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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC45A2-CCDC125

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC45A2-CCDC125
FusionPDB ID: 83321
FusionGDB2.0 ID: 83321
HgeneTgene
Gene symbol

SLC45A2

CCDC125

Gene ID

51151

202243

Gene namesolute carrier family 45 member 2coiled-coil domain containing 125
Synonyms1A1|AIM1|MATP|OCA4|SHEP5KENAE
Cytomap

5p13.2

5q13.2

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated transporter proteinmelanoma antigen AIM1protein AIM-1underwhitecoiled-coil domain-containing protein 125Kenae
Modification date2020031320200313
UniProtAcc

Q9UMX9

Q86Z20

Ensembl transtripts involved in fusion geneENST idsENST00000296589, ENST00000345083, 
ENST00000382102, ENST00000509381, 
ENST00000342059, 		ENST00000383374, 
ENST00000460090, ENST00000511257, 
ENST00000396496, ENST00000396499, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 1 X 3=92 X 2 X 2=8
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC45A2 [Title/Abstract] AND CCDC125 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC45A2(33982341)-CCDC125(68581294), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCDC125

GO:0035024

negative regulation of Rho protein signal transduction

19787194

TgeneCCDC125

GO:0090630

activation of GTPase activity

19787194

TgeneCCDC125

GO:2000146

negative regulation of cell motility

19787194


check buttonFusion gene breakpoints across SLC45A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC125 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9L4-01ASLC45A2chr5

33982341

-CCDC125chr5

68581294

-
ChimerDB4PRADTCGA-ZG-A9L4SLC45A2chr5

33982341

-CCDC125chr5

68581294

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296589SLC45A2chr533982341-ENST00000396496CCDC125chr568581294-3700709481145365
ENST00000296589SLC45A2chr533982341-ENST00000396499CCDC125chr568581294-3180709481145365
ENST00000382102SLC45A2chr533982341-ENST00000396496CCDC125chr568581294-3611620581056332
ENST00000382102SLC45A2chr533982341-ENST00000396499CCDC125chr568581294-3091620581056332
ENST00000509381SLC45A2chr533982341-ENST00000396496CCDC125chr568581294-3614623611059332
ENST00000509381SLC45A2chr533982341-ENST00000396499CCDC125chr568581294-3094623611059332
ENST00000345083SLC45A2chr533982341-ENST00000396496CCDC125chr568581294-3645654921090332
ENST00000345083SLC45A2chr533982341-ENST00000396499CCDC125chr568581294-3125654921090332

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296589ENST00000396496SLC45A2chr533982341-CCDC125chr568581294-0.0010857750.99891424
ENST00000296589ENST00000396499SLC45A2chr533982341-CCDC125chr568581294-0.0014479380.998552
ENST00000382102ENST00000396496SLC45A2chr533982341-CCDC125chr568581294-0.0009878220.9990121
ENST00000382102ENST00000396499SLC45A2chr533982341-CCDC125chr568581294-0.0013016370.99869835
ENST00000509381ENST00000396496SLC45A2chr533982341-CCDC125chr568581294-0.0009859970.999014
ENST00000509381ENST00000396499SLC45A2chr533982341-CCDC125chr568581294-0.0012887170.99871135
ENST00000345083ENST00000396496SLC45A2chr533982341-CCDC125chr568581294-0.0010344180.9989656
ENST00000345083ENST00000396499SLC45A2chr533982341-CCDC125chr568581294-0.0013576790.99864227

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83321_83321_1_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000296589_CCDC125_chr5_68581294_ENST00000396496_length(amino acids)=365AA_BP=220
MLGQAPRQIQFETQTLGPRRRWWARRKVPLPVAMGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMI
GVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEE
ALAHQRKVSYMLARALEDKDTASNENKEKNPIKENFPFNNPWRKTSEFSVLGDPIHSSVCILNSVGCICSIQHSQIDPNYRTLKRSHSLP

--------------------------------------------------------------

>83321_83321_2_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000296589_CCDC125_chr5_68581294_ENST00000396499_length(amino acids)=365AA_BP=220
MLGQAPRQIQFETQTLGPRRRWWARRKVPLPVAMGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMI
GVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEE
ALAHQRKVSYMLARALEDKDTASNENKEKNPIKENFPFNNPWRKTSEFSVLGDPIHSSVCILNSVGCICSIQHSQIDPNYRTLKRSHSLP

--------------------------------------------------------------

>83321_83321_3_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000345083_CCDC125_chr5_68581294_ENST00000396496_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

>83321_83321_4_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000345083_CCDC125_chr5_68581294_ENST00000396499_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

>83321_83321_5_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000382102_CCDC125_chr5_68581294_ENST00000396496_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

>83321_83321_6_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000382102_CCDC125_chr5_68581294_ENST00000396499_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

>83321_83321_7_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000509381_CCDC125_chr5_68581294_ENST00000396496_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

>83321_83321_8_SLC45A2-CCDC125_SLC45A2_chr5_33982341_ENST00000509381_CCDC125_chr5_68581294_ENST00000396499_length(amino acids)=332AA_BP=187
MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGS
ASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
HYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEEALAHQRKVSYMLARALEDKDTASNENKEKNPIK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33982341/chr5:68581294)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC45A2

Q9UMX9

CCDC125

Q86Z20

FUNCTION: Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). {ECO:0000250}.FUNCTION: May be involved in the regulation of cell migration. {ECO:0000269|PubMed:19787194}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27132_138187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27160_184187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-271_46187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-2768_68187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-2790_110187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26132_138187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26160_184187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-261_46187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-2668_68187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-2690_110187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27111_131187.33333333333334531.0TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27139_159187.33333333333334531.0TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-2747_67187.33333333333334531.0TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-2769_89187.33333333333334531.0TransmembraneHelical%3B Name%3D2
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26111_131187.33333333333334461.0TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26139_159187.33333333333334461.0TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-2647_67187.33333333333334461.0TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-2669_89187.33333333333334461.0TransmembraneHelical%3B Name%3D2
TgeneCCDC125chr5:33982341chr5:68581294ENST000005112571013293_325241.33333333333334387.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27206_216187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27238_318187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27340_366187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27388_398187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27420_425187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27447_477187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27499_504187.33333333333334531.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27526_530187.33333333333334531.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16132_1380472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16160_1840472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-161_460472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16206_2160472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16238_3180472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16340_3660472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16388_3980472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16420_4250472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16447_4770472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16499_5040472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16526_5300472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-1668_680472.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-1690_1100472.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26206_216187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26238_318187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26340_366187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26388_398187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26420_425187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26447_477187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26499_504187.33333333333334461.0Topological domainExtracellular
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26526_530187.33333333333334461.0Topological domainCytoplasmic
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27185_205187.33333333333334531.0TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27217_237187.33333333333334531.0TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27319_339187.33333333333334531.0TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27367_387187.33333333333334531.0TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27399_419187.33333333333334531.0TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27426_446187.33333333333334531.0TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27478_498187.33333333333334531.0TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000296589-27505_525187.33333333333334531.0TransmembraneHelical%3B Name%3D12
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16111_1310472.0TransmembraneHelical%3B Name%3D3
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16139_1590472.0TransmembraneHelical%3B Name%3D4
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16185_2050472.0TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16217_2370472.0TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16319_3390472.0TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16367_3870472.0TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16399_4190472.0TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16426_4460472.0TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16478_4980472.0TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-1647_670472.0TransmembraneHelical%3B Name%3D1
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-16505_5250472.0TransmembraneHelical%3B Name%3D12
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000342059-1669_890472.0TransmembraneHelical%3B Name%3D2
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26185_205187.33333333333334461.0TransmembraneHelical%3B Name%3D5
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26217_237187.33333333333334461.0TransmembraneHelical%3B Name%3D6
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26319_339187.33333333333334461.0TransmembraneHelical%3B Name%3D7
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26367_387187.33333333333334461.0TransmembraneHelical%3B Name%3D8
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26399_419187.33333333333334461.0TransmembraneHelical%3B Name%3D9
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26426_446187.33333333333334461.0TransmembraneHelical%3B Name%3D10
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26478_498187.33333333333334461.0TransmembraneHelical%3B Name%3D11
HgeneSLC45A2chr5:33982341chr5:68581294ENST00000382102-26505_525187.33333333333334461.0TransmembraneHelical%3B Name%3D12
TgeneCCDC125chr5:33982341chr5:68581294ENST00000396496912105_243366.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC125chr5:33982341chr5:68581294ENST00000396496912293_325366.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC125chr5:33982341chr5:68581294ENST00000396499811105_243366.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC125chr5:33982341chr5:68581294ENST00000396499811293_325366.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC125chr5:33982341chr5:68581294ENST000005112571013105_243241.33333333333334387.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>723_SLC45A2_33982341_CCDC125_68581294_ranked_0.pdbSLC45A23398234133982341ENST00000396499CCDC125chr568581294-
MLGQAPRQIQFETQTLGPRRRWWARRKVPLPVAMGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMI
GVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFPSPRSKKTFGQRLLGMLPSENSSKRMEDQDSPQEVLKMLIDLLNDKEE
ALAHQRKVSYMLARALEDKDTASNENKEKNPIKENFPFNNPWRKTSEFSVLGDPIHSSVCILNSVGCICSIQHSQIDPNYRTLKRSHSLP
365


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC45A2_pLDDT.png
all structure
all structure
CCDC125_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC45A2
CCDC125


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC45A2-CCDC125


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC45A2-CCDC125


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource