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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SPTBN1-SPAG5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SPTBN1-SPAG5
FusionPDB ID: 86140
FusionGDB2.0 ID: 86140
HgeneTgene
Gene symbol

SPTBN1

SPAG5

Gene ID

6711

10615

Gene namespectrin beta, non-erythrocytic 1sperm associated antigen 5
SynonymsELF|HEL102|SPTB2|betaSpIIDEEPEST|MAP126|hMAP126
Cytomap

2p16.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionspectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein
Modification date2020032920200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000333896, ENST00000356805, 
ENST00000321765, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 20 X 9=43205 X 7 X 5=175
# samples 268
** MAII scorelog2(26/4320*10)=-4.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SPTBN1 [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SPTBN1(54826380)-SPAG5(26920084), # samples:4
Anticipated loss of major functional domain due to fusion event.SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPTBN1-SPAG5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SPTBN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPAG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01ASPTBN1chr2

54826380

-SPAG5chr17

26920084

-
ChimerDB4STADTCGA-VQ-A922-01ASPTBN1chr2

54826380

+SPAG5chr17

26920084

-
ChimerDB4STADTCGA-VQ-A922SPTBN1chr2

54826380

+SPAG5chr17

26920084

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356805SPTBN1chr254826380+ENST00000321765SPAG5chr1726920084-411158126639851239
ENST00000333896SPTBN1chr254826380+ENST00000321765SPAG5chr1726920084-417664631340501245

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356805ENST00000321765SPTBN1chr254826380+SPAG5chr1726920084-0.0051630660.9948369
ENST00000333896ENST00000321765SPTBN1chr254826380+SPAG5chr1726920084-0.0052952660.9947048

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86140_86140_1_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000333896_SPAG5_chr17_26920084_ENST00000321765_length(amino acids)=1245AA_BP=111
MDGSGRGLERDFQGAVLRGVTPGIMELQRTSSISGPLSPAYTGQVPYNYNQLEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLY
TDLRDGRMLIKLLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVK
TIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSK
ESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCL
TPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKST
NTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLK
ESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK
DAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK
LTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLC
QLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENL
TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTP
VPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE
KLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQE

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>86140_86140_2_SPTBN1-SPAG5_SPTBN1_chr2_54826380_ENST00000356805_SPAG5_chr17_26920084_ENST00000321765_length(amino acids)=1239AA_BP=105
MRQFKMTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDG
RMLIKLLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVP
SPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSR
TEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVE
MESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTG
LVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMG
QALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIV
LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQ
QALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSN
EEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAS
TIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGS
DKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQAL
CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:54826380/chr17:26920084)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124545_60859.01194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124759_86859.01194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124979_117459.01194.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG5chr2:54826380chr17:26920084ENST00000321765124617_78959.01194.0Compositional biasNote=Gln-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231173_27887.02156.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312197_230787.02156.0DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+23154_15887.02156.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336173_278100.02365.0DomainCalponin-homology (CH) 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362197_2307100.02365.0DomainPH
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+33654_158100.02365.0DomainCalponin-homology (CH) 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312_27587.02156.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362_275100.02365.0RegionNote=Actin-binding
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311063_116687.02156.0RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311170_125887.02156.0RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311276_137687.02156.0RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311381_148287.02156.0RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311486_159087.02156.0RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311592_169687.02156.0RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311698_180187.02156.0RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311805_190787.02156.0RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311914_201487.02156.0RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2312018_209787.02156.0RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231303_41187.02156.0RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231423_52587.02156.0RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231530_63687.02156.0RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231639_74287.02156.0RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231745_84787.02156.0RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231850_95287.02156.0RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+231957_106087.02156.0RepeatSpectrin 7
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361063_1166100.02365.0RepeatSpectrin 8
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361170_1258100.02365.0RepeatSpectrin 9
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361276_1376100.02365.0RepeatSpectrin 10
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361381_1482100.02365.0RepeatSpectrin 11
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361486_1590100.02365.0RepeatSpectrin 12
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361592_1696100.02365.0RepeatSpectrin 13
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361698_1801100.02365.0RepeatSpectrin 14
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361805_1907100.02365.0RepeatSpectrin 15
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361914_2014100.02365.0RepeatSpectrin 16
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3362018_2097100.02365.0RepeatSpectrin 17
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336303_411100.02365.0RepeatSpectrin 1
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336423_525100.02365.0RepeatSpectrin 2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336530_636100.02365.0RepeatSpectrin 3
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336639_742100.02365.0RepeatSpectrin 4
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336745_847100.02365.0RepeatSpectrin 5
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336850_952100.02365.0RepeatSpectrin 6
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+336957_1060100.02365.0RepeatSpectrin 7


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1960_SPTBN1_54826380_SPAG5_26920084_ranked_0.pdbSPTBN15482638054826380ENST00000321765SPAG5chr1726920084-
MDGSGRGLERDFQGAVLRGVTPGIMELQRTSSISGPLSPAYTGQVPYNYNQLEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLY
TDLRDGRMLIKLLEVLSGERLEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVK
TIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSK
ESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCL
TPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKST
NTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLK
ESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK
DAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK
LTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLC
QLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENL
TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTP
VPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE
KLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQE
1245


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SPTBN1_pLDDT.png
all structure
all structure
SPAG5_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SPTBN1
SPAG5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000333896+2311563_209387.02156.0ANK2
HgeneSPTBN1chr2:54826380chr17:26920084ENST00000356805+3361563_2093100.02365.0ANK2


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Related Drugs to SPTBN1-SPAG5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SPTBN1-SPAG5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource