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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TBC1D22A-FBLN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TBC1D22A-FBLN1
FusionPDB ID: 89290
FusionGDB2.0 ID: 89290
HgeneTgene
Gene symbol

TBC1D22A

FBLN1

Gene ID

25771

2192

Gene nameTBC1 domain family member 22Afibulin 1
SynonymsC22orf4|HSC79E021FBLN|FIBL1
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 22Aputative GTPase activatorfibulin-1
Modification date2020031320200313
UniProtAcc.

P23142

Ensembl transtripts involved in fusion geneENST idsENST00000337137, ENST00000380995, 
ENST00000406733, ENST00000355704, 
ENST00000407381, ENST00000472791, 
ENST00000476366, ENST00000262722, 
ENST00000327858, ENST00000340923, 
ENST00000348697, ENST00000402984, 
ENST00000442170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score34 X 18 X 14=856822 X 22 X 9=4356
# samples 3727
** MAII scorelog2(37/8568*10)=-4.53336130423394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4356*10)=-4.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TBC1D22A [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TBC1D22A(47193517)-FBLN1(45946372), # samples:3
Anticipated loss of major functional domain due to fusion event.TBC1D22A-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D22A-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D22A-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D22A-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

TgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

TgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

TgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

TgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

TgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

TgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

TgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726


check buttonFusion gene breakpoints across TBC1D22A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A50M-01ATBC1D22Achr22

47193517

-FBLN1chr22

45946372

+
ChimerDB4LUSCTCGA-85-A50M-01ATBC1D22Achr22

47193517

+FBLN1chr22

45946372

+
ChimerDB4LUSCTCGA-85-A50MTBC1D22Achr22

47193517

+FBLN1chr22

45946371

+
ChimerDB4LUSCTCGA-85-A50MTBC1D22Achr22

47193517

+FBLN1chr22

45946372

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337137TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946372+20308031661341391
ENST00000337137TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946372+13688031661281371
ENST00000337137TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946372+13788031661281371
ENST00000337137TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946372+20318031661341391
ENST00000337137TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946372+17458031661035289
ENST00000337137TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946372+1568803166930254
ENST00000380995TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946372+20197921551330391
ENST00000380995TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946372+13577921551270371
ENST00000380995TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946372+13677921551270371
ENST00000380995TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946372+20207921551330391
ENST00000380995TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946372+17347921551024289
ENST00000380995TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946372+1557792155919254
ENST00000406733TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946372+21118842411422393
ENST00000406733TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946372+14498842411362373
ENST00000406733TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946372+14598842411362373
ENST00000406733TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946372+21128842411422393
ENST00000406733TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946372+18268842411116291
ENST00000406733TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946372+16498842411011256
ENST00000337137TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946371+20308031661341391
ENST00000337137TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946371+13688031661281371
ENST00000337137TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946371+13788031661281371
ENST00000337137TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946371+20318031661341391
ENST00000337137TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946371+17458031661035289
ENST00000337137TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946371+1568803166930254
ENST00000380995TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946371+20197921551330391
ENST00000380995TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946371+13577921551270371
ENST00000380995TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946371+13677921551270371
ENST00000380995TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946371+20207921551330391
ENST00000380995TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946371+17347921551024289
ENST00000380995TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946371+1557792155919254
ENST00000406733TBC1D22Achr2247193517+ENST00000348697FBLN1chr2245946371+21118842411422393
ENST00000406733TBC1D22Achr2247193517+ENST00000402984FBLN1chr2245946371+14498842411362373
ENST00000406733TBC1D22Achr2247193517+ENST00000262722FBLN1chr2245946371+14598842411362373
ENST00000406733TBC1D22Achr2247193517+ENST00000327858FBLN1chr2245946371+21128842411422393
ENST00000406733TBC1D22Achr2247193517+ENST00000442170FBLN1chr2245946371+18268842411116291
ENST00000406733TBC1D22Achr2247193517+ENST00000340923FBLN1chr2245946371+16498842411011256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337137ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946372+0.0058897170.9941103
ENST00000337137ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946372+0.0472592230.9527408
ENST00000337137ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946372+0.0486580470.9513419
ENST00000337137ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946372+0.0063169920.993683
ENST00000337137ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946372+0.0054315050.99456847
ENST00000337137ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946372+0.0048937390.9951062
ENST00000380995ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946372+0.0061782340.99382174
ENST00000380995ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946372+0.0501223880.9498777
ENST00000380995ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946372+0.0515212230.94847876
ENST00000380995ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946372+0.0067003230.9932996
ENST00000380995ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946372+0.0057752530.9942247
ENST00000380995ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946372+0.0054323560.99456763
ENST00000406733ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946372+0.0064269060.993573
ENST00000406733ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946372+0.06737070.9326293
ENST00000406733ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946372+0.068125050.931875
ENST00000406733ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946372+0.0070029430.9929971
ENST00000406733ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946372+0.0105032650.9894967
ENST00000406733ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946372+0.0073282920.9926717
ENST00000337137ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946371+0.0058897170.9941103
ENST00000337137ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946371+0.0472592230.9527408
ENST00000337137ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946371+0.0486580470.9513419
ENST00000337137ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946371+0.0063169920.993683
ENST00000337137ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946371+0.0054315050.99456847
ENST00000337137ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946371+0.0048937390.9951062
ENST00000380995ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946371+0.0061782340.99382174
ENST00000380995ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946371+0.0501223880.9498777
ENST00000380995ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946371+0.0515212230.94847876
ENST00000380995ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946371+0.0067003230.9932996
ENST00000380995ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946371+0.0057752530.9942247
ENST00000380995ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946371+0.0054323560.99456763
ENST00000406733ENST00000348697TBC1D22Achr2247193517+FBLN1chr2245946371+0.0064269060.993573
ENST00000406733ENST00000402984TBC1D22Achr2247193517+FBLN1chr2245946371+0.06737070.9326293
ENST00000406733ENST00000262722TBC1D22Achr2247193517+FBLN1chr2245946371+0.068125050.931875
ENST00000406733ENST00000327858TBC1D22Achr2247193517+FBLN1chr2245946371+0.0070029430.9929971
ENST00000406733ENST00000442170TBC1D22Achr2247193517+FBLN1chr2245946371+0.0105032650.9894967
ENST00000406733ENST00000340923TBC1D22Achr2247193517+FBLN1chr2245946371+0.0073282920.9926717

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89290_89290_1_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000262722_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_2_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000327858_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCR
PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_3_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000340923_length(amino acids)=254AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------

>89290_89290_4_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000348697_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK
EDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_5_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000402984_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_6_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946371_ENST00000442170_length(amino acids)=289AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK

--------------------------------------------------------------

>89290_89290_7_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000262722_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_8_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000327858_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCR
PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_9_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000340923_length(amino acids)=254AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------

>89290_89290_10_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000348697_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK
EDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_11_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000402984_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_12_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000337137_FBLN1_chr22_45946372_ENST00000442170_length(amino acids)=289AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK

--------------------------------------------------------------

>89290_89290_13_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000262722_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_14_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000327858_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCR
PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_15_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000340923_length(amino acids)=254AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------

>89290_89290_16_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000348697_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK
EDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_17_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000402984_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_18_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946371_ENST00000442170_length(amino acids)=289AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK

--------------------------------------------------------------

>89290_89290_19_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000262722_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_20_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000327858_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCR
PNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_21_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000340923_length(amino acids)=254AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS

--------------------------------------------------------------

>89290_89290_22_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000348697_length(amino acids)=391AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK
EDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHA

--------------------------------------------------------------

>89290_89290_23_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000402984_length(amino acids)=371AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKL
PLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSSFV

--------------------------------------------------------------

>89290_89290_24_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000380995_FBLN1_chr22_45946372_ENST00000442170_length(amino acids)=289AA_BP=212
MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLN
SEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
DPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSK

--------------------------------------------------------------

>89290_89290_25_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000262722_length(amino acids)=373AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS
KLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSS

--------------------------------------------------------------

>89290_89290_26_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000327858_length(amino acids)=393AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKS
CRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPF

--------------------------------------------------------------

>89290_89290_27_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000340923_length(amino acids)=256AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG

--------------------------------------------------------------

>89290_89290_28_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000348697_length(amino acids)=393AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS
SKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPF

--------------------------------------------------------------

>89290_89290_29_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000402984_length(amino acids)=373AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS
KLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSS

--------------------------------------------------------------

>89290_89290_30_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946371_ENST00000442170_length(amino acids)=291AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS

--------------------------------------------------------------

>89290_89290_31_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000262722_length(amino acids)=373AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS
KLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSS

--------------------------------------------------------------

>89290_89290_32_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000327858_length(amino acids)=393AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKS
CRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPF

--------------------------------------------------------------

>89290_89290_33_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000340923_length(amino acids)=256AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG

--------------------------------------------------------------

>89290_89290_34_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000348697_length(amino acids)=393AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS
SKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPF

--------------------------------------------------------------

>89290_89290_35_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000402984_length(amino acids)=373AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS
KLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLSRHGTVSS

--------------------------------------------------------------

>89290_89290_36_TBC1D22A-FBLN1_TBC1D22A_chr22_47193517_ENST00000406733_FBLN1_chr22_45946372_ENST00000442170_length(amino acids)=291AA_BP=214
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:47193517/chr22:45946372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBLN1

P23142

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215525_578524.3333333333334684.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217525_578524.3333333333334704.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215525_578524.3333333333334567.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215525_578524.3333333333334684.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217525_578524.3333333333334704.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215525_578524.3333333333334567.0DomainEGF-like 9%3B calcium-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D22Achr22:47193517chr22:45946371ENST00000337137+413222_446212.33333333333334518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:45946371ENST00000355704+111222_4460440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:45946371ENST00000380995+49222_446165.33333333333334325.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:45946372ENST00000337137+413222_446212.33333333333334518.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:45946372ENST00000355704+111222_4460440.0DomainRab-GAP TBC
HgeneTBC1D22Achr22:47193517chr22:45946372ENST00000380995+49222_446165.33333333333334325.0DomainRab-GAP TBC
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215112_144524.3333333333334684.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215176_215524.3333333333334684.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215216_261524.3333333333334684.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215262_307524.3333333333334684.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215308_355524.3333333333334684.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215356_398524.3333333333334684.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000262722121536_76524.3333333333334684.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215399_440524.3333333333334684.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215441_480524.3333333333334684.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215481_524524.3333333333334684.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000262722121577_111524.3333333333334684.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217112_144524.3333333333334704.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217176_215524.3333333333334704.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217216_261524.3333333333334704.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217262_307524.3333333333334704.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217308_355524.3333333333334704.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217356_398524.3333333333334704.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000327858121736_76524.3333333333334704.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217399_440524.3333333333334704.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217441_480524.3333333333334704.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217481_524524.3333333333334704.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000327858121777_111524.3333333333334704.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215112_144524.3333333333334567.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215176_215524.3333333333334567.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215216_261524.3333333333334567.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215262_307524.3333333333334567.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215308_355524.3333333333334567.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215356_398524.3333333333334567.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000340923121536_76524.3333333333334567.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215399_440524.3333333333334567.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215441_480524.3333333333334567.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215481_524524.3333333333334567.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946371ENST00000340923121577_111524.3333333333334567.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215112_144524.3333333333334684.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215176_215524.3333333333334684.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215216_261524.3333333333334684.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215262_307524.3333333333334684.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215308_355524.3333333333334684.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215356_398524.3333333333334684.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000262722121536_76524.3333333333334684.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215399_440524.3333333333334684.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215441_480524.3333333333334684.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215481_524524.3333333333334684.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000262722121577_111524.3333333333334684.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217112_144524.3333333333334704.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217176_215524.3333333333334704.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217216_261524.3333333333334704.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217262_307524.3333333333334704.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217308_355524.3333333333334704.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217356_398524.3333333333334704.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000327858121736_76524.3333333333334704.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217399_440524.3333333333334704.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217441_480524.3333333333334704.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217481_524524.3333333333334704.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000327858121777_111524.3333333333334704.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215112_144524.3333333333334567.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215176_215524.3333333333334567.0DomainEGF-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215216_261524.3333333333334567.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215262_307524.3333333333334567.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215308_355524.3333333333334567.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215356_398524.3333333333334567.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000340923121536_76524.3333333333334567.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215399_440524.3333333333334567.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215441_480524.3333333333334567.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215481_524524.3333333333334567.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:47193517chr22:45946372ENST00000340923121577_111524.3333333333334567.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:47193517chr22:45946371ENST000002627221215356_440524.3333333333334684.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003278581217356_440524.3333333333334704.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:47193517chr22:45946371ENST000003409231215356_440524.3333333333334567.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000002627221215356_440524.3333333333334684.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003278581217356_440524.3333333333334704.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:47193517chr22:45946372ENST000003409231215356_440524.3333333333334567.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>789_TBC1D22A_47193517_FBLN1_45946372_ranked_0.pdbTBC1D22A4719351747193517ENST00000340923FBLN1chr2245946372+
MAPPGWGKTRLAVLGSRDSSGVSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAES
LNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGG
TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGS
SKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPF
393


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TBC1D22A_pLDDT.png
all structure
all structure
FBLN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TBC1D22A
FBLN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TBC1D22A-FBLN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TBC1D22A-FBLN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource