDLG1chr3:196532254chr3:196869639ENST00000392382525162_212179.0872.0SH3 domains
TgeneDLG1chr3:196532254chr3:196869639ENST00000419354626162_212212.0905.0SH3 domains
TgeneDLG1chr3:196532254chr3:196869639ENST00000448528626162_212212.0905.0SH3 domains
TgeneDLG1chr3:196532254chr3:196869639ENST00000450955424162_212179.0894.0SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000346964526162_212194.0927.0SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000419354526162_212194.0905.0SH3 domains
TgeneDLG1chr3:196532254chr3:196876667ENST00000448528526162_212194.0905.0SH3 domains


Top

Related Drugs to PAK2-DLG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PAK2-DLG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource