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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PLG-LPA

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PLG-LPA
FusionPDB ID: 66345
FusionGDB2.0 ID: 66345
HgeneTgene
Gene symbol

PLG

LPA

Gene ID

5340

4018

Gene nameplasminogenlipoprotein(a)
Synonyms-AK38|APOA|LP
Cytomap

6q26

6q25.3-q26

Type of geneprotein-codingprotein-coding
Descriptionplasminogenplasminapolipoprotein(a)antiangiogenic AK38 proteinapo(a)lipoprotein, Lp(a)lp(a)
Modification date2020031320200321
UniProtAcc

Q9HBL7

P43657

Ensembl transtripts involved in fusion geneENST idsENST00000462918, ENST00000308192, 
ENST00000366924, 		ENST00000316300, 
ENST00000447678, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 7 X 2=564 X 8 X 3=96
# samples 88
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PLG [Title/Abstract] AND LPA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LPA(160958887)-PLG(161173147), # samples:4
PLG(161152146)-LPA(161020555), # samples:7
Anticipated loss of major functional domain due to fusion event.PLG-LPA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLG-LPA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLG-LPA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLG-LPA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLG-LPA seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PLG-LPA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLG

GO:0006508

proteolysis

9603964

HgenePLG

GO:0010812

negative regulation of cell-substrate adhesion

14699093

HgenePLG

GO:0022617

extracellular matrix disassembly

14699093

HgenePLG

GO:0042730

fibrinolysis

14688145|17307854|22025510

HgenePLG

GO:0051702

interaction with symbiont

12818429

HgenePLG

GO:0051918

negative regulation of fibrinolysis

14726399

HgenePLG

GO:0051919

positive regulation of fibrinolysis

6438154|26667841


check buttonFusion gene breakpoints across PLG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BC-A10W-11APLGchr6

161173292

+LPAchr6

160952922

-
ChimerDB4Non-CancerTCGA-BC-A216-11APLGchr6

161152154

+LPAchr6

161020547

-
ChimerDB4Non-CancerTCGA-CZ-4864-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-DD-A114-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-DD-A114-11APLGchr6

161173292

+LPAchr6

160952922

-
ChimerDB4Non-CancerTCGA-DD-A116-11APLGchr6

161152200

+LPAchr6

160998191

-
ChimerDB4Non-CancerTCGA-DD-A119-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-DD-A1EJ-11APLGchr6

161152154

+LPAchr6

161020547

-
ChimerDB4Non-CancerTCGA-DD-A1EL-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-DD-A39W-11APLGchr6

161152154

+LPAchr6

161020547

-
ChimerDB4Non-CancerTCGA-DD-A3A2-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-EP-A26S-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-EP-A26S-11APLGchr6

161152154

+LPAchr6

161020547

-
ChimerDB4Non-CancerTCGA-ES-A2HT-11APLGchr6

161134122

+LPAchr6

160978593

-
ChimerDB4Non-CancerTCGA-FV-A2QR-11APLGchr6

161152146

+LPAchr6

161020555

-
ChimerDB4Non-CancerTCGA-FV-A2QR-11APLGchr6

161152154

+LPAchr6

161020547

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000308192PLGchr6161152146+ENST00000316300LPAchr6161020555-4543143724754541689
ENST00000308192PLGchr6161152146+ENST00000447678LPAchr6161020555-4543143724754541689
ENST00000308192PLGchr6161173292+ENST00000316300LPAchr6160952922-27422334182495825
ENST00000308192PLGchr6161152154+ENST00000316300LPAchr6161020547-4527142924674524686
ENST00000308192PLGchr6161152154+ENST00000447678LPAchr6161020547-4527142924674524686
ENST00000308192PLGchr6161152200+ENST00000316300LPAchr6160998191-31451383181331437
ENST00000308192PLGchr6161152200+ENST00000447678LPAchr6160998191-31451383181331437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000308192ENST00000316300PLGchr6161152146+LPAchr6161020555-0.0004555730.99954444
ENST00000308192ENST00000447678PLGchr6161152146+LPAchr6161020555-0.0004555730.99954444
ENST00000308192ENST00000316300PLGchr6161173292+LPAchr6160952922-0.0001461010.99985385
ENST00000308192ENST00000316300PLGchr6161152154+LPAchr6161020547-0.0003811960.99961877
ENST00000308192ENST00000447678PLGchr6161152154+LPAchr6161020547-0.0003811960.99961877
ENST00000308192ENST00000316300PLGchr6161152200+LPAchr6160998191-0.0002319940.99976796
ENST00000308192ENST00000447678PLGchr6161152200+LPAchr6160998191-0.0002319940.99976796

