UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PHF21A-ACSL6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PHF21A-ACSL6
	FusionPDB ID: 64836
	FusionGDB2.0 ID: 64836
		Hgene	Tgene
	Gene symbol	PHF21A	ACSL6
	Gene ID	51317	23305
	Gene name	PHD finger protein 21A	acyl-CoA synthetase long chain family member 6
	Synonyms	BHC80\|BM-006\|IDDBCS\|NEDMS	ACS2\|FACL6\|LACS 6\|LACS2\|LACS5
	Cytomap	11p11.2	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa)	long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2
	Modification date	20200327	20200313
	UniProtAcc	.	Q9UKU0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000257821, ENST00000323180, ENST00000418153, ENST00000527753,	ENST00000296869, ENST00000357096, ENST00000379240, ENST00000379244, ENST00000379246, ENST00000379255, ENST00000431707, ENST00000477640, ENST00000543479, ENST00000544770, ENST00000379249, ENST00000379264, ENST00000379272,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 12=2964	6 X 8 X 8=384
	# samples	22	10
	** MAII score	log2(22/2964*10)=-3.75197001878117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PHF21A [Title/Abstract] AND ACSL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PHF21A(46098305)-ACSL6(131309093), # samples:3
Anticipated loss of major functional domain due to fusion event.	PHF21A-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PHF21A-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACSL6	GO:0001676	long-chain fatty acid metabolic process	24269233

Fusion gene breakpoints across PHF21A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-ZG-A9LZ-01A	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-
ChimerDB4	PRAD	TCGA-ZG-A9LZ	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000257821	PHF21A	chr11	46098305	-	ENST00000379249	ACSL6	chr5	131309093	-	1788	777	624	1787	387
ENST00000257821	PHF21A	chr11	46098305	-	ENST00000379264	ACSL6	chr5	131309093	-	6139	777	624	1877	417
ENST00000257821	PHF21A	chr11	46098305	-	ENST00000379272	ACSL6	chr5	131309093	-	4508	777	624	1877	417
ENST00000323180	PHF21A	chr11	46098305	-	ENST00000379249	ACSL6	chr5	131309093	-	1532	521	368	1531	388
ENST00000323180	PHF21A	chr11	46098305	-	ENST00000379264	ACSL6	chr5	131309093	-	5883	521	368	1621	417
ENST00000323180	PHF21A	chr11	46098305	-	ENST00000379272	ACSL6	chr5	131309093	-	4252	521	368	1621	417
ENST00000418153	PHF21A	chr11	46098305	-	ENST00000379249	ACSL6	chr5	131309093	-	1364	353	200	1363	388
ENST00000418153	PHF21A	chr11	46098305	-	ENST00000379264	ACSL6	chr5	131309093	-	5715	353	200	1453	417
ENST00000418153	PHF21A	chr11	46098305	-	ENST00000379272	ACSL6	chr5	131309093	-	4084	353	200	1453	417

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000257821	ENST00000379249	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.004653637	0.99534637
ENST00000257821	ENST00000379264	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.00033263	0.9996674
ENST00000257821	ENST00000379272	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.000581424	0.9994186
ENST00000323180	ENST00000379249	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.006862048	0.9931379
ENST00000323180	ENST00000379264	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.00033536	0.99966466
ENST00000323180	ENST00000379272	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.000642978	0.99935704
ENST00000418153	ENST00000379249	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.004120343	0.99587965
ENST00000418153	ENST00000379264	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.000293139	0.9997068
ENST00000418153	ENST00000379272	PHF21A	chr11	46098305	-	ACSL6	chr5	131309093	-	0.000507724	0.9994923

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64836_64836_1_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000257821_ACSL6_chr5_131309093_ENST00000379249_length(amino acids)=387AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_2_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000257821_ACSL6_chr5_131309093_ENST00000379264_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_3_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000257821_ACSL6_chr5_131309093_ENST00000379272_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_4_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000323180_ACSL6_chr5_131309093_ENST00000379249_length(amino acids)=388AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_5_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000323180_ACSL6_chr5_131309093_ENST00000379264_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_6_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000323180_ACSL6_chr5_131309093_ENST00000379272_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_7_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000418153_ACSL6_chr5_131309093_ENST00000379249_length(amino acids)=388AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_8_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000418153_ACSL6_chr5_131309093_ENST00000379264_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

>64836_64836_9_PHF21A-ACSL6_PHF21A_chr11_46098305_ENST00000418153_ACSL6_chr5_131309093_ENST00000379272_length(amino acids)=417AA_BP=46
MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL
NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ
TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL
KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46098305/chr5:131309093)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACSL6 Q9UKU0
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000357096

46_697

0.0

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379255

46_697

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000357096

25_45

0.0

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379255

25_45

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000257821

558_603

51.0

682.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000323180

558_603

51.0

635.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000418153

558_603

51.0

681.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000257821

4_108

51.0

682.0

Compositional bias

Note=Gln-rich

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000323180

4_108

51.0

635.0

Compositional bias

Note=Gln-rich

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000418153

4_108

51.0

681.0

Compositional bias

Note=Gln-rich

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000257821

425_437

51.0

682.0

DNA binding

Note=A.T hook

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000323180

425_437

51.0

635.0

DNA binding

Note=A.T hook

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000418153

425_437

51.0

681.0

DNA binding

Note=A.T hook

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000257821

486_680

51.0

682.0

Region

Note=Required for transcriptional repression

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000323180

486_680

51.0

635.0

Region

Note=Required for transcriptional repression

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000418153

486_680

51.0

681.0

Region

Note=Required for transcriptional repression

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000257821

488_535

51.0

682.0

Zinc finger

PHD-type

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000323180

488_535

51.0

635.0

Zinc finger

PHD-type

Hgene

PHF21A

chr11:46098305

chr5:131309093

ENST00000418153

488_535

51.0

681.0

Zinc finger

PHD-type

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000296869

46_697

356.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379240

46_697

331.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379244

46_697

331.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379246

46_697

342.0

709.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379249

46_697

331.0

668.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379264

46_697

356.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379272

46_697

346.0

713.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000543479

46_697

331.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000296869

25_45

356.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379240

25_45

331.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379244

25_45

331.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379246

25_45

342.0

709.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379249

25_45

331.0

668.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379264

25_45

356.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000379272

25_45

346.0

713.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr11:46098305

chr5:131309093

ENST00000543479

25_45

331.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>857_PHF21A_46098305_ACSL6_131309093_857_PHF21A_46098305_ACSL6_131309093_ranked_0.pdb	PHF21A	46098305	46098305	ENST00000379272	ACSL6	chr5	131309093	-	MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLL NRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQ TECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTL KIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVR	417

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PHF21A_pLDDT.png

ACSL6_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PHF21A
ACSL6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PHF21A-ACSL6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PHF21A-ACSL6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source