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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PSMD3-UNC45B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PSMD3-UNC45B
	FusionPDB ID: 69699
	FusionGDB2.0 ID: 69699
		Hgene	Tgene
	Gene symbol	PSMD3	UNC45B
	Gene ID	5709	146862
	Gene name	proteasome 26S subunit, non-ATPase 3	unc-45 myosin chaperone B
	Synonyms	P58\|RPN3\|S3\|TSTA2	CMYA4\|CTRCT43\|SMUNC45\|UNC-45B\|UNC45
	Cytomap	17q21.1	17q12
	Type of gene	protein-coding	protein-coding
	Description	26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2	protein unc-45 homolog Bcardiomyopathy associated 4striated muscle UNC45unc-45 homolog B
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264639, ENST00000541736,	ENST00000268876, ENST00000378449, ENST00000394570, ENST00000433649, ENST00000591048,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 5 X 7=280	7 X 9 X 6=378
	# samples	12	10
	** MAII score	log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PSMD3 [Title/Abstract] AND UNC45B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PSMD3(38142965)-UNC45B(33498341), # samples:3
Anticipated loss of major functional domain due to fusion event.	PSMD3-UNC45B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PSMD3-UNC45B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PSMD3-UNC45B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PSMD3-UNC45B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PSMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UNC45B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-P5-A5EV-01A	PSMD3	chr17	38142965	-	UNC45B	chr17	33498341	+
ChimerDB4	LGG	TCGA-P5-A5EV-01A	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+
ChimerDB4	LGG	TCGA-P5-A5EV	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264639	PSMD3	chr17	38142965	+	ENST00000378449	UNC45B	chr17	33498341	+	4606	723	174	1823	549
ENST00000264639	PSMD3	chr17	38142965	+	ENST00000433649	UNC45B	chr17	33498341	+	4606	723	174	1823	549
ENST00000264639	PSMD3	chr17	38142965	+	ENST00000268876	UNC45B	chr17	33498341	+	4610	723	174	1823	549
ENST00000264639	PSMD3	chr17	38142965	+	ENST00000394570	UNC45B	chr17	33498341	+	4602	723	174	1823	549
ENST00000264639	PSMD3	chr17	38142965	+	ENST00000591048	UNC45B	chr17	33498341	+	1824	723	174	1823	549
ENST00000541736	PSMD3	chr17	38142965	+	ENST00000378449	UNC45B	chr17	33498341	+	4302	419	260	1519	419
ENST00000541736	PSMD3	chr17	38142965	+	ENST00000433649	UNC45B	chr17	33498341	+	4302	419	260	1519	419
ENST00000541736	PSMD3	chr17	38142965	+	ENST00000268876	UNC45B	chr17	33498341	+	4306	419	260	1519	419
ENST00000541736	PSMD3	chr17	38142965	+	ENST00000394570	UNC45B	chr17	33498341	+	4298	419	260	1519	419
ENST00000541736	PSMD3	chr17	38142965	+	ENST00000591048	UNC45B	chr17	33498341	+	1520	419	260	1519	420

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264639	ENST00000378449	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000668588	0.9993315
ENST00000264639	ENST00000433649	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000668588	0.9993315
ENST00000264639	ENST00000268876	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000666444	0.99933356
ENST00000264639	ENST00000394570	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000669754	0.9993303
ENST00000264639	ENST00000591048	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.006861567	0.9931384
ENST00000541736	ENST00000378449	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000709666	0.99929035
ENST00000541736	ENST00000433649	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000709666	0.99929035
ENST00000541736	ENST00000268876	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000704266	0.9992957
ENST00000541736	ENST00000394570	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.000702418	0.9992976
ENST00000541736	ENST00000591048	PSMD3	chr17	38142965	+	UNC45B	chr17	33498341	+	0.004824896	0.9951751

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>69699_69699_1_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000264639_UNC45B_chr17_33498341_ENST00000268876_length(amino acids)=549AA_BP=183
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE
PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL
LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT
AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM

--------------------------------------------------------------

>69699_69699_2_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000264639_UNC45B_chr17_33498341_ENST00000378449_length(amino acids)=549AA_BP=183
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE
PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL
LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT
AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM

--------------------------------------------------------------

>69699_69699_3_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000264639_UNC45B_chr17_33498341_ENST00000394570_length(amino acids)=549AA_BP=183
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE
PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL
LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT
AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM

--------------------------------------------------------------

>69699_69699_4_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000264639_UNC45B_chr17_33498341_ENST00000433649_length(amino acids)=549AA_BP=183
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE
PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL
LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT
AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM

--------------------------------------------------------------

>69699_69699_5_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000264639_UNC45B_chr17_33498341_ENST00000591048_length(amino acids)=549AA_BP=183
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE
PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL
LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG
LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT
AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM

--------------------------------------------------------------

>69699_69699_6_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000541736_UNC45B_chr17_33498341_ENST00000268876_length(amino acids)=419AA_BP=53
MLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFS
KQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKV
KAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAAT
ECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIA

--------------------------------------------------------------

>69699_69699_7_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000541736_UNC45B_chr17_33498341_ENST00000378449_length(amino acids)=419AA_BP=53
MLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFS
KQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKV
KAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAAT
ECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIA

--------------------------------------------------------------

>69699_69699_8_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000541736_UNC45B_chr17_33498341_ENST00000394570_length(amino acids)=419AA_BP=53
MLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFS
KQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKV
KAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAAT
ECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIA

--------------------------------------------------------------

>69699_69699_9_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000541736_UNC45B_chr17_33498341_ENST00000433649_length(amino acids)=419AA_BP=53
MLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFS
KQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKV
KAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAAT
ECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIA

--------------------------------------------------------------

>69699_69699_10_PSMD3-UNC45B_PSMD3_chr17_38142965_ENST00000541736_UNC45B_chr17_33498341_ENST00000591048_length(amino acids)=420AA_BP=53
MLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFS
KQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKV
KAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAAT
ECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38142965/chr17:33498341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSMD3

chr17:38142965

chr17:33498341

ENST00000264639

26_32

183.0

535.0

Compositional bias

Note=Poly-Pro

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

751_790

565.0

932.0

Repeat

Note=ARM 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

751_790

484.0

851.0

Repeat

Note=ARM 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

751_790

563.0

930.0

Repeat

Note=ARM 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

751_790

563.0

930.0

Repeat

Note=ARM 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

751_790

484.0

851.0

Repeat

Note=ARM 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PSMD3

chr17:38142965

chr17:33498341

ENST00000264639

286_465

183.0

535.0

Domain

PCI

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

169_208

565.0

932.0

Repeat

Note=ARM 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

211_250

565.0

932.0

Repeat

Note=ARM 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

43_76

565.0

932.0

Repeat

Note=TPR 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

6_39

565.0

932.0

Repeat

Note=TPR 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000268876

77_110

565.0

932.0

Repeat

Note=TPR 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

169_208

484.0

851.0

Repeat

Note=ARM 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

211_250

484.0

851.0

Repeat

Note=ARM 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

43_76

484.0

851.0

Repeat

Note=TPR 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

6_39

484.0

851.0

Repeat

Note=TPR 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000378449

77_110

484.0

851.0

Repeat

Note=TPR 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

169_208

563.0

930.0

Repeat

Note=ARM 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

211_250

563.0

930.0

Repeat

Note=ARM 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

43_76

563.0

930.0

Repeat

Note=TPR 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

6_39

563.0

930.0

Repeat

Note=TPR 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000394570

77_110

563.0

930.0

Repeat

Note=TPR 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

169_208

563.0

930.0

Repeat

Note=ARM 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

211_250

563.0

930.0

Repeat

Note=ARM 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

43_76

563.0

930.0

Repeat

Note=TPR 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

6_39

563.0

930.0

Repeat

Note=TPR 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000433649

77_110

563.0

930.0

Repeat

Note=TPR 3

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

169_208

484.0

851.0

Repeat

Note=ARM 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

211_250

484.0

851.0

Repeat

Note=ARM 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

43_76

484.0

851.0

Repeat

Note=TPR 2

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

6_39

484.0

851.0

Repeat

Note=TPR 1

Tgene

UNC45B

chr17:38142965

chr17:33498341

ENST00000591048

77_110

484.0

851.0

Repeat

Note=TPR 3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1176_PSMD3_38142965_UNC45B_33498341_1176_PSMD3_38142965_UNC45B_33498341_ranked_0.pdb	PSMD3	38142965	38142965	ENST00000591048	UNC45B	chr17	33498341	+	MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKE PRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR YKETSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKEL LARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLG LTNLSGRSDKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAAGALAMLT AAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKKAEVVQTARECLIKCM	549

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PSMD3_pLDDT.png

UNC45B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PSMD3
UNC45B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PSMD3-UNC45B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PSMD3-UNC45B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source