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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PI4KA-RREB1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PI4KA-RREB1
FusionPDB ID: 65082
FusionGDB2.0 ID: 65082
HgeneTgene
Gene symbol

PI4KA

RREB1

Gene ID

5297

6239

Gene namephosphatidylinositol 4-kinase alpharas responsive element binding protein 1
SynonymsPI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230FINB|HNT|LZ321|RREB-1|Zep-1
Cytomap

22q11.21

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, aras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000255882, ENST00000572273, 
ENST00000414196, ENST00000466162, 
ENST00000334984, ENST00000349384, 
ENST00000379933, ENST00000379938, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 14 X 12=336013 X 10 X 5=650
# samples 2114
** MAII scorelog2(21/3360*10)=-4
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/650*10)=-2.21501289097085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PI4KA [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PI4KA(21188850)-RREB1(7211037), # samples:3
Anticipated loss of major functional domain due to fusion event.PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PI4KA-RREB1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePI4KA

GO:0016310

phosphorylation

25327288

TgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445


check buttonFusion gene breakpoints across PI4KA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RREB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-1081-01API4KAchr22

21188850

-RREB1chr6

7211037

+
ChimerDB4LUSCTCGA-21-1081PI4KAchr22

21188849

-RREB1chr6

7211036

+
ChimerDB4LUSCTCGA-21-1081PI4KAchr22

21188850

-RREB1chr6

7211037

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572273PI4KAchr2221188850-ENST00000379933RREB1chr67211037+536942433850621574
ENST00000572273PI4KAchr2221188850-ENST00000379938RREB1chr67211037+824042433852271629
ENST00000572273PI4KAchr2221188850-ENST00000334984RREB1chr67211037+547442433844291363
ENST00000572273PI4KAchr2221188850-ENST00000349384RREB1chr67211037+712542433850621574
ENST00000572273PI4KAchr2221188849-ENST00000379933RREB1chr67211036+536942433850621574
ENST00000572273PI4KAchr2221188849-ENST00000379938RREB1chr67211036+824042433852271629
ENST00000572273PI4KAchr2221188849-ENST00000334984RREB1chr67211036+547442433844291363
ENST00000572273PI4KAchr2221188849-ENST00000349384RREB1chr67211036+712542433850621574

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572273ENST00000379933PI4KAchr2221188850-RREB1chr67211037+0.0158839930.984116
ENST00000572273ENST00000379938PI4KAchr2221188850-RREB1chr67211037+0.00365840.9963415
ENST00000572273ENST00000334984PI4KAchr2221188850-RREB1chr67211037+0.0070816260.9929183
ENST00000572273ENST00000349384PI4KAchr2221188850-RREB1chr67211037+0.0056566090.9943434
ENST00000572273ENST00000379933PI4KAchr2221188849-RREB1chr67211036+0.0158839930.984116
ENST00000572273ENST00000379938PI4KAchr2221188849-RREB1chr67211036+0.00365840.9963415
ENST00000572273ENST00000334984PI4KAchr2221188849-RREB1chr67211036+0.0070816260.9929183
ENST00000572273ENST00000349384PI4KAchr2221188849-RREB1chr67211036+0.0056566090.9943434

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65082_65082_1_PI4KA-RREB1_PI4KA_chr22_21188849_ENST00000572273_RREB1_chr6_7211036_ENST00000334984_length(amino acids)=1363AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTGQKPFPCQKCDAFF
STKSNCERHQLRKHGVTTCSLRRNGLIPQSKESDVGSHDSTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEED
SENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPIL

--------------------------------------------------------------

>65082_65082_2_PI4KA-RREB1_PI4KA_chr22_21188849_ENST00000572273_RREB1_chr6_7211036_ENST00000349384_length(amino acids)=1574AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGE
VLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFK
LAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAP
AEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKH
SLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSE

--------------------------------------------------------------

>65082_65082_3_PI4KA-RREB1_PI4KA_chr22_21188849_ENST00000572273_RREB1_chr6_7211036_ENST00000379933_length(amino acids)=1574AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGE
VLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFK
LAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAP
AEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKH
SLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSE

--------------------------------------------------------------

>65082_65082_4_PI4KA-RREB1_PI4KA_chr22_21188849_ENST00000572273_RREB1_chr6_7211036_ENST00000379938_length(amino acids)=1629AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTGQKPFPCQKCDAFF
STKSNCERHQLRKHGVTTCSLRRNGLIPQSKESDVGSHDSTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAET
ASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTL
SRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTD
SPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENE
STHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATAD

--------------------------------------------------------------

>65082_65082_5_PI4KA-RREB1_PI4KA_chr22_21188850_ENST00000572273_RREB1_chr6_7211037_ENST00000334984_length(amino acids)=1363AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTGQKPFPCQKCDAFF
STKSNCERHQLRKHGVTTCSLRRNGLIPQSKESDVGSHDSTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEED
SENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPIL

--------------------------------------------------------------

>65082_65082_6_PI4KA-RREB1_PI4KA_chr22_21188850_ENST00000572273_RREB1_chr6_7211037_ENST00000349384_length(amino acids)=1574AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGE
VLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFK
LAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAP
AEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKH
SLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSE

--------------------------------------------------------------

>65082_65082_7_PI4KA-RREB1_PI4KA_chr22_21188850_ENST00000572273_RREB1_chr6_7211037_ENST00000379933_length(amino acids)=1574AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTDSQSDAETAAAAGE
VLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFK
LAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAP
AEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKH
SLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSE

--------------------------------------------------------------

>65082_65082_8_PI4KA-RREB1_PI4KA_chr22_21188850_ENST00000572273_RREB1_chr6_7211037_ENST00000379938_length(amino acids)=1629AA_BP=28
MCGSLPSSTSQRSSKSVLGRRKHSSERQRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKK
ADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRK
FPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEP
LPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQI
LKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLL
QSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFA
FSGVLRAHVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSSAAE
LVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGP
AEAPAAEASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQENISFLSPS
SLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQ
LAVPIYSSALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVADPGPASTGSNTTASDS
LGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKF
SPFLQTAEDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQRHMLTHTGQKPFPCQKCDAFF
STKSNCERHQLRKHGVTTCSLRRNGLIPQSKESDVGSHDSTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAET
ASPVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEAGAGGAASQEQKLACDTCGKSFKFLGTL
SRHRKAHGRQEPKDEKGDGASTAEEGPQPAPEQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTD
SPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQRIHQKARHAKHHGKDSDKEERGEEDSENE
STHSGNNAVSENEAELAPNASNHMAVTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATAD

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:21188850/chr6:7211037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512481_546141.666666666666661477.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512877_880141.666666666666661477.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512969_1064141.666666666666661477.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512481_546141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512877_880141.666666666666661688.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512969_1064141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512481_546141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512877_880141.666666666666661688.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512969_1064141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513481_546141.666666666666661743.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513877_880141.666666666666661743.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513969_1064141.666666666666661743.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512481_546141.666666666666661477.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512877_880141.666666666666661477.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512969_1064141.666666666666661477.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512481_546141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512877_880141.666666666666661688.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512969_1064141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512481_546141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512877_880141.666666666666661688.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512969_1064141.666666666666661688.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513481_546141.666666666666661743.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513877_880141.666666666666661743.0Compositional biasNote=Poly-Pro
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513969_1064141.666666666666661743.0Compositional biasNote=Pro-rich
TgeneRREB1chr22:21188849chr6:7211036ENST000003349845121246_1268141.666666666666661477.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188849chr6:7211036ENST000003349845121393_1415141.666666666666661477.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188849chr6:7211036ENST000003349845121512_1534141.666666666666661477.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188849chr6:7211036ENST000003349845121540_1562141.666666666666661477.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512208_230141.666666666666661477.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512235_258141.666666666666661477.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512316_338141.666666666666661477.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512643_665141.666666666666661477.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512671_693141.666666666666661477.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512699_722141.666666666666661477.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512753_775141.666666666666661477.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512790_815141.666666666666661477.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188849chr6:7211036ENST000003493845121246_1268141.666666666666661688.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188849chr6:7211036ENST000003493845121393_1415141.666666666666661688.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188849chr6:7211036ENST000003493845121512_1534141.666666666666661688.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188849chr6:7211036ENST000003493845121540_1562141.666666666666661688.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512208_230141.666666666666661688.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512235_258141.666666666666661688.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512316_338141.666666666666661688.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512643_665141.666666666666661688.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512671_693141.666666666666661688.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512699_722141.666666666666661688.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512753_775141.666666666666661688.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512790_815141.666666666666661688.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188849chr6:7211036ENST000003799335121246_1268141.666666666666661688.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188849chr6:7211036ENST000003799335121393_1415141.666666666666661688.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188849chr6:7211036ENST000003799335121512_1534141.666666666666661688.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188849chr6:7211036ENST000003799335121540_1562141.666666666666661688.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512208_230141.666666666666661688.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512235_258141.666666666666661688.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512316_338141.666666666666661688.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512643_665141.666666666666661688.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512671_693141.666666666666661688.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512699_722141.666666666666661688.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512753_775141.666666666666661688.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512790_815141.666666666666661688.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188849chr6:7211036ENST000003799385131246_1268141.666666666666661743.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188849chr6:7211036ENST000003799385131393_1415141.666666666666661743.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188849chr6:7211036ENST000003799385131512_1534141.666666666666661743.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188849chr6:7211036ENST000003799385131540_1562141.666666666666661743.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513208_230141.666666666666661743.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513235_258141.666666666666661743.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513316_338141.666666666666661743.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513643_665141.666666666666661743.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513671_693141.666666666666661743.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513699_722141.666666666666661743.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513753_775141.666666666666661743.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513790_815141.666666666666661743.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188850chr6:7211037ENST000003349845121246_1268141.666666666666661477.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188850chr6:7211037ENST000003349845121393_1415141.666666666666661477.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188850chr6:7211037ENST000003349845121512_1534141.666666666666661477.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188850chr6:7211037ENST000003349845121540_1562141.666666666666661477.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512208_230141.666666666666661477.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512235_258141.666666666666661477.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512316_338141.666666666666661477.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512643_665141.666666666666661477.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512671_693141.666666666666661477.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512699_722141.666666666666661477.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512753_775141.666666666666661477.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512790_815141.666666666666661477.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188850chr6:7211037ENST000003493845121246_1268141.666666666666661688.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188850chr6:7211037ENST000003493845121393_1415141.666666666666661688.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188850chr6:7211037ENST000003493845121512_1534141.666666666666661688.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188850chr6:7211037ENST000003493845121540_1562141.666666666666661688.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512208_230141.666666666666661688.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512235_258141.666666666666661688.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512316_338141.666666666666661688.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512643_665141.666666666666661688.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512671_693141.666666666666661688.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512699_722141.666666666666661688.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512753_775141.666666666666661688.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512790_815141.666666666666661688.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188850chr6:7211037ENST000003799335121246_1268141.666666666666661688.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188850chr6:7211037ENST000003799335121393_1415141.666666666666661688.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188850chr6:7211037ENST000003799335121512_1534141.666666666666661688.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188850chr6:7211037ENST000003799335121540_1562141.666666666666661688.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512208_230141.666666666666661688.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512235_258141.666666666666661688.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512316_338141.666666666666661688.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512643_665141.666666666666661688.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512671_693141.666666666666661688.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512699_722141.666666666666661688.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512753_775141.666666666666661688.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512790_815141.666666666666661688.0Zinc fingerC2H2-type 11
TgeneRREB1chr22:21188850chr6:7211037ENST000003799385131246_1268141.666666666666661743.0Zinc fingerC2H2-type 12
TgeneRREB1chr22:21188850chr6:7211037ENST000003799385131393_1415141.666666666666661743.0Zinc fingerC2H2-type 13
TgeneRREB1chr22:21188850chr6:7211037ENST000003799385131512_1534141.666666666666661743.0Zinc fingerC2H2-type 14
TgeneRREB1chr22:21188850chr6:7211037ENST000003799385131540_1562141.666666666666661743.0Zinc fingerC2H2-type 15
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513208_230141.666666666666661743.0Zinc fingerC2H2-type 4
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513235_258141.666666666666661743.0Zinc fingerC2H2-type 5
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513316_338141.666666666666661743.0Zinc fingerC2H2-type 6
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513643_665141.666666666666661743.0Zinc fingerC2H2-type 7
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513671_693141.666666666666661743.0Zinc fingerC2H2-type 8
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513699_722141.666666666666661743.0Zinc fingerC2H2-type 9
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513753_775141.666666666666661743.0Zinc fingerC2H2-type 10
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513790_815141.666666666666661743.0Zinc fingerC2H2-type 11

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePI4KAchr22:21188849chr6:7211036ENST00000414196-1231530_17180855.0DomainPIK helical
HgenePI4KAchr22:21188849chr6:7211036ENST00000414196-1231846_20790855.0DomainPI3K/PI4K
HgenePI4KAchr22:21188849chr6:7211036ENST00000572273-3551530_171864.333333333333332045.0DomainPIK helical
HgenePI4KAchr22:21188849chr6:7211036ENST00000572273-3551846_207964.333333333333332045.0DomainPI3K/PI4K
HgenePI4KAchr22:21188850chr6:7211037ENST00000414196-1231530_17180855.0DomainPIK helical
HgenePI4KAchr22:21188850chr6:7211037ENST00000414196-1231846_20790855.0DomainPI3K/PI4K
HgenePI4KAchr22:21188850chr6:7211037ENST00000572273-3551530_171864.333333333333332045.0DomainPIK helical
HgenePI4KAchr22:21188850chr6:7211037ENST00000572273-3551846_207964.333333333333332045.0DomainPI3K/PI4K
TgeneRREB1chr22:21188849chr6:7211036ENST00000334984512125_147141.666666666666661477.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188849chr6:7211036ENST0000033498451266_88141.666666666666661477.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188849chr6:7211036ENST0000033498451297_119141.666666666666661477.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188849chr6:7211036ENST00000349384512125_147141.666666666666661688.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188849chr6:7211036ENST0000034938451266_88141.666666666666661688.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188849chr6:7211036ENST0000034938451297_119141.666666666666661688.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188849chr6:7211036ENST00000379933512125_147141.666666666666661688.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188849chr6:7211036ENST0000037993351266_88141.666666666666661688.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188849chr6:7211036ENST0000037993351297_119141.666666666666661688.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188849chr6:7211036ENST00000379938513125_147141.666666666666661743.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188849chr6:7211036ENST0000037993851366_88141.666666666666661743.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188849chr6:7211036ENST0000037993851397_119141.666666666666661743.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188850chr6:7211037ENST00000334984512125_147141.666666666666661477.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188850chr6:7211037ENST0000033498451266_88141.666666666666661477.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188850chr6:7211037ENST0000033498451297_119141.666666666666661477.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188850chr6:7211037ENST00000349384512125_147141.666666666666661688.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188850chr6:7211037ENST0000034938451266_88141.666666666666661688.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188850chr6:7211037ENST0000034938451297_119141.666666666666661688.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188850chr6:7211037ENST00000379933512125_147141.666666666666661688.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188850chr6:7211037ENST0000037993351266_88141.666666666666661688.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188850chr6:7211037ENST0000037993351297_119141.666666666666661688.0Zinc fingerC2H2-type 2
TgeneRREB1chr22:21188850chr6:7211037ENST00000379938513125_147141.666666666666661743.0Zinc fingerC2H2-type 3
TgeneRREB1chr22:21188850chr6:7211037ENST0000037993851366_88141.666666666666661743.0Zinc fingerC2H2-type 1
TgeneRREB1chr22:21188850chr6:7211037ENST0000037993851397_119141.666666666666661743.0Zinc fingerC2H2-type 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PI4KA_pLDDT.png
all structure
all structure
RREB1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PI4KA
RREB1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PI4KA-RREB1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PI4KA-RREB1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource