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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPN13-AFF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPN13-AFF1
FusionPDB ID: 70206
FusionGDB2.0 ID: 70206
HgeneTgene
Gene symbol

PTPN13

AFF1

Gene ID

5783

4299

Gene nameprotein tyrosine phosphatase non-receptor type 13AF4/FMR2 family member 1
SynonymsFAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1EAF4|MLLT2|PBM1
Cytomap

4q21.3

4q21.3-q22.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatasAF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4
Modification date2020031320200313
UniProtAcc

PRY,PRY2

P51825

Ensembl transtripts involved in fusion geneENST idsENST00000316707, ENST00000411767, 
ENST00000427191, ENST00000436978, 
ENST00000502971, ENST00000511467, 
ENST00000511996, ENST00000395146, 
ENST00000544085, ENST00000307808, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 11 X 4=35219 X 137 X 9=23427
# samples 10141
** MAII scorelog2(10/352*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(141/23427*10)=-4.05440515056027
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPN13 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract]

The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: 25500544)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AFF1(87869723)-PTPN13(87556405), # samples:3
PTPN13(87610343)-AFF1(88005272), # samples:2
PTPN13(87556524)-AFF1(87869649), # samples:2
Anticipated loss of major functional domain due to fusion event.AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN13

GO:0006470

protein dephosphorylation

17657516|19307596

HgenePTPN13

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317


check buttonFusion gene breakpoints across PTPN13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AFF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A0VN-01APTPN13chr4

87695684

+AFF1chr4

87894982

+
ChimerDB4CESCTCGA-EA-A5ZD-01APTPN13chr4

87610343

+AFF1chr4

88005272

+
ChimerDB4CESCTCGA-EA-A5ZDPTPN13chr4

87610343

+AFF1chr4

88005272

+
ChimerDB4ESCATCGA-JY-A6FDPTPN13chr4

87556524

+AFF1chr4

87869649

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000427191PTPN13chr487610343+ENST00000395146AFF1chr488005272+8977102648036231047
ENST00000427191PTPN13chr487610343+ENST00000307808AFF1chr488005272+8958102648036201046
ENST00000436978PTPN13chr487610343+ENST00000395146AFF1chr488005272+8977102648036231047
ENST00000436978PTPN13chr487610343+ENST00000307808AFF1chr488005272+8958102648036201046
ENST00000502971PTPN13chr487610343+ENST00000395146AFF1chr488005272+8975102447836211047
ENST00000502971PTPN13chr487610343+ENST00000307808AFF1chr488005272+8956102447836181046
ENST00000411767PTPN13chr487610343+ENST00000395146AFF1chr488005272+85606096332061047
ENST00000411767PTPN13chr487610343+ENST00000307808AFF1chr488005272+85416096332031046
ENST00000316707PTPN13chr487610343+ENST00000395146AFF1chr488005272+85606096332061047
ENST00000316707PTPN13chr487610343+ENST00000307808AFF1chr488005272+85416096332031046
ENST00000511467PTPN13chr487610343+ENST00000395146AFF1chr488005272+8502551531481047
ENST00000511467PTPN13chr487610343+ENST00000307808AFF1chr488005272+8483551531451046

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000427191ENST00000395146PTPN13chr487610343+AFF1chr488005272+0.0001053290.9998946
ENST00000427191ENST00000307808PTPN13chr487610343+AFF1chr488005272+0.0001044550.9998956
ENST00000436978ENST00000395146PTPN13chr487610343+AFF1chr488005272+0.0001053290.9998946
ENST00000436978ENST00000307808PTPN13chr487610343+AFF1chr488005272+0.0001044550.9998956
ENST00000502971ENST00000395146PTPN13chr487610343+AFF1chr488005272+0.000104330.9998957
ENST00000502971ENST00000307808PTPN13chr487610343+AFF1chr488005272+0.0001034970.9998965
ENST00000411767ENST00000395146PTPN13chr487610343+AFF1chr488005272+5.73E-050.99994266
ENST00000411767ENST00000307808PTPN13chr487610343+AFF1chr488005272+5.81E-050.99994195
ENST00000316707ENST00000395146PTPN13chr487610343+AFF1chr488005272+5.73E-050.99994266
ENST00000316707ENST00000307808PTPN13chr487610343+AFF1chr488005272+5.81E-050.99994195
ENST00000511467ENST00000395146PTPN13chr487610343+AFF1chr488005272+5.14E-050.9999486
ENST00000511467ENST00000307808PTPN13chr487610343+AFF1chr488005272+5.22E-050.9999478

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70206_70206_1_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000316707_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_2_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000316707_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

>70206_70206_3_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000411767_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_4_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000411767_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

>70206_70206_5_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000427191_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_6_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000427191_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

>70206_70206_7_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000436978_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_8_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000436978_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

>70206_70206_9_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000502971_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_10_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000502971_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

>70206_70206_11_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000511467_AFF1_chr4_88005272_ENST00000307808_length(amino acids)=1046AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLT

--------------------------------------------------------------

>70206_70206_12_PTPN13-AFF1_PTPN13_chr4_87610343_ENST00000511467_AFF1_chr4_88005272_ENST00000395146_length(amino acids)=1047AA_BP=0
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:87869723/chr4:87556405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN13

PRY,PRY2

AFF1

P51825

147

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+54556_59182.02295.0Compositional biasNote=Poly-Leu
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+54856_59182.02486.0Compositional biasNote=Poly-Leu
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+54756_59182.02467.0Compositional biasNote=Poly-Leu
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+54856_59182.02491.0Compositional biasNote=Poly-Leu
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+44756_59182.02491.0Compositional biasNote=Poly-Leu
TgeneAFF1chr4:87610343chr4:88005272ENST00000307808220483_492346.01211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr4:87610343chr4:88005272ENST00000307808220835_843346.01211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr4:87610343chr4:88005272ENST00000307808220866_869346.01211.0Compositional biasNote=Poly-Pro
TgeneAFF1chr4:87610343chr4:88005272ENST00000307808220871_874346.01211.0Compositional biasNote=Poly-Ser
TgeneAFF1chr4:87610343chr4:88005272ENST00000395146321483_492353.01219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr4:87610343chr4:88005272ENST00000395146321835_843353.01219.0Compositional biasNote=Poly-Ser
TgeneAFF1chr4:87610343chr4:88005272ENST00000395146321866_869353.01219.0Compositional biasNote=Poly-Pro
TgeneAFF1chr4:87610343chr4:88005272ENST00000395146321871_874353.01219.0Compositional biasNote=Poly-Ser

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+545469_504182.02295.0Coiled coilOntology_term=ECO:0000255
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+548469_504182.02486.0Coiled coilOntology_term=ECO:0000255
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+547469_504182.02467.0Coiled coilOntology_term=ECO:0000255
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+548469_504182.02491.0Coiled coilOntology_term=ECO:0000255
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+447469_504182.02491.0Coiled coilOntology_term=ECO:0000255
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451742_1749182.02295.0Compositional biasNote=Poly-Ser
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481742_1749182.02486.0Compositional biasNote=Poly-Ser
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471742_1749182.02467.0Compositional biasNote=Poly-Ser
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481742_1749182.02491.0Compositional biasNote=Poly-Ser
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471742_1749182.02491.0Compositional biasNote=Poly-Ser
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451093_1178182.02295.0DomainPDZ 1
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451368_1452182.02295.0DomainPDZ 2
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451501_1588182.02295.0DomainPDZ 3
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451788_1868182.02295.0DomainPDZ 4
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5451882_1965182.02295.0DomainPDZ 5
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5452213_2467182.02295.0DomainTyrosine-protein phosphatase
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5453_190182.02295.0DomainKIND
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+545572_872182.02295.0DomainFERM
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481093_1178182.02486.0DomainPDZ 1
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481368_1452182.02486.0DomainPDZ 2
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481501_1588182.02486.0DomainPDZ 3
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481788_1868182.02486.0DomainPDZ 4
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5481882_1965182.02486.0DomainPDZ 5
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5482213_2467182.02486.0DomainTyrosine-protein phosphatase
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5483_190182.02486.0DomainKIND
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+548572_872182.02486.0DomainFERM
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471093_1178182.02467.0DomainPDZ 1
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471368_1452182.02467.0DomainPDZ 2
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471501_1588182.02467.0DomainPDZ 3
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471788_1868182.02467.0DomainPDZ 4
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5471882_1965182.02467.0DomainPDZ 5
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5472213_2467182.02467.0DomainTyrosine-protein phosphatase
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5473_190182.02467.0DomainKIND
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+547572_872182.02467.0DomainFERM
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481093_1178182.02491.0DomainPDZ 1
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481368_1452182.02491.0DomainPDZ 2
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481501_1588182.02491.0DomainPDZ 3
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481788_1868182.02491.0DomainPDZ 4
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5481882_1965182.02491.0DomainPDZ 5
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5482213_2467182.02491.0DomainTyrosine-protein phosphatase
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5483_190182.02491.0DomainKIND
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+548572_872182.02491.0DomainFERM
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471093_1178182.02491.0DomainPDZ 1
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471368_1452182.02491.0DomainPDZ 2
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471501_1588182.02491.0DomainPDZ 3
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471788_1868182.02491.0DomainPDZ 4
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4471882_1965182.02491.0DomainPDZ 5
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4472213_2467182.02491.0DomainTyrosine-protein phosphatase
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4473_190182.02491.0DomainKIND
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+447572_872182.02491.0DomainFERM
HgenePTPN13chr4:87610343chr4:88005272ENST00000316707+5452408_2414182.02295.0RegionSubstrate binding
HgenePTPN13chr4:87610343chr4:88005272ENST00000411767+5482408_2414182.02486.0RegionSubstrate binding
HgenePTPN13chr4:87610343chr4:88005272ENST00000427191+5472408_2414182.02467.0RegionSubstrate binding
HgenePTPN13chr4:87610343chr4:88005272ENST00000436978+5482408_2414182.02491.0RegionSubstrate binding
HgenePTPN13chr4:87610343chr4:88005272ENST00000511467+4472408_2414182.02491.0RegionSubstrate binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1828_PTPN13_87610343_AFF1_88005272_ranked_0.pdbPTPN138761034387610343ENST00000307808AFF1chr488005272+
MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSL
TSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
SGQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSED
SDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQ
PAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASAR
AGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALV
PLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAG
KKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKR
SRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKM
KQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFR
CKKDIAIKYSRTLNKHFESSSKVAQAPSPCIARSTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVL
1047


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PTPN13_pLDDT.png
all structure
all structure
AFF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
AFF1MLLT1, CCNT1, NT5E, MLLT3, CDK9, AFF4, KMT2A, AFF1, BRD4, RELA, NPM1, PCSK1, MLLT10, DOT1L, POLR2A, DDX6, HEXIM1, HIST3H3, NSD1, CARM1, SIAH1, SIAH2, SMAD9, tat, MED26, EAF1, ELL2, LARP7, ELL3, HDAC1, MYH7, SLC16A6, ZNF526, Mllt1, Mad2l1bp, Rrbp1, Rcc1, VDR, PIP4K2A, CAMKV, TRIM25, HNRNPL, ESR2, KIAA1429, SASH1, DYRK1A, ARFIP1, MRPL12, KIF20A, CCAR2, FGF12, PLCD3, EPB41L1, EPB41L3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPN13
AFF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PTPN13-AFF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPN13-AFF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource