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Fusion Protein:ARID5B-KAT6A |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ARID5B-KAT6A | FusionPDB ID: 6505 | FusionGDB2.0 ID: 6505 | Hgene | Tgene | Gene symbol | ARID5B | KAT6A | Gene ID | 84159 | 7994 |
| Gene name | AT-rich interaction domain 5B | lysine acetyltransferase 6A | |
| Synonyms | DESRT|MRF-2|MRF2 | ARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220 | |
| Cytomap | 10q21.2 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 5BARID domain-containing protein 5BAT-rich interactive domain 5B (MRF1-like)MRF1-like proteinmodulator recognition factor 2 (MRF2) | histone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q14865 | Q92794 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000279873, ENST00000309334, | ENST00000265713, ENST00000396930, ENST00000406337, ENST00000485568, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 18 X 15 X 7=1890 | 6 X 11 X 6=396 |
| # samples | 18 | 12 | |
| ** MAII score | log2(18/1890*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ARID5B [Title/Abstract] AND KAT6A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARID5B(63852460)-KAT6A(41839472), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ARID5B-KAT6A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ARID5B-KAT6A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ARID5B-KAT6A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ARID5B-KAT6A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ARID5B-KAT6A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARID5B | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8649988 |
| Hgene | ARID5B | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 21532585 |
| Tgene | KAT6A | GO:0006473 | protein acetylation | 23431171 |
| Tgene | KAT6A | GO:0016573 | histone acetylation | 11742995|17925393 |
| Tgene | KAT6A | GO:0030099 | myeloid cell differentiation | 11742995 |
| Tgene | KAT6A | GO:0043966 | histone H3 acetylation | 16387653 |
| Tgene | KAT6A | GO:0045892 | negative regulation of transcription, DNA-templated | 11742995 |
| Tgene | KAT6A | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995|11965546|18794358 |
| Fusion gene breakpoints across ARID5B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KAT6A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-Y6-A9XI-01A | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - |
| ChimerDB4 | PRAD | TCGA-Y6-A9XI | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000309334 | ARID5B | chr10 | 63852460 | + | ENST00000406337 | KAT6A | chr8 | 41839472 | - | 9333 | 1301 | 1297 | 6606 | 1769 |
| ENST00000309334 | ARID5B | chr10 | 63852460 | + | ENST00000265713 | KAT6A | chr8 | 41839472 | - | 9333 | 1301 | 1297 | 6606 | 1769 |
| ENST00000309334 | ARID5B | chr10 | 63852460 | + | ENST00000396930 | KAT6A | chr8 | 41839472 | - | 9333 | 1301 | 1297 | 6606 | 1769 |
| ENST00000309334 | ARID5B | chr10 | 63852460 | + | ENST00000485568 | KAT6A | chr8 | 41839472 | - | 3772 | 1301 | 1297 | 3039 | 580 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000309334 | ENST00000406337 | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - | 0.001891217 | 0.99810874 |
| ENST00000309334 | ENST00000265713 | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - | 0.001891217 | 0.99810874 |
| ENST00000309334 | ENST00000396930 | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - | 0.001891217 | 0.99810874 |
| ENST00000309334 | ENST00000485568 | ARID5B | chr10 | 63852460 | + | KAT6A | chr8 | 41839472 | - | 0.00075725 | 0.9992428 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >6505_6505_1_ARID5B-KAT6A_ARID5B_chr10_63852460_ENST00000309334_KAT6A_chr8_41839472_ENST00000265713_length(amino acids)=1769AA_BP=1 MGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAA QIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTK FFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQ VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCL LAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSD LGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLR WTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRR GRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSP EALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVL DEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKN SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKE EEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHD ADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE LIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVR SVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQS SCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPP QQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMD PHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHI SIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQ -------------------------------------------------------------- >6505_6505_2_ARID5B-KAT6A_ARID5B_chr10_63852460_ENST00000309334_KAT6A_chr8_41839472_ENST00000396930_length(amino acids)=1769AA_BP=1 MGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAA QIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTK FFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQ VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCL LAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSD LGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLR WTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRR GRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSP EALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVL DEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKN SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKE EEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHD ADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE LIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVR SVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQS SCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPP QQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMD PHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHI SIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQ -------------------------------------------------------------- >6505_6505_3_ARID5B-KAT6A_ARID5B_chr10_63852460_ENST00000309334_KAT6A_chr8_41839472_ENST00000406337_length(amino acids)=1769AA_BP=1 MGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAA QIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTK FFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQ VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCL LAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSD LGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLR WTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRR GRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSP EALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVL DEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPVSLLRKRDVKN SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKE EEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHD ADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEE LIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHNSPISSVQSHPSQSVR SVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNSSSQS SCSYGGLSSSSSLTQSSCVVTQQMASMGSSCSMMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPP QQQPQQQPQPQPQQPPPPPPPQQQPPLSQCSMNNSFTPAPMIMEIPESGSTGNISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMD PHAMPYSHSPAVTSYATSVSLSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQRLQGQMPVKGHI SIRSKSAPLPSAAAHQQQLYGRSPSAVAMQAGPRALAVQRGMNMGVNLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQ -------------------------------------------------------------- >6505_6505_4_ARID5B-KAT6A_ARID5B_chr10_63852460_ENST00000309334_KAT6A_chr8_41839472_ENST00000485568_length(amino acids)=580AA_BP=1 MGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAA QIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTK FFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQ VRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCL LAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSD LGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:63852460/chr8:41839472) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID5B | KAT6A |
| FUNCTION: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. {ECO:0000269|PubMed:21532585}. | FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1019_1026 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1069_1078 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1147_1150 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1221_1242 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1267_1302 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1411_1414 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1593_1597 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1643_1704 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Gln/Pro-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1897_1977 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Met-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 371_379 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 788_801 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 989_995 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1019_1026 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1069_1078 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1147_1150 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1221_1242 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1267_1302 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1411_1414 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1593_1597 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1643_1704 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Gln/Pro-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1897_1977 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Met-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 371_379 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 788_801 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 989_995 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1019_1026 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1069_1078 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1147_1150 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Lys | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1221_1242 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1267_1302 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Glu-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1411_1414 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1593_1597 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1643_1704 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Gln/Pro-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1897_1977 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Met-rich | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 371_379 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 788_801 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 989_995 | 236.33333333333334 | 2005.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 504_778 | 236.33333333333334 | 2005.0 | Domain | MYST-type HAT | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 504_778 | 236.33333333333334 | 2005.0 | Domain | MYST-type HAT | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 504_778 | 236.33333333333334 | 2005.0 | Domain | MYST-type HAT | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1913_1948 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 488_778 | 236.33333333333334 | 2005.0 | Region | Note=Catalytic | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 645_649 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 654_660 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1913_1948 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 488_778 | 236.33333333333334 | 2005.0 | Region | Note=Catalytic | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 645_649 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 654_660 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1913_1948 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 488_778 | 236.33333333333334 | 2005.0 | Region | Note=Catalytic | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 645_649 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 654_660 | 236.33333333333334 | 2005.0 | Region | Acetyl-CoA binding | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 259_313 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 537_562 | 236.33333333333334 | 2005.0 | Zinc finger | C2HC MYST-type | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 259_313 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 537_562 | 236.33333333333334 | 2005.0 | Zinc finger | C2HC MYST-type | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 259_313 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 2 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 537_562 | 236.33333333333334 | 2005.0 | Zinc finger | C2HC MYST-type |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARID5B | chr10:63852460 | chr8:41839472 | ENST00000279873 | + | 1 | 10 | 318_410 | 0 | 1189.0 | Domain | ARID |
| Hgene | ARID5B | chr10:63852460 | chr8:41839472 | ENST00000309334 | + | 1 | 7 | 318_410 | 0 | 946.0 | Domain | ARID |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 95_171 | 236.33333333333334 | 2005.0 | Domain | H15 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 95_171 | 236.33333333333334 | 2005.0 | Domain | H15 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 95_171 | 236.33333333333334 | 2005.0 | Domain | H15 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 1_144 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-1 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 52_166 | 236.33333333333334 | 2005.0 | Region | Note=Required for nuclear localization | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 1_144 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-1 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 52_166 | 236.33333333333334 | 2005.0 | Region | Note=Required for nuclear localization | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 1_144 | 236.33333333333334 | 2005.0 | Region | Note=Required for activation of RUNX1-1 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 52_166 | 236.33333333333334 | 2005.0 | Region | Note=Required for nuclear localization | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 206_265 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 1 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 206_265 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 1 | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 206_265 | 236.33333333333334 | 2005.0 | Zinc finger | PHD-type 1 |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
ARID5B_pLDDT.png  |
KAT6A_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
Top |
Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| KAT6A | ING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, Myo1c, Rpl35, Tpx2, Srsf1, Tubgcp6, HEMGN, HNRNPL, KIAA1429, RANGAP1, BRD1, BRPF3, ING4, KAT7, JADE3, KAT6B, JADE2, JADE1, HIST1H2BO, HRG, CSNK2A2, APEX1, CENPA, DANCR, ZBTB2, CSNK2B, CSNK2A1, RFWD2, HSPD1, CMAS, HIST2H2BF, CASP2, TRIM65, HGH1, TTC4, PPP2R5C, OTUD3, DBNL, PIP4K2C, ATIC, NUDT12, B3GALTL, ATG4B, PABPN1, DEK, SF3A3, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ARID5B | |
| KAT6A |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000265713 | 2 | 17 | 144_664 | 236.33333333333334 | 2005.0 | PML | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000396930 | 3 | 18 | 144_664 | 236.33333333333334 | 2005.0 | PML | |
| Tgene | KAT6A | chr10:63852460 | chr8:41839472 | ENST00000406337 | 3 | 18 | 144_664 | 236.33333333333334 | 2005.0 | PML |
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Related Drugs to ARID5B-KAT6A |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ARID5B-KAT6A |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KAT6A | C4225396 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 32 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Tgene | KAT6A | C4511003 | Acute myeloid leukemia with t(8;16)(p11;p13) translocation | 2 | ORPHANET |
| Tgene | KAT6A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | KAT6A | C0025149 | Medulloblastoma | 1 | CTD_human |
| Tgene | KAT6A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | KAT6A | C0205833 | Medullomyoblastoma | 1 | CTD_human |
| Tgene | KAT6A | C0278510 | Childhood Medulloblastoma | 1 | CTD_human |
| Tgene | KAT6A | C0278876 | Adult Medulloblastoma | 1 | CTD_human |
| Tgene | KAT6A | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Tgene | KAT6A | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human |
| Tgene | KAT6A | C1275668 | Melanotic medulloblastoma | 1 | CTD_human |
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