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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PDE7A-NRG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PDE7A-NRG1
FusionPDB ID: 63789
FusionGDB2.0 ID: 63789
HgeneTgene
Gene symbol

PDE7A

NRG1

Gene ID

5150

3084

Gene namephosphodiesterase 7Aneuregulin 1
SynonymsHCP1|PDE7ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
Cytomap

8q13.1

8p12

Type of geneprotein-codingprotein-coding
Descriptionhigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7ATM22phosphodiesterase isozyme 7pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
Modification date2020031320200320
UniProtAcc.

Q02297

Ensembl transtripts involved in fusion geneENST idsENST00000379419, ENST00000396642, 
ENST00000401827, ENST00000518667, 
ENST00000523681, ENST00000287842, 
ENST00000287845, ENST00000338921, 
ENST00000341377, ENST00000356819, 
ENST00000405005, ENST00000519301, 
ENST00000520407, ENST00000520502, 
ENST00000521670, ENST00000523079, 
ENST00000539990, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 10 X 7=105025 X 17 X 14=5950
# samples 1727
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/5950*10)=-4.46185835603184
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PDE7A [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PDE7A(66691955)-NRG1(32585467), # samples:3
Anticipated loss of major functional domain due to fusion event.PDE7A-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE7A-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE7A-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE7A-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNRG1

GO:0003222

ventricular trabecula myocardium morphogenesis

17336907

TgeneNRG1

GO:0031334

positive regulation of protein complex assembly

10559227

TgeneNRG1

GO:0038127

ERBB signaling pathway

11389077

TgeneNRG1

GO:0038129

ERBB3 signaling pathway

27353365

TgeneNRG1

GO:0045892

negative regulation of transcription, DNA-templated

15073182

TgeneNRG1

GO:0051048

negative regulation of secretion

10559227

TgeneNRG1

GO:0060379

cardiac muscle cell myoblast differentiation

17336907

TgeneNRG1

GO:0060956

endocardial cell differentiation

17336907


check buttonFusion gene breakpoints across PDE7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-5334-01APDE7Achr8

66691955

-NRG1chr8

32585467

+
ChimerDB4HNSCTCGA-CQ-5334PDE7Achr8

66691955

-NRG1chr8

32585467

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401827PDE7Achr866691955-ENST00000519301NRG1chr832585467+21667274442162572
ENST00000401827PDE7Achr866691955-ENST00000520407NRG1chr832585467+140772723604193
ENST00000401827PDE7Achr866691955-ENST00000523079NRG1chr832585467+20677274441487347
ENST00000401827PDE7Achr866691955-ENST00000338921NRG1chr832585467+28007274442171575
ENST00000401827PDE7Achr866691955-ENST00000356819NRG1chr832585467+27917274442162572
ENST00000401827PDE7Achr866691955-ENST00000287845NRG1chr832585467+27917274442162572
ENST00000401827PDE7Achr866691955-ENST00000341377NRG1chr832585467+28357279682206412
ENST00000401827PDE7Achr866691955-ENST00000287842NRG1chr832585467+22487274442138564
ENST00000401827PDE7Achr866691955-ENST00000521670NRG1chr832585467+18867274441613389
ENST00000401827PDE7Achr866691955-ENST00000405005NRG1chr832585467+22177274442147567
ENST00000401827PDE7Achr866691955-ENST00000520502NRG1chr832585467+139072723604193
ENST00000401827PDE7Achr866691955-ENST00000539990NRG1chr832585467+22457274442138564
ENST00000396642PDE7Achr866691955-ENST00000519301NRG1chr832585467+172228301718572
ENST00000396642PDE7Achr866691955-ENST00000520407NRG1chr832585467+9632830506168
ENST00000396642PDE7Achr866691955-ENST00000523079NRG1chr832585467+162328301043347
ENST00000396642PDE7Achr866691955-ENST00000338921NRG1chr832585467+235628301727575
ENST00000396642PDE7Achr866691955-ENST00000356819NRG1chr832585467+234728301718572
ENST00000396642PDE7Achr866691955-ENST00000287845NRG1chr832585467+234728301718572
ENST00000396642PDE7Achr866691955-ENST00000341377NRG1chr832585467+23912835241762412
ENST00000396642PDE7Achr866691955-ENST00000287842NRG1chr832585467+180428301694564
ENST00000396642PDE7Achr866691955-ENST00000521670NRG1chr832585467+144228301169389
ENST00000396642PDE7Achr866691955-ENST00000405005NRG1chr832585467+177328301703567
ENST00000396642PDE7Achr866691955-ENST00000520502NRG1chr832585467+9462830506168
ENST00000396642PDE7Achr866691955-ENST00000539990NRG1chr832585467+180128301694564
ENST00000379419PDE7Achr866691955-ENST00000519301NRG1chr832585467+1787348921783563
ENST00000379419PDE7Achr866691955-ENST00000520407NRG1chr832585467+102834892571159
ENST00000379419PDE7Achr866691955-ENST00000523079NRG1chr832585467+1688348921108338
ENST00000379419PDE7Achr866691955-ENST00000338921NRG1chr832585467+2421348921792566
ENST00000379419PDE7Achr866691955-ENST00000356819NRG1chr832585467+2412348921783563
ENST00000379419PDE7Achr866691955-ENST00000287845NRG1chr832585467+2412348921783563
ENST00000379419PDE7Achr866691955-ENST00000341377NRG1chr832585467+24563485891827412
ENST00000379419PDE7Achr866691955-ENST00000287842NRG1chr832585467+1869348921759555
ENST00000379419PDE7Achr866691955-ENST00000521670NRG1chr832585467+1507348921234380
ENST00000379419PDE7Achr866691955-ENST00000405005NRG1chr832585467+1838348921768558
ENST00000379419PDE7Achr866691955-ENST00000520502NRG1chr832585467+101134892571159
ENST00000379419PDE7Achr866691955-ENST00000539990NRG1chr832585467+1866348921759555

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401827ENST00000519301PDE7Achr866691955-NRG1chr832585467+0.0237740860.976226
ENST00000401827ENST00000520407PDE7Achr866691955-NRG1chr832585467+0.07739620.9226038
ENST00000401827ENST00000523079PDE7Achr866691955-NRG1chr832585467+0.0214895680.9785104
ENST00000401827ENST00000338921PDE7Achr866691955-NRG1chr832585467+0.0097221060.9902778
ENST00000401827ENST00000356819PDE7Achr866691955-NRG1chr832585467+0.0098856590.99011433
ENST00000401827ENST00000287845PDE7Achr866691955-NRG1chr832585467+0.0098856590.99011433
ENST00000401827ENST00000341377PDE7Achr866691955-NRG1chr832585467+0.0065627070.99343723
ENST00000401827ENST00000287842PDE7Achr866691955-NRG1chr832585467+0.0146252260.9853748
ENST00000401827ENST00000521670PDE7Achr866691955-NRG1chr832585467+0.084633310.9153667
ENST00000401827ENST00000405005PDE7Achr866691955-NRG1chr832585467+0.014477030.985523
ENST00000401827ENST00000520502PDE7Achr866691955-NRG1chr832585467+0.065780570.93421936
ENST00000401827ENST00000539990PDE7Achr866691955-NRG1chr832585467+0.0147989870.985201
ENST00000396642ENST00000519301PDE7Achr866691955-NRG1chr832585467+0.0257349720.97426504
ENST00000396642ENST00000520407PDE7Achr866691955-NRG1chr832585467+0.0356817840.9643182
ENST00000396642ENST00000523079PDE7Achr866691955-NRG1chr832585467+0.0173981080.9826019
ENST00000396642ENST00000338921PDE7Achr866691955-NRG1chr832585467+0.0076237380.99237627
ENST00000396642ENST00000356819PDE7Achr866691955-NRG1chr832585467+0.0079838020.9920162
ENST00000396642ENST00000287845PDE7Achr866691955-NRG1chr832585467+0.0079838020.9920162
ENST00000396642ENST00000341377PDE7Achr866691955-NRG1chr832585467+0.0048022320.99519783
ENST00000396642ENST00000287842PDE7Achr866691955-NRG1chr832585467+0.0146563680.98534364
ENST00000396642ENST00000521670PDE7Achr866691955-NRG1chr832585467+0.098091350.90190864
ENST00000396642ENST00000405005PDE7Achr866691955-NRG1chr832585467+0.0139509940.98604906
ENST00000396642ENST00000520502PDE7Achr866691955-NRG1chr832585467+0.031263980.96873605
ENST00000396642ENST00000539990PDE7Achr866691955-NRG1chr832585467+0.0149328390.9850671
ENST00000379419ENST00000519301PDE7Achr866691955-NRG1chr832585467+0.0095762080.99042374
ENST00000379419ENST00000520407PDE7Achr866691955-NRG1chr832585467+0.034875560.9651245
ENST00000379419ENST00000523079PDE7Achr866691955-NRG1chr832585467+0.0072675540.99273247
ENST00000379419ENST00000338921PDE7Achr866691955-NRG1chr832585467+0.0037036110.99629635
ENST00000379419ENST00000356819PDE7Achr866691955-NRG1chr832585467+0.0027182130.9972818
ENST00000379419ENST00000287845PDE7Achr866691955-NRG1chr832585467+0.0027182130.9972818
ENST00000379419ENST00000341377PDE7Achr866691955-NRG1chr832585467+0.0036659790.99633396
ENST00000379419ENST00000287842PDE7Achr866691955-NRG1chr832585467+0.0059693870.99403054
ENST00000379419ENST00000521670PDE7Achr866691955-NRG1chr832585467+0.0218573290.9781426
ENST00000379419ENST00000405005PDE7Achr866691955-NRG1chr832585467+0.0058006680.9941994
ENST00000379419ENST00000520502PDE7Achr866691955-NRG1chr832585467+0.0349247050.96507525
ENST00000379419ENST00000539990PDE7Achr866691955-NRG1chr832585467+0.006156340.9938437

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63789_63789_1_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=555AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC
KTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSP
KSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQ

--------------------------------------------------------------

>63789_63789_2_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=563AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVG
IMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTV
TQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPV
DFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYET
TQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGR

--------------------------------------------------------------

>63789_63789_3_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=566AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALL
VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHS
TTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARM
SPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEE
YETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNP

--------------------------------------------------------------

>63789_63789_4_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>63789_63789_5_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=563AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVG
IMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTV
TQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPV
DFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYET
TQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGR

--------------------------------------------------------------

>63789_63789_6_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=558AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVV
AYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPS
HSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTP
SSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYE
PAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQE

--------------------------------------------------------------

>63789_63789_7_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=563AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVG
IMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTV
TQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPV
DFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYET
TQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGR

--------------------------------------------------------------

>63789_63789_8_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=159AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS

--------------------------------------------------------------

>63789_63789_9_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=159AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS

--------------------------------------------------------------

>63789_63789_10_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=380AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVV
AYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPS
HSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQ

--------------------------------------------------------------

>63789_63789_11_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=338AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC
KTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW

--------------------------------------------------------------

>63789_63789_12_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000379419_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=555AA_BP=86
MLPSRRERLCSGLLIDPMGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSTSTS
TTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC
KTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSP
KSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQ

--------------------------------------------------------------

>63789_63789_13_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=564AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYE
TTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG

--------------------------------------------------------------

>63789_63789_14_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_15_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=575AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>63789_63789_16_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>63789_63789_17_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_18_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=567AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIAL
LVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHH
STTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPAR
MSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDE
EYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTN

--------------------------------------------------------------

>63789_63789_19_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_20_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=168AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF

--------------------------------------------------------------

>63789_63789_21_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=168AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF

--------------------------------------------------------------

>63789_63789_22_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=389AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIAL
LVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHH
STTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRN

--------------------------------------------------------------

>63789_63789_23_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=347AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT

--------------------------------------------------------------

>63789_63789_24_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000396642_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=564AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYE
TTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG

--------------------------------------------------------------

>63789_63789_25_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=564AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYE
TTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG

--------------------------------------------------------------

>63789_63789_26_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_27_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=575AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>63789_63789_28_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>63789_63789_29_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_30_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=567AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIAL
LVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHH
STTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPAR
MSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDE
EYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTN

--------------------------------------------------------------

>63789_63789_31_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=572AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>63789_63789_32_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=193AA_BP=
MGLAAGSSCLFLHCFAPFVLRSNSAVRVPAPLGRGAPGRRGSLSDFACAGPACTPSPLAWSEARAGPGNWRRGRRGAFPPAARAEGWGWG
GVSAASQPGVGPRPPCPRLGPEPPSRGPLPLQGPAAAAGRAPRGGRAGVFNGSVLPAAGTAPGQAGPPARPQPPRSHQLQLQLRSLRLPQ

--------------------------------------------------------------

>63789_63789_33_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=193AA_BP=
MGLAAGSSCLFLHCFAPFVLRSNSAVRVPAPLGRGAPGRRGSLSDFACAGPACTPSPLAWSEARAGPGNWRRGRRGAFPPAARAEGWGWG
GVSAASQPGVGPRPPCPRLGPEPPSRGPLPLQGPAAAAGRAPRGGRAGVFNGSVLPAAGTAPGQAGPPARPQPPRSHQLQLQLRSLRLPQ

--------------------------------------------------------------

>63789_63789_34_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=389AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIAL
LVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHH
STTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRN

--------------------------------------------------------------

>63789_63789_35_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=347AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT

--------------------------------------------------------------

>63789_63789_36_PDE7A-NRG1_PDE7A_chr8_66691955_ENST00000401827_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=564AA_BP=95
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVV
GIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSP
VDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYE
TTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:66691955/chr8:32585467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NRG1

Q02297

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:1348215, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:7902537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE7Achr8:66691955chr8:32585467ENST00000379419-31328_3368.33333333333333457.0Compositional biasNote=Poly-Ser
HgenePDE7Achr8:66691955chr8:32585467ENST00000396642-31228_3394.33333333333333425.0Compositional biasNote=Poly-Ser
HgenePDE7Achr8:66691955chr8:32585467ENST00000401827-31328_3394.33333333333333483.0Compositional biasNote=Poly-Ser
TgeneNRG1chr8:66691955chr8:32585467ENST00000287842412165_177167.33333333333334638.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000341377413165_177167.33333333333334525.3333333333334Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000356819413165_177167.33333333333334646.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000405005412165_177167.33333333333334641.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000519301211165_177112.33333333333333591.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000521670413165_177167.33333333333334477.3333333333333Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000523079411165_177167.33333333333334421.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST00000287842412178_222167.33333333333334638.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000341377413178_222167.33333333333334525.3333333333334DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000356819413178_222167.33333333333334646.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000405005412178_222167.33333333333334641.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000519301211178_222112.33333333333333591.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000521670413178_222167.33333333333334477.3333333333333DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000523079411178_222167.33333333333334421.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST00000287842412266_640167.33333333333334638.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000341377413266_640167.33333333333334525.3333333333334Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000356819413266_640167.33333333333334646.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000405005412266_640167.33333333333334641.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000519301211266_640112.33333333333333591.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST0000052050203266_640222.33333333333334297.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000521670413266_640167.33333333333334477.3333333333333Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000523079411266_640167.33333333333334421.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST00000287842412243_265167.33333333333334638.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000341377413243_265167.33333333333334525.3333333333334TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000356819413243_265167.33333333333334646.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000405005412243_265167.33333333333334641.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000519301211243_265112.33333333333333591.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST0000052050203243_265222.33333333333334297.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000521670413243_265167.33333333333334477.3333333333333TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG1chr8:66691955chr8:32585467ENST00000523079411243_265167.33333333333334421.0TransmembraneHelical%3B Note%3DInternal signal sequence

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE7Achr8:66691955chr8:32585467ENST00000379419-313136_45868.33333333333333457.0DomainPDEase
HgenePDE7Achr8:66691955chr8:32585467ENST00000396642-312136_45894.33333333333333425.0DomainPDEase
HgenePDE7Achr8:66691955chr8:32585467ENST00000401827-313136_45894.33333333333333483.0DomainPDEase
TgeneNRG1chr8:66691955chr8:32585467ENST0000052040725165_177348.3333333333333423.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST0000052050203165_177222.33333333333334297.0Compositional biasNote=Ser/Thr-rich
TgeneNRG1chr8:66691955chr8:32585467ENST0000028784241237_128167.33333333333334638.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000034137741337_128167.33333333333334525.3333333333334DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000035681941337_128167.33333333333334646.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000040500541237_128167.33333333333334641.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000051930121137_128112.33333333333333591.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000052040725178_222348.3333333333333423.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST000005204072537_128348.3333333333333423.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000052050203178_222222.33333333333334297.0DomainEGF-like
TgeneNRG1chr8:66691955chr8:32585467ENST000005205020337_128222.33333333333334297.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000052167041337_128167.33333333333334477.3333333333333DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000052307941137_128167.33333333333334421.0DomainNote=Ig-like C2-type
TgeneNRG1chr8:66691955chr8:32585467ENST0000028784241220_242167.33333333333334638.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000034137741320_242167.33333333333334525.3333333333334Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000035681941320_242167.33333333333334646.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000040500541220_242167.33333333333334641.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000051930121120_242112.33333333333333591.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST000005204072520_242348.3333333333333423.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000052040725266_640348.3333333333333423.0Topological domainCytoplasmic
TgeneNRG1chr8:66691955chr8:32585467ENST000005205020320_242222.33333333333334297.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000052167041320_242167.33333333333334477.3333333333333Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000052307941120_242167.33333333333334421.0Topological domainExtracellular
TgeneNRG1chr8:66691955chr8:32585467ENST0000052040725243_265348.3333333333333423.0TransmembraneHelical%3B Note%3DInternal signal sequence


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1232_PDE7A_66691955_NRG1_32585467_1232_PDE7A_66691955_NRG1_32585467_ranked_0.pdbPDE7A6669195566691955ENST00000539990NRG1chr832585467+
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDF
RIFHSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF
575


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PDE7A_pLDDT.png
all structure
all structure
NRG1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PDE7A
NRG1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PDE7A-NRG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PDE7A-NRG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRG1C0036341Schizophrenia7CTD_human
TgeneNRG1C0005586Bipolar Disorder5PSYGENET
TgeneNRG1C0024809Marijuana Abuse3PSYGENET
TgeneNRG1C0011570Mental Depression2PSYGENET
TgeneNRG1C0011581Depressive disorder2PSYGENET
TgeneNRG1C0006142Malignant neoplasm of breast1CTD_human
TgeneNRG1C0006870Cannabis Dependence1PSYGENET
TgeneNRG1C0007621Neoplastic Cell Transformation1CTD_human
TgeneNRG1C0011616Contact Dermatitis1CTD_human
TgeneNRG1C0018801Heart failure1CTD_human
TgeneNRG1C0018802Congestive heart failure1CTD_human
TgeneNRG1C0019569Hirschsprung Disease1CTD_human
TgeneNRG1C0023212Left-Sided Heart Failure1CTD_human
TgeneNRG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNRG1C0024121Lung Neoplasms1CTD_human
TgeneNRG1C0026650Movement Disorders1CTD_human
TgeneNRG1C0027626Neoplasm Invasiveness1CTD_human
TgeneNRG1C0030193Pain1CTD_human
TgeneNRG1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneNRG1C0038358Gastric ulcer1CTD_human
TgeneNRG1C0085758Aganglionosis, Colonic1CTD_human
TgeneNRG1C0087031Juvenile-Onset Still Disease1CTD_human
TgeneNRG1C0162351Contact hypersensitivity1CTD_human
TgeneNRG1C0234230Pain, Burning1CTD_human
TgeneNRG1C0234238Ache1CTD_human
TgeneNRG1C0234254Radiating pain1CTD_human
TgeneNRG1C0235527Heart Failure, Right-Sided1CTD_human
TgeneNRG1C0236733Amphetamine-Related Disorders1CTD_human
TgeneNRG1C0236804Amphetamine Addiction1CTD_human
TgeneNRG1C0236807Amphetamine Abuse1CTD_human
TgeneNRG1C0242379Malignant neoplasm of lung1CTD_human
TgeneNRG1C0266487Etat Marbre1CTD_human
TgeneNRG1C0458257Pain, Splitting1CTD_human
TgeneNRG1C0458259Pain, Crushing1CTD_human
TgeneNRG1C0678222Breast Carcinoma1CTD_human
TgeneNRG1C0751407Pain, Migratory1CTD_human
TgeneNRG1C0751408Suffering, Physical1CTD_human
TgeneNRG1C0876994Cardiotoxicity1CTD_human
TgeneNRG1C1136382Sclerocystic Ovaries1CTD_human
TgeneNRG1C1257840Aganglionosis, Rectosigmoid Colon1CTD_human
TgeneNRG1C1257931Mammary Neoplasms, Human1CTD_human
TgeneNRG1C1458155Mammary Neoplasms1CTD_human
TgeneNRG1C1959583Myocardial Failure1CTD_human
TgeneNRG1C1961112Heart Decompensation1CTD_human
TgeneNRG1C3495559Juvenile arthritis1CTD_human
TgeneNRG1C3661523Congenital Intestinal Aganglionosis1CTD_human
TgeneNRG1C3714758Juvenile psoriatic arthritis1CTD_human
TgeneNRG1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneNRG1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneNRG1C4704874Mammary Carcinoma, Human1CTD_human