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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:POMK-ANK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: POMK-ANK1
FusionPDB ID: 67149
FusionGDB2.0 ID: 67149
HgeneTgene
Gene symbol

POMK

ANK1

Gene ID

84197

286

Gene nameprotein O-mannose kinaseankyrin 1
SynonymsMDDGA12|MDDGC12|SGK196ANK|SPH1|SPH2
Cytomap

8p11.21

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein O-mannose kinaseSugen kinase 196probable inactive protein kinase-like protein SgK196protein kinase-like protein SgK196ankyrin-1ANK-1ankyrin 1, erythrocyticankyrin-Rerythrocyte ankyrin
Modification date2020031320200313
UniProtAcc.

P16157

Ensembl transtripts involved in fusion geneENST idsENST00000331373, ENST00000314214, 
ENST00000457297, ENST00000521407, 
ENST00000522231, ENST00000522543, 
ENST00000265709, ENST00000289734, 
ENST00000347528, ENST00000352337, 
ENST00000379758, ENST00000396942, 
ENST00000396945, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 3 X 7=14715 X 9 X 9=1215
# samples 718
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1215*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: POMK [Title/Abstract] AND ANK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)POMK(42958973)-ANK1(41591587), # samples:2
Anticipated loss of major functional domain due to fusion event.POMK-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POMK-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POMK-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
POMK-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOMK

GO:0006493

protein O-linked glycosylation

23929950

HgenePOMK

GO:0046835

carbohydrate phosphorylation

23929950

TgeneANK1

GO:0006888

ER to Golgi vesicle-mediated transport

18768923


check buttonFusion gene breakpoints across POMK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-UF-A7JK-01APOMKchr8

42958973

+ANK1chr8

41591587

-
ChimerDB4HNSCTCGA-UF-A7JKPOMKchr8

42958973

+ANK1chr8

41591587

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331373POMKchr842958973+ENST00000347528ANK1chr841591587-85615376060531997
ENST00000331373POMKchr842958973+ENST00000289734ANK1chr841591587-86215376060501996
ENST00000331373POMKchr842958973+ENST00000379758ANK1chr841591587-84145376059121950
ENST00000331373POMKchr842958973+ENST00000396942ANK1chr841591587-86905376061252021
ENST00000331373POMKchr842958973+ENST00000396945ANK1chr841591587-83305376058281922
ENST00000331373POMKchr842958973+ENST00000352337ANK1chr841591587-85495376059841974
ENST00000331373POMKchr842958973+ENST00000265709ANK1chr841591587-64065376060021980

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331373ENST00000347528POMKchr842958973+ANK1chr841591587-0.0031789690.99682105
ENST00000331373ENST00000289734POMKchr842958973+ANK1chr841591587-0.0030635330.99693644
ENST00000331373ENST00000379758POMKchr842958973+ANK1chr841591587-0.0024617610.9975382
ENST00000331373ENST00000396942POMKchr842958973+ANK1chr841591587-0.0036506310.99634933
ENST00000331373ENST00000396945POMKchr842958973+ANK1chr841591587-0.0035199360.99648005
ENST00000331373ENST00000352337POMKchr842958973+ANK1chr841591587-0.0036436010.99635637
ENST00000331373ENST00000265709POMKchr842958973+ANK1chr841591587-0.0057940550.994206

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67149_67149_1_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000265709_length(amino acids)=1980AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAM
PETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKP
QKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEEL
EKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEP
RRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFA
TLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQ
SFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMK
MAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPD
RRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLE
CSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGH
QRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQP
EAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEDHTSTPNP

--------------------------------------------------------------

>67149_67149_2_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000289734_length(amino acids)=1996AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD
RDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVELRGSGLQPDLIEGR

--------------------------------------------------------------

>67149_67149_3_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000347528_length(amino acids)=1997AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD
RDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVD

--------------------------------------------------------------

>67149_67149_4_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000352337_length(amino acids)=1974AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD

--------------------------------------------------------------

>67149_67149_5_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000379758_length(amino acids)=1950AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD

--------------------------------------------------------------

>67149_67149_6_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000396942_length(amino acids)=2021AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD
RDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVD

--------------------------------------------------------------

>67149_67149_7_POMK-ANK1_POMK_chr8_42958973_ENST00000331373_ANK1_chr8_41591587_ENST00000396945_length(amino acids)=1922AA_BP=159
MLCNPENGLQERKNWASAWESIVETQGVSRPVPGRQLEYGLTRYLDGDLSWRRRCAWEEIAEAVNMEKQPQNSRRGLAPREVPPAVGLLL
IMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRNGLNGLHLASKEGHVKMVVEL
LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQ
GHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH
IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI
TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL
QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG
HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYT
PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV
DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD
VLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRS
EEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPP
LAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRI
ITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRP
IGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELT
AVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
MPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHL
GLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDY
SLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD
ATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARIT
HSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQAD

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42958973/chr8:41591587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANK1

P16157

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOMKchr8:42958973chr8:41591587ENST00000331373+451_2094.0351.0Topological domainCytoplasmic
HgenePOMKchr8:42958973chr8:41591587ENST00000331373+4521_4394.0351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneANK1chr8:42958973chr8:41591587ENST000002657091431070_121676.01898.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000002657091431403_148776.01898.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143913_106876.01898.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000002897341431070_121643.02699.6666666666665DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000002897341431403_148743.02699.6666666666665DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143913_106843.02699.6666666666665DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST00000314214051070_12160159.66666666666666DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST00000314214051403_14870159.66666666666666DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405913_10680159.66666666666666DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000003475281421070_121643.01882.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000003475281421403_148743.01882.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142913_106843.01882.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000003523371421070_121643.02675.6666666666665DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000003523371421403_148743.02675.6666666666665DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142913_106843.02675.6666666666665DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000003797581411070_121643.01835.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000003797581411403_148743.01835.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141913_106843.01835.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000003969421431070_121643.02722.6666666666665DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000003969421431403_148743.02722.6666666666665DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143913_106843.02722.6666666666665DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000003969451401070_121643.01807.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST000003969451401403_148743.01807.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140913_106843.01807.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST00000457297031070_12160110.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST00000457297031403_14870110.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703913_10680110.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST00000522543041070_12160157.0DomainZU5 2
TgeneANK1chr8:42958973chr8:41591587ENST00000522543041403_14870157.0DomainDeath
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304913_10680157.0DomainZU5 1
TgeneANK1chr8:42958973chr8:41591587ENST000002657091431234_136276.01898.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000002657091431383_188176.01898.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST000002897341431234_136243.02699.6666666666665RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000002897341431383_188143.02699.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST00000314214051234_13620159.66666666666666RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST00000314214051383_18810159.66666666666666RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST00000314214051_8270159.66666666666666RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003475281421234_136243.01882.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000003475281421383_188143.01882.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST000003523371421234_136243.02675.6666666666665RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000003523371421383_188143.02675.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST000003797581411234_136243.01835.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000003797581411383_188143.01835.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969421431234_136243.02722.6666666666665RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969421431383_188143.02722.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969451401234_136243.01807.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969451401383_188143.01807.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST00000457297031234_13620110.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST00000457297031383_18810110.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST00000457297031_8270110.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST00000522543041234_13620157.0RegionUPA domain
TgeneANK1chr8:42958973chr8:41591587ENST00000522543041383_18810157.0RegionNote=55 kDa regulatory domain
TgeneANK1chr8:42958973chr8:41591587ENST00000522543041_8270157.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143110_13976.01898.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143143_17276.01898.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143174_20176.01898.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143205_23476.01898.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143238_26776.01898.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143271_30076.01898.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143304_33376.01898.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143337_36676.01898.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143370_39976.01898.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143403_43276.01898.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143436_46576.01898.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143469_49876.01898.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143502_53176.01898.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143535_56476.01898.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143568_59776.01898.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143601_63076.01898.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143634_66376.01898.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143667_69676.01898.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143700_72976.01898.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143733_76276.01898.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000265709143766_79576.01898.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000026570914377_10676.01898.0RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143110_13943.02699.6666666666665RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143143_17243.02699.6666666666665RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143174_20143.02699.6666666666665RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143205_23443.02699.6666666666665RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143238_26743.02699.6666666666665RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143271_30043.02699.6666666666665RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143304_33343.02699.6666666666665RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143337_36643.02699.6666666666665RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143370_39943.02699.6666666666665RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143403_43243.02699.6666666666665RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143436_46543.02699.6666666666665RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000028973414344_7343.02699.6666666666665RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143469_49843.02699.6666666666665RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143502_53143.02699.6666666666665RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143535_56443.02699.6666666666665RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143568_59743.02699.6666666666665RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143601_63043.02699.6666666666665RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143634_66343.02699.6666666666665RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143667_69643.02699.6666666666665RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143700_72943.02699.6666666666665RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143733_76243.02699.6666666666665RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000289734143766_79543.02699.6666666666665RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000028973414377_10643.02699.6666666666665RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405110_1390159.66666666666666RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405143_1720159.66666666666666RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405174_2010159.66666666666666RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405205_2340159.66666666666666RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405238_2670159.66666666666666RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405271_3000159.66666666666666RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405304_3330159.66666666666666RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405337_3660159.66666666666666RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405370_3990159.66666666666666RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405403_4320159.66666666666666RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405436_4650159.66666666666666RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST000003142140544_730159.66666666666666RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405469_4980159.66666666666666RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405502_5310159.66666666666666RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405535_5640159.66666666666666RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405568_5970159.66666666666666RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405601_6300159.66666666666666RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405634_6630159.66666666666666RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405667_6960159.66666666666666RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405700_7290159.66666666666666RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405733_7620159.66666666666666RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST0000031421405766_7950159.66666666666666RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST000003142140577_1060159.66666666666666RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142110_13943.01882.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142143_17243.01882.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142174_20143.01882.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142205_23443.01882.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142238_26743.01882.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142271_30043.01882.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142304_33343.01882.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142337_36643.01882.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142370_39943.01882.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142403_43243.01882.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142436_46543.01882.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000034752814244_7343.01882.0RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142469_49843.01882.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142502_53143.01882.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142535_56443.01882.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142568_59743.01882.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142601_63043.01882.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142634_66343.01882.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142667_69643.01882.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142700_72943.01882.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142733_76243.01882.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000347528142766_79543.01882.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000034752814277_10643.01882.0RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142110_13943.02675.6666666666665RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142143_17243.02675.6666666666665RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142174_20143.02675.6666666666665RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142205_23443.02675.6666666666665RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142238_26743.02675.6666666666665RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142271_30043.02675.6666666666665RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142304_33343.02675.6666666666665RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142337_36643.02675.6666666666665RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142370_39943.02675.6666666666665RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142403_43243.02675.6666666666665RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142436_46543.02675.6666666666665RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000035233714244_7343.02675.6666666666665RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142469_49843.02675.6666666666665RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142502_53143.02675.6666666666665RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142535_56443.02675.6666666666665RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142568_59743.02675.6666666666665RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142601_63043.02675.6666666666665RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142634_66343.02675.6666666666665RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142667_69643.02675.6666666666665RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142700_72943.02675.6666666666665RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142733_76243.02675.6666666666665RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000352337142766_79543.02675.6666666666665RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000035233714277_10643.02675.6666666666665RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141110_13943.01835.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141143_17243.01835.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141174_20143.01835.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141205_23443.01835.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141238_26743.01835.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141271_30043.01835.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141304_33343.01835.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141337_36643.01835.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141370_39943.01835.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141403_43243.01835.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141436_46543.01835.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000037975814144_7343.01835.0RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141469_49843.01835.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141502_53143.01835.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141535_56443.01835.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141568_59743.01835.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141601_63043.01835.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141634_66343.01835.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141667_69643.01835.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141700_72943.01835.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141733_76243.01835.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000379758141766_79543.01835.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000037975814177_10643.01835.0RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143110_13943.02722.6666666666665RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143143_17243.02722.6666666666665RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143174_20143.02722.6666666666665RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143205_23443.02722.6666666666665RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143238_26743.02722.6666666666665RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143271_30043.02722.6666666666665RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143304_33343.02722.6666666666665RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143337_36643.02722.6666666666665RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143370_39943.02722.6666666666665RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143403_43243.02722.6666666666665RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143436_46543.02722.6666666666665RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000039694214344_7343.02722.6666666666665RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143469_49843.02722.6666666666665RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143502_53143.02722.6666666666665RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143535_56443.02722.6666666666665RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143568_59743.02722.6666666666665RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143601_63043.02722.6666666666665RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143634_66343.02722.6666666666665RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143667_69643.02722.6666666666665RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143700_72943.02722.6666666666665RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143733_76243.02722.6666666666665RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000396942143766_79543.02722.6666666666665RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000039694214377_10643.02722.6666666666665RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140110_13943.01807.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140143_17243.01807.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140174_20143.01807.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140205_23443.01807.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140238_26743.01807.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140271_30043.01807.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140304_33343.01807.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140337_36643.01807.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140370_39943.01807.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140403_43243.01807.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140436_46543.01807.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST0000039694514044_7343.01807.0RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140469_49843.01807.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140502_53143.01807.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140535_56443.01807.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140568_59743.01807.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140601_63043.01807.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140634_66343.01807.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140667_69643.01807.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140700_72943.01807.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140733_76243.01807.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST00000396945140766_79543.01807.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST0000039694514077_10643.01807.0RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703110_1390110.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703143_1720110.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703174_2010110.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703205_2340110.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703238_2670110.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703271_3000110.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703304_3330110.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703337_3660110.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703370_3990110.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703403_4320110.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703436_4650110.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST000004572970344_730110.0RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703469_4980110.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703502_5310110.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703535_5640110.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703568_5970110.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703601_6300110.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703634_6630110.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703667_6960110.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703700_7290110.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703733_7620110.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST0000045729703766_7950110.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST000004572970377_1060110.0RepeatNote=ANK 2
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304110_1390157.0RepeatNote=ANK 3
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304143_1720157.0RepeatNote=ANK 4
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304174_2010157.0RepeatNote=ANK 5
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304205_2340157.0RepeatNote=ANK 6
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304238_2670157.0RepeatNote=ANK 7
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304271_3000157.0RepeatNote=ANK 8
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304304_3330157.0RepeatNote=ANK 9
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304337_3660157.0RepeatNote=ANK 10
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304370_3990157.0RepeatNote=ANK 11
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304403_4320157.0RepeatNote=ANK 12
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304436_4650157.0RepeatNote=ANK 13
TgeneANK1chr8:42958973chr8:41591587ENST000005225430444_730157.0RepeatNote=ANK 1
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304469_4980157.0RepeatNote=ANK 14
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304502_5310157.0RepeatNote=ANK 15
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304535_5640157.0RepeatNote=ANK 16
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304568_5970157.0RepeatNote=ANK 17
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304601_6300157.0RepeatNote=ANK 18
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304634_6630157.0RepeatNote=ANK 19
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304667_6960157.0RepeatNote=ANK 20
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304700_7290157.0RepeatNote=ANK 21
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304733_7620157.0RepeatNote=ANK 22
TgeneANK1chr8:42958973chr8:41591587ENST0000052254304766_7950157.0RepeatNote=ANK 23
TgeneANK1chr8:42958973chr8:41591587ENST000005225430477_1060157.0RepeatNote=ANK 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOMKchr8:42958973chr8:41591587ENST00000331373+4581_35094.0351.0DomainProtein kinase
HgenePOMKchr8:42958973chr8:41591587ENST00000331373+4544_35094.0351.0Topological domainLumenal
TgeneANK1chr8:42958973chr8:41591587ENST000002657091431_82776.01898.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000002897341431_82743.02699.6666666666665RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003475281421_82743.01882.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003523371421_82743.02675.6666666666665RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003797581411_82743.01835.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969421431_82743.02722.6666666666665RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST000003969451401_82743.01807.0RegionNote=89 kDa domain
TgeneANK1chr8:42958973chr8:41591587ENST0000026570914344_7376.01898.0RepeatNote=ANK 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
POMK_pLDDT.png
all structure
all structure
ANK1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
POMK
ANK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to POMK-ANK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to POMK-ANK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource