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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RUNX2-RUNX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RUNX2-RUNX1
FusionPDB ID: 78710
FusionGDB2.0 ID: 78710
HgeneTgene
Gene symbol

RUNX2

RUNX1

Gene ID

860

861

Gene nameRUNX family transcription factor 2RUNX family transcription factor 1
SynonymsAML3|CBF-alpha-1|CBFA1|CCD|CCD1|CLCD|OSF-2|OSF2|PEA2aA|PEBP2aAAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

6p21.1

21q22.12

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 2PEA2-alpha APEBP2-alpha ASL3-3 enhancer factor 1 alpha A subunitSL3/AKV core-binding factor alpha A subunitacute myeloid leukemia 3 proteincore-binding factor, runt domain, alpha subunit 1oncogene AML-3osteoblastrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2020032220200322
UniProtAcc.

Q06455

Ensembl transtripts involved in fusion geneENST idsENST00000352853, ENST00000359524, 
ENST00000371432, ENST00000371436, 
ENST00000371438, ENST00000465038, 
ENST00000541979, ENST00000576263, 
ENST00000483243, 		ENST00000358356, 
ENST00000494829, ENST00000300305, 
ENST00000325074, ENST00000344691, 
ENST00000399240, ENST00000437180, 
ENST00000486278, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 5=32036 X 59 X 13=27612
# samples 963
** MAII scorelog2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(63/27612*10)=-5.45379975055797
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RUNX2 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RUNX2(45390694)-RUNX1(36253010), # samples:2
Anticipated loss of major functional domain due to fusion event.RUNX2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX2-RUNX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX2

GO:0045892

negative regulation of transcription, DNA-templated

11965546

HgeneRUNX2

GO:0045893

positive regulation of transcription, DNA-templated

11965546

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check buttonFusion gene breakpoints across RUNX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RUNX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer235NRUNX2chr6

45390694

+RUNX1chr21

36253010

-
ChimerDB4Non-Cancer2397NRUNX2chr6

45390694

+RUNX1chr21

36253010

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541979RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-605362701718572
ENST00000541979RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-605362701718572
ENST00000541979RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-605362701718572
ENST00000541979RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-605362701718572
ENST00000541979RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-187662701526508
ENST00000541979RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-9246270923307
ENST00000465038RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-605362701718572
ENST00000465038RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-605362701718572
ENST00000465038RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-605362701718572
ENST00000465038RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-605362701718572
ENST00000465038RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-187662701526508
ENST00000465038RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-9246270923307
ENST00000352853RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-605362701718572
ENST00000352853RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-605362701718572
ENST00000352853RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-605362701718572
ENST00000352853RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-605362701718572
ENST00000352853RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-187662701526508
ENST00000352853RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-9246270923307
ENST00000371438RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-6207781431872609
ENST00000371438RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-6207781431872609
ENST00000371438RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-6207781431872609
ENST00000371438RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-6207781431872609
ENST00000371438RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-2030781431680545
ENST00000371438RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-1078781431077345
ENST00000371436RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-584942301514504
ENST00000371436RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-584942301514504
ENST00000371436RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-584942301514504
ENST00000371436RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-584942301514504
ENST00000371436RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-167242301322440
ENST00000371436RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-7204230719239
ENST00000576263RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-584942301514504
ENST00000576263RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-584942301514504
ENST00000576263RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-584942301514504
ENST00000576263RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-584942301514504
ENST00000576263RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-167242301322440
ENST00000576263RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-7204230719239
ENST00000371432RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-62077814001872490
ENST00000371432RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-62077814001872490
ENST00000371432RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-62077814001872490
ENST00000371432RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-62077814001872490
ENST00000371432RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-20307814001680426
ENST00000371432RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-10787814001077226
ENST00000359524RUNX2chr645390694+ENST00000344691RUNX1chr2136253010-5899473921564490
ENST00000359524RUNX2chr645390694+ENST00000325074RUNX1chr2136253010-5899473921564490
ENST00000359524RUNX2chr645390694+ENST00000437180RUNX1chr2136253010-5899473921564490
ENST00000359524RUNX2chr645390694+ENST00000300305RUNX1chr2136253010-5899473921564490
ENST00000359524RUNX2chr645390694+ENST00000399240RUNX1chr2136253010-1722473921372426
ENST00000359524RUNX2chr645390694+ENST00000486278RUNX1chr2136253010-77047392769226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541979ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000541979ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000541979ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000541979ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000541979ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0382975340.9617024
ENST00000541979ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0105441090.9894559
ENST00000465038ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000465038ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000465038ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000465038ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000465038ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0382975340.9617024
ENST00000465038ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0105441090.9894559
ENST00000352853ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000352853ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000352853ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000352853ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0027252220.9972748
ENST00000352853ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0382975340.9617024
ENST00000352853ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0105441090.9894559
ENST00000371438ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0010051740.9989949
ENST00000371438ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0010051740.9989949
ENST00000371438ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0010051740.9989949
ENST00000371438ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0010051740.9989949
ENST00000371438ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0265461190.9734538
ENST00000371438ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0103044680.98969555
ENST00000371436ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000371436ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000371436ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000371436ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000371436ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0355443660.9644556
ENST00000371436ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0044588320.99554116
ENST00000576263ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000576263ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000576263ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000576263ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0012998990.9987
ENST00000576263ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0355443660.9644556
ENST00000576263ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0044588320.99554116
ENST00000371432ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0036772420.99632275
ENST00000371432ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0036772420.99632275
ENST00000371432ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0036772420.99632275
ENST00000371432ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0036772420.99632275
ENST00000371432ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0326539760.967346
ENST00000371432ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0093188310.99068123
ENST00000359524ENST00000344691RUNX2chr645390694+RUNX1chr2136253010-0.0030859420.996914
ENST00000359524ENST00000325074RUNX2chr645390694+RUNX1chr2136253010-0.0030859420.996914
ENST00000359524ENST00000437180RUNX2chr645390694+RUNX1chr2136253010-0.0030859420.996914
ENST00000359524ENST00000300305RUNX2chr645390694+RUNX1chr2136253010-0.0030859420.996914
ENST00000359524ENST00000399240RUNX2chr645390694+RUNX1chr2136253010-0.0244570260.97554296
ENST00000359524ENST00000486278RUNX2chr645390694+RUNX1chr2136253010-0.0035549510.9964451

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>78710_78710_1_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_2_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_3_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_4_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=508AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSD
PRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE

--------------------------------------------------------------

>78710_78710_5_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_6_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000352853_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=307AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT

--------------------------------------------------------------

>78710_78710_7_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_8_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_9_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_10_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=426AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTA
PDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSY

--------------------------------------------------------------

>78710_78710_11_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_12_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000359524_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=226AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG

--------------------------------------------------------------

>78710_78710_13_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_14_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_15_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_16_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=426AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTA
PDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSY

--------------------------------------------------------------

>78710_78710_17_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=490AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------

>78710_78710_18_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371432_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=226AA_BP=0
MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVE
IIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG

--------------------------------------------------------------

>78710_78710_19_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_20_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_21_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_22_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=440AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGM
TTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASS

--------------------------------------------------------------

>78710_78710_23_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_24_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371436_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=239AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA

--------------------------------------------------------------

>78710_78710_25_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=609AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQL
RRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASA

--------------------------------------------------------------

>78710_78710_26_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=609AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQL
RRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASA

--------------------------------------------------------------

>78710_78710_27_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=609AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQL
RRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASA

--------------------------------------------------------------

>78710_78710_28_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=545AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPS
VHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPY
PGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEA

--------------------------------------------------------------

>78710_78710_29_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=609AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQL
RRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASA

--------------------------------------------------------------

>78710_78710_30_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000371438_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=345AA_BP=124
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS

--------------------------------------------------------------

>78710_78710_31_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_32_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_33_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_34_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=508AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSD
PRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE

--------------------------------------------------------------

>78710_78710_35_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_36_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000465038_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=307AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT

--------------------------------------------------------------

>78710_78710_37_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_38_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_39_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_40_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=508AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSD
PRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE

--------------------------------------------------------------

>78710_78710_41_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=572AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT
VFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQ
DTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPT
PVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPN

--------------------------------------------------------------

>78710_78710_42_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000541979_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=307AA_BP=4
MLHSPHKQPQNHKCGANFLQEDSKKSLVFKWLISAGHYQPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPS
TSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAE
LVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTIT

--------------------------------------------------------------

>78710_78710_43_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000300305_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_44_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000325074_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_45_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000344691_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_46_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000399240_length(amino acids)=440AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGM
TTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASS

--------------------------------------------------------------

>78710_78710_47_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000437180_length(amino acids)=504AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA
RFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPT
PNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQF
PALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPP

--------------------------------------------------------------

>78710_78710_48_RUNX2-RUNX1_RUNX2_chr6_45390694_ENST00000576263_RUNX1_chr21_36253010_ENST00000486278_length(amino acids)=239AA_BP=19
MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAV
PRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:45390694/chr21:36253010)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RUNX1

Q06455

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+1749_71127.0508.0Compositional biasNote=Poly-Gln
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+1773_89127.0508.0Compositional biasNote=Poly-Ala
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+2749_71141.0500.0Compositional biasNote=Poly-Gln
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+2773_89141.0500.0Compositional biasNote=Poly-Ala
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+2849_71141.0522.0Compositional biasNote=Poly-Gln
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+2873_89141.0522.0Compositional biasNote=Poly-Ala
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+3949_71141.0522.0Compositional biasNote=Poly-Gln
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+3973_89141.0522.0Compositional biasNote=Poly-Ala
TgeneRUNX1chr6:45390694chr21:36253010ENST0000030030528187_453117.0481.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr6:45390694chr21:36253010ENST0000032507417187_453105.0469.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr6:45390694chr21:36253010ENST0000034469106187_45390.0454.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr6:45390694chr21:36253010ENST0000035835605187_45390.0251.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr6:45390694chr21:36253010ENST0000043718039187_453117.0481.0Compositional biasNote=Pro/Ser/Thr-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+17237_521127.0508.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+27237_521141.0500.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+28237_521141.0522.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+39237_521141.0522.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+17101_229127.0508.0DomainRunt
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+27101_229141.0500.0DomainRunt
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+28101_229141.0522.0DomainRunt
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+39101_229141.0522.0DomainRunt
TgeneRUNX1chr6:45390694chr21:36253010ENST000003003052850_178117.0481.0DomainRunt
TgeneRUNX1chr6:45390694chr21:36253010ENST000003250741750_178105.0469.0DomainRunt
TgeneRUNX1chr6:45390694chr21:36253010ENST000003446910650_17890.0454.0DomainRunt
TgeneRUNX1chr6:45390694chr21:36253010ENST000003583560550_17890.0251.0DomainRunt
TgeneRUNX1chr6:45390694chr21:36253010ENST000004371803950_178117.0481.0DomainRunt


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1286_RUNX2_45390694_RUNX1_36253010_1286_RUNX2_45390694_RUNX1_36253010_ranked_0.pdbRUNX24539069445390694ENST00000486278RUNX1chr2136253010-
MVNLRRSLPATETNRVSECSLTTVYAVIVGPSNICSFSFCFVSLLFTCYQLHNFLTEKNKYKVYVLQAYCKTKTRFGYGLYFQFKAASSI
YNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAA
AAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTLVTVMAGNDENYS
AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQL
RRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASA
609


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RUNX2_pLDDT.png
all structure
all structure
RUNX1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, tat, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, Vdr, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, Cep72, CDK6, vif, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2, Cbfb, CTNNB1, WWP1, RNF38, RNF44, DTX2, TRIM5, UHRF2, DZIP3, NEDD4, NKX2-1, HIF1A, ACTB, ARID1A, ARID3A, ASH2L, ACTL6A, BRD9, C2orf44, CCNK, CDC16, CDKN2AIP, CLTC, NELFB, CPSF3, CPSF6, CSTF2, CSTF2T, CTPS1, DDX1, DDX17, DDX21, DDX3X, DDX41, DDX5, DHX15, DHX36, DHX9, DPF2, EEF1A1, EEF1A2, EWSR1, EZR, FAF1, FERMT3, FIP1L1, FUBP1, FUS, GATAD2A, GATAD2B, GMPS, HIC2, HNRNPH1, HNRNPM, HNRNPR, HNRNPU, HSPA1A, HSPA2, HSPA5, HSPA8, HSPA9, IGF2BP1, INTS10, INTS9, KHSRP, KIF2B, LARP7, LCP1, LMNA, LMNB1, LRRC40, LRWD1, MED1, MED12, MED16, MED17, MED26, MEN1, MLLT1, MTA2, NDC80, NOP56, NONO, NUP85, ORC2, PABPC1, PABPC4, PAXIP1, PRMT5, PSIP1, PSPC1, RAD18, RANGAP1, RARS, RBBP5, RBM39, RPA1, RPAP2, SF1, SF3B2, SF3B3, SFPQ, SMARCC2, SMARCD1, SNRNP70, SNRPD1, SNX9, U2SURP, SRP68, SYNCRIP, TAF15, TFRC, TKT, TRAP1, TRIM25, TUBA1B, TUBB2A, UBP1, USP39, WDR76, XRCC6, XRN2, ZNF326, DMBT1, DNAJA3, DNAJB11, DPYSL2, DYNLL1, EIF3A, EIF3G, EIF4A2, EMG1, DCPS, IKZF3, IKZF1, MAD2L2, KIAA1429, Hipk2, HIST1H4A, ORF3b, MAPK1, TEAD2, SNRPC, BAG3, TEKT5, BAG4, NFKBID, VPS37C, FAM222B, OLIG3, GCC1, HGS, TEAD4, FBXO17, CIC, GSK3A, ATG7, FBXW12, RUNX2, FOXF2, NAAA, GPR55, BTF3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RUNX2
RUNX1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+17336_439127.0508.0KAT6A
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+27336_439141.0500.0KAT6A
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+28336_439141.0522.0KAT6A
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+39336_439141.0522.0KAT6A
HgeneRUNX2chr6:45390694chr21:36253010ENST00000359524+17374_468127.0508.0KAT6B
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371436+27374_468141.0500.0KAT6B
HgeneRUNX2chr6:45390694chr21:36253010ENST00000371438+28374_468141.0522.0KAT6B
HgeneRUNX2chr6:45390694chr21:36253010ENST00000465038+39374_468141.0522.0KAT6B
TgeneRUNX1chr6:45390694chr21:36253010ENST000003003052880_84117.0481.0DNA
TgeneRUNX1chr6:45390694chr21:36253010ENST000003250741780_84105.0469.0DNA
TgeneRUNX1chr6:45390694chr21:36253010ENST000003446910680_8490.0454.0DNA
TgeneRUNX1chr6:45390694chr21:36253010ENST000003583560580_8490.0251.0DNA
TgeneRUNX1chr6:45390694chr21:36253010ENST000004371803980_84117.0481.0DNA


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Related Drugs to RUNX2-RUNX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RUNX2-RUNX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy11CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute4CGI;CTD_human;GENOMICS_ENGLAND
TgeneRUNX1C0026998Acute Myeloid Leukemia, M13CTD_human
TgeneRUNX1C1879321Acute Myeloid Leukemia (AML-M2)3CTD_human
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0006413Burkitt Lymphoma1ORPHANET
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneRUNX1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneRUNX1C0023473Myeloid Leukemia, Chronic1ORPHANET
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0040034Thrombocytopenia1GENOMICS_ENGLAND
TgeneRUNX1C0334588Giant Cell Glioblastoma1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C0376358Malignant neoplasm of prostate1CTD_human
TgeneRUNX1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneRUNX1C1621958Glioblastoma Multiforme1CTD_human
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneRUNX1C2713368Hematopoetic Myelodysplasia1CTD_human
TgeneRUNX1C3463824MYELODYSPLASTIC SYNDROME1CTD_human