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66345_66345_1_PLG-LPA_PLG_chr6_161152146_ENST00000308192_LPA_chr6_161020555_ENST00000316300_length(amino acids)=689AA_BP=59
MTTVISLSVTVCLGMGKDTGARRQPLLLGRHARNGLPRSPIDTARSFQGQINGQVWKKIGLTMNYCRNPDADTGPWCFTMDPSIRWEYCN
LTRCSDTEGTVVAPPTVIQVPSLGPPSEQAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTENYC
RNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS
SMIPHWHQRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPTENSTGVQDCY
RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVV
PVPSTELPSEEAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNV
RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRN

--------------------------------------------------------------

>66345_66345_2_PLG-LPA_PLG_chr6_161152146_ENST00000308192_LPA_chr6_161020555_ENST00000447678_length(amino acids)=689AA_BP=59
MTTVISLSVTVCLGMGKDTGARRQPLLLGRHARNGLPRSPIDTARSFQGQINGQVWKKIGLTMNYCRNPDADTGPWCFTMDPSIRWEYCN
LTRCSDTEGTVVAPPTVIQVPSLGPPSEQAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTENYC
RNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS
SMIPHWHQRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPTENSTGVQDCY
RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVV
PVPSTELPSEEAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNV
RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRN

--------------------------------------------------------------

>66345_66345_3_PLG-LPA_PLG_chr6_161152154_ENST00000308192_LPA_chr6_161020547_ENST00000316300_length(amino acids)=686AA_BP=173
MTTVISLSVTVCLGMGKDTGARRQPLLLGRHARNGLPRSPIDTARSFQGQINGQVWKKIGLTMNYCRNPDADTGPWCFTMDPSIRWEYCN
LTRCSDTEGTVVAPPTVIQVPSLGPPSEQAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTENYC
RNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS
SMIPHWHQRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPTENSTGVQDCY
RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVV
PVPSTELPSEEAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNV
RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRN

--------------------------------------------------------------

>66345_66345_4_PLG-LPA_PLG_chr6_161152154_ENST00000308192_LPA_chr6_161020547_ENST00000447678_length(amino acids)=686AA_BP=173
MTTVISLSVTVCLGMGKDTGARRQPLLLGRHARNGLPRSPIDTARSFQGQINGQVWKKIGLTMNYCRNPDADTGPWCFTMDPSIRWEYCN
LTRCSDTEGTVVAPPTVIQVPSLGPPSEQAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTENYC
RNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS
SMIPHWHQRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPTENSTGVQDCY
RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVV
PVPSTELPSEEAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNV
RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRN

--------------------------------------------------------------

>66345_66345_5_PLG-LPA_PLG_chr6_161152200_ENST00000308192_LPA_chr6_160998191_ENST00000316300_length(amino acids)=437AA_BP=160
MGLGPTFWALLASPKMEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVI
MAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCY
TTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWE
LCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWE

--------------------------------------------------------------

>66345_66345_6_PLG-LPA_PLG_chr6_161152200_ENST00000308192_LPA_chr6_160998191_ENST00000447678_length(amino acids)=437AA_BP=160
MGLGPTFWALLASPKMEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVI
MAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCY
TTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWE
LCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWE

--------------------------------------------------------------

>66345_66345_7_PLG-LPA_PLG_chr6_161173292_ENST00000308192_LPA_chr6_160952922_ENST00000316300_length(amino acids)=825AA_BP=380
MGLGPTFWALLASPKMEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVI
MAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCY
TTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWE
LCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWE
YCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGP
WCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAG
LEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPE
WVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWG
ETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYAR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:160958887/chr6:161173147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PLG

Q9HBL7

LPA

P43657

FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9. {ECO:0000269|PubMed:21940822}.FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. {ECO:0000269|PubMed:18297070}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLGchr6:161173292chr6:160952922ENST00000308192+1819184_262757.0811.0DomainKringle 2
HgenePLGchr6:161173292chr6:160952922ENST00000308192+181920_98757.0811.0DomainPAN
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391043_115602041.0DomainKringle 10
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391157_127002041.0DomainKringle 11
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391271_138402041.0DomainKringle 12
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039131_24402041.0DomainKringle 2
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391385_149802041.0DomainKringle 13
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391499_161202041.0DomainKringle 14
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391613_172602041.0DomainKringle 15
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391727_184002041.0DomainKringle 16
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391841_195402041.0DomainKringle 17
TgeneLPAchr6:161152146chr6:161020555ENST000003163000391955_206802041.0DomainKringle 18
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392069_218202041.0DomainKringle 19
TgeneLPAchr6:161152146chr6:161020555ENST0000031630003920_13002041.0DomainKringle 1
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392183_229602041.0DomainKringle 20
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392297_241002041.0DomainKringle 21
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392411_252402041.0DomainKringle 22
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039245_35802041.0DomainKringle 3
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392525_263802041.0DomainKringle 23
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392639_275202041.0DomainKringle 24
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392753_286602041.0DomainKringle 25
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392867_298002041.0DomainKringle 26
TgeneLPAchr6:161152146chr6:161020555ENST000003163000392981_309402041.0DomainKringle 27
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393095_320802041.0DomainKringle 28
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393209_332202041.0DomainKringle 29
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393323_343602041.0DomainKringle 30
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393437_355002041.0DomainKringle 31
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393551_366402041.0DomainKringle 32
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039359_47202041.0DomainKringle 4
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393665_377002041.0DomainKringle 33
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393771_388402041.0DomainKringle 34
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393885_399802041.0DomainKringle 35
TgeneLPAchr6:161152146chr6:161020555ENST000003163000393999_411202041.0DomainKringle 36
TgeneLPAchr6:161152146chr6:161020555ENST000003163000394113_422602041.0DomainKringle 37
TgeneLPAchr6:161152146chr6:161020555ENST000003163000394227_432702041.0DomainKringle 38
TgeneLPAchr6:161152146chr6:161020555ENST000003163000394328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039473_58602041.0DomainKringle 5
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039587_70002041.0DomainKringle 6
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039701_81402041.0DomainKringle 7
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039815_92802041.0DomainKringle 8
TgeneLPAchr6:161152146chr6:161020555ENST00000316300039929_104202041.0DomainKringle 9
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401043_115602041.0DomainKringle 10
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401157_127002041.0DomainKringle 11
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401271_138402041.0DomainKringle 12
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040131_24402041.0DomainKringle 2
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401385_149802041.0DomainKringle 13
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401499_161202041.0DomainKringle 14
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401613_172602041.0DomainKringle 15
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401727_184002041.0DomainKringle 16
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401841_195402041.0DomainKringle 17
TgeneLPAchr6:161152146chr6:161020555ENST000004476780401955_206802041.0DomainKringle 18
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402069_218202041.0DomainKringle 19
TgeneLPAchr6:161152146chr6:161020555ENST0000044767804020_13002041.0DomainKringle 1
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402183_229602041.0DomainKringle 20
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402297_241002041.0DomainKringle 21
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402411_252402041.0DomainKringle 22
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040245_35802041.0DomainKringle 3
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402525_263802041.0DomainKringle 23
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402639_275202041.0DomainKringle 24
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402753_286602041.0DomainKringle 25
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402867_298002041.0DomainKringle 26
TgeneLPAchr6:161152146chr6:161020555ENST000004476780402981_309402041.0DomainKringle 27
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403095_320802041.0DomainKringle 28
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403209_332202041.0DomainKringle 29
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403323_343602041.0DomainKringle 30
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403437_355002041.0DomainKringle 31
