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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RET-TRIM33

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RET-TRIM33
FusionPDB ID: 73568
FusionGDB2.0 ID: 73568
HgeneTgene
Gene symbol

RET

TRIM33

Gene ID

5979

51592

Gene nameret proto-oncogenetripartite motif containing 33
SynonymsCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1ECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMA
Cytomap

10q11.21

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullaryE3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma
Modification date2020032220200313
UniProtAcc

RTL1

Q9UPN9

Ensembl transtripts involved in fusion geneENST idsENST00000340058, ENST00000355710, 
ENST00000476908, ENST00000358465, 
ENST00000369543, ENST00000450349, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 4=2164 X 4 X 3=48
# samples 94
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RET [Title/Abstract] AND TRIM33 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIM33(114964058)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRET

GO:0030155

regulation of cell adhesion

21357690

HgeneRET

GO:0030335

positive regulation of cell migration

20702524

HgeneRET

GO:0033619

membrane protein proteolysis

21357690

HgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

HgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

HgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099

TgeneTRIM33

GO:0016567

protein ubiquitination

19135894

TgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

TgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894


check buttonFusion gene breakpoints across RET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIM33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..RETchr10

43610184

+TRIM33chr1

114944085

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355710RETchr1043610184+ENST00000358465TRIM33chr1114944085-773123682322859875
ENST00000355710RETchr1043610184+ENST00000369543TRIM33chr1114944085-284923682322808858
ENST00000355710RETchr1043610184+ENST00000450349TRIM33chr1114944085-288723682322859875
ENST00000340058RETchr1043610184+ENST00000358465TRIM33chr1114944085-767923161802807875
ENST00000340058RETchr1043610184+ENST00000369543TRIM33chr1114944085-279723161802756858
ENST00000340058RETchr1043610184+ENST00000450349TRIM33chr1114944085-283523161802807875

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73568_73568_1_RET-TRIM33_RET_chr10_43610184_ENST00000340058_TRIM33_chr1_114944085_ENST00000358465_length(amino acids)=875AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEV

--------------------------------------------------------------

>73568_73568_2_RET-TRIM33_RET_chr10_43610184_ENST00000340058_TRIM33_chr1_114944085_ENST00000369543_length(amino acids)=858AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAVALYFEDKLTE

--------------------------------------------------------------

>73568_73568_3_RET-TRIM33_RET_chr10_43610184_ENST00000340058_TRIM33_chr1_114944085_ENST00000450349_length(amino acids)=875AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEV

--------------------------------------------------------------

>73568_73568_4_RET-TRIM33_RET_chr10_43610184_ENST00000355710_TRIM33_chr1_114944085_ENST00000358465_length(amino acids)=875AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEV

--------------------------------------------------------------

>73568_73568_5_RET-TRIM33_RET_chr10_43610184_ENST00000355710_TRIM33_chr1_114944085_ENST00000369543_length(amino acids)=858AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAVALYFEDKLTE

--------------------------------------------------------------

>73568_73568_6_RET-TRIM33_RET_chr10_43610184_ENST00000355710_TRIM33_chr1_114944085_ENST00000450349_length(amino acids)=875AA_BP=712
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILKCERLLLY
LYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:114964058/chr1:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RET

RTL1

TRIM33

Q9UPN9

1358FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (685) >>>685.pdbFusion protein BP residue: 712
CIF file (685) >>>685.cif		RETchr1043610184+TRIM33chr1114944085-
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPL
LYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRS
LDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFF
NTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNI
SVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAR
EEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRAT
VHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSV
LLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSM
ENQVSVDAFKILKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMD
LSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAV
ALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKS
858
3D view using mol* of 685 (AA BP:712)
PDB file (693) >>>693.pdbFusion protein BP residue: 712
CIF file (693) >>>693.cif		RETchr1043610184+TRIM33chr1114944085-
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPL
LYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRS
LDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFF
NTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNI
SVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAR
EEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRAT
VHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSV
LLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSM
ENQVSVDAFKILKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMD
LSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQ
EINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVT
875
3D view using mol* of 693 (AA BP:712)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RET_pLDDT.png
all structure
all structure
TRIM33_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RET_TRIM33_685_pLDDT.png (AA BP:712)
all structure
RET_TRIM33_685_pLDDT_and_active_sites.png (AA BP:712)
all structure
RET_TRIM33_685_violinplot.png (AA BP:712)
all structure
RET_TRIM33_693_pLDDT.png (AA BP:712)
all structure
RET_TRIM33_693_pLDDT_and_active_sites.png (AA BP:712)
all structure
RET_TRIM33_693_violinplot.png (AA BP:712)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
RET_TRIM33_685.png
all structure
RET_TRIM33_693.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
6851.0872350.915372.8410.3880.8281.090.3181.6020.1980.765Chain A: 33,36,37,38,39,41,44,50,51,52,54,148,150,
154,160,163,164,166,167,168,169,170,171,172,174,18
5,186,187,188,189,190,191,192,193,241,256,258
6931.1761060.925164.9830.3650.9611.2950.3381.8160.1861.064Chain A: 32,33,36,37,38,39,50,51,52,54,166,167,168
,170,172,174,185,186,187,188,189,190,191,192,193,2
04,241,256,258

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
693ZINC000000004319DB00598Labetalol-7.61208-7.63968
693ZINC000000034157DB06707Levonordefrin-7.20013-7.21763
693ZINC000006382803DB00352Tioguanine-6.26526-7.18506
693ZINC000000896546DB01099Flucytosine-7.05749-7.05799
693ZINC000000004321DB00909Zonisamide-7.02246-7.02386
693ZINC000000388081DB05381Histamine-6.50847-6.96347
693ZINC000000403011DB00598Labetalol-4.86974-6.80754
693ZINC000018279854DB00441Gemcitabine-6.70388-6.70988
693ZINC000003803652DB00399Zoledronic acid-6.19528-6.70168
693ZINC000004097426DB00491Miglitol-6.60629-6.68749
693ZINC000007997568DB00698Nitrofurantoin-5.38298-6.66408
693ZINC000003651680DB00237Butabarbital-4.97745-6.65805
693ZINC000000000416DB00598Labetalol-6.6296-6.6572
693ZINC000013545634DB00312Pentobarbital-4.9589-6.6469
693ZINC000000000882DB00173Adenine-6.59149-6.61219
693ZINC000001543475DB14126Tenofovir-6.0196-6.6055
693ZINC000000001688DB00244Mesalazine-6.58609-6.58939
693ZINC000034676245DB00260Cycloserine-6.33944-6.58644
693ZINC000100032379DB02631-6.38641-6.56161
693ZINC000003801919DB00630Alendronic acid-5.78449-6.52749

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000000034157DB06707LevonordefrinSmall moleculeC[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000006382803DB00352TioguanineSmall moleculeNC1=NC(=S)C2=C(N1)N=CN2Approved
ZINC000000896546DB01099FlucytosineSmall moleculeNC1=C(F)C=NC(=O)N1Approved|Investigational
ZINC000000004321DB00909ZonisamideSmall moleculeNS(=O)(=O)CC1=NOC2=CC=CC=C12Approved|Investigational
ZINC000000388081DB05381HistamineSmall moleculeNCCC1=CNC=N1Approved|Investigational
ZINC000000403011DB00598LabetalolSmall moleculeCC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1Approved
ZINC000018279854DB00441GemcitabineSmall moleculeNC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)FApproved
ZINC000003803652DB00399Zoledronic acidSmall moleculeOC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=OApproved
ZINC000004097426DB00491MiglitolSmall moleculeOCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1COApproved
ZINC000007997568DB00698NitrofurantoinSmall molecule[O-][N+](=O)C1=CC=C(O1)C=NN1CC(=O)NC1=OApproved|Vet_approved
ZINC000003651680DB00237ButabarbitalSmall moleculeCCC(C)C1(CC)C(=O)NC(=O)NC1=OApproved|Illicit
ZINC000013545634DB00312PentobarbitalSmall moleculeCCCC(C)C1(CC)C(=O)NC(=O)NC1=OApproved|Investigational|Vet_approved
ZINC000000000882DB00173AdenineSmall moleculeNC1=C2NC=NC2=NC=N1Approved|Nutraceutical
ZINC000001543475DB14126TenofovirSmall moleculeC[C@H](CN1C=NC2=C1N=CN=C2N)OCP(O)(O)=OExperimental|Investigational
ZINC000000001688DB00244MesalazineSmall moleculeNC1=CC(C(O)=O)=C(O)C=C1Approved
ZINC000034676245DB00260CycloserineSmall moleculeN[C@@H]1CONC1=OApproved
ZINC000003801919DB00630Alendronic acidSmall moleculeNCCCC(O)(P(O)(O)=O)P(O)(O)=OApproved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000000004319328.415.655664.549169.051199.646295.85201140.61545.459.067270.58900
ZINC000000004319328.413.937652.909170.739198.631283.53901134.88245.459.364270.66200
ZINC000000034157183.2071.584399.847106.772186.848106.2270646.19954.28.948252.10900
ZINC000000034157183.2072.284398.836105.841186.106106.8890643.15454.28.781252.1900
ZINC000006382803167.1882.913334.0990174.67282.56276.865508.157458.609368.38600
ZINC000006382803167.18810.353334.2370175.32682.48776.423508.122458.464368.2800
ZINC000006382803167.1883.972333.7640164.06191.94377.76507.0323.848.378369.61600
ZINC000000896546129.0945.933283.8030174.82165.19643.787412.204349.417259.95700
ZINC000000004321212.2236.978398.51740.32185.554172.6440642.453269.667365.95900
ZINC000000388081111.1464.788315.23192.229118.535104.4680466.77632.59.295265.25300
ZINC000000388081111.1465.535313.53290.818116.688106.0260465.559339.188264.91700
ZINC000000388081111.1464.794316.56991.628116.549108.3930470.46832.59.292265.82300
ZINC000000403011328.415.963663.486168.781199.564295.14101140.57745.459.137270.60500
ZINC000000403011328.415.239606.942175.803170.799260.3401103.55145.459.225375.4400
ZINC000018279854263.210.474423.15483.804223.92656.63858.786714.42849.19.324253.02900
ZINC000018279854263.27.85433.98294.875220.08768.50850.512725.80849.19.17253.89700
ZINC000003803652272.0916.149414.00425.436272.399109.4776.692698.61218.759.817123.48901
ZINC000003803652272.09110.346412.62622.493273.968109.2846.881697.13318.758.891123.12401
ZINC000003803652272.0912.82416.54522.709279.09108.4066.34697.54618.759.904121.99201
ZINC000003803652272.09111.882412.71124.614274.426108.4675.205696.7418.759.026122.96801
ZINC000003803652272.09112.418410.05122.071274.507110.8272.646702.50318.758.712123.16601
ZINC000003803652272.09112.445414.59323.463272.373114.5554.201705.32118.758.718123.72201
ZINC000004097426207.2265.235402.682190.115212.56700678.661510.59.106238.11300
ZINC000004097426207.2264.011416.06196.16219.900688.72510.59.443236.46801
ZINC000004097426207.2266.983409.831185.038224.79400681.08510.59.206235.3701
ZINC000007997568238.1593.316407.12169.119245.79692.2060666.2641510.204254.46600
ZINC000007997568238.1593.57404.71369.965243.59391.1550662.7141510.161254.83400
ZINC000003651680212.2481.066391.506259.902131.60400688.2042410.898385.63600
ZINC000003651680212.2480.957390.147261.047129.100682.6432410.865385.98800
ZINC000003651680212.2481.015390.421261.22129.20100681.7872410.865385.94200
ZINC000000000416328.415.718665.292169.819199.85295.62301140.60345.459.123270.54700
ZINC000000000416328.416.318651.677168.706200.025282.94601135.81245.459.228270.41600
ZINC000013545634226.2751.089425.933294.315131.61900750.2842410.895388.09600
ZINC000013545634226.2750.956422.135293.451128.68400742.3912410.865388.62400
ZINC000013545634226.2751.043423.46294.264129.19600742.392410.862388.54400
ZINC000000000882135.1282.734303.1530170.481132.6720451.892348.538368.3800
ZINC000000000882135.1289.438304.2780171.466132.8120454.287348.639368.21400
ZINC000001543475287.2148.348504.272135.683258.29105.9154.383848.06410.78.314131.42801
ZINC000001543475287.2148.376485.449129.583251.84599.7254.296831.981410.78.324132.55201
ZINC000000001688153.1374.232332.7310205.917126.8140509.6792.52.758.076254.8900
ZINC000034676245102.0934.945262.74482.71180.03400374.74635.29.761245.72700
ZINC000034676245102.0934.751261.73782.916178.82200371.29335.29.725245.88500
ZINC000003801919249.0976.598414.71786.372321.66706.67968037.759.261011
ZINC000003801919249.09713.583415.3388.33320.80706.194681.1837.759.1221011
ZINC000003801919249.0977.425414.52587.312321.45505.758680.61137.759.2441011


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000000004319C[C@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000000034157C[C@H](N)[C@H](O)c1ccc(O)c(O)c10.1350791920.302260037
ZINC000006382803Nc1nc2nc[nH]c2c(=S)[nH]10.100054570.571375233
ZINC000000896546Nc1nc(=O)[nH]cc1F0.1160196950.475808288
ZINC000000004321NS(=O)(=O)Cc1noc2ccccc120.2545692540.46155884
ZINC000000388081NCCc1cnc[nH]10.2129447840.352067312
ZINC000000403011C[C@@H](CCc1ccccc1)NC[C@@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000018279854Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n10.0570816530.313846274
ZINC000003803652O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O0.1000522680.353941778
ZINC000004097426OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO0.0589747120.528182923
ZINC000007997568O=C1CN(/N=Cc2ccc([N+](=O)[O-])o2)C(=O)N10.1440232560.52186584
ZINC000003651680CC[C@@H](C)C1(CC)C(=O)NC(=O)NC1=O0.0922144390.461001225
ZINC000000000416C[C@H](CCc1ccccc1)NC[C@@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000013545634CCC[C@@H](C)C1(CC)C(=O)NC(=O)NC1=O0.0970868490.452896771
ZINC000000000882Nc1ncnc2[nH]cnc120.1746372290.465480638
ZINC000001543475C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O0.0923712960.318784803
ZINC000000001688Nc1ccc(O)c(C(=O)O)c10.4488432760.439462293
ZINC000034676245N[C@@H]1CON=C1O0.0253140150.650044735
ZINC000100032379N=C1CCCN1Cc1[nH]c(=O)[nH]c(=O)c1Cl0.1131881990.388278234
ZINC000003801919NCCCC(O)(P(=O)(O)O)P(=O)(O)O0.1119100590.475661392


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,
TRIM33NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, Trim24, Nfe2l2, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25, MAPK6, TRIM28, UBE2D2, ESR2, EZH2, CYLD, TP53BP1, BRCA1, MDC1, KIAA1429, MYC, RPS6KA6, PLEKHA4, ESR1, IMMP1L, THOC1, BRD1, SP100, VCP, PNMA2, NID2, ERC1, KPNA6, BCKDHB, BCKDHA, KPNA1, SKIV2L, KIAA1551, CALU, TTC37, DBT, PNMA1, RCN1, GNB2L1, RCN2, FBN2, NIN, PEX5, DNAJC10, ANGEL1, DCAF7, ASS1, AOX1, TRAF2, ADCK3, UNC80, CHAMP1, GCDH, FAM53C, NT5DC2, SKI, FHL3, MLKL, LRP2, PELO, BAG2, TMX3, EDEM3, HDAC6, UACA, GPX1, NELL2, BTBD18, SDF4, CAV1, ZNF43, TRIM4, GFOD1, POLR2C, KDM5C, SLFN11, PJA2, SCO2, ZFP82, CHEK1, PER1, SAT1, DGKE, TIMM50, POGZ, ANKRD28, TUBG1, RNF31, GGCX, EGFR, BRD4, CEP78, SUMO2, PDIA4, SOD1, DPP7, CALM1, TPM3, LCE3D, TRIM37, ASF1A, CBX3, NUP50, TERF2IP, Pias1, THRSP, ZNF484, TRIM52, HSPB2, ZNF776, KRT37, PYCRL, ZNF418, TGM7, CCT8L2, KRT39, MAGEA9, NUP62, MAD2L1, ZNF460, CRYAA, SHARPIN, KRT38, SSSCA1, FOXF2, ZNF333, ZNF747, SOHLH1, HSPA8, ZNF44, LOXL4, KCTD17, ZNF764, C12orf74, ELF4, ELF5, FOS, HNF4A, KLF8, LHX4, MYOD1, SOX17, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RETall structure
TRIM33all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RET-TRIM33


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RET-TRIM33


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
HgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
HgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
HgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
HgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneRETC0009404Colorectal Neoplasms2CTD_human
HgeneRETC0019569Hirschsprung Disease2CTD_human
HgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
HgeneRETC0085758Aganglionosis, Colonic2CTD_human
HgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
HgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
HgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
HgeneRETC0006413Burkitt Lymphoma1CTD_human
HgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC0038220Status Epilepticus1CTD_human
HgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
HgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneRETC0206693Medullary carcinoma1CTD_human
HgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
HgeneRETC0270823Petit mal status1CTD_human
HgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
HgeneRETC0343640African Burkitt's lymphoma1CTD_human
HgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
HgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
HgeneRETC0740340Amyloidosis, Familial1CTD_human
HgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
HgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
HgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
HgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
HgeneRETC4721444Burkitt Leukemia1CTD_human
TgeneTRIM33C0238463Papillary thyroid carcinoma2ORPHANET