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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TLK1-CREG2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TLK1-CREG2
	FusionPDB ID: 91139
	FusionGDB2.0 ID: 91139
		Hgene	Tgene
	Gene symbol	TLK1	CREG2
	Gene ID	9874	200407
	Gene name	tousled like kinase 1	cellular repressor of E1A stimulated genes 2
	Synonyms	PKU-beta	-
	Cytomap	2q31.1	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase tousled-like 1SNARE protein kinase SNAKserine threonine