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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RAD17-SEC24A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RAD17-SEC24A
	FusionPDB ID: 71682
	FusionGDB2.0 ID: 71682
		Hgene	Tgene
	Gene symbol	RAD17	SEC24A
	Gene ID	5884	10802
	Gene name	RAD17 checkpoint clamp loader component	SEC24 homolog A, COPII coat complex component
	Synonyms	CCYC\|HRAD17\|R24L\|RAD17SP\|RAD24	-
	Cytomap	5q13.2	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)	protein transport protein Sec24ASEC24 family, member ASEC24 related gene family, member ASEC24-related protein A
	Modification date	20200313	20200327
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000282891, ENST00000305138, ENST00000345306, ENST00000354312, ENST00000354868, ENST00000361732, ENST00000380774, ENST00000509734, ENST00000358030, ENST00000521422, ENST00000504177,	ENST00000322887, ENST00000398844,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 3=27	6 X 7 X 4=168
	# samples	4	7
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RAD17 [Title/Abstract] AND SEC24A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RAD17(68670538)-SEC24A(134050714), # samples:3
Anticipated loss of major functional domain due to fusion event.	RAD17-SEC24A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD17-SEC24A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD17-SEC24A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAD17-SEC24A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SEC24A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Fusion gene breakpoints across RAD17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC24A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5524-01A	RAD17	chr5	68670538	-	SEC24A	chr5	134050714	+
ChimerDB4	PRAD	TCGA-EJ-5524-01A	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+
ChimerDB4	PRAD	TCGA-EJ-5524	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+
ChimerDB4	PRAD	TCGA-EJ-5524	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361732	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	4115	831	480	1385	301
ENST00000509734	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	4346	1062	636	1616	326
ENST00000354868	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	4173	889	538	1443	301
ENST00000354312	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	4056	772	421	1326	301
ENST00000345306	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	3902	618	267	1172	301
ENST00000305138	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	4277	993	642	1547	301
ENST00000282891	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	3689	405	312	959	215
ENST00000380774	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050714	+	3730	446	20	1000	326
ENST00000361732	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	4115	831	480	1385	301
ENST00000509734	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	4346	1062	636	1616	326
ENST00000354868	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	4173	889	538	1443	301
ENST00000354312	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	4056	772	421	1326	301
ENST00000345306	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	3902	618	267	1172	301
ENST00000305138	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	4277	993	642	1547	301
ENST00000282891	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	3689	405	312	959	215
ENST00000380774	RAD17	chr5	68670538	+	ENST00000398844	SEC24A	chr5	134050713	+	3730	446	20	1000	326

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361732	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000193572	0.99980646
ENST00000509734	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000180059	0.99981993
ENST00000354868	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000182177	0.9998179
ENST00000354312	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000183584	0.9998165
ENST00000345306	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000178812	0.99982125
ENST00000305138	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000182543	0.99981743
ENST00000282891	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000747469	0.9992525
ENST00000380774	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050714	+	0.000165693	0.9998343
ENST00000361732	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000193572	0.99980646
ENST00000509734	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000180059	0.99981993
ENST00000354868	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000182177	0.9998179
ENST00000354312	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000183584	0.9998165
ENST00000345306	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000178812	0.99982125
ENST00000305138	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000182543	0.99981743
ENST00000282891	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000747469	0.9992525
ENST00000380774	ENST00000398844	RAD17	chr5	68670538	+	SEC24A	chr5	134050713	+	0.000165693	0.9998343

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71682_71682_1_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000282891_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=215AA_BP=30
MNQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQP
PILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDE

--------------------------------------------------------------

>71682_71682_2_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000282891_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=215AA_BP=30
MNQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQP
PILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDE

--------------------------------------------------------------

>71682_71682_3_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000305138_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_4_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000305138_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_5_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000345306_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_6_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000345306_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_7_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000354312_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_8_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000354312_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_9_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000354868_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_10_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000354868_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_11_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000361732_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_12_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000361732_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=301AA_BP=116
MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQH
ELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQ
LSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMK

--------------------------------------------------------------

>71682_71682_13_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000380774_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=326AA_BP=141
MQVLNYGWELLQFIMSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIY
GLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY
RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA

--------------------------------------------------------------

>71682_71682_14_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000380774_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=326AA_BP=141
MQVLNYGWELLQFIMSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIY
GLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY
RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA

--------------------------------------------------------------

>71682_71682_15_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000509734_SEC24A_chr5_134050713_ENST00000398844_length(amino acids)=326AA_BP=141
MQVLNYGWELLQFIMSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIY
GLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY
RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA

--------------------------------------------------------------

>71682_71682_16_RAD17-SEC24A_RAD17_chr5_68670538_ENST00000509734_SEC24A_chr5_134050714_ENST00000398844_length(amino acids)=326AA_BP=141
MQVLNYGWELLQFIMSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIY
GLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY
RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:68670538/chr5:134050714)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000322887

89_237

614.0

Compositional bias

Note=Pro-rich

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000322887

89_237

614.0

Compositional bias

Note=Pro-rich

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000322887

431_455

614.0

Region

Note=Zinc finger-like

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000322887

431_455

614.0

Region

Note=Zinc finger-like

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000322887

966_1038

614.0

Repeat

Gelsolin-like

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000398844

966_1038

909.0

1094.0

Repeat

Gelsolin-like

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000322887

966_1038

614.0

Repeat

Gelsolin-like

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000398844

966_1038

909.0

1094.0

Repeat

Gelsolin-like

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000282891

137_144

31.0

585.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000305138

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000345306

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000354312

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000354868

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000358030

137_144

506.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000361732

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000380774

137_144

128.0

682.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000509734

137_144

128.0

682.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050713

ENST00000521422

137_144

506.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000282891

137_144

31.0

585.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000305138

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000345306

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000354312

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000354868

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000358030

137_144

506.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000361732

137_144

117.0

671.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000380774

137_144

128.0

682.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000509734

137_144

128.0

682.0

Nucleotide binding

ATP

Hgene

RAD17

chr5:68670538

chr5:134050714

ENST00000521422

137_144

506.0

Nucleotide binding

ATP

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000398844

89_237

909.0

1094.0

Compositional bias

Note=Pro-rich

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000398844

89_237

909.0

1094.0

Compositional bias

Note=Pro-rich

Tgene

SEC24A

chr5:68670538

chr5:134050713

ENST00000398844

431_455

909.0

1094.0

Region

Note=Zinc finger-like

Tgene

SEC24A

chr5:68670538

chr5:134050714

ENST00000398844

431_455

909.0

1094.0

Region

Note=Zinc finger-like

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>605_RAD17_68670538_SEC24A_134050714_ranked_0.pdb	RAD17	68670538	68670538	ENST00000398844	SEC24A	chr5	134050714	+	MQVLNYGWELLQFIMSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIY GLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLY RVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIA	326

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RAD17_pLDDT.png

SEC24A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RAD17
SEC24A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000282891	+	3	16	432_681	31.0	585.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000305138	+	4	17	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000345306	+	4	17	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000354312	+	5	18	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000354868	+	6	19	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000358030	+	3	16	432_681	0	506.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000361732	+	5	18	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000380774	+	3	16	432_681	128.0	682.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000509734	+	5	18	432_681	128.0	682.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050713	ENST00000521422	+	4	17	432_681	0	506.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000282891	+	3	16	432_681	31.0	585.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000305138	+	4	17	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000345306	+	4	17	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000354312	+	5	18	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000354868	+	6	19	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000358030	+	3	16	432_681	0	506.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000361732	+	5	18	432_681	117.0	671.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000380774	+	3	16	432_681	128.0	682.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000509734	+	5	18	432_681	128.0	682.0	MCM7
Hgene	RAD17	chr5:68670538	chr5:134050714	ENST00000521422	+	4	17	432_681	0	506.0	MCM7

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Related Drugs to RAD17-SEC24A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RAD17-SEC24A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source