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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP2R4-PHYHD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP2R4-PHYHD1
FusionPDB ID: 68057
FusionGDB2.0 ID: 68057
HgeneTgene
Gene symbol

PPP2R4

PHYHD1

Gene ID

5524

254295

Gene nameprotein phosphatase 2 phosphatase activatorphytanoyl-CoA dioxygenase domain containing 1
SynonymsPP2A|PPP2R4|PR53-
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosphphytanoyl-CoA dioxygenase domain-containing protein 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000337738, ENST00000347048, 
ENST00000348141, ENST00000355007, 
ENST00000357197, ENST00000358994, 
ENST00000393370, ENST00000452489, 
ENST00000414510, ENST00000419582, 
ENST00000423100, ENST00000432124, 
ENST00000432651, ENST00000434095, 
ENST00000435132, ENST00000435305, 
ENST00000436883, ENST00000524946, 
ENST00000487504, ENST00000308941, 
ENST00000353176, ENST00000372592, 
ENST00000421063, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 9 X 8=7203 X 8 X 3=72
# samples 126
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP2R4 [Title/Abstract] AND PHYHD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP2R4(131882889)-PHYHD1(131689316), # samples:2
Anticipated loss of major functional domain due to fusion event.PPP2R4-PHYHD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP2R4-PHYHD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R4

GO:0032515

negative regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0032516

positive regulation of phosphoprotein phosphatase activity

16916641

HgenePPP2R4

GO:0035307

positive regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0035308

negative regulation of protein dephosphorylation

16916641

HgenePPP2R4

GO:0043065

positive regulation of apoptotic process

17333320

HgenePPP2R4

GO:0043666

regulation of phosphoprotein phosphatase activity

16916641


check buttonFusion gene breakpoints across PPP2R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHYHD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1714-01APPP2R4chr9

131882889

+PHYHD1chr9

131689317

+
ChimerDB4OVTCGA-30-1714PPP2R4chr9

131882889

+PHYHD1chr9

131689316

+
ChimerDB4UCECTCGA-A5-A1OJPPP2R4chr9

131882889

+PHYHD1chr9

131689316

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358994PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+150834181183391
ENST00000358994PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+148734181201397
ENST00000358994PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+144634181120370
ENST00000358994PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+144934181120370
ENST00000393370PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+15794121691254361
ENST00000393370PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+15584121691272367
ENST00000393370PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+15174121691191340
ENST00000393370PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+15204121691191340
ENST00000337738PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+15633961531238361
ENST00000337738PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+15423961531256367
ENST00000337738PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+15013961531175340
ENST00000337738PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+15043961531175340
ENST00000348141PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+14813142511156301
ENST00000348141PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+14603142511174307
ENST00000348141PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+14193142511093280
ENST00000348141PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+14223142511093280
ENST00000452489PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+1509342991184361
ENST00000452489PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+1488342991202367
ENST00000452489PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+1447342991121340
ENST00000452489PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+1450342991121340
ENST00000357197PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+1488321781163361
ENST00000357197PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+1467321781181367
ENST00000357197PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+1426321781100340
ENST00000357197PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+1429321781100340
ENST00000347048PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+1488321781163361
ENST00000347048PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+1467321781181367
ENST00000347048PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+1426321781100340
ENST00000347048PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+1429321781100340
ENST00000355007PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689316+1483316731158361
ENST00000355007PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689316+1462316731176367
ENST00000355007PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689316+1421316731095340
ENST00000355007PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689316+1424316731095340
ENST00000358994PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+150834181183391
ENST00000358994PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+148734181201397
ENST00000358994PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+144634181120370
ENST00000358994PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+144934181120370
ENST00000393370PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+15794121691254361
ENST00000393370PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+15584121691272367
ENST00000393370PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+15174121691191340
ENST00000393370PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+15204121691191340
ENST00000337738PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+15633961531238361
ENST00000337738PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+15423961531256367
ENST00000337738PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+15013961531175340
ENST00000337738PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+15043961531175340
ENST00000348141PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+14813142511156301
ENST00000348141PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+14603142511174307
ENST00000348141PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+14193142511093280
ENST00000348141PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+14223142511093280
ENST00000452489PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+1509342991184361
ENST00000452489PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+1488342991202367
ENST00000452489PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+1447342991121340
ENST00000452489PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+1450342991121340
ENST00000357197PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+1488321781163361
ENST00000357197PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+1467321781181367
ENST00000357197PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+1426321781100340
ENST00000357197PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+1429321781100340
ENST00000347048PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+1488321781163361
ENST00000347048PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+1467321781181367
ENST00000347048PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+1426321781100340
ENST00000347048PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+1429321781100340
ENST00000355007PPP2R4chr9131882889+ENST00000372592PHYHD1chr9131689317+1483316731158361
ENST00000355007PPP2R4chr9131882889+ENST00000308941PHYHD1chr9131689317+1462316731176367
ENST00000355007PPP2R4chr9131882889+ENST00000353176PHYHD1chr9131689317+1421316731095340
ENST00000355007PPP2R4chr9131882889+ENST00000421063PHYHD1chr9131689317+1424316731095340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358994ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0458647270.95413524
ENST00000358994ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.24324650.7567535
ENST00000358994ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.0274312680.97256875
ENST00000358994ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.028201480.97179854
ENST00000393370ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0201809870.97981906
ENST00000393370ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.300377370.6996227
ENST00000393370ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.0175978760.98240215
ENST00000393370ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.0180658830.9819341
ENST00000337738ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0211429670.97885704
ENST00000337738ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.31060850.6893915
ENST00000337738ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.0184284360.9815716
ENST00000337738ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.0188206210.9811794
ENST00000348141ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.063802060.93619794
ENST00000348141ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.391991380.60800856
ENST00000348141ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.0633626950.9366373
ENST00000348141ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.063566210.93643385
ENST00000452489ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0224245410.9775754
ENST00000452489ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.338728520.66127145
ENST00000452489ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.02066890.9793311
ENST00000452489ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.0210265780.97897345
ENST00000357197ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0220367350.97796327
ENST00000357197ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.333724050.6662759
ENST00000357197ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.02032990.97967005
ENST00000357197ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.0208865960.9791134
ENST00000347048ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0220367350.97796327
ENST00000347048ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.333724050.6662759
ENST00000347048ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.02032990.97967005
ENST00000347048ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.0208865960.9791134
ENST00000355007ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689316+0.0212858820.97871417
ENST00000355007ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689316+0.332789240.6672107
ENST00000355007ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689316+0.0198110580.98018897
ENST00000355007ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689316+0.020359460.97964054
ENST00000358994ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0458647270.95413524
ENST00000358994ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.24324650.7567535
ENST00000358994ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.0274312680.97256875
ENST00000358994ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.028201480.97179854
ENST00000393370ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0201809870.97981906
ENST00000393370ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.300377370.6996227
ENST00000393370ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.0175978760.98240215
ENST00000393370ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.0180658830.9819341
ENST00000337738ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0211429670.97885704
ENST00000337738ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.31060850.6893915
ENST00000337738ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.0184284360.9815716
ENST00000337738ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.0188206210.9811794
ENST00000348141ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.063802060.93619794
ENST00000348141ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.391991380.60800856
ENST00000348141ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.0633626950.9366373
ENST00000348141ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.063566210.93643385
ENST00000452489ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0224245410.9775754
ENST00000452489ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.338728520.66127145
ENST00000452489ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.02066890.9793311
ENST00000452489ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.0210265780.97897345
ENST00000357197ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0220367350.97796327
ENST00000357197ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.333724050.6662759
ENST00000357197ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.02032990.97967005
ENST00000357197ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.0208865960.9791134
ENST00000347048ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0220367350.97796327
ENST00000347048ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.333724050.6662759
ENST00000347048ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.02032990.97967005
ENST00000347048ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.0208865960.9791134
ENST00000355007ENST00000372592PPP2R4chr9131882889+PHYHD1chr9131689317+0.0212858820.97871417
ENST00000355007ENST00000308941PPP2R4chr9131882889+PHYHD1chr9131689317+0.332789240.6672107
ENST00000355007ENST00000353176PPP2R4chr9131882889+PHYHD1chr9131689317+0.0198110580.98018897
ENST00000355007ENST00000421063PPP2R4chr9131882889+PHYHD1chr9131689317+0.020359460.97964054

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68057_68057_1_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_2_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_3_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_4_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_5_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_6_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_7_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_8_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000337738_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_9_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_10_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_11_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_12_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_13_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_14_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_15_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_16_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000347048_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_17_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=307AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQW
RMPRWRTAVSGSSLAPTPVVCQEGWSGPLLAQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRP

--------------------------------------------------------------

>68057_68057_18_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=280AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_19_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=301AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRV
LGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAY

--------------------------------------------------------------

>68057_68057_20_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=280AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_21_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=307AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQW
RMPRWRTAVSGSSLAPTPVVCQEGWSGPLLAQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRP

--------------------------------------------------------------

>68057_68057_22_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=280AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_23_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=301AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRV
LGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAY

--------------------------------------------------------------

>68057_68057_24_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000348141_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=280AA_BP=21
MAGARWLRASGSRRQVPFGTVFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_25_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_26_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_27_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_28_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_29_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_30_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_31_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_32_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000355007_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_33_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_34_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_35_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_36_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_37_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_38_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_39_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_40_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000357197_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_41_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=397AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQW
RMPRWRTAVSGSSLAPTPVVCQEGWSGPLLAQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRP

--------------------------------------------------------------

>68057_68057_42_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=370AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_43_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=391AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRV
LGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAY

--------------------------------------------------------------

>68057_68057_44_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=370AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_45_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=397AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQW
RMPRWRTAVSGSSLAPTPVVCQEGWSGPLLAQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRP

--------------------------------------------------------------

>68057_68057_46_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=370AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_47_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=391AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRV
LGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAY

--------------------------------------------------------------

>68057_68057_48_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000358994_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=370AA_BP=110
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIP
GSHTSGVSRRMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPT

--------------------------------------------------------------

>68057_68057_49_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_50_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_51_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_52_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_53_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_54_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_55_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_56_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000393370_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_57_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689316_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_58_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689316_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_59_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689316_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_60_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689316_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_61_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689317_ENST00000308941_length(amino acids)=367AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQWRMPRWRTAVSGSSLAPTPVVCQEGWSGPLL
AQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRPLAPPGARRTGSSQQLNCPFPNCTPKGSRRA

--------------------------------------------------------------

>68057_68057_62_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689317_ENST00000353176_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

--------------------------------------------------------------

>68057_68057_63_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689317_ENST00000372592_length(amino acids)=361AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSR
RMVRAPVGSAPGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQPTAELPFPQLY

--------------------------------------------------------------

>68057_68057_64_PPP2R4-PHYHD1_PPP2R4_chr9_131882889_ENST00000452489_PHYHD1_chr9_131689317_ENST00000421063_length(amino acids)=340AA_BP=80
MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQFQQDGFLVL
EGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAH
DPVFKSITHSFKVQQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSAPGTSFLGSEPA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131882889/chr9:131689316)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHYHD1chr9:131882889chr9:131689316ENST00000308941212156_15811.0298.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689316ENST00000353176212156_15811.0271.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689316ENST00000372592213156_15811.0292.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689316ENST00000421063010156_15811.0271.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689317ENST00000308941212156_15811.0298.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689317ENST00000353176212156_15811.0271.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689317ENST00000372592213156_15811.0292.0RegionAlpha-ketoglutarate binding
TgenePHYHD1chr9:131882889chr9:131689317ENST00000421063010156_15811.0271.0RegionAlpha-ketoglutarate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP2R4chr9:131882889chr9:131689316ENST00000337738+211183_18943.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000337738+211240_24243.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000337738+211342_34343.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000355007+29183_18943.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000355007+29240_24243.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000355007+29342_34343.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000357197+29183_18943.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000357197+29240_24243.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000357197+29342_34343.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000358994+311183_18943.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000358994+311240_24243.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000358994+311342_34343.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000393370+210183_18943.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000393370+210240_24243.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689316ENST00000393370+210342_34343.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000337738+211183_18943.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000337738+211240_24243.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000337738+211342_34343.0359.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000355007+29183_18943.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000355007+29240_24243.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000355007+29342_34343.0282.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000357197+29183_18943.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000357197+29240_24243.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000357197+29342_34343.0295.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000358994+311183_18943.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000358994+311240_24243.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000358994+311342_34343.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000393370+210183_18943.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000393370+210240_24243.0324.0Nucleotide bindingNote=ATP
HgenePPP2R4chr9:131882889chr9:131689317ENST00000393370+210342_34343.0324.0Nucleotide bindingNote=ATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>798_PPP2R4_131882889_PHYHD1_131689316_ranked_0.pdbPPP2R4131882889131882889ENST00000421063PHYHD1chr9131689316+
MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN
FIIPKKEIHTVPDMGKWKRSQFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYFLSSGDKIRFF
FEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQSMYIFKSPLIRTPPSCTRSPWAGCWACGSQW
RMPRWRTAVSGSSLAPTPVVCQEGWSGPLLAQRLVPASLGQSQPGITASLCPPQCREGPWSSSMEKWYTRASRTSLTARARPTLSTSWRP
397


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
PHYHD1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP2R4
PHYHD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP2R4-PHYHD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP2R4-PHYHD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource