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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RUNX1T1-ZC2HC1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RUNX1T1-ZC2HC1A
FusionPDB ID: 78692
FusionGDB2.0 ID: 78692
HgeneTgene
Gene symbol

RUNX1T1

ZC2HC1A

Gene ID

862

51101

Gene nameRUNX1 partner transcriptional co-repressor 1zinc finger C2HC-type containing 1A
SynonymsAML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2C8orf70|CGI-62|FAM164A
Cytomap

8q21.3

8q21.13

Type of geneprotein-codingprotein-coding
Descriptionprotein CBFA2T1RUNX1 translocation partner 1acute myelogenous leukemia 1 translocation 1, cyclin-D relatedcore-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-relatedeight twenty one proteinmyeloid translocation gene on 8q2zinc finger C2HC domain-containing protein 1Afamily with sequence similarity 164, member Aprotein FAM164A
Modification date2020031520200313
UniProtAcc

Q06455

Q96GY0

Ensembl transtripts involved in fusion geneENST idsENST00000265814, ENST00000396218, 
ENST00000518844, ENST00000523629, 
ENST00000360348, ENST00000522163, 
ENST00000422361, ENST00000436581, 
ENST00000520724, ENST00000521553, 
ENST00000521176, ENST00000263849, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 31 X 5=18605 X 6 X 4=120
# samples 277
** MAII scorelog2(27/1860*10)=-2.78427130894456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RUNX1T1 [Title/Abstract] AND ZC2HC1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RUNX1T1(93088193)-ZC2HC1A(79590798), # samples:2
RUNX1T1(93115084)-ZC2HC1A(79590797), # samples:2
RUNX1T1(93088192)-ZC2HC1A(79590797), # samples:2
RUNX1T1(93074773)-ZC2HC1A(79590797), # samples:2
RUNX1T1(93107255)-ZC2HC1A(79590797), # samples:2
Anticipated loss of major functional domain due to fusion event.RUNX1T1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1T1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1T1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RUNX1T1-ZC2HC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1T1

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check buttonFusion gene breakpoints across RUNX1T1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZC2HC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GG-01ARUNX1T1chr8

93088193

-ZC2HC1Achr8

79590798

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93074773

-ZC2HC1Achr8

79590797

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93074774

-ZC2HC1Achr8

79590798

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93088192

-ZC2HC1Achr8

79590797

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93088193

-ZC2HC1Achr8

79590798

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93093461

-ZC2HC1Achr8

79590797

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93107255

-ZC2HC1Achr8

79590797

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93107256

-ZC2HC1Achr8

79590798

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93115084

-ZC2HC1Achr8

79590797

+
ChimerDB4ESCATCGA-2H-A9GGRUNX1T1chr8

93115085

-ZC2HC1Achr8

79590798

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000523629RUNX1T1chr893088193-ENST00000263849ZC2HC1Achr879590798+37005435281427299
ENST00000265814RUNX1T1chr893088193-ENST00000263849ZC2HC1Achr879590798+33291721571056299
ENST00000523629RUNX1T1chr893088192-ENST00000263849ZC2HC1Achr879590797+37005435281427299
ENST00000265814RUNX1T1chr893088192-ENST00000263849ZC2HC1Achr879590797+33291721571056299
ENST00000396218RUNX1T1chr893074773-ENST00000263849ZC2HC1Achr879590797+35754184151302295
ENST00000396218RUNX1T1chr893074774-ENST00000263849ZC2HC1Achr879590798+35754184151302295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000523629ENST00000263849RUNX1T1chr893088193-ZC2HC1Achr879590798+0.900578440.09942153
ENST00000265814ENST00000263849RUNX1T1chr893088193-ZC2HC1Achr879590798+0.91607360.08392642
ENST00000523629ENST00000263849RUNX1T1chr893088192-ZC2HC1Achr879590797+0.900578440.09942153
ENST00000265814ENST00000263849RUNX1T1chr893088192-ZC2HC1Achr879590797+0.91607360.08392642
ENST00000396218ENST00000263849RUNX1T1chr893074773-ZC2HC1Achr879590797+0.87408880.1259111
ENST00000396218ENST00000263849RUNX1T1chr893074774-ZC2HC1Achr879590798+0.87408880.1259111

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>78692_78692_1_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93074773_ENST00000396218_ZC2HC1A_chr8_79590797_ENST00000263849_length(amino acids)=295AA_BP=1
MKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYI
QCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSGKVSS
SSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNLPKFC

--------------------------------------------------------------

>78692_78692_2_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93074774_ENST00000396218_ZC2HC1A_chr8_79590798_ENST00000263849_length(amino acids)=295AA_BP=1
MKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYDPDYI
QCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSGKVSS
SSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNLPKFC

--------------------------------------------------------------

>78692_78692_3_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93088192_ENST00000265814_ZC2HC1A_chr8_79590797_ENST00000263849_length(amino acids)=299AA_BP=5
MNIVKKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYD
PDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSG
KVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNL

--------------------------------------------------------------

>78692_78692_4_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93088192_ENST00000523629_ZC2HC1A_chr8_79590797_ENST00000263849_length(amino acids)=299AA_BP=5
MNIVKKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYD
PDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSG
KVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNL

--------------------------------------------------------------

>78692_78692_5_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93088193_ENST00000265814_ZC2HC1A_chr8_79590798_ENST00000263849_length(amino acids)=299AA_BP=5
MNIVKKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYD
PDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSG
KVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNL

--------------------------------------------------------------

>78692_78692_6_RUNX1T1-ZC2HC1A_RUNX1T1_chr8_93088193_ENST00000523629_ZC2HC1A_chr8_79590798_ENST00000263849_length(amino acids)=299AA_BP=5
MNIVKKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYD
PDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSG
KVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:93088193/chr8:79590798)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1T1

Q06455

ZC2HC1A

Q96GY0

FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111102_1080605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111290_2970605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111408_4130605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-11157_600605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111102_1082.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111290_2972.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111408_4132.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-11157_602.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-11057_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111102_1080616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111290_2970616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111408_4130616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-11157_600616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515102_1082.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515290_2972.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515408_4132.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-51557_602.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112102_1080605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112290_2970605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112408_4130605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-11257_600605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111102_1080605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111290_2970605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111408_4130605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-11157_600605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111102_1082.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111290_2972.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111408_4132.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-11157_602.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-11057_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111102_1080616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111290_2970616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111408_4130616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-11157_600616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515102_1082.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515290_2972.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515408_4132.3333333333333335578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-51557_602.3333333333333335578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112102_1080605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112290_2970605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112408_4130605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-11257_600605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111102_10829.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111290_29729.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111408_41329.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-11157_6029.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111102_1080578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111290_2970578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111408_4130578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-11157_600578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-11057_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111102_1080616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111290_2970616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111408_4130616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-11157_600616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415102_1080578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415290_2970578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415408_4130578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-41557_600578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212102_10829.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212290_29729.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212408_41329.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-21257_6029.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111102_10829.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111290_29729.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111408_41329.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-11157_6029.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111102_1080578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111290_2970578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111408_4130578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-11157_600578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-11057_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111102_1080616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111290_2970616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111408_4130616.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-11157_600616.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415102_1080578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415290_2970578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415408_4130578.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-41557_600578.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111102_1080568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111290_2970568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111408_4130568.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-11157_600568.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212102_10829.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212290_29729.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212408_41329.333333333333332605.0Compositional biasNote=Poly-Ser
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-21257_6029.333333333333332605.0Compositional biasNote=Poly-Pro
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111120_2150605.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111120_2152.3333333333333335578.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111120_2150616.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515120_2152.3333333333333335578.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112120_2150605.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111120_2150605.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111120_2152.3333333333333335578.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111120_2150616.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515120_2152.3333333333333335578.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112120_2150605.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111120_21529.333333333333332605.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111120_2150578.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111120_2150616.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415120_2150578.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212120_21529.333333333333332605.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111120_21529.333333333333332605.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111120_2150578.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111120_2150616.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415120_2150578.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111120_2150568.0DomainTAFH
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212120_21529.333333333333332605.0DomainTAFH
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111337_3830605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111443_4920605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111337_3832.3333333333333335578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111443_4922.3333333333333335578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111337_3830616.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111443_4920616.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515337_3832.3333333333333335578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515443_4922.3333333333333335578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112337_3830605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112443_4920605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111337_3830605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111443_4920605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111337_3832.3333333333333335578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111443_4922.3333333333333335578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111337_3830616.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111443_4920616.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515337_3832.3333333333333335578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515443_4922.3333333333333335578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112337_3830605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112443_4920605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111337_38329.333333333333332605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111443_49229.333333333333332605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111337_3830578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111443_4920578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111337_3830616.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111443_4920616.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415337_3830578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415443_4920578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212337_38329.333333333333332605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212443_49229.333333333333332605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111337_38329.333333333333332605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111443_49229.333333333333332605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111337_3830578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111443_4920578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111337_3830616.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111443_4920616.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415337_3830578.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415443_4920578.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111337_3830568.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111443_4920568.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212337_38329.333333333333332605.0RegionNervy homology region 2 (NHR2)
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212443_49229.333333333333332605.0RegionNervy homology region 3 (NHR3)
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000265814-111515_5510605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000360348-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000396218-111515_5512.3333333333333335578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000422361-110515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000436581-111515_5510616.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000518844-515515_5512.3333333333333335578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000520724-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074773chr8:79590797ENST00000523629-112515_5510605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000265814-111515_5510605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000360348-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000396218-111515_5512.3333333333333335578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000422361-110515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000436581-111515_5510616.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000518844-515515_5512.3333333333333335578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000520724-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93074774chr8:79590798ENST00000523629-112515_5510605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000265814-111515_55129.333333333333332605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000360348-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000396218-111515_5510578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000422361-110515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000436581-111515_5510616.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000518844-415515_5510578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000520724-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088192chr8:79590797ENST00000523629-212515_55129.333333333333332605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000265814-111515_55129.333333333333332605.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000360348-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000396218-111515_5510578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000422361-110515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000436581-111515_5510616.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000518844-415515_5510578.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000520724-111515_5510568.0Zinc fingerMYND-type
HgeneRUNX1T1chr8:93088193chr8:79590798ENST00000523629-212515_55129.333333333333332605.0Zinc fingerMYND-type
TgeneZC2HC1Achr8:93074773chr8:79590797ENST000002638491915_3931.0326.0Zinc fingerNote=C2HC-type
TgeneZC2HC1Achr8:93074774chr8:79590798ENST000002638491915_3931.0326.0Zinc fingerNote=C2HC-type
TgeneZC2HC1Achr8:93088192chr8:79590797ENST000002638491915_3931.0326.0Zinc fingerNote=C2HC-type
TgeneZC2HC1Achr8:93088193chr8:79590798ENST000002638491915_3931.0326.0Zinc fingerNote=C2HC-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>537_RUNX1T1_93088193_ZC2HC1A_79590798_ranked_0.pdbRUNX1T19307477493088193ENST00000263849ZC2HC1Achr879590798+
MNIVKKKHGPICQKTATKKRKTFDSSRQRAEGTDIPTVKPLKPRPEPPKKPSNWRRKHEEFIATIRAAKGLDQALKEGGKLPPPPPPSYD
PDYIQCPYCQRRFNENAADRHINFCKEQAARISNKGKFSTDTKGKPTSRTQVYKPPALKKSNSPGTASSGSSRLPQPSGAGKTVVGVPSG
KVSSSSSSLGNKLQTLSPSHKGIAAPHAGANVKPRNSTPPSLARNPAPGVLTNKRKTYTESYIARPDGDCASSLNGGNIKGIEGHSPGNL
299


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RUNX1T1_pLDDT.png
all structure
all structure
ZC2HC1A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RUNX1T1all structure
ZC2HC1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RUNX1T1-ZC2HC1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RUNX1T1-ZC2HC1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1T1C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneRUNX1T1C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneRUNX1T1C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneRUNX1T1C0149925Small cell carcinoma of lung1CTD_human