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403551_366402041.0DomainKringle 32
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040359_47202041.0DomainKringle 4
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403665_377002041.0DomainKringle 33
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403771_388402041.0DomainKringle 34
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403885_399802041.0DomainKringle 35
TgeneLPAchr6:161152146chr6:161020555ENST000004476780403999_411202041.0DomainKringle 36
TgeneLPAchr6:161152146chr6:161020555ENST000004476780404113_422602041.0DomainKringle 37
TgeneLPAchr6:161152146chr6:161020555ENST000004476780404227_432702041.0DomainKringle 38
TgeneLPAchr6:161152146chr6:161020555ENST000004476780404328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040473_58602041.0DomainKringle 5
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040587_70002041.0DomainKringle 6
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040701_81402041.0DomainKringle 7
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040815_92802041.0DomainKringle 8
TgeneLPAchr6:161152146chr6:161020555ENST00000447678040929_104202041.0DomainKringle 9
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391043_115602041.0DomainKringle 10
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391157_127002041.0DomainKringle 11
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391271_138402041.0DomainKringle 12
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039131_24402041.0DomainKringle 2
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391385_149802041.0DomainKringle 13
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391499_161202041.0DomainKringle 14
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391613_172602041.0DomainKringle 15
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391727_184002041.0DomainKringle 16
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391841_195402041.0DomainKringle 17
TgeneLPAchr6:161152154chr6:161020547ENST000003163000391955_206802041.0DomainKringle 18
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392069_218202041.0DomainKringle 19
TgeneLPAchr6:161152154chr6:161020547ENST0000031630003920_13002041.0DomainKringle 1
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392183_229602041.0DomainKringle 20
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392297_241002041.0DomainKringle 21
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392411_252402041.0DomainKringle 22
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039245_35802041.0DomainKringle 3
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392525_263802041.0DomainKringle 23
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392639_275202041.0DomainKringle 24
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392753_286602041.0DomainKringle 25
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392867_298002041.0DomainKringle 26
TgeneLPAchr6:161152154chr6:161020547ENST000003163000392981_309402041.0DomainKringle 27
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393095_320802041.0DomainKringle 28
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393209_332202041.0DomainKringle 29
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393323_343602041.0DomainKringle 30
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393437_355002041.0DomainKringle 31
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393551_366402041.0DomainKringle 32
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039359_47202041.0DomainKringle 4
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393665_377002041.0DomainKringle 33
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393771_388402041.0DomainKringle 34
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393885_399802041.0DomainKringle 35
TgeneLPAchr6:161152154chr6:161020547ENST000003163000393999_411202041.0DomainKringle 36
TgeneLPAchr6:161152154chr6:161020547ENST000003163000394113_422602041.0DomainKringle 37
TgeneLPAchr6:161152154chr6:161020547ENST000003163000394227_432702041.0DomainKringle 38
TgeneLPAchr6:161152154chr6:161020547ENST000003163000394328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039473_58602041.0DomainKringle 5
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039587_70002041.0DomainKringle 6
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039701_81402041.0DomainKringle 7
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039815_92802041.0DomainKringle 8
TgeneLPAchr6:161152154chr6:161020547ENST00000316300039929_104202041.0DomainKringle 9
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401043_115602041.0DomainKringle 10
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401157_127002041.0DomainKringle 11
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401271_138402041.0DomainKringle 12
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040131_24402041.0DomainKringle 2
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401385_149802041.0DomainKringle 13
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401499_161202041.0DomainKringle 14
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401613_172602041.0DomainKringle 15
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401727_184002041.0DomainKringle 16
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401841_195402041.0DomainKringle 17
TgeneLPAchr6:161152154chr6:161020547ENST000004476780401955_206802041.0DomainKringle 18
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402069_218202041.0DomainKringle 19
TgeneLPAchr6:161152154chr6:161020547ENST0000044767804020_13002041.0DomainKringle 1
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402183_229602041.0DomainKringle 20
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402297_241002041.0DomainKringle 21
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402411_252402041.0DomainKringle 22
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040245_35802041.0DomainKringle 3
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402525_263802041.0DomainKringle 23
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402639_275202041.0DomainKringle 24
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402753_286602041.0DomainKringle 25
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402867_298002041.0DomainKringle 26
TgeneLPAchr6:161152154chr6:161020547ENST000004476780402981_309402041.0DomainKringle 27
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403095_320802041.0DomainKringle 28
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403209_332202041.0DomainKringle 29
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403323_343602041.0DomainKringle 30
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403437_355002041.0DomainKringle 31
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403551_366402041.0DomainKringle 32
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040359_47202041.0DomainKringle 4
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403665_377002041.0DomainKringle 33
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403771_388402041.0DomainKringle 34
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403885_399802041.0DomainKringle 35
TgeneLPAchr6:161152154chr6:161020547ENST000004476780403999_411202041.0DomainKringle 36
TgeneLPAchr6:161152154chr6:161020547ENST000004476780404113_422602041.0DomainKringle 37
TgeneLPAchr6:161152154chr6:161020547ENST000004476780404227_432702041.0DomainKringle 38
TgeneLPAchr6:161152154chr6:161020547ENST000004476780404328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040473_58602041.0DomainKringle 5
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040587_70002041.0DomainKringle 6
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040701_81402041.0DomainKringle 7
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040815_92802041.0DomainKringle 8
TgeneLPAchr6:161152154chr6:161020547ENST00000447678040929_104202041.0DomainKringle 9
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391043_115602041.0DomainKringle 10
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391157_127002041.0DomainKringle 11
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391271_138402041.0DomainKringle 12
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039131_24402041.0DomainKringle 2
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391385_149802041.0DomainKringle 13
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391499_161202041.0DomainKringle 14
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391613_172602041.0DomainKringle 15
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391727_184002041.0DomainKringle 16
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391841_195402041.0DomainKringle 17
TgeneLPAchr6:161152200chr6:160998191ENST000003163000391955_206802041.0DomainKringle 18
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392069_218202041.0DomainKringle 19
TgeneLPAchr6:161152200chr6:160998191ENST0000031630003920_13002041.0DomainKringle 1
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392183_229602041.0DomainKringle 20
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392297_241002041.0DomainKringle 21
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392411_252402041.0DomainKringle 22
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039245_35802041.0DomainKringle 3
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392525_263802041.0DomainKringle 23
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392639_275202041.0DomainKringle 24
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392753_286602041.0DomainKringle 25
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392867_298002041.0DomainKringle 26
TgeneLPAchr6:161152200chr6:160998191ENST000003163000392981_309402041.0DomainKringle 27
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393095_320802041.0DomainKringle 28
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393209_332202041.0DomainKringle 29
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393323_343602041.0DomainKringle 30
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393437_355002041.0DomainKringle 31
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393551_366402041.0DomainKringle 32
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039359_47202041.0DomainKringle 4
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393665_377002041.0DomainKringle 33
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393771_388402041.0DomainKringle 34
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393885_399802041.0DomainKringle 35
TgeneLPAchr6:161152200chr6:160998191ENST000003163000393999_411202041.0DomainKringle 36
TgeneLPAchr6:161152200chr6:160998191ENST000003163000394113_422602041.0DomainKringle 37
TgeneLPAchr6:161152200chr6:160998191ENST000003163000394227_432702041.0DomainKringle 38
TgeneLPAchr6:161152200chr6:160998191ENST000003163000394328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039473_58602041.0DomainKringle 5
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039587_70002041.0DomainKringle 6
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039701_81402041.0DomainKringle 7
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039815_92802041.0DomainKringle 8
TgeneLPAchr6:161152200chr6:160998191ENST00000316300039929_104202041.0DomainKringle 9
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401043_115602041.0DomainKringle 10
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401157_127002041.0DomainKringle 11
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401271_138402041.0DomainKringle 12
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040131_24402041.0DomainKringle 2
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401385_149802041.0DomainKringle 13
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401499_161202041.0DomainKringle 14
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401613_172602041.0DomainKringle 15
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401727_184002041.0DomainKringle 16
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401841_195402041.0DomainKringle 17
TgeneLPAchr6:161152200chr6:160998191ENST000004476780401955_206802041.0DomainKringle 18
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402069_218202041.0DomainKringle 19
TgeneLPAchr6:161152200chr6:160998191ENST0000044767804020_13002041.0DomainKringle 1
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402183_229602041.0DomainKringle 20
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402297_241002041.0DomainKringle 21
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402411_252402041.0DomainKringle 22
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040245_35802041.0DomainKringle 3
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402525_263802041.0DomainKringle 23
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402639_275202041.0DomainKringle 24
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402753_286602041.0DomainKringle 25
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402867_298002041.0DomainKringle 26
TgeneLPAchr6:161152200chr6:160998191ENST000004476780402981_309402041.0DomainKringle 27
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403095_320802041.0DomainKringle 28
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403209_332202041.0DomainKringle 29
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403323_343602041.0DomainKringle 30
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403437_355002041.0DomainKringle 31
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403551_366402041.0DomainKringle 32
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040359_47202041.0DomainKringle 4
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403665_377002041.0DomainKringle 33
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403771_388402041.0DomainKringle 34
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403885_399802041.0DomainKringle 35
TgeneLPAchr6:161152200chr6:160998191ENST000004476780403999_411202041.0DomainKringle 36
TgeneLPAchr6:161152200chr6:160998191ENST000004476780404113_422602041.0DomainKringle 37
TgeneLPAchr6:161152200chr6:160998191ENST000004476780404227_432702041.0DomainKringle 38
TgeneLPAchr6:161152200chr6:160998191ENST000004476780404328_454602041.0DomainPeptidase S1
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040473_58602041.0DomainKringle 5
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040587_70002041.0DomainKringle 6
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040701_81402041.0DomainKringle 7
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040815_92802041.0DomainKringle 8
TgeneLPAchr6:161152200chr6:160998191ENST00000447678040929_104202041.0DomainKringle 9
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392069_21821987.02041.0DomainKringle 19
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392183_22961987.02041.0DomainKringle 20
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392297_24101987.02041.0DomainKringle 21
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392411_25241987.02041.0DomainKringle 22
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392525_26381987.02041.0DomainKringle 23
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392639_27521987.02041.0DomainKringle 24
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392753_28661987.02041.0DomainKringle 25
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392867_29801987.02041.0DomainKringle 26
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037392981_30941987.02041.0DomainKringle 27
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393095_32081987.02041.0DomainKringle 28
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393209_33221987.02041.0DomainKringle 29
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393323_34361987.02041.0DomainKringle 30
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393437_35501987.02041.0DomainKringle 31
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393551_36641987.02041.0DomainKringle 32
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393665_37701987.02041.0DomainKringle 33
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393771_38841987.02041.0DomainKringle 34
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393885_39981987.02041.0DomainKringle 35
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037393999_41121987.02041.0DomainKringle 36
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037394113_42261987.02041.0DomainKringle 37
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037394227_43271987.02041.0DomainKringle 38
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037394328_45461987.02041.0DomainPeptidase S1
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402069_21821987.02041.0DomainKringle 19
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402183_22961987.02041.0DomainKringle 20
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402297_24101987.02041.0DomainKringle 21
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402411_25241987.02041.0DomainKringle 22
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402525_26381987.02041.0DomainKringle 23
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402639_27521987.02041.0DomainKringle 24
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402753_28661987.02041.0DomainKringle 25
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402867_29801987.02041.0DomainKringle 26
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838402981_30941987.02041.0DomainKringle 27
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403095_32081987.02041.0DomainKringle 28
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403209_33221987.02041.0DomainKringle 29
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403323_34361987.02041.0DomainKringle 30
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403437_35501987.02041.0DomainKringle 31
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403551_36641987.02041.0DomainKringle 32
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403665_37701987.02041.0DomainKringle 33
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403771_38841987.02041.0DomainKringle 34
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403885_39981987.02041.0DomainKringle 35
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838403999_41121987.02041.0DomainKringle 36
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838404113_42261987.02041.0DomainKringle 37
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838404227_43271987.02041.0DomainKringle 38
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838404328_45461987.02041.0DomainPeptidase S1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLGchr6:161152146chr6:161020555ENST00000308192+119184_2620811.0DomainKringle 2
HgenePLGchr6:161152146chr6:161020555ENST00000308192+11920_980811.0DomainPAN
HgenePLGchr6:161152146chr6:161020555ENST00000308192+119581_8080811.0DomainPeptidase S1
HgenePLGchr6:161152154chr6:161020547ENST00000308192+119184_2620811.0DomainKringle 2
HgenePLGchr6:161152154chr6:161020547ENST00000308192+11920_980811.0DomainPAN
HgenePLGchr6:161152154chr6:161020547ENST00000308192+119581_8080811.0DomainPeptidase S1
HgenePLGchr6:161152200chr6:160998191ENST00000308192+119184_2620811.0DomainKringle 2
HgenePLGchr6:161152200chr6:160998191ENST00000308192+11920_980811.0DomainPAN
HgenePLGchr6:161152200chr6:160998191ENST00000308192+119581_8080811.0DomainPeptidase S1
HgenePLGchr6:161173292chr6:160952922ENST00000308192+1819581_808757.0811.0DomainPeptidase S1
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391043_11561987.02041.0DomainKringle 10
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391157_12701987.02041.0DomainKringle 11
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391271_13841987.02041.0DomainKringle 12
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739131_2441987.02041.0DomainKringle 2
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391385_14981987.02041.0DomainKringle 13
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391499_16121987.02041.0DomainKringle 14
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391613_17261987.02041.0DomainKringle 15
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391727_18401987.02041.0DomainKringle 16
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391841_19541987.02041.0DomainKringle 17
TgeneLPAchr6:161173292chr6:160952922ENST0000031630037391955_20681987.02041.0DomainKringle 18
TgeneLPAchr6:161173292chr6:160952922ENST00000316300373920_1301987.02041.0DomainKringle 1
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739245_3581987.02041.0DomainKringle 3
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739359_4721987.02041.0DomainKringle 4
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739473_5861987.02041.0DomainKringle 5
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739587_7001987.02041.0DomainKringle 6
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739701_8141987.02041.0DomainKringle 7
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739815_9281987.02041.0DomainKringle 8
TgeneLPAchr6:161173292chr6:160952922ENST000003163003739929_10421987.02041.0DomainKringle 9
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401043_11561987.02041.0DomainKringle 10
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401157_12701987.02041.0DomainKringle 11
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401271_13841987.02041.0DomainKringle 12
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840131_2441987.02041.0DomainKringle 2
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401385_14981987.02041.0DomainKringle 13
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401499_16121987.02041.0DomainKringle 14
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401613_17261987.02041.0DomainKringle 15
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401727_18401987.02041.0DomainKringle 16
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401841_19541987.02041.0DomainKringle 17
TgeneLPAchr6:161173292chr6:160952922ENST0000044767838401955_20681987.02041.0DomainKringle 18
TgeneLPAchr6:161173292chr6:160952922ENST00000447678384020_1301987.02041.0DomainKringle 1
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840245_3581987.02041.0DomainKringle 3
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840359_4721987.02041.0DomainKringle 4
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840473_5861987.02041.0DomainKringle 5
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840587_7001987.02041.0DomainKringle 6
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840701_8141987.02041.0DomainKringle 7
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840815_9281987.02041.0DomainKringle 8
TgeneLPAchr6:161173292chr6:160952922ENST000004476783840929_10421987.02041.0DomainKringle 9


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1412_PLG_161152146_LPA_161020555_ranked_0.pdbPLG161152200161152146ENST00000447678LPAchr6161020555-
MTTVISLSVTVCLGMGKDTGARRQPLLLGRHARNGLPRSPIDTARSFQGQINGQVWKKIGLTMNYCRNPDADTGPWCFTMDPSIRWEYCN
LTRCSDTEGTVVAPPTVIQVPSLGPPSEQAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTENYC
RNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS
SMIPHWHQRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPTENSTGVQDCY
RGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVV
PVPSTELPSEEAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNV
RWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRN
689


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PLG_pLDDT.png
all structure
all structure
LPA_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PLG
LPA


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PLG-LPA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PLG-LPA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource