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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STK11-TYK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STK11-TYK2
	FusionPDB ID: 87457
	FusionGDB2.0 ID: 87457
		Hgene	Tgene
	Gene symbol	STK11	TYK2
	Gene ID	6794	7297
	Gene name	serine/threonine kinase 11	tyrosine kinase 2
	Synonyms	LKB1\|PJS\|hLKB1	IMD35\|JTK1
	Cytomap	19p13.3	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1	non-receptor tyrosine-protein kinase TYK2
	Modification date	20200329	20200329
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000326873, ENST00000585748,	ENST00000529422, ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 3 X 8=312	52 X 14 X 18=13104
	# samples	17	54
	** MAII score	log2(17/312*10)=-0.876011282724546 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(54/13104*10)=-4.60090404459018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: STK11 [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	STK11(1207202)-TYK2(10473333), # samples:3
Anticipated loss of major functional domain due to fusion event.	STK11-TYK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-TYK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-TYK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-TYK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STK11	GO:0006468	protein phosphorylation	12805220\|25329316
Hgene	STK11	GO:0007050	cell cycle arrest	12805220\|17216128
Hgene	STK11	GO:0046777	protein autophosphorylation	11430832
Hgene	STK11	GO:0071493	cellular response to UV-B	25329316
Hgene	STK11	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	11430832

Fusion gene breakpoints across STK11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TYK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AQ-A04L-01B	STK11	chr19	1207202	+	TYK2	chr19	10473333	-
ChimerDB4	BRCA	TCGA-AQ-A04L-01B	STK11	chr19	1207202	+	TYK2	chr19	10476574	-
ChimerDB4	BRCA	TCGA-AQ-A04L	STK11	chr19	1207202	+	TYK2	chr19	10473333	-
ChimerDB4	BRCA	TCGA-AQ-A04L	STK11	chr19	1207202	+	TYK2	chr19	10476574	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000326873	STK11	chr19	1207202	+	ENST00000264818	TYK2	chr19	10473333	-	3961	1463	1011	3659	882
ENST00000326873	STK11	chr19	1207202	+	ENST00000524462	TYK2	chr19	10473333	-	3961	1463	1011	3659	882
ENST00000326873	STK11	chr19	1207202	+	ENST00000525621	TYK2	chr19	10473333	-	3961	1463	1011	3659	882
ENST00000326873	STK11	chr19	1207202	+	ENST00000529370	TYK2	chr19	10473333	-	2941	1463	1011	2861	616
ENST00000326873	STK11	chr19	1207202	+	ENST00000264818	TYK2	chr19	10476574	-	4699	1463	1011	4397	1128
ENST00000326873	STK11	chr19	1207202	+	ENST00000524462	TYK2	chr19	10476574	-	4699	1463	1011	4397	1128
ENST00000326873	STK11	chr19	1207202	+	ENST00000525621	TYK2	chr19	10476574	-	4699	1463	1011	4397	1128
ENST00000326873	STK11	chr19	1207202	+	ENST00000529370	TYK2	chr19	10476574	-	3679	1463	1011	3599	862

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326873	ENST00000264818	STK11	chr19	1207202	+	TYK2	chr19	10473333	-	0.008050469	0.99194956
ENST00000326873	ENST00000524462	STK11	chr19	1207202	+	TYK2	chr19	10473333	-	0.008050469	0.99194956
ENST00000326873	ENST00000525621	STK11	chr19	1207202	+	TYK2	chr19	10473333	-	0.008050469	0.99194956
ENST00000326873	ENST00000529370	STK11	chr19	1207202	+	TYK2	chr19	10473333	-	0.046642467	0.9533575
ENST00000326873	ENST00000264818	STK11	chr19	1207202	+	TYK2	chr19	10476574	-	0.009323784	0.99067616
ENST00000326873	ENST00000524462	STK11	chr19	1207202	+	TYK2	chr19	10476574	-	0.009323784	0.99067616
ENST00000326873	ENST00000525621	STK11	chr19	1207202	+	TYK2	chr19	10476574	-	0.009323784	0.99067616
ENST00000326873	ENST00000529370	STK11	chr19	1207202	+	TYK2	chr19	10476574	-	0.010773768	0.9892263

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87457_87457_1_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10473333_ENST00000264818_length(amino acids)=882AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLN
LSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLT
SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD
CGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLA
ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIA

--------------------------------------------------------------

>87457_87457_2_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10473333_ENST00000524462_length(amino acids)=882AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLN
LSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLT
SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD
CGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLA
ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIA

--------------------------------------------------------------

>87457_87457_3_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10473333_ENST00000525621_length(amino acids)=882AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLN
LSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLT
SQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD
CGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLA
ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIA

--------------------------------------------------------------

>87457_87457_4_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10473333_ENST00000529370_length(amino acids)=616AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEPFVQAKLRPEDGLYLIHWSTSHPYRLIL
TVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLN
LSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPWALPAVGAPPRNPEDRI

--------------------------------------------------------------

>87457_87457_5_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10476574_ENST00000264818_length(amino acids)=1128AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKNFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSL
VDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQ
QDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGT
RTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY
VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWL
APECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL
QPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI
IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVP
EGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK

--------------------------------------------------------------

>87457_87457_6_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10476574_ENST00000524462_length(amino acids)=1128AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKNFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSL
VDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQ
QDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGT
RTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY
VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWL
APECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL
QPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI
IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVP
EGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK

--------------------------------------------------------------

>87457_87457_7_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10476574_ENST00000525621_length(amino acids)=1128AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKNFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSL
VDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQ
QDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGT
RTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY
VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWL
APECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL
QPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI
IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVP
EGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK

--------------------------------------------------------------

>87457_87457_8_STK11-TYK2_STK11_chr19_1207202_ENST00000326873_TYK2_chr19_10476574_ENST00000529370_length(amino acids)=862AA_BP=151
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKNFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSL
VDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQ
QDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGT
RTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY
VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWL
APECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPWALPAVGAPPRNPEDRIRAQSCIPSGLVTSSLSGLPAGGPL

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1207202/chr19:10473333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK11

chr19:1207202

chr19:10473333

ENST00000326873

55_63

96.66666666666667

225.33333333333334

Nucleotide binding

ATP

Hgene

STK11

chr19:1207202

chr19:10476574

ENST00000326873

55_63

96.66666666666667

225.33333333333334

Nucleotide binding

ATP

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000264818

589_875

455.6666666666667

1188.0

Domain

Protein kinase 1

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000264818

897_1176

455.6666666666667

1188.0

Domain

Protein kinase 2

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000525621

589_875

455.6666666666667

1188.0

Domain

Protein kinase 1

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000525621

897_1176

455.6666666666667

1188.0

Domain

Protein kinase 2

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000264818

450_529

209.66666666666666

1188.0

Domain

Note=SH2%3B atypical

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000264818

589_875

209.66666666666666

1188.0

Domain

Protein kinase 1

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000264818

897_1176

209.66666666666666

1188.0

Domain

Protein kinase 2

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000525621

450_529

209.66666666666666

1188.0

Domain

Note=SH2%3B atypical

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000525621

589_875

209.66666666666666

1188.0

Domain

Protein kinase 1

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000525621

897_1176

209.66666666666666

1188.0

Domain

Protein kinase 2

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000264818

903_911

455.6666666666667

1188.0

Nucleotide binding

ATP

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000525621

903_911

455.6666666666667

1188.0

Nucleotide binding

ATP

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000264818

903_911

209.66666666666666

1188.0

Nucleotide binding

ATP

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000525621

903_911

209.66666666666666

1188.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK11

chr19:1207202

chr19:10473333

ENST00000326873

49_309

96.66666666666667

225.33333333333334

Domain

Protein kinase

Hgene

STK11

chr19:1207202

chr19:10476574

ENST00000326873

49_309

96.66666666666667

225.33333333333334

Domain

Protein kinase

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000264818

26_431

455.6666666666667

1188.0

Domain

FERM

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000264818

450_529

455.6666666666667

1188.0

Domain

Note=SH2%3B atypical

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000525621

26_431

455.6666666666667

1188.0

Domain

FERM

Tgene

TYK2

chr19:1207202

chr19:10473333

ENST00000525621

450_529

455.6666666666667

1188.0

Domain

Note=SH2%3B atypical

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000264818

26_431

209.66666666666666

1188.0

Domain

FERM

Tgene

TYK2

chr19:1207202

chr19:10476574

ENST00000525621

26_431

209.66666666666666

1188.0

Domain

FERM

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1878_STK11_1207202_TYK2_10476574_ranked_0.pdb	STK11	1207202	1207202	ENST00000529370	TYK2	chr19	10476574	-	MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKNFKDCIPRSFRRHIRQHSALTRLRLRNVFR RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV EEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSL VDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQ QDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGT RTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWL APECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL QPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHI IKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVP EGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK	1128

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

STK11_pLDDT.png

TYK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STK11
TYK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STK11-TYK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STK11-TYK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source