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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PRKAR2A-CACNA2D3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PRKAR2A-CACNA2D3
	FusionPDB ID: 68675
	FusionGDB2.0 ID: 68675
		Hgene	Tgene
	Gene symbol	PRKAR2A	CACNA2D3
	Gene ID	5576	55799
	Gene name	protein kinase cAMP-dependent type II regulatory subunit alpha	calcium voltage-gated channel auxiliary subunit alpha2delta 3
	Synonyms	PKR2\|PRKAR2	HSA272268
	Cytomap	3p21.31	3p21.1-p14.3
	Type of gene	protein-coding	protein-coding
	Description	cAMP-dependent protein kinase type II-alpha regulatory subunitcAMP-dependent protein kinase regulatory subunit RII alphaprotein kinase A, RII-alpha subunitprotein kinase, cAMP-dependent, regulatory subunit type II alpha	voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a
	Modification date	20200313	20200313
	UniProtAcc	P13861	Q8IZS8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265563, ENST00000296446, ENST00000454963,	ENST00000478261, ENST00000288197, ENST00000415676, ENST00000474759, ENST00000490478,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 7 X 7=539	16 X 13 X 9=1872
	# samples	11	16
	** MAII score	log2(11/539*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1872*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PRKAR2A [Title/Abstract] AND CACNA2D3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PRKAR2A(48884768)-CACNA2D3(54537519), # samples:3
Anticipated loss of major functional domain due to fusion event.	PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRKAR2A-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKAR2A	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	21812984

Fusion gene breakpoints across PRKAR2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CACNA2D3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THYM	TCGA-ZB-A96L-01A	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+
ChimerDB4	THYM	TCGA-ZB-A96L	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265563	PRKAR2A	chr3	48884768	-	ENST00000415676	CACNA2D3	chr3	54537519	+	3674	512	329	3406	1025
ENST00000265563	PRKAR2A	chr3	48884768	-	ENST00000288197	CACNA2D3	chr3	54537519	+	3754	512	329	3406	1025
ENST00000265563	PRKAR2A	chr3	48884768	-	ENST00000474759	CACNA2D3	chr3	54537519	+	3758	512	329	3406	1025
ENST00000265563	PRKAR2A	chr3	48884768	-	ENST00000490478	CACNA2D3	chr3	54537519	+	3758	512	329	3406	1025
ENST00000454963	PRKAR2A	chr3	48884768	-	ENST00000415676	CACNA2D3	chr3	54537519	+	3632	470	287	3364	1025
ENST00000454963	PRKAR2A	chr3	48884768	-	ENST00000288197	CACNA2D3	chr3	54537519	+	3712	470	287	3364	1025
ENST00000454963	PRKAR2A	chr3	48884768	-	ENST00000474759	CACNA2D3	chr3	54537519	+	3716	470	287	3364	1025
ENST00000454963	PRKAR2A	chr3	48884768	-	ENST00000490478	CACNA2D3	chr3	54537519	+	3716	470	287	3364	1025
ENST00000296446	PRKAR2A	chr3	48884768	-	ENST00000415676	CACNA2D3	chr3	54537519	+	3656	494	311	3388	1025
ENST00000296446	PRKAR2A	chr3	48884768	-	ENST00000288197	CACNA2D3	chr3	54537519	+	3736	494	311	3388	1025
ENST00000296446	PRKAR2A	chr3	48884768	-	ENST00000474759	CACNA2D3	chr3	54537519	+	3740	494	311	3388	1025
ENST00000296446	PRKAR2A	chr3	48884768	-	ENST00000490478	CACNA2D3	chr3	54537519	+	3740	494	311	3388	1025

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265563	ENST00000415676	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.001030044	0.9989699
ENST00000265563	ENST00000288197	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000893213	0.9991067
ENST00000265563	ENST00000474759	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000889663	0.9991103
ENST00000265563	ENST00000490478	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000889663	0.9991103
ENST00000454963	ENST00000415676	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000996187	0.9990038
ENST00000454963	ENST00000288197	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000866235	0.99913377
ENST00000454963	ENST00000474759	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000863002	0.999137
ENST00000454963	ENST00000490478	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000863002	0.999137
ENST00000296446	ENST00000415676	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.001018355	0.99898165
ENST00000296446	ENST00000288197	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000885741	0.9991142
ENST00000296446	ENST00000474759	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000882307	0.9991177
ENST00000296446	ENST00000490478	PRKAR2A	chr3	48884768	-	CACNA2D3	chr3	54537519	+	0.000882307	0.9991177

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68675_68675_1_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_2_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_3_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_4_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000265563_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_5_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_6_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_7_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_8_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000296446_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_9_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000288197_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_10_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000415676_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_11_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000474759_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

>68675_68675_12_PRKAR2A-CACNA2D3_PRKAR2A_chr3_48884768_ENST00000454963_CACNA2D3_chr3_54537519_ENST00000490478_length(amino acids)=1025AA_BP=61
MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP
NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW
YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG
MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD
VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY
KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY
TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF
DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP
FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD
FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL
EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48884768/chr3:54537519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PRKAR2A P13861	CACNA2D3 Q8IZS8
FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.	FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

256_438

127.0

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

452_549

127.0

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

256_438

127.0

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

452_549

127.0

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

256_438

127.0

1092.0

Domain

VWFA

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

452_549

127.0

1092.0

Domain

Note=Cache

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

256_438

33.0

998.0

Domain

VWFA

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

452_549

33.0

998.0

Domain

Note=Cache

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

262_266

127.0

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

262_266

127.0

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

262_266

127.0

1092.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

262_266

33.0

998.0

Motif

Note=MIDAS-like motif

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

1090_1091

127.0

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

1090_1091

127.0

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

1090_1091

127.0

1092.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

1090_1091

33.0

998.0

Topological domain

Cytoplasmic

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

1069_1089

127.0

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

1069_1089

127.0

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

1069_1089

127.0

1092.0

Transmembrane

Helical

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

1069_1089

33.0

998.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000265563

139_260

87.33333333333333

405.0

Nucleotide binding

Note=cAMP 1

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000265563

261_404

87.33333333333333

405.0

Nucleotide binding

Note=cAMP 2

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000454963

139_260

87.33333333333333

423.0

Nucleotide binding

Note=cAMP 1

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000454963

261_404

87.33333333333333

423.0

Nucleotide binding

Note=cAMP 2

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000265563

2_138

87.33333333333333

405.0

Region

Note=Dimerization and phosphorylation

Hgene

PRKAR2A

chr3:48884768

chr3:54537519

ENST00000454963

2_138

87.33333333333333

423.0

Region

Note=Dimerization and phosphorylation

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000288197

29_1068

127.0

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000415676

29_1068

127.0

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000474759

29_1068

127.0

1092.0

Topological domain

Extracellular

Tgene

CACNA2D3

chr3:48884768

chr3:54537519

ENST00000490478

29_1068

33.0

998.0

Topological domain

Extracellular

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1805_PRKAR2A_48884768_CACNA2D3_54537519_ranked_0.pdb	PRKAR2A	48884768	48884768	ENST00000490478	CACNA2D3	chr3	54537519	+	MTSSNSQWSTSPACARPAPQPQSCPPPPHARAWATPRQNPARTVSPTPKGTASRRRTRTWKYEYFNAVLINERDKDGNFLELGKEFILAP NDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKW YIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIG MLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLAD VQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKY KLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYY TDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF DAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIP FSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGD FFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTL EPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCH	1025

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PRKAR2A_pLDDT.png

CACNA2D3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PRKAR2A
CACNA2D3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PRKAR2A-CACNA2D3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PRKAR2A-CACNA2D3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source