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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:REV1-AFF3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: REV1-AFF3
	FusionPDB ID: 73569
	FusionGDB2.0 ID: 73569
		Hgene	Tgene
	Gene symbol	REV1	AFF3
	Gene ID	51455	3899
	Gene name	REV1 DNA directed polymerase	AF4/FMR2 family member 3
	Synonyms	AIBP80\|REV1L	LAF4\|MLLT2-like
	Cytomap	2q11.2	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase	AF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4
	Modification date	20200313	20200313
	UniProtAcc	.	P51826
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000258428, ENST00000393445, ENST00000465835,	ENST00000483600, ENST00000317233, ENST00000356421, ENST00000409236, ENST00000409579,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 11 X 6=858	14 X 19 X 6=1596
	# samples	13	16
	** MAII score	log2(13/858*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1596*10)=-3.31831684133498 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: REV1 [Title/Abstract] AND AFF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	REV1(100065798)-AFF3(100185377), # samples:3
Anticipated loss of major functional domain due to fusion event.	REV1-AFF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. REV1-AFF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	REV1	GO:0009411	response to UV	11485998

Fusion gene breakpoints across REV1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AFF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PAAD	TCGA-HZ-8637-01A	REV1	chr2	100065798	-	AFF3	chr2	100185377	-
ChimerDB4	PAAD	TCGA-HZ-8637	REV1	chr2	100065798	-	AFF3	chr2	100185377	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393445	REV1	chr2	100065798	-	ENST00000409236	AFF3	chr2	100185377	-	6893	517	35	1279	414
ENST00000393445	REV1	chr2	100065798	-	ENST00000356421	AFF3	chr2	100185377	-	5498	517	35	1279	414
ENST00000393445	REV1	chr2	100065798	-	ENST00000317233	AFF3	chr2	100185377	-	5498	517	35	1279	414
ENST00000393445	REV1	chr2	100065798	-	ENST00000409579	AFF3	chr2	100185377	-	1633	517	35	1279	414
ENST00000258428	REV1	chr2	100065798	-	ENST00000409236	AFF3	chr2	100185377	-	6955	579	43	1341	432
ENST00000258428	REV1	chr2	100065798	-	ENST00000356421	AFF3	chr2	100185377	-	5560	579	43	1341	432
ENST00000258428	REV1	chr2	100065798	-	ENST00000317233	AFF3	chr2	100185377	-	5560	579	43	1341	432
ENST00000258428	REV1	chr2	100065798	-	ENST00000409579	AFF3	chr2	100185377	-	1695	579	43	1341	432

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393445	ENST00000409236	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000676485	0.9993235
ENST00000393445	ENST00000356421	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000698211	0.9993018
ENST00000393445	ENST00000317233	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000698211	0.9993018
ENST00000393445	ENST00000409579	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.004150337	0.9958496
ENST00000258428	ENST00000409236	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000685102	0.9993149
ENST00000258428	ENST00000356421	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000707969	0.999292
ENST00000258428	ENST00000317233	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.000707969	0.999292
ENST00000258428	ENST00000409579	REV1	chr2	100065798	-	AFF3	chr2	100185377	-	0.004667295	0.99533266

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73569_73569_1_REV1-AFF3_REV1_chr2_100065798_ENST00000258428_AFF3_chr2_100185377_ENST00000317233_length(amino acids)=432AA_BP=178
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERP
RSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALC
YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRI

--------------------------------------------------------------

>73569_73569_2_REV1-AFF3_REV1_chr2_100065798_ENST00000258428_AFF3_chr2_100185377_ENST00000356421_length(amino acids)=432AA_BP=178
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERP
RSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALC
YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRI

--------------------------------------------------------------

>73569_73569_3_REV1-AFF3_REV1_chr2_100065798_ENST00000258428_AFF3_chr2_100185377_ENST00000409236_length(amino acids)=432AA_BP=178
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERP
RSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALC
YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRI

--------------------------------------------------------------

>73569_73569_4_REV1-AFF3_REV1_chr2_100065798_ENST00000258428_AFF3_chr2_100185377_ENST00000409579_length(amino acids)=432AA_BP=178
MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK
LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERP
RSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALC
YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRI

--------------------------------------------------------------

>73569_73569_5_REV1-AFF3_REV1_chr2_100065798_ENST00000393445_AFF3_chr2_100185377_ENST00000317233_length(amino acids)=414AA_BP=160
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERPRSADYFMQEAKRMKHKAD
AMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDH
AVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSY

--------------------------------------------------------------

>73569_73569_6_REV1-AFF3_REV1_chr2_100065798_ENST00000393445_AFF3_chr2_100185377_ENST00000356421_length(amino acids)=414AA_BP=160
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERPRSADYFMQEAKRMKHKAD
AMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDH
AVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSY

--------------------------------------------------------------

>73569_73569_7_REV1-AFF3_REV1_chr2_100065798_ENST00000393445_AFF3_chr2_100185377_ENST00000409236_length(amino acids)=414AA_BP=160
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERPRSADYFMQEAKRMKHKAD
AMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDH
AVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSY

--------------------------------------------------------------

>73569_73569_8_REV1-AFF3_REV1_chr2_100065798_ENST00000393445_AFF3_chr2_100185377_ENST00000409579_length(amino acids)=414AA_BP=160
MPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSS
TIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERPRSADYFMQEAKRMKHKAD
AMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDH
AVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSY

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:100065798/chr2:100185377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AFF3 P51826
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000258428

419_653

116.66666666666667

1252.0

Domain

UmuC

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000258428

44_131

116.66666666666667

1252.0

Domain

BRCT

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000393445

419_653

116.66666666666667

1251.0

Domain

UmuC

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000393445

44_131

116.66666666666667

1251.0

Domain

BRCT

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000258428

1071_1078

116.66666666666667

1252.0

Motif

Nuclear localization signal

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000393445

1071_1078

116.66666666666667

1251.0

Motif

Nuclear localization signal

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000258428

423_427

116.66666666666667

1252.0

Nucleotide binding

dCTP binding

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000258428

510_516

116.66666666666667

1252.0

Nucleotide binding

dCTP binding

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000393445

423_427

116.66666666666667

1251.0

Nucleotide binding

dCTP binding

Hgene

REV1

chr2:100065798

chr2:100185377

ENST00000393445

510_516

116.66666666666667

1251.0

Nucleotide binding

dCTP binding

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000317233

413_419

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000317233

422_432

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000317233

440_445

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000317233

670_679

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000356421

413_419

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000356421

422_432

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000356421

440_445

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000356421

670_679

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409236

413_419

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409236

422_432

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409236

440_445

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409236

670_679

972.6666666666666

1227.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409579

413_419

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409579

422_432

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409579

440_445

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

Tgene

AFF3

chr2:100065798

chr2:100185377

ENST00000409579

670_679

997.6666666666666

1252.0

Compositional bias

Note=Poly-Ser

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>905_REV1_100065798_AFF3_100185377_905_REV1_100065798_AFF3_100185377_ranked_0.pdb	REV1	100065798	100065798	ENST00000409579	AFF3	chr2	100185377	-	MVAASVGERGPRRCSAVGLPSPGPPPWSLARALAAAGPGSARPEKAAGPGHGGLGQRGRSSTMRRGGWRKRAENDGWETWGGYMAAKVQK LEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVERP RSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALC YRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRI	432

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

REV1_pLDDT.png

AFF3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
REV1
AFF3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000258428	-	4	23	352_362	116.66666666666667	1252.0	target DNA
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000258428	-	4	23	653_656	116.66666666666667	1252.0	target DNA
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000258428	-	4	23	709_717	116.66666666666667	1252.0	target DNA
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000393445	-	4	23	352_362	116.66666666666667	1251.0	target DNA
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000393445	-	4	23	653_656	116.66666666666667	1251.0	target DNA
Hgene	REV1	chr2:100065798	chr2:100185377	ENST00000393445	-	4	23	709_717	116.66666666666667	1251.0	target DNA

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Related Drugs to REV1-AFF3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to REV1-AFF3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	AFF3	C0003873	Rheumatoid Arthritis	2	CTD_human
Tgene	AFF3	C0013146	Drug abuse	1	CTD_human
Tgene	AFF3	C0013170	Drug habituation	1	CTD_human
Tgene	AFF3	C0013222	Drug Use Disorders	1	CTD_human
Tgene	AFF3	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	AFF3	C0036572	Seizures	1	GENOMICS_ENGLAND
Tgene	AFF3	C0038580	Substance Dependence	1	CTD_human
Tgene	AFF3	C0038586	Substance Use Disorders	1	CTD_human
Tgene	AFF3	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	AFF3	C0740858	Substance abuse problem	1	CTD_human
Tgene	AFF3	C1510472	Drug Dependence	1	CTD_human
Tgene	AFF3	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	AFF3	C4316881	Prescription Drug Abuse	1	CTD_human