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Fusion Protein:ROCK1-DCC |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ROCK1-DCC | FusionPDB ID: 75304 | FusionGDB2.0 ID: 75304 | Hgene | Tgene | Gene symbol | ROCK1 | DCC | Gene ID | 6093 | 1630 |
| Gene name | Rho associated coiled-coil containing protein kinase 1 | DCC netrin 1 receptor | |
| Synonyms | P160ROCK|ROCK-I | CRC18|CRCR1|HGPPS2|IGDCC1|MRMV1|NTN1R1 | |
| Cytomap | 18q11.1 | 18q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | netrin receptor DCCcolorectal cancer suppressordeleted in colorectal carcinomaimmunoglobulin superfamily DCC subclass member 1putative colorectal tumor suppressortumor suppressor protein DCC | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | . | P43146 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000399799, | ENST00000580146, ENST00000412726, ENST00000442544, ENST00000581580, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 24 X 16 X 12=4608 | 19 X 19 X 6=2166 |
| # samples | 31 | 20 | |
| ** MAII score | log2(31/4608*10)=-3.89380059616807 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/2166*10)=-3.4369613378336 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ROCK1 [Title/Abstract] AND DCC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ROCK1(18586312)-DCC(50912413), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ROCK1-DCC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-DCC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-DCC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-DCC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK1 | GO:0006468 | protein phosphorylation | 23093407 |
| Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
| Hgene | ROCK1 | GO:0018105 | peptidyl-serine phosphorylation | 18573880 |
| Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
| Hgene | ROCK1 | GO:0030334 | regulation of cell migration | 23093407 |
| Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
| Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
| Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
| Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
| Hgene | ROCK1 | GO:0070507 | regulation of microtubule cytoskeleton organization | 23093407 |
| Fusion gene breakpoints across ROCK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DCC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CV-5434-01A | ROCK1 | chr18 | 18586312 | - | DCC | chr18 | 50912413 | + |
| ChimerDB4 | HNSC | TCGA-CV-5434 | ROCK1 | chr18 | 18586311 | - | DCC | chr18 | 50912412 | + |
| ChimerDB4 | HNSC | TCGA-CV-5434 | ROCK1 | chr18 | 18586312 | - | DCC | chr18 | 50912413 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000399799 | ROCK1 | chr18 | 18586312 | - | ENST00000442544 | DCC | chr18 | 50912413 | + | 5572 | 2826 | 899 | 4810 | 1303 |
| ENST00000399799 | ROCK1 | chr18 | 18586312 | - | ENST00000412726 | DCC | chr18 | 50912413 | + | 3715 | 2826 | 899 | 3616 | 905 |
| ENST00000399799 | ROCK1 | chr18 | 18586312 | - | ENST00000581580 | DCC | chr18 | 50912413 | + | 4754 | 2826 | 899 | 4732 | 1277 |
| ENST00000399799 | ROCK1 | chr18 | 18586311 | - | ENST00000442544 | DCC | chr18 | 50912412 | + | 5572 | 2826 | 899 | 4810 | 1303 |
| ENST00000399799 | ROCK1 | chr18 | 18586311 | - | ENST00000412726 | DCC | chr18 | 50912412 | + | 3715 | 2826 | 899 | 3616 | 905 |
| ENST00000399799 | ROCK1 | chr18 | 18586311 | - | ENST00000581580 | DCC | chr18 | 50912412 | + | 4754 | 2826 | 899 | 4732 | 1277 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000399799 | ENST00000442544 | ROCK1 | chr18 | 18586312 | - | DCC | chr18 | 50912413 | + | 0.001225991 | 0.998774 |
| ENST00000399799 | ENST00000412726 | ROCK1 | chr18 | 18586312 | - | DCC | chr18 | 50912413 | + | 0.000475718 | 0.99952424 |
| ENST00000399799 | ENST00000581580 | ROCK1 | chr18 | 18586312 | - | DCC | chr18 | 50912413 | + | 0.001330667 | 0.9986694 |
| ENST00000399799 | ENST00000442544 | ROCK1 | chr18 | 18586311 | - | DCC | chr18 | 50912412 | + | 0.001225991 | 0.998774 |
| ENST00000399799 | ENST00000412726 | ROCK1 | chr18 | 18586311 | - | DCC | chr18 | 50912412 | + | 0.000475718 | 0.99952424 |
| ENST00000399799 | ENST00000581580 | ROCK1 | chr18 | 18586311 | - | DCC | chr18 | 50912412 | + | 0.001330667 | 0.9986694 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >75304_75304_1_ROCK1-DCC_ROCK1_chr18_18586311_ENST00000399799_DCC_chr18_50912412_ENST00000412726_length(amino acids)=905AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEAN GKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQDTGVTINLVN -------------------------------------------------------------- >75304_75304_2_ROCK1-DCC_ROCK1_chr18_18586311_ENST00000399799_DCC_chr18_50912412_ENST00000442544_length(amino acids)=1303AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW ADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVI TREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKV EHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRA THSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSL AARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLP PSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPE -------------------------------------------------------------- >75304_75304_3_ROCK1-DCC_ROCK1_chr18_18586311_ENST00000399799_DCC_chr18_50912412_ENST00000581580_length(amino acids)=1277AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEAN GKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWP VDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLW IHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNN PAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACV RPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVEMEWVKQ -------------------------------------------------------------- >75304_75304_4_ROCK1-DCC_ROCK1_chr18_18586312_ENST00000399799_DCC_chr18_50912413_ENST00000412726_length(amino acids)=905AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEAN GKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQDTGVTINLVN -------------------------------------------------------------- >75304_75304_5_ROCK1-DCC_ROCK1_chr18_18586312_ENST00000399799_DCC_chr18_50912413_ENST00000442544_length(amino acids)=1303AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSW ADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVI TREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKV EHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRA THSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSL AARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLP PSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPE -------------------------------------------------------------- >75304_75304_6_ROCK1-DCC_ROCK1_chr18_18586312_ENST00000399799_DCC_chr18_50912413_ENST00000581580_length(amino acids)=1277AA_BP=642 MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDY EVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWE TLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLE EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRD RGHDSEMIGDLQESSSHYVISLKAFNNAGEGVPLYESATTRSITDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR WRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEAN GKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWP VDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLW IHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNN PAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACV RPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVEMEWVKQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:18586312/chr18:50912413) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DCC |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:8187090, ECO:0000269|PubMed:8861902}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 341_409 | 628.3333333333334 | 1355.0 | Domain | AGC-kinase C-terminal |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 479_556 | 628.3333333333334 | 1355.0 | Domain | REM-1 |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 76_338 | 628.3333333333334 | 1355.0 | Domain | Protein kinase |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 341_409 | 628.3333333333334 | 1355.0 | Domain | AGC-kinase C-terminal |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 479_556 | 628.3333333333334 | 1355.0 | Domain | REM-1 |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 76_338 | 628.3333333333334 | 1355.0 | Domain | Protein kinase |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 82_90 | 628.3333333333334 | 1355.0 | Nucleotide binding | ATP |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 82_90 | 628.3333333333334 | 1355.0 | Nucleotide binding | ATP |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 846_942 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 5 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 947_1044 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 6 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 846_942 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 5 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 947_1044 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 6 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 1123_1447 | 786.3333333333334 | 1448.0 | Topological domain | Cytoplasmic | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 1123_1447 | 786.3333333333334 | 1448.0 | Topological domain | Cytoplasmic | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 1098_1122 | 786.3333333333334 | 1448.0 | Transmembrane | Helical | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 1098_1122 | 786.3333333333334 | 1448.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 1011_1102 | 628.3333333333334 | 1355.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 422_692 | 628.3333333333334 | 1355.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 1011_1102 | 628.3333333333334 | 1355.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 422_692 | 628.3333333333334 | 1355.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 636_980 | 628.3333333333334 | 1355.0 | Compositional bias | Note=Glu-rich |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 636_980 | 628.3333333333334 | 1355.0 | Compositional bias | Note=Glu-rich |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 1118_1317 | 628.3333333333334 | 1355.0 | Domain | PH |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 949_1015 | 628.3333333333334 | 1355.0 | Domain | RhoBD |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 1118_1317 | 628.3333333333334 | 1355.0 | Domain | PH |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 949_1015 | 628.3333333333334 | 1355.0 | Domain | RhoBD |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 1115_1354 | 628.3333333333334 | 1355.0 | Region | Note=Auto-inhibitory |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 707_946 | 628.3333333333334 | 1355.0 | Region | SHROOM3 binding |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 998_1010 | 628.3333333333334 | 1355.0 | Region | Note=RHOA binding |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 1115_1354 | 628.3333333333334 | 1355.0 | Region | Note=Auto-inhibitory |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 707_946 | 628.3333333333334 | 1355.0 | Region | SHROOM3 binding |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 998_1010 | 628.3333333333334 | 1355.0 | Region | Note=RHOA binding |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 1228_1281 | 628.3333333333334 | 1355.0 | Zinc finger | Phorbol-ester/DAG-type |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 1228_1281 | 628.3333333333334 | 1355.0 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 139_229 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 234_326 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 26_135 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 331_416 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 431_524 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 1 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 530_620 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 2 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 625_718 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 3 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 728_821 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 4 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 139_229 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 234_326 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 26_135 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 331_416 | 786.3333333333334 | 1448.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 431_524 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 1 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 530_620 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 2 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 625_718 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 3 | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 728_821 | 786.3333333333334 | 1448.0 | Domain | Fibronectin type-III 4 | |
| Tgene | DCC | chr18:18586311 | chr18:50912412 | ENST00000442544 | 14 | 29 | 26_1097 | 786.3333333333334 | 1448.0 | Topological domain | Extracellular | |
| Tgene | DCC | chr18:18586312 | chr18:50912413 | ENST00000442544 | 14 | 29 | 26_1097 | 786.3333333333334 | 1448.0 | Topological domain | Extracellular |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
Top |
pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
ROCK1_pLDDT.png  |
DCC_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
Top |
Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ROCK1 | |
| DCC |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ROCK1 | chr18:18586311 | chr18:50912412 | ENST00000399799 | - | 16 | 33 | 368_727 | 628.3333333333334 | 1355.0 | FHOD1 |
| Hgene | ROCK1 | chr18:18586312 | chr18:50912413 | ENST00000399799 | - | 16 | 33 | 368_727 | 628.3333333333334 | 1355.0 | FHOD1 |
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Related Drugs to ROCK1-DCC |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ROCK1-DCC |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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