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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATF3-USH2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATF3-USH2A
FusionPDB ID: 7421
FusionGDB2.0 ID: 7421
HgeneTgene
Gene symbol

ATF3

USH2A

Gene ID

467

7399

Gene nameactivating transcription factor 3usherin
Synonyms-RP39|US2|USH2|dJ1111A8.1
Cytomap

1q32.3

1q41

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-dependent transcription factor ATF-3cAMP-dependent transcription factor ATF-3usherinUsher syndrome 2A (autosomal recessive, mild)usher syndrome type IIa proteinusher syndrome type-2A protein
Modification date2020032220200313
UniProtAcc

P18847

.
Ensembl transtripts involved in fusion geneENST idsENST00000336937, ENST00000341491, 
ENST00000366983, ENST00000366985, 
ENST00000366987, ENST00000492118, 
ENST00000366942, ENST00000307340, 
ENST00000366943, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 2 X 3=187 X 7 X 5=245
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATF3 [Title/Abstract] AND USH2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATF3(212791576)-USH2A(216011445), # samples:3
Anticipated loss of major functional domain due to fusion event.ATF3-USH2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF3-USH2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF3-USH2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATF3-USH2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATF3

GO:0000122

negative regulation of transcription by RNA polymerase II

8622660

HgeneATF3

GO:0045944

positive regulation of transcription by RNA polymerase II

16300731

HgeneATF3

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

24939851


check buttonFusion gene breakpoints across ATF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USH2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VN-A943-01AATF3chr1

212791576

-USH2Achr1

216011445

-
ChimerDB4PRADTCGA-VN-A943-01AATF3chr1

212791576

+USH2Achr1

216011445

-
ChimerDB4PRADTCGA-VN-A943ATF3chr1

212791576

+USH2Achr1

216011445

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366987ATF3chr1212791576+ENST00000366943USH2Achr1216011445-979148113369032256
ENST00000366987ATF3chr1212791576+ENST00000307340USH2Achr1216011445-971948113368312232
ENST00000341491ATF3chr1212791576+ENST00000366943USH2Achr1216011445-992361323570352266
ENST00000341491ATF3chr1212791576+ENST00000307340USH2Achr1216011445-985161323569632242
ENST00000366985ATF3chr1212791576+ENST00000366943USH2Achr1216011445-95722621066842224
ENST00000366985ATF3chr1212791576+ENST00000307340USH2Achr1216011445-95002621066122200
ENST00000336937ATF3chr1212791576+ENST00000366943USH2Achr1216011445-9571261066832227
ENST00000336937ATF3chr1212791576+ENST00000307340USH2Achr1216011445-9499261066112203
ENST00000366983ATF3chr1212791576+ENST00000366943USH2Achr1216011445-9658348067702256
ENST00000366983ATF3chr1212791576+ENST00000307340USH2Achr1216011445-9586348066982232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366987ENST00000366943ATF3chr1212791576+USH2Achr1216011445-0.0001108470.99988914
ENST00000366987ENST00000307340ATF3chr1212791576+USH2Achr1216011445-0.0003032120.99969685
ENST00000341491ENST00000366943ATF3chr1212791576+USH2Achr1216011445-0.0001364780.9998635
ENST00000341491ENST00000307340ATF3chr1212791576+USH2Achr1216011445-0.0003763260.99962366
ENST00000366985ENST00000366943ATF3chr1212791576+USH2Achr1216011445-0.0001067960.9998932
ENST00000366985ENST00000307340ATF3chr1212791576+USH2Achr1216011445-0.0002929840.99970704
ENST00000336937ENST00000366943ATF3chr1212791576+USH2Achr1216011445-9.60E-050.99990404
ENST00000336937ENST00000307340ATF3chr1212791576+USH2Achr1216011445-0.0002629580.9997371
ENST00000366983ENST00000366943ATF3chr1212791576+USH2Achr1216011445-9.26E-050.9999074
ENST00000366983ENST00000307340ATF3chr1212791576+USH2Achr1216011445-0.0002540870.9997459

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7421_7421_1_ATF3-USH2A_ATF3_chr1_212791576_ENST00000336937_USH2A_chr1_216011445_ENST00000307340_length(amino acids)=2203AA_BP=87
MMLQHPGQVSASEEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEV
CTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESI
CGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCG
RMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCC
ETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEE
TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRN
GIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVG
KGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSR
NGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNV
LLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIIN
YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPE
SPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKEN
GRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKST
SVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTL
QAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSI
TTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWT
MEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSP
SAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS
SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYE
YQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFT
NYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTG
LGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDT
TLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHK
EPYIRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMD

--------------------------------------------------------------

>7421_7421_2_ATF3-USH2A_ATF3_chr1_212791576_ENST00000336937_USH2A_chr1_216011445_ENST00000366943_length(amino acids)=2227AA_BP=87
MMLQHPGQVSASEEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEV
CTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESI
CGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCG
RMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCC
ETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEE
TIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRN
GIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVG
KGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSR
NGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNV
LLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIIN
YFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPE
SPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKEN
GRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKST
SVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTL
QAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSI
TTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWT
MEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSP
SAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS
SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYE
YQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFT
NYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTG
LGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDT
TLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHK
EPYIRERPPLVPLQKRMSPLNVYPPGENHMFDSVADISDVSSNVTLKSYTMHFEGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLT

--------------------------------------------------------------

>7421_7421_3_ATF3-USH2A_ATF3_chr1_212791576_ENST00000341491_USH2A_chr1_216011445_ENST00000307340_length(amino acids)=2242AA_BP=126
MAAPSGAWSKMMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAE
VAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGII
LGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEA
QPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPG
MFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEAT
EHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQ
GVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVP
ESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAA
PEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMS
TPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFV
KTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGS
VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYR
IGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTL
TLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTER
NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFS
FDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLA
GQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGL
ETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKII
HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYY
ELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGK
PNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWS
PPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSV
DSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGS
RSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRS

--------------------------------------------------------------

>7421_7421_4_ATF3-USH2A_ATF3_chr1_212791576_ENST00000341491_USH2A_chr1_216011445_ENST00000366943_length(amino acids)=2266AA_BP=126
MAAPSGAWSKMMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAE
VAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGII
LGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEA
QPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPG
MFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEAT
EHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQ
GVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVP
ESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAA
PEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMS
TPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFV
KTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGS
VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYR
IGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTL
TLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTER
NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFS
FDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLA
GQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGL
ETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKII
HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYY
ELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGK
PNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWS
PPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSV
DSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGS
RSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMFDSVADISDVSSNVTLKSYTM
HFEGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKD

--------------------------------------------------------------

>7421_7421_5_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366983_USH2A_chr1_216011445_ENST00000307340_length(amino acids)=2232AA_BP=116
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK
RRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTW
YPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY
YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVN
MSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF
TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKI
DNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA
LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRH
IIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN
ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL
NSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT
LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG
EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC
AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL
QPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD
EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSH
LQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT
PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFG
MQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ
PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL
FSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH
SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVN
WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE
LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQN

--------------------------------------------------------------

>7421_7421_6_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366983_USH2A_chr1_216011445_ENST00000366943_length(amino acids)=2256AA_BP=116
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK
RRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTW
YPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY
YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVN
MSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF
TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKI
DNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA
LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRH
IIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN
ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL
NSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT
LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG
EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC
AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL
QPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD
EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSH
LQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT
PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFG
MQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ
PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL
FSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH
SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVN
WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE
LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMFDSVADISDVSSNVTLKSYTMHFEGLADTKI
PRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTT

--------------------------------------------------------------

>7421_7421_7_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366985_USH2A_chr1_216011445_ENST00000307340_length(amino acids)=2200AA_BP=84
MEQNDASTPRPELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEVCTI
YACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESICGH
ICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMP
YSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCETE
LIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIH
TGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIE
RFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGL
IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGN
LLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLN
DGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFI
YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPN
GIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRA
LLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVE
LSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAP
PEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTL
EAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEA
LPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAP
SGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDW
TFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQV
WAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYS
IGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQ
KASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLY
IPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPY
IRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDNSL

--------------------------------------------------------------

>7421_7421_8_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366985_USH2A_chr1_216011445_ENST00000366943_length(amino acids)=2224AA_BP=84
MEQNDASTPRPELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKVEVCTI
YACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESICGH
ICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGYYARILPGEVCCPDEQHNRVSVGIGDSCCGRMP
YSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCETE
LIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNFTSHICTVIRGSHNSTGKASIEEMCSSAEETIH
TGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIE
RFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGL
IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGN
LLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLN
DGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFI
YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPN
GIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRA
LLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVE
LSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAP
PEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTL
EAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEA
LPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAP
SGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDW
TFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQV
WAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYS
IGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQ
KASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLY
IPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPY
IRERPPLVPLQKRMSPLNVYPPGENHMFDSVADISDVSSNVTLKSYTMHFEGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQ

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>7421_7421_9_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366987_USH2A_chr1_216011445_ENST00000307340_length(amino acids)=2232AA_BP=116
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK
RRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTW
YPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY
YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVN
MSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF
TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKI
DNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA
LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRH
IIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN
ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL
NSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT
LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG
EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC
AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL
QPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD
EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSH
LQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT
PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFG
MQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ
PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL
FSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH
SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVN
WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE
LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQN

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>7421_7421_10_ATF3-USH2A_ATF3_chr1_212791576_ENST00000366987_USH2A_chr1_216011445_ENST00000366943_length(amino acids)=2256AA_BP=116
MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKK
RRRERNKIAAAKCRNKKKEKTECLQKVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTW
YPCAKTQKLVQDQSDELCKAVRCQKPESICGHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY
YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIVSNDLECCGGEEGVVYNRLPGMFCCGQDYVN
MSDTICCSASSGESKAHIKKNDPVPVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF
TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKI
DNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA
LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRH
IIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN
ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL
NSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT
LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG
EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC
AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL
QPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD
EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLLVSH
LQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT
PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFG
MQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ
PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL
FSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH
SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLSVVCVN
WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE
LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMFDSVADISDVSSNVTLKSYTMHFEGLADTKI
PRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDNSLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:212791576/chr1:216011445)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATF3

P18847

.
FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. {ECO:0000269|PubMed:7515060}.; FUNCTION: [Isoform 2]: Activates transcription presumably by sequestering inhibitory cofactors away from the promoters. {ECO:0000269|PubMed:7515060}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF3chr1:212791576chr1:216011445ENST00000341491+3488_110116.0182.0RegionBasic motif
HgeneATF3chr1:212791576chr1:216011445ENST00000366983+2388_110116.0136.0RegionBasic motif
HgeneATF3chr1:212791576chr1:216011445ENST00000366987+3488_110116.0182.0RegionBasic motif
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723113_32093086.05203.0DomainFibronectin type-III 18
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723403_34973086.05203.0DomainFibronectin type-III 19
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723501_35893086.05203.0DomainFibronectin type-III 20
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723592_36823086.05203.0DomainFibronectin type-III 21
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723684_37703086.05203.0DomainFibronectin type-III 22
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723774_38653086.05203.0DomainFibronectin type-III 23
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723866_39633086.05203.0DomainFibronectin type-III 24
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723964_40673086.05203.0DomainFibronectin type-III 25
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724068_41533086.05203.0DomainFibronectin type-III 26
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724157_42613086.05203.0DomainFibronectin type-III 27
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724262_43573086.05203.0DomainFibronectin type-III 28
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724358_44453086.05203.0DomainFibronectin type-III 29
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724446_45303086.05203.0DomainFibronectin type-III 30
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724534_46303086.05203.0DomainFibronectin type-III 31
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724636_47333086.05203.0DomainFibronectin type-III 32
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724734_48273086.05203.0DomainFibronectin type-III 33
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045724828_49273086.05203.0DomainFibronectin type-III 34
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211002_105201547.0DomainLaminin EGF-like 10
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211058_114601547.0DomainFibronectin type-III 1
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211148_124401547.0DomainFibronectin type-III 2
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211245_136301547.0DomainFibronectin type-III 3
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211364_146801547.0DomainFibronectin type-III 4
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211517_170901547.0DomainLaminin G-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211714_189101547.0DomainLaminin G-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211869_195501547.0DomainFibronectin type-III 5
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420211957_205401547.0DomainFibronectin type-III 6
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212055_214401547.0DomainFibronectin type-III 7
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212145_223901547.0DomainFibronectin type-III 8
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212243_233001547.0DomainFibronectin type-III 9
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212331_243301547.0DomainFibronectin type-III 10
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212437_253101547.0DomainFibronectin type-III 11
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212535_262201547.0DomainFibronectin type-III 12
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212624_272201547.0DomainFibronectin type-III 13
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021271_51701547.0DomainLaminin N-terminal
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212726_281901547.0DomainFibronectin type-III 14
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212820_292301547.0DomainFibronectin type-III 15
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420212927_301801547.0DomainFibronectin type-III 16
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213022_311201547.0DomainFibronectin type-III 17
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213113_320901547.0DomainFibronectin type-III 18
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213403_349701547.0DomainFibronectin type-III 19
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213501_358901547.0DomainFibronectin type-III 20
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213592_368201547.0DomainFibronectin type-III 21
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213684_377001547.0DomainFibronectin type-III 22
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213774_386501547.0DomainFibronectin type-III 23
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213866_396301547.0DomainFibronectin type-III 24
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420213964_406701547.0DomainFibronectin type-III 25
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214068_415301547.0DomainFibronectin type-III 26
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214157_426101547.0DomainFibronectin type-III 27
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214262_435701547.0DomainFibronectin type-III 28
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214358_444501547.0DomainFibronectin type-III 29
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214446_453001547.0DomainFibronectin type-III 30
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214534_463001547.0DomainFibronectin type-III 31
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214636_473301547.0DomainFibronectin type-III 32
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214734_482701547.0DomainFibronectin type-III 33
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420214828_492701547.0DomainFibronectin type-III 34
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021518_57401547.0DomainLaminin EGF-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021575_64001547.0DomainLaminin EGF-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021641_69301547.0DomainLaminin EGF-like 3
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021694_74601547.0DomainLaminin EGF-like 4
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021747_79401547.0DomainLaminin EGF-like 5
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021795_84601547.0DomainLaminin EGF-like 6
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021847_89901547.0DomainLaminin EGF-like 7
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021900_95001547.0DomainLaminin EGF-like 8
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366942021951_100101547.0DomainLaminin EGF-like 9
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733113_32093086.05227.0DomainFibronectin type-III 18
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733403_34973086.05227.0DomainFibronectin type-III 19
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733501_35893086.05227.0DomainFibronectin type-III 20
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733592_36823086.05227.0DomainFibronectin type-III 21
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733684_37703086.05227.0DomainFibronectin type-III 22
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733774_38653086.05227.0DomainFibronectin type-III 23
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733866_39633086.05227.0DomainFibronectin type-III 24
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733964_40673086.05227.0DomainFibronectin type-III 25
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734068_41533086.05227.0DomainFibronectin type-III 26
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734157_42613086.05227.0DomainFibronectin type-III 27
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734262_43573086.05227.0DomainFibronectin type-III 28
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734358_44453086.05227.0DomainFibronectin type-III 29
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734446_45303086.05227.0DomainFibronectin type-III 30
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734534_46303086.05227.0DomainFibronectin type-III 31
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734636_47333086.05227.0DomainFibronectin type-III 32
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734734_48273086.05227.0DomainFibronectin type-III 33
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345734828_49273086.05227.0DomainFibronectin type-III 34
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045725200_52023086.05203.0MotifNote=PDZ-binding
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420215200_520201547.0MotifNote=PDZ-binding
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345735200_52023086.05227.0MotifNote=PDZ-binding
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045725064_52023086.05203.0Topological domainCytoplasmic
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694202132_504201547.0Topological domainExtracellular
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420215064_520201547.0Topological domainCytoplasmic
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345735064_52023086.05227.0Topological domainCytoplasmic
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045725043_50633086.05203.0TransmembraneHelical
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669420215043_506301547.0TransmembraneHelical
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345735043_50633086.05227.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATF3chr1:212791576chr1:216011445ENST00000336937+3486_14987.0107.0DomainbZIP
HgeneATF3chr1:212791576chr1:216011445ENST00000341491+3486_149116.0182.0DomainbZIP
HgeneATF3chr1:212791576chr1:216011445ENST00000366983+2386_149116.0136.0DomainbZIP
HgeneATF3chr1:212791576chr1:216011445ENST00000366985+4586_14959.0125.0DomainbZIP
HgeneATF3chr1:212791576chr1:216011445ENST00000366987+3486_149116.0182.0DomainbZIP
HgeneATF3chr1:212791576chr1:216011445ENST00000336937+34114_14287.0107.0RegionLeucine-zipper
HgeneATF3chr1:212791576chr1:216011445ENST00000336937+3488_11087.0107.0RegionBasic motif
HgeneATF3chr1:212791576chr1:216011445ENST00000341491+34114_142116.0182.0RegionLeucine-zipper
HgeneATF3chr1:212791576chr1:216011445ENST00000366983+23114_142116.0136.0RegionLeucine-zipper
HgeneATF3chr1:212791576chr1:216011445ENST00000366985+45114_14259.0125.0RegionLeucine-zipper
HgeneATF3chr1:212791576chr1:216011445ENST00000366985+4588_11059.0125.0RegionBasic motif
HgeneATF3chr1:212791576chr1:216011445ENST00000366987+34114_142116.0182.0RegionLeucine-zipper
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721002_10523086.05203.0DomainLaminin EGF-like 10
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721058_11463086.05203.0DomainFibronectin type-III 1
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721148_12443086.05203.0DomainFibronectin type-III 2
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721245_13633086.05203.0DomainFibronectin type-III 3
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721364_14683086.05203.0DomainFibronectin type-III 4
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721517_17093086.05203.0DomainLaminin G-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721714_18913086.05203.0DomainLaminin G-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721869_19553086.05203.0DomainFibronectin type-III 5
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045721957_20543086.05203.0DomainFibronectin type-III 6
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722055_21443086.05203.0DomainFibronectin type-III 7
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722145_22393086.05203.0DomainFibronectin type-III 8
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722243_23303086.05203.0DomainFibronectin type-III 9
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722331_24333086.05203.0DomainFibronectin type-III 10
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722437_25313086.05203.0DomainFibronectin type-III 11
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722535_26223086.05203.0DomainFibronectin type-III 12
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722624_27223086.05203.0DomainFibronectin type-III 13
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572271_5173086.05203.0DomainLaminin N-terminal
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722726_28193086.05203.0DomainFibronectin type-III 14
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722820_29233086.05203.0DomainFibronectin type-III 15
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045722927_30183086.05203.0DomainFibronectin type-III 16
TgeneUSH2Achr1:212791576chr1:216011445ENST0000030734045723022_31123086.05203.0DomainFibronectin type-III 17
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572518_5743086.05203.0DomainLaminin EGF-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572575_6403086.05203.0DomainLaminin EGF-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572641_6933086.05203.0DomainLaminin EGF-like 3
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572694_7463086.05203.0DomainLaminin EGF-like 4
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572747_7943086.05203.0DomainLaminin EGF-like 5
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572795_8463086.05203.0DomainLaminin EGF-like 6
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572847_8993086.05203.0DomainLaminin EGF-like 7
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572900_9503086.05203.0DomainLaminin EGF-like 8
TgeneUSH2Achr1:212791576chr1:216011445ENST000003073404572951_10013086.05203.0DomainLaminin EGF-like 9
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731002_10523086.05227.0DomainLaminin EGF-like 10
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731058_11463086.05227.0DomainFibronectin type-III 1
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731148_12443086.05227.0DomainFibronectin type-III 2
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731245_13633086.05227.0DomainFibronectin type-III 3
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731364_14683086.05227.0DomainFibronectin type-III 4
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731517_17093086.05227.0DomainLaminin G-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731714_18913086.05227.0DomainLaminin G-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731869_19553086.05227.0DomainFibronectin type-III 5
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345731957_20543086.05227.0DomainFibronectin type-III 6
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732055_21443086.05227.0DomainFibronectin type-III 7
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732145_22393086.05227.0DomainFibronectin type-III 8
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732243_23303086.05227.0DomainFibronectin type-III 9
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732331_24333086.05227.0DomainFibronectin type-III 10
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732437_25313086.05227.0DomainFibronectin type-III 11
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732535_26223086.05227.0DomainFibronectin type-III 12
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732624_27223086.05227.0DomainFibronectin type-III 13
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573271_5173086.05227.0DomainLaminin N-terminal
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732726_28193086.05227.0DomainFibronectin type-III 14
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732820_29233086.05227.0DomainFibronectin type-III 15
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345732927_30183086.05227.0DomainFibronectin type-III 16
TgeneUSH2Achr1:212791576chr1:216011445ENST0000036694345733022_31123086.05227.0DomainFibronectin type-III 17
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573518_5743086.05227.0DomainLaminin EGF-like 1
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573575_6403086.05227.0DomainLaminin EGF-like 2
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573641_6933086.05227.0DomainLaminin EGF-like 3
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573694_7463086.05227.0DomainLaminin EGF-like 4
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573747_7943086.05227.0DomainLaminin EGF-like 5
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573795_8463086.05227.0DomainLaminin EGF-like 6
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573847_8993086.05227.0DomainLaminin EGF-like 7
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573900_9503086.05227.0DomainLaminin EGF-like 8
TgeneUSH2Achr1:212791576chr1:216011445ENST000003669434573951_10013086.05227.0DomainLaminin EGF-like 9
TgeneUSH2Achr1:212791576chr1:216011445ENST00000307340457232_50423086.05203.0Topological domainExtracellular
TgeneUSH2Achr1:212791576chr1:216011445ENST00000366943457332_50423086.05227.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATF3_pLDDT.png
all structure
all structure
USH2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATF3
USH2A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATF3-USH2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATF3-USH2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource