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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SLC27A1-KIAA0391

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC27A1-KIAA0391
	FusionPDB ID: 82767
	FusionGDB2.0 ID: 82767
		Hgene	Tgene
	Gene symbol	SLC27A1	KIAA0391
	Gene ID	376497	9692
	Gene name	solute carrier family 27 member 1	protein only RNase P catalytic subunit
	Synonyms	ACSVL5\|FATP\|FATP-1\|FATP1	KIAA0391\|MRPP3
	Cytomap	19p13.11	14q13.2
	Type of gene	protein-coding	protein-coding
	Description	long-chain fatty acid transport protein 1fatty acid transport protein 1solute carrier family 27 (fatty acid transporter), member 1	mitochondrial ribonuclease P catalytic subunitmitochondrial RNase P protein 3mitochondrial RNase P subunit 3mitochondrial ribonuclease P protein 3proteinaceous RNase P
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000252595, ENST00000442725, ENST00000598424, ENST00000598848,	ENST00000603588, ENST00000250377, ENST00000321130, ENST00000534898, ENST00000557565, ENST00000603544, ENST00000604948, ENST00000605870,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 3 X 4=60	10 X 6 X 7=420
	# samples	5	14
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/420*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SLC27A1 [Title/Abstract] AND KIAA0391 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC27A1(17599926)-KIAA0391(35735933), # samples:4
Anticipated loss of major functional domain due to fusion event.	SLC27A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC27A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC27A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC27A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KIAA0391	GO:0097745	mitochondrial tRNA 5'-end processing	25953853

Fusion gene breakpoints across SLC27A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIAA0391 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NF-A4WX-01A	SLC27A1	chr19	17599926	-	KIAA0391	chr14	35735933	+
ChimerDB4	UCS	TCGA-NF-A4WX-01A	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+
ChimerDB4	UCS	TCGA-NF-A4WX	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000604948	KIAA0391	chr14	35735933	+	1840	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000557565	KIAA0391	chr14	35735933	+	3440	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000250377	KIAA0391	chr14	35735933	+	2212	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000321130	KIAA0391	chr14	35735933	+	2110	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000534898	KIAA0391	chr14	35735933	+	2215	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000603544	KIAA0391	chr14	35735933	+	1820	1239	186	1715	509
ENST00000442725	SLC27A1	chr19	17599926	+	ENST00000605870	KIAA0391	chr14	35735933	+	2167	1239	186	1715	509
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000604948	KIAA0391	chr14	35735933	+	1694	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000557565	KIAA0391	chr14	35735933	+	3294	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000250377	KIAA0391	chr14	35735933	+	2066	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000321130	KIAA0391	chr14	35735933	+	1964	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000534898	KIAA0391	chr14	35735933	+	2069	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000603544	KIAA0391	chr14	35735933	+	1674	1093	97	1569	490
ENST00000252595	SLC27A1	chr19	17599926	+	ENST00000605870	KIAA0391	chr14	35735933	+	2021	1093	97	1569	490
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000604948	KIAA0391	chr14	35735933	+	1963	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000557565	KIAA0391	chr14	35735933	+	3563	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000250377	KIAA0391	chr14	35735933	+	2335	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000321130	KIAA0391	chr14	35735933	+	2233	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000534898	KIAA0391	chr14	35735933	+	2338	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000603544	KIAA0391	chr14	35735933	+	1943	1362	858	1838	326
ENST00000598424	SLC27A1	chr19	17599926	+	ENST00000605870	KIAA0391	chr14	35735933	+	2290	1362	858	1838	326

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000442725	ENST00000604948	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.044263095	0.95573694
ENST00000442725	ENST00000557565	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.01808876	0.98191124
ENST00000442725	ENST00000250377	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.0322559	0.9677441
ENST00000442725	ENST00000321130	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.036140706	0.96385926
ENST00000442725	ENST00000534898	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.03236229	0.9676377
ENST00000442725	ENST00000603544	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.044504575	0.9554955
ENST00000442725	ENST00000605870	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.034416184	0.9655838
ENST00000252595	ENST00000604948	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.03534151	0.96465856
ENST00000252595	ENST00000557565	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.014856383	0.9851436
ENST00000252595	ENST00000250377	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.027886635	0.9721133
ENST00000252595	ENST00000321130	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.02877032	0.9712297
ENST00000252595	ENST00000534898	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.027867544	0.9721325
ENST00000252595	ENST00000603544	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.036783874	0.9632161
ENST00000252595	ENST00000605870	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.02967364	0.97032636
ENST00000598424	ENST00000604948	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.01490353	0.9850965
ENST00000598424	ENST00000557565	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.005098831	0.9949012
ENST00000598424	ENST00000250377	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.010703119	0.98929685
ENST00000598424	ENST00000321130	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.012546399	0.9874536
ENST00000598424	ENST00000534898	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.01074311	0.9892569
ENST00000598424	ENST00000603544	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.01500106	0.984999
ENST00000598424	ENST00000605870	SLC27A1	chr19	17599926	+	KIAA0391	chr14	35735933	+	0.011838632	0.98816144

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82767_82767_1_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000250377_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_2_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000321130_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_3_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000534898_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_4_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000557565_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_5_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000603544_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_6_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000604948_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_7_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000252595_KIAA0391_chr14_35735933_ENST00000605870_length(amino acids)=490AA_BP=332
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQP
ERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALI
FGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMA
AFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRNLRLLVLGRKHMLRRSS
QWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRIL

--------------------------------------------------------------

>82767_82767_8_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000250377_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_9_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000321130_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_10_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000534898_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_11_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000557565_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_12_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000603544_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_13_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000604948_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_14_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000442725_KIAA0391_chr14_35735933_ENST00000605870_length(amino acids)=509AA_BP=351
MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH
QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN
LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG
TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA
KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH

--------------------------------------------------------------

>82767_82767_15_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000250377_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_16_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000321130_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_17_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000534898_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_18_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000557565_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_19_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000603544_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_20_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000604948_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

>82767_82767_21_SLC27A1-KIAA0391_SLC27A1_chr19_17599926_ENST00000598424_KIAA0391_chr14_35735933_ENST00000605870_length(amino acids)=326AA_BP=168
MVHPRPREGACPAVTMTHVLGTTAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTG
LPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLAKRN
LRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17599926/chr14:35735933)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000252595

246_257

332.0

647.0

Nucleotide binding

AMP

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000442725

246_257

332.0

647.0

Nucleotide binding

AMP

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000252595

1_13

332.0

647.0

Topological domain

Extracellular

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000442725

1_13

332.0

647.0

Topological domain

Extracellular

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000252595

14_34

332.0

647.0

Transmembrane

Helical

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000442725

14_34

332.0

647.0

Transmembrane

Helical

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000250377

342_578

330.0

489.0

Domain

Note=PRORP

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000604948

342_578

330.0

489.0

Domain

Note=PRORP

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000605870

342_578

53.0

212.0

Domain

Note=PRORP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000252595

191_475

332.0

647.0

Region

Sufficient for oligomerization

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000442725

191_475

332.0

647.0

Region

Sufficient for oligomerization

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000252595

35_646

332.0

647.0

Topological domain

Cytoplasmic

Hgene

SLC27A1

chr19:17599926

chr14:35735933

ENST00000442725

35_646

332.0

647.0

Topological domain

Cytoplasmic

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000321130

342_578

409.0

568.0

Domain

Note=PRORP

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000534898

342_578

425.0

584.0

Domain

Note=PRORP

Tgene

KIAA0391

chr19:17599926

chr14:35735933

ENST00000603544

342_578

409.0

568.0

Domain

Note=PRORP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1084_SLC27A1_17599926_KIAA0391_35735933_1084_SLC27A1_17599926_KIAA0391_35735933_ranked_0.pdb	SLC27A1	17599926	17599926	ENST00000605870	KIAA0391	chr14	35735933	+	MPASCLSFWETEGTACSFRMRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH QRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVN LRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSG TTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTLLNVVSQLA KRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGH	509

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SLC27A1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SLC27A1
KIAA0391

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to SLC27A1-KIAA0391

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SLC27A1-KIAA0391

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source