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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STIM1-NUP98

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STIM1-NUP98
	FusionPDB ID: 87401
	FusionGDB2.0 ID: 87401
		Hgene	Tgene
	Gene symbol	STIM1	NUP98
	Gene ID	6786	4928
	Gene name	stromal interaction molecule 1	nucleoporin 98 and 96 precursor
	Synonyms	D11S4896E\|GOK\|IMD10\|STRMK\|TAM\|TAM1	ADIR2\|NUP196\|NUP96\|Nup98-96
	Cytomap	11p15.4	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	stromal interaction molecule 1	nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 96nucleoporin 98kDnucleoporin 98kDa
	Modification date	20200329	20200313
	UniProtAcc	.	P52948
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000300737, ENST00000527651, ENST00000527484, ENST00000533977,	ENST00000488828, ENST00000324932, ENST00000355260, ENST00000359171, ENST00000397004, ENST00000397007,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 13 X 12=3276	17 X 18 X 10=3060
	# samples	23	18
	** MAII score	log2(23/3276*10)=-3.83222959069663 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/3060*10)=-4.08746284125034 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: STIM1 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	STIM1(3877639)-NUP98(3756554), # samples:3
Anticipated loss of major functional domain due to fusion event.	STIM1-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STIM1-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STIM1	GO:0002115	store-operated calcium entry	28219928
Hgene	STIM1	GO:0005513	detection of calcium ion	16005298
Hgene	STIM1	GO:0032237	activation of store-operated calcium channel activity	16005298\|26322679\|28219928
Hgene	STIM1	GO:0045762	positive regulation of adenylate cyclase activity	19171672
Hgene	STIM1	GO:0051924	regulation of calcium ion transport	16005298

Fusion gene breakpoints across STIM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP98 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-93-A4JP-01A	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-
ChimerDB4	LUAD	TCGA-93-A4JP-01A	STIM1	chr11	3968954	-	NUP98	chr11	3765879	-
ChimerDB4	LUAD	TCGA-93-A4JP	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300737	STIM1	chr11	3877639	+	ENST00000324932	NUP98	chr11	3756554	-	5852	708	554	4702	1382
ENST00000300737	STIM1	chr11	3877639	+	ENST00000359171	NUP98	chr11	3756554	-	5649	708	554	4216	1220
ENST00000300737	STIM1	chr11	3877639	+	ENST00000355260	NUP98	chr11	3756554	-	4841	708	554	4480	1308
ENST00000300737	STIM1	chr11	3877639	+	ENST00000397004	NUP98	chr11	3756554	-	3053	708	554	2062	502
ENST00000300737	STIM1	chr11	3877639	+	ENST00000397007	NUP98	chr11	3756554	-	2771	708	554	2062	502
ENST00000527651	STIM1	chr11	3877639	+	ENST00000324932	NUP98	chr11	3756554	-	5372	228	74	4222	1382
ENST00000527651	STIM1	chr11	3877639	+	ENST00000359171	NUP98	chr11	3756554	-	5169	228	74	3736	1220
ENST00000527651	STIM1	chr11	3877639	+	ENST00000355260	NUP98	chr11	3756554	-	4361	228	74	4000	1308
ENST00000527651	STIM1	chr11	3877639	+	ENST00000397004	NUP98	chr11	3756554	-	2573	228	74	1582	502
ENST00000527651	STIM1	chr11	3877639	+	ENST00000397007	NUP98	chr11	3756554	-	2291	228	74	1582	502

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300737	ENST00000324932	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.001875601	0.9981244
ENST00000300737	ENST00000359171	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.001086265	0.99891376
ENST00000300737	ENST00000355260	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.0038921	0.9961079
ENST00000300737	ENST00000397004	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.000739375	0.9992606
ENST00000300737	ENST00000397007	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.001113033	0.998887
ENST00000527651	ENST00000324932	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.000934078	0.99906594
ENST00000527651	ENST00000359171	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.000548691	0.99945134
ENST00000527651	ENST00000355260	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.001981694	0.99801826
ENST00000527651	ENST00000397004	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.000367305	0.9996327
ENST00000527651	ENST00000397007	STIM1	chr11	3877639	+	NUP98	chr11	3756554	-	0.000584576	0.9994154

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87401_87401_1_STIM1-NUP98_STIM1_chr11_3877639_ENST00000300737_NUP98_chr11_3756554_ENST00000324932_length(amino acids)=1382AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSI
TADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFL
TQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLD
YIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAP

--------------------------------------------------------------

>87401_87401_2_STIM1-NUP98_STIM1_chr11_3877639_ENST00000300737_NUP98_chr11_3756554_ENST00000355260_length(amino acids)=1308AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRH
CQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPER
SSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTS

--------------------------------------------------------------

>87401_87401_3_STIM1-NUP98_STIM1_chr11_3877639_ENST00000300737_NUP98_chr11_3756554_ENST00000359171_length(amino acids)=1220AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRH
CQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPER

--------------------------------------------------------------

>87401_87401_4_STIM1-NUP98_STIM1_chr11_3877639_ENST00000300737_NUP98_chr11_3756554_ENST00000397004_length(amino acids)=502AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL

--------------------------------------------------------------

>87401_87401_5_STIM1-NUP98_STIM1_chr11_3877639_ENST00000300737_NUP98_chr11_3756554_ENST00000397007_length(amino acids)=502AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL

--------------------------------------------------------------

>87401_87401_6_STIM1-NUP98_STIM1_chr11_3877639_ENST00000527651_NUP98_chr11_3756554_ENST00000324932_length(amino acids)=1382AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSI
TADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFL
TQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLD
YIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAP

--------------------------------------------------------------

>87401_87401_7_STIM1-NUP98_STIM1_chr11_3877639_ENST00000527651_NUP98_chr11_3756554_ENST00000355260_length(amino acids)=1308AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRH
CQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPER
SSLIQDWETSGLVYLDYIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTS

--------------------------------------------------------------

>87401_87401_8_STIM1-NUP98_STIM1_chr11_3877639_ENST00000527651_NUP98_chr11_3756554_ENST00000359171_length(amino acids)=1220AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL
QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS
ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV
QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN
SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV
IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF
SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK
RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDSIREKAVRELLTRH
CQLLETPESWAKETFLTQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPER

--------------------------------------------------------------

>87401_87401_9_STIM1-NUP98_STIM1_chr11_3877639_ENST00000527651_NUP98_chr11_3756554_ENST00000397004_length(amino acids)=502AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL

--------------------------------------------------------------

>87401_87401_10_STIM1-NUP98_STIM1_chr11_3877639_ENST00000527651_NUP98_chr11_3756554_ENST00000397007_length(amino acids)=502AA_BP=51
MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD
PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN
RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS
EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR
RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:3877639/chr11:3756554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NUP98 P52948
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133). {ECO:0000269\|PubMed:23523133}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000324932

890_894

469.3333333333333

1801.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000355260

890_894

469.3333333333333

1727.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397004

890_894

469.3333333333333

921.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397007

890_894

486.3333333333333

938.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000324932

738_880

469.3333333333333

1801.0

Domain

Peptidase S59

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000355260

738_880

469.3333333333333

1727.0

Domain

Peptidase S59

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397004

738_880

469.3333333333333

921.0

Domain

Peptidase S59

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397007

738_880

486.3333333333333

938.0

Domain

Peptidase S59

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

76_87

46.333333333333336

686.0

Calcium binding

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

248_442

46.333333333333336

686.0

Coiled coil

Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

270_336

46.333333333333336

686.0

Compositional bias

Note=Glu-rich

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

600_629

46.333333333333336

686.0

Compositional bias

Note=Pro/Ser-rich

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

672_685

46.333333333333336

686.0

Compositional bias

Note=Lys-rich

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

132_200

46.333333333333336

686.0

Domain

SAM

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

63_98

46.333333333333336

686.0

Domain

Note=EF-hand

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

642_645

46.333333333333336

686.0

Motif

Note=Microtubule tip localization signal

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

334_444

46.333333333333336

686.0

Region

Note=SOAR/CAD

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

235_685

46.333333333333336

686.0

Topological domain

Cytoplasmic

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

23_213

46.333333333333336

686.0

Topological domain

Extracellular

Hgene

STIM1

chr11:3877639

chr11:3756554

ENST00000300737

214_234

46.333333333333336

686.0

Transmembrane

Helical

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000324932

7_480

469.3333333333333

1801.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000355260

7_480

469.3333333333333

1727.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397004

7_480

469.3333333333333

921.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397007

7_480

486.3333333333333

938.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000324932

1_156

469.3333333333333

1801.0

Region

Note=FG repeats 1

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000324932

214_480

469.3333333333333

1801.0

Region

Note=FG repeats 2

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000355260

1_156

469.3333333333333

1727.0

Region

Note=FG repeats 1

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000355260

214_480

469.3333333333333

1727.0

Region

Note=FG repeats 2

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397004

1_156

469.3333333333333

921.0

Region

Note=FG repeats 1

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397004

214_480

469.3333333333333

921.0

Region

Note=FG repeats 2

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397007

1_156

486.3333333333333

938.0

Region

Note=FG repeats 1

Tgene

NUP98

chr11:3877639

chr11:3756554

ENST00000397007

214_480

486.3333333333333

938.0

Region

Note=FG repeats 2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2031_STIM1_3877639_NUP98_3756554_ranked_0.pdb	STIM1	3877639	3877639	ENST00000397007	NUP98	chr11	3756554	-	MRPRVMDVCVRLALWLLWGLLLHQGQSLSHSHSEKATGTSSGANSEESTAAALTDPNASAAQQAVLQQHINSLTYSPFGDSPLFRNPMSD PKKKEERLKPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLDDDEPSLANGAFMPKKSIKKLVLKNLNNSNLFSPVN RDSENLASPSEYPENGERFSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNKHSNSNSVDDTIVALNMRAALRNGLEGSS EETSFHDESLQDDREEIENNSYHMHPAGIILTKVGYYTIPSMDDLAKITNEKGECIVSDFTIGRKGYGSIYFEGDVNLTNLNLDDIVHIR RKEVVVYLDDNQKPPVGEGLNRKAEVTLDGVWPTDKTSRCLIKSPDRLADINYEGRLEAVSRKQGAQFKEYRPETGSWVFKVSHFSKYGL QDSDEEEEEHPSKTSTKKLKTAPLPPASQTTPLQMALNGKPAPPPQSQSPEVEQLGRVVELDSDMVDITQEPVLDTMLEESMPEDQEPVS ASTHIASSLGINPHVLQIMKASLLTDEEDVDMALDQRFSRLPSKADTSQEICSPRLPISASHSSKTRSLVGGLLQSKFTSGAFLSPSVSV QECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMGRSFRVGWGPNWTLAN SGEQLNGSHELENHQIADSMEFGFLPNPVAVKPLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAV IHDYADWVKEASGDLPEAQIVKHWSLTWTLCEALWGHLKELDSQLNEPREYIQILERRRAFSRWLSCTATPQIEEEVSLTQKNSPVEAVF SYLTGKRISEACSLAQQSGDHRLALLLSQFVGSQSVRELLTMQLVDWHQLQADSFIQDERLRIFALLAGKPVWQLSEKKQINVCSQLDWK RSLAIHLWYLLPPTASISRALSMYEEAFQNTSDSDRYACSPLPSYLEGSGCVIAEEQNSQTPLRDVCFHLLKLYSDRHYDLNQLLEPRSI TADPLDYRLSWHLWEVLRALNYTHLSAQCEGVLQASYAGQLESEGLWEWAIFVLLHIDNSGIREKAVRELLTRHCQLLETPESWAKETFL TQKLRVPAKWIHEAKAVRAHMESDKHLEALCLFKAEHWNRCHKLIIRHLASDAIINENYDYLKGFLEDLAPPERSSLIQDWETSGLVYLD YIRVIEMLRHIQQVDCSGNDLEQLHIKVTSLCSRIEQIQCYSAKDRLAQSDMAKRVANLLRVVLSLHHPPDRTSDSTPDPQRVPLRLLAP	1382

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

STIM1_pLDDT.png

NUP98_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

NUP98

MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, Rae1, KPNB1, RAE1, TNPO2, CRM1, KAP104, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, tat, NUP82, NUP159, Nup188, Nup98, Nup107, Nup214, SIRT7, NUP107, RAPGEF3, rev, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, Ranbp2, Ube2i, Ssna1, Rcc1, Xpo1, Kifc1, Nup155, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, ORF10, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1, CTNNB1, TGFB1, NKX2-1, ESR2, NUP155, EZH2, DCPS, CDK9, DYNLT1, TOMM20, KIAA1429, DISC1, NR2C2, AGRN, HIST1H4A, PTPMT1, ORF6, BIRC3, LMBR1L, FAM105A, PLEKHA4, TTC9, HIST1H2BH, HIST3H3, M, nsp16, nsp4, nsp6, ORF7b, GLE1, NEK4, CIT, KIF14, KIF20A, PRC1, ARHGEF19, MYO9A, PTPN1, SEC61B, NFX1, HULC, NUPR1, BRD4, LGALS9, DYRK1A, NUP37, DDX58, CKAP4, DERL1, EMD, HSD17B11, HSD3B7, LMNB1, LRRC59, METTL7A, NUP50, REEP5, SEC62, SSR1, STIM1, SYNE3, TMPO, WDR5, NAA40, OCIAD1, CADPS, TACSTD2, RGPD1, TPST2, CD40, SLFN11, FBXO32, RCHY1, SIRT6, ETV6,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STIM1
NUP98

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STIM1-NUP98

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STIM1-NUP98

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NUP98	C0002871	Anemia	1	CTD_human
Tgene	NUP98	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Tgene	NUP98	C0024312	Lymphopenia	1	CTD_human
Tgene	NUP98	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Tgene	NUP98	C0027947	Neutropenia	1	CTD_human
Tgene	NUP98	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Tgene	NUP98	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	NUP98	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	NUP98	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	NUP98	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human