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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SF1-CST6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SF1-CST6
FusionPDB ID: 81007
FusionGDB2.0 ID: 81007
HgeneTgene
Gene symbol

SF1

CST6

Gene ID

7536

1476

Gene namesplicing factor 1cystatin B
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162CPI-B|CST6|EPM1|EPM1A|PME|STFB|ULD
Cytomap

11q13.1

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162cystatin-Bcystatin B (stefin B)epididymis secretory sperm binding proteinliver thiol proteinase inhibitor
Modification date2020031820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000422298, ENST00000227503, 
ENST00000334944, ENST00000377387, 
ENST00000377390, ENST00000377394, 
ENST00000433274, ENST00000489544, 
ENST00000312134, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 11 X 13=30032 X 2 X 1=4
# samples 263
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/4*10)=2.90689059560852
Context (manual curation of fusion genes in FusionPDB)

PubMed: SF1 [Title/Abstract] AND CST6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SF1(64545834)-CST6(65779657), # samples:3
Anticipated loss of major functional domain due to fusion event.SF1-CST6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-CST6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-CST6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-CST6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCST6

GO:0010466

negative regulation of peptidase activity

6203523

TgeneCST6

GO:0045861

negative regulation of proteolysis

3488317


check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CST6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1489-01ASF1chr11

64545834

-CST6chr11

65779657

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545458

-CST6chr11

65779656

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545833

-CST6chr11

65779656

+
ChimerDB4OVTCGA-13-1489-02ASF1chr11

64545834

-CST6chr11

65779657

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377390SF1chr1164545834-ENST00000312134CST6chr1165779657+78236964659195
ENST00000377394SF1chr1164545834-ENST00000312134CST6chr1165779657+79938666376195
ENST00000227503SF1chr1164545834-ENST00000312134CST6chr1165779657+79938666376195
ENST00000334944SF1chr1164545834-ENST00000312134CST6chr1165779657+838425702115195
ENST00000377387SF1chr1164545458-ENST00000312134CST6chr1165779656+8974837610254
ENST00000377390SF1chr1164545833-ENST00000312134CST6chr1165779656+7833696470216
ENST00000377394SF1chr1164545833-ENST00000312134CST6chr1165779656+8003866642221
ENST00000227503SF1chr1164545833-ENST00000312134CST6chr1165779656+8003866642221
ENST00000334944SF1chr1164545833-ENST00000312134CST6chr1165779656+83942570311230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377390ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0145291810.9854708
ENST00000377394ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0227122270.97728777
ENST00000227503ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0227122270.97728777
ENST00000334944ENST00000312134SF1chr1164545834-CST6chr1165779657+0.0225714780.9774285
ENST00000377387ENST00000312134SF1chr1164545458-CST6chr1165779656+0.0441414970.9558585
ENST00000377390ENST00000312134SF1chr1164545833-CST6chr1165779656+0.0335589160.9664411
ENST00000377394ENST00000312134SF1chr1164545833-CST6chr1165779656+0.37364060.6263594
ENST00000227503ENST00000312134SF1chr1164545833-CST6chr1165779656+0.37364060.6263594
ENST00000334944ENST00000312134SF1chr1164545833-CST6chr1165779656+0.381785750.6182142

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81007_81007_1_SF1-CST6_SF1_chr11_64545458_ENST00000377387_CST6_chr11_65779656_ENST00000312134_length(amino acids)=254AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHLLRRRPGPAAGPYAAAGVAAAAAATRAGRAAAEGAAAAAGTRRRGTVAVEAAAAAGEAEGAAAEAAEAAPRRGRPRSGPPSSPRAGA

--------------------------------------------------------------

>81007_81007_2_SF1-CST6_SF1_chr11_64545833_ENST00000227503_CST6_chr11_65779656_ENST00000312134_length(amino acids)=221AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------

>81007_81007_3_SF1-CST6_SF1_chr11_64545833_ENST00000334944_CST6_chr11_65779656_ENST00000312134_length(amino acids)=230AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------

>81007_81007_4_SF1-CST6_SF1_chr11_64545833_ENST00000377390_CST6_chr11_65779656_ENST00000312134_length(amino acids)=216AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------

>81007_81007_5_SF1-CST6_SF1_chr11_64545833_ENST00000377394_CST6_chr11_65779656_ENST00000312134_length(amino acids)=221AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHPTAWRSLRSPWRPRGQAPAPAFPLRRLLLRKPPGGRGPECAAGARGARPLTRRAAAARDAQRGRREGTAGAGRGRRGRGLDWAGPRR

--------------------------------------------------------------

>81007_81007_6_SF1-CST6_SF1_chr11_64545834_ENST00000227503_CST6_chr11_65779657_ENST00000312134_length(amino acids)=195AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------

>81007_81007_7_SF1-CST6_SF1_chr11_64545834_ENST00000334944_CST6_chr11_65779657_ENST00000312134_length(amino acids)=195AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------

>81007_81007_8_SF1-CST6_SF1_chr11_64545834_ENST00000377390_CST6_chr11_65779657_ENST00000312134_length(amino acids)=195AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------

>81007_81007_9_SF1-CST6_SF1_chr11_64545834_ENST00000377394_CST6_chr11_65779657_ENST00000312134_length(amino acids)=195AA_BP=1
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64545834/chr11:65779657)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-11315_19135.33333333333334674.0MotifNuclear localization signal
TgeneCST6chr11:64545458chr11:65779656ENST000003121340380_840150.0MotifNote=Secondary area of contact
TgeneCST6chr11:64545833chr11:65779656ENST000003121340380_840150.0MotifNote=Secondary area of contact
TgeneCST6chr11:64545834chr11:65779657ENST000003121340380_840150.0MotifNote=Secondary area of contact

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113324_6370549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114324_6370639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113324_637135.33333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113324_6370640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113324_6370572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113324_63710.333333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114324_63710.333333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113324_6370674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113324_63710.333333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113324_63710.333333333333334572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113324_63710.333333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114324_63710.333333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113324_6370674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113324_63710.333333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113324_63710.333333333333334572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113324_6370614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113141_2220549.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114141_2220639.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113141_222135.33333333333334674.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113141_2220640.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113141_2220572.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113141_22210.333333333333334549.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114141_22210.333333333333334639.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113141_2220674.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113141_22210.333333333333334640.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113141_22210.333333333333334572.0DomainKH
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113141_22210.333333333333334549.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114141_22210.333333333333334639.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113141_2220674.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113141_22210.333333333333334640.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113141_22210.333333333333334572.0DomainKH
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113141_2220614.0DomainKH
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-11315_190549.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-11415_190639.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-11315_190640.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-11315_190572.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-11315_1910.333333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-11415_1910.333333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-11315_190674.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-11315_1910.333333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-11315_1910.333333333333334572.0MotifNuclear localization signal
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-11315_1910.333333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-11415_1910.333333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-11315_190674.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-11315_1910.333333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-11315_1910.333333333333334572.0MotifNuclear localization signal
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-11315_190614.0MotifNuclear localization signal
HgeneSF1chr11:64545458chr11:65779656ENST00000227503-113277_2960549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000334944-114277_2960639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377387-113277_296135.33333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377390-113277_2960640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000377394-113277_2960572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545458chr11:65779656ENST00000433274-113277_2960614.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000227503-113277_29610.333333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000334944-114277_29610.333333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377387-113277_2960674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377390-113277_29610.333333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000377394-113277_29610.333333333333334572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545833chr11:65779656ENST00000433274-113277_2960614.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000227503-113277_29610.333333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000334944-114277_29610.333333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377387-113277_2960674.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377390-113277_29610.333333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000377394-113277_29610.333333333333334572.0Zinc fingerCCHC-type
HgeneSF1chr11:64545834chr11:65779657ENST00000433274-113277_2960614.0Zinc fingerCCHC-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>249_SF1_64545834_CST6_65779657_ranked_0.pdbSF16454583364545834ENST00000312134CST6chr1165779657+
MRGVLPGNHKDLKVTAQLLLLRPCCQGASGEVDVVSSDPGLAAVCAPHLHRQEVLDAGHQLALRLDDVRVSEVVDAVAAHVVAGHGRLRR
LLHQRRGVRSGRHGAPGDRHRHLLFLCGGFSFASLPGGGDPNALPERAEPVLSRGGRRRRETHKEGGERAPRGRAGGGGAGAWIGPGRGE
195


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SF1_pLDDT.png
all structure
all structure
CST6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SF1
CST6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SF1-CST6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SF1-CST6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource