UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PPFIA2-TRHDE

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIA2-TRHDE
FusionPDB ID: 67441
FusionGDB2.0 ID: 67441
HgeneTgene
Gene symbol

PPFIA2

TRHDE

Gene ID

8499

29953

Gene namePTPRF interacting protein alpha 2thyrotropin releasing hormone degrading enzyme
Synonyms-PAP-II|PGPEP2|TRH-DE
Cytomap

12q21.31

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionliprin-alpha-2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2thyrotropin-releasing hormone-degrading ectoenzymeTRH-degrading ectoenzymeTRH-specific aminopeptidasepyroglutamyl aminopeptidase IIpyroglutamyl-peptidase IIthyroliberinase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000333447, ENST00000548586, 
ENST00000549325, ENST00000549396, 
ENST00000550584, ENST00000552948, 
ENST00000407050, ENST00000443686, 
ENST00000541017, ENST00000541570, 
ENST00000545296, ENST00000550359, 
ENST00000549138, ENST00000261180, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 14 X 4=95219 X 12 X 7=1596
# samples 1821
** MAII scorelog2(18/952*10)=-2.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1596*10)=-2.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIA2 [Title/Abstract] AND TRHDE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPFIA2(82147752)-TRHDE(72771775), # samples:3
Anticipated loss of major functional domain due to fusion event.PPFIA2-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-TRHDE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIA2-TRHDE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPFIA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRHDE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3NK-01APPFIA2chr12

82147752

-TRHDEchr12

72771775

+
ChimerDB4SARCTCGA-QC-AA9N-01APPFIA2chr12

82147752

-TRHDEchr12

72771775

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000549396PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+48794101612431756
ENST00000550584PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+50145452962566756
ENST00000549325PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+49915222732543756
ENST00000333447PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+471824902270756
ENST00000548586PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+49745052562526756
ENST00000552948PPFIA2chr1282147752-ENST00000261180TRHDEchr1272771775+49684992502520756

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000549396ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.0003149290.99968505
ENST00000550584ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.000313610.99968636
ENST00000549325ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.0003046910.9996953
ENST00000333447ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.0002919120.9997081
ENST00000548586ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.0003047790.9996953
ENST00000552948ENST00000261180PPFIA2chr1282147752-TRHDEchr1272771775+0.0003075850.99969244

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67441_67441_1_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000333447_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

>67441_67441_2_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000548586_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

>67441_67441_3_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000549325_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

>67441_67441_4_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000549396_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

>67441_67441_5_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000550584_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

>67441_67441_6_PPFIA2-TRHDE_PPFIA2_chr12_82147752_ENST00000552948_TRHDE_chr12_72771775_ENST00000261180_length(amino acids)=756AA_BP=83
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:82147752/chr12:72771775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRHDEchr12:82147752chr12:72771775ENST00000261180119404_408351.01025.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-1291081_110701033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-129185_54101033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-12929_15401033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-129643_69501033.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-1281081_110701153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-128185_54101153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-12829_15401153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-128643_69501153.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-1221081_11070557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-122185_5410557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-12229_1540557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-122643_6950557.6666666666666Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-1201081_11070784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-120185_5410784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-12029_1540784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-120643_6950784.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-2311081_110783.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-231185_54183.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-23129_15483.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-231643_69583.01252.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-2311081_110783.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-231185_54183.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-23129_15483.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-231643_69583.01233.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-3331081_110783.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-333185_54183.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-33329_15483.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-333643_69583.01700.6666666666667Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-2301081_110783.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-230185_54183.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-23029_15483.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-230643_69583.01237.0Coiled coilOntology_term=ECO:0000255
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-129115_52801033.6666666666667Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-129622_62701033.6666666666667Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-128115_52801153.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-128622_62701153.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-122115_5280557.6666666666666Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-122622_6270557.6666666666666Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-120115_5280784.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-120622_6270784.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-231115_52883.01252.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-231622_62783.01252.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-231115_52883.01233.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-231622_62783.01233.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-333115_52883.01700.6666666666667Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-333622_62783.01700.6666666666667Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-230115_52883.01237.0Compositional biasNote=Glu-rich
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-230622_62783.01237.0Compositional biasNote=Poly-Asp
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-1291020_108401033.6666666666667DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-1291108_117701033.6666666666667DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000407050-129898_96401033.6666666666667DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-1281020_108401153.0DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-1281108_117701153.0DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000443686-128898_96401153.0DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-1221020_10840557.6666666666666DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-1221108_11770557.6666666666666DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541017-122898_9640557.6666666666666DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-1201020_10840784.0DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-1201108_11770784.0DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000541570-120898_9640784.0DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-2311020_108483.01252.0DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-2311108_117783.01252.0DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000548586-231898_96483.01252.0DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-2311020_108483.01233.0DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-2311108_117783.01233.0DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549325-231898_96483.01233.0DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-3331020_108483.01700.6666666666667DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-3331108_117783.01700.6666666666667DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000549396-333898_96483.01700.6666666666667DomainSAM 1
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-2301020_108483.01237.0DomainSAM 2
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-2301108_117783.01237.0DomainSAM 3
HgenePPFIA2chr12:82147752chr12:72771775ENST00000552948-230898_96483.01237.0DomainSAM 1
TgeneTRHDEchr12:82147752chr12:72771775ENST000002611801191_40351.01025.0Topological domainCytoplasmic
TgeneTRHDEchr12:82147752chr12:72771775ENST0000026118011962_1024351.01025.0Topological domainExtracellular
TgeneTRHDEchr12:82147752chr12:72771775ENST0000026118011941_61351.01025.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1523_PPFIA2_82147752_TRHDE_72771775_ranked_0.pdbPPFIA28214775282147752ENST00000261180TRHDEchr1272771775+
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQVRLYARP
DAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFG
DLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLA
NFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTK
ALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRA
GLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASY
QHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDR
NLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGV
756


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PPFIA2_pLDDT.png
all structure
all structure
TRHDE_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIA2
TRHDE


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to PPFIA2-TRHDE


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PPFIA2-TRHDE


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource