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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TANK-SLC38A6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TANK-SLC38A6
FusionPDB ID: 88996
FusionGDB2.0 ID: 88996
HgeneTgene
Gene symbol

TANK

SLC38A6

Gene ID

10010

145389

Gene nameTRAF family member associated NFKB activatorsolute carrier family 38 member 6
SynonymsI-TRAF|ITRAF|TRAF2NAT-1|SNAT6
Cytomap

2q24.2

14q23.1

Type of geneprotein-codingprotein-coding
DescriptionTRAF family member-associated NF-kappa-B activatorTRAF-interacting proteinprobable sodium-coupled neutral amino acid transporter 6N system amino acid transporter NAT-1N-system amino acid transporter 1Na(+)-coupled neutral amino acid transporter 6
Modification date2020031320200313
UniProtAcc

TBKBP1

Q8IZM9

Ensembl transtripts involved in fusion geneENST idsENST00000259075, ENST00000392749, 
ENST00000402568, ENST00000403609, 
ENST00000405852, ENST00000406287, 
ENST00000457476, ENST00000461338, 
ENST00000554304, ENST00000267488, 
ENST00000354886, ENST00000456840, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 8 X 6=4324 X 4 X 3=48
# samples 95
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TANK [Title/Abstract] AND SLC38A6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TANK(162036272)-SLC38A6(61449226), # samples:3
Anticipated loss of major functional domain due to fusion event.TANK-SLC38A6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TANK-SLC38A6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TANK-SLC38A6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TANK-SLC38A6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TANK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC38A6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-6545-01ATANKchr2

162036272

-SLC38A6chr14

61449226

+
ChimerDB4LUSCTCGA-56-6545-01ATANKchr2

162036272

+SLC38A6chr14

61449226

+
ChimerDB4LUSCTCGA-56-6545TANKchr2

162036272

+SLC38A6chr14

61449225

+
ChimerDB4LUSCTCGA-56-6545TANKchr2

162036272

+SLC38A6chr14

61449226

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259075TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1785304971764555
ENST00000259075TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1771304971569490
ENST00000259075TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1790304971731544
ENST00000457476TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1738257501717555
ENST00000457476TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1724257501522490
ENST00000457476TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1743257501684544
ENST00000392749TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+18193382391798519
ENST00000392749TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+18053382391603454
ENST00000392749TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+18243382391765508
ENST00000402568TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1895414361874612
ENST00000402568TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1881414361679547
ENST00000402568TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1900414361841601
ENST00000406287TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1895414361874612
ENST00000406287TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1881414361679547
ENST00000406287TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1900414361841601
ENST00000405852TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1677196971656519
ENST00000405852TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1663196971461454
ENST00000405852TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1682196971623508
ENST00000403609TANKchr2162036272+ENST00000354886SLC38A6chr1461449226+1622141421601519
ENST00000403609TANKchr2162036272+ENST00000267488SLC38A6chr1461449226+1608141421406454
ENST00000403609TANKchr2162036272+ENST00000456840SLC38A6chr1461449226+1627141421568508
ENST00000259075TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1785304971764555
ENST00000259075TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1771304971569490
ENST00000259075TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1790304971731544
ENST00000457476TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1738257501717555
ENST00000457476TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1724257501522490
ENST00000457476TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1743257501684544
ENST00000392749TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+18193382391798519
ENST00000392749TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+18053382391603454
ENST00000392749TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+18243382391765508
ENST00000402568TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1895414361874612
ENST00000402568TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1881414361679547
ENST00000402568TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1900414361841601
ENST00000406287TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1895414361874612
ENST00000406287TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1881414361679547
ENST00000406287TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1900414361841601
ENST00000405852TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1677196971656519
ENST00000405852TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1663196971461454
ENST00000405852TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1682196971623508
ENST00000403609TANKchr2162036272+ENST00000354886SLC38A6chr1461449225+1622141421601519
ENST00000403609TANKchr2162036272+ENST00000267488SLC38A6chr1461449225+1608141421406454
ENST00000403609TANKchr2162036272+ENST00000456840SLC38A6chr1461449225+1627141421568508

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259075ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0016729960.99832696
ENST00000259075ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0016583090.9983417
ENST00000259075ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0011243010.9988757
ENST00000457476ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0016785780.99832135
ENST00000457476ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0016093610.9983907
ENST00000457476ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0011267390.9988733
ENST00000392749ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0023566630.9976433
ENST00000392749ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0021283250.99787164
ENST00000392749ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.001581170.9984188
ENST00000402568ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0007851570.99921477
ENST00000402568ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0005256290.99947435
ENST00000402568ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0005526330.9994474
ENST00000406287ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0007851570.99921477
ENST00000406287ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0005256290.99947435
ENST00000406287ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0005526330.9994474
ENST00000405852ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0020057080.9979943
ENST00000405852ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0018922330.9981078
ENST00000405852ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0013437150.9986563
ENST00000403609ENST00000354886TANKchr2162036272+SLC38A6chr1461449226+0.0018831660.99811685
ENST00000403609ENST00000267488TANKchr2162036272+SLC38A6chr1461449226+0.0016268970.99837303
ENST00000403609ENST00000456840TANKchr2162036272+SLC38A6chr1461449226+0.0012546530.9987453
ENST00000259075ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0016729960.99832696
ENST00000259075ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0016583090.9983417
ENST00000259075ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0011243010.9988757
ENST00000457476ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0016785780.99832135
ENST00000457476ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0016093610.9983907
ENST00000457476ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0011267390.9988733
ENST00000392749ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0023566630.9976433
ENST00000392749ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0021283250.99787164
ENST00000392749ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.001581170.9984188
ENST00000402568ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0007851570.99921477
ENST00000402568ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0005256290.99947435
ENST00000402568ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0005526330.9994474
ENST00000406287ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0007851570.99921477
ENST00000406287ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0005256290.99947435
ENST00000406287ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0005526330.9994474
ENST00000405852ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0020057080.9979943
ENST00000405852ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0018922330.9981078
ENST00000405852ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0013437150.9986563
ENST00000403609ENST00000354886TANKchr2162036272+SLC38A6chr1461449225+0.0018831660.99811685
ENST00000403609ENST00000267488TANKchr2162036272+SLC38A6chr1461449225+0.0016268970.99837303
ENST00000403609ENST00000456840TANKchr2162036272+SLC38A6chr1461449225+0.0012546530.9987453

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88996_88996_1_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=490AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL

--------------------------------------------------------------

>88996_88996_2_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=555AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTGRDTMEMCTQRKGHARTQQEGNCLQAKGRGLRRTKRV

--------------------------------------------------------------

>88996_88996_3_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=544AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTEKEEIPWRCAPRGKATQGHSKKATVYKPREEASGEPN

--------------------------------------------------------------

>88996_88996_4_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=490AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL

--------------------------------------------------------------

>88996_88996_5_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=555AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTGRDTMEMCTQRKGHARTQQEGNCLQAKGRGLRRTKRV

--------------------------------------------------------------

>88996_88996_6_TANK-SLC38A6_TANK_chr2_162036272_ENST00000259075_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=544AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTEKEEIPWRCAPRGKATQGHSKKATVYKPREEASGEPN

--------------------------------------------------------------

>88996_88996_7_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_8_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_9_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_10_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_11_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_12_TANK-SLC38A6_TANK_chr2_162036272_ENST00000392749_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_13_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=547AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALI

--------------------------------------------------------------

>88996_88996_14_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=612AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_15_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=601AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_16_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=547AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALI

--------------------------------------------------------------

>88996_88996_17_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=612AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_18_TANK-SLC38A6_TANK_chr2_162036272_ENST00000402568_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=601AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_19_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_20_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_21_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_22_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_23_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_24_TANK-SLC38A6_TANK_chr2_162036272_ENST00000403609_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_25_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_26_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_27_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_28_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=454AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALIIFD

--------------------------------------------------------------

>88996_88996_29_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=519AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_30_TANK-SLC38A6_TANK_chr2_162036272_ENST00000405852_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=508AA_BP=33
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYS
VHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPL
ALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCE
LQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSN
FPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCL

--------------------------------------------------------------

>88996_88996_31_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=547AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALI

--------------------------------------------------------------

>88996_88996_32_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=612AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_33_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=601AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_34_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=547AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALI

--------------------------------------------------------------

>88996_88996_35_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=612AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_36_TANK-SLC38A6_TANK_chr2_162036272_ENST00000406287_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=601AA_BP=126
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN

--------------------------------------------------------------

>88996_88996_37_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449225_ENST00000267488_length(amino acids)=490AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL

--------------------------------------------------------------

>88996_88996_38_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449225_ENST00000354886_length(amino acids)=555AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTGRDTMEMCTQRKGHARTQQEGNCLQAKGRGLRRTKRV

--------------------------------------------------------------

>88996_88996_39_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449225_ENST00000456840_length(amino acids)=544AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTEKEEIPWRCAPRGKATQGHSKKATVYKPREEASGEPN

--------------------------------------------------------------

>88996_88996_40_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449226_ENST00000267488_length(amino acids)=490AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL

--------------------------------------------------------------

>88996_88996_41_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449226_ENST00000354886_length(amino acids)=555AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTGRDTMEMCTQRKGHARTQQEGNCLQAKGRGLRRTKRV

--------------------------------------------------------------

>88996_88996_42_TANK-SLC38A6_TANK_chr2_162036272_ENST00000457476_SLC38A6_chr14_61449226_ENST00000456840_length(amino acids)=544AA_BP=69
MSSSLQRNSLQRKTCNLEKRPVIYSILYSDATGRRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMN
AIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTE
LPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTD
DCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHD
VVVMTVKLCILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYL
KLSREDFLSWKKLGGLILSHRLACSGVISAHCNLCLPDSSNPPTSASRVAETTEKEEIPWRCAPRGKATQGHSKKATVYKPREEASGEPN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:162036272/chr14:61449226)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANK

TBKBP1

SLC38A6

Q8IZM9

615FUNCTION: Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate. {ECO:0000250|UniProtKB:G3UVW3}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016111_13135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016170_19035.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016191_21135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016250_27035.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016288_30835.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016327_34735.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016371_39135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016394_41435.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST0000026748801642_6235.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000267488016431_45135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST0000026748801685_10535.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017111_13135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017170_19035.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017191_21135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017250_27035.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017288_30835.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017327_34735.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017371_39135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017394_41435.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST0000035488601742_6235.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST00000354886017431_45135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449225ENST0000035488601785_10535.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016111_13135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016170_19035.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016191_21135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016250_27035.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016288_30835.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016327_34735.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016371_39135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016394_41435.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST0000026748801642_6235.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000267488016431_45135.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST0000026748801685_10535.0457.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017111_13135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017170_19035.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017191_21135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017250_27035.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017288_30835.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017327_34735.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017371_39135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017394_41435.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST0000035488601742_6235.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST00000354886017431_45135.0522.0TransmembraneHelical
TgeneSLC38A6chr2:162036272chr14:61449226ENST0000035488601785_10535.0522.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTANKchr2:162036272chr14:61449225ENST00000259075+2822_6233.0426.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449225ENST00000392749+2822_6233.0426.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449225ENST00000403609+1322_6233.0120.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449225ENST00000457476+2422_6233.0120.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449226ENST00000259075+2822_6233.0426.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449226ENST00000392749+2822_6233.0426.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449226ENST00000403609+1322_6233.0120.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449226ENST00000457476+2422_6233.0120.0Coiled coilOntology_term=ECO:0000255
HgeneTANKchr2:162036272chr14:61449225ENST00000259075+28393_42033.0426.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449225ENST00000392749+28393_42033.0426.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449225ENST00000403609+13393_42033.0120.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449225ENST00000457476+24393_42033.0120.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449226ENST00000259075+28393_42033.0426.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449226ENST00000392749+28393_42033.0426.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449226ENST00000403609+13393_42033.0120.0Zinc fingerUBZ1-type
HgeneTANKchr2:162036272chr14:61449226ENST00000457476+24393_42033.0120.0Zinc fingerUBZ1-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1293_TANK_162036272_SLC38A6_61449226_1293_TANK_162036272_SLC38A6_61449226_ranked_0.pdbTANK162036272162036272ENST00000456840SLC38A6chr1461449226+
MPSELEQNATSGWSHSARRRRPEGRGNAAESVNCEMLLTSYNKGEMVVKEVKKRREIEGKENDLPSYRGWNTHPNERPVIYSILYSDATG
RRGMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKELHRQRSPGVSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLA
SYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYSRYWYLDGQTLLIIICVGIV
FPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPCPLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPI
YCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKLCILFAVLLTVPLIHFPARKAVTMMF
FSNFPFSWIRHFLITLALNIIIVLLAIYVPDIRNVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGGLILSHRLACSGVISAHCN
612


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TANK_pLDDT.png
all structure
all structure
SLC38A6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TANK
SLC38A6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTANKchr2:162036272chr14:61449225ENST00000259075+28133_17233.0426.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449225ENST00000392749+28133_17233.0426.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449225ENST00000403609+13133_17233.0120.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449225ENST00000457476+24133_17233.0120.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449226ENST00000259075+28133_17233.0426.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449226ENST00000392749+28133_17233.0426.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449226ENST00000403609+13133_17233.0120.0TBK1 and IKBKE
HgeneTANKchr2:162036272chr14:61449226ENST00000457476+24133_17233.0120.0TBK1 and IKBKE


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Related Drugs to TANK-SLC38A6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TANK-SLC38A6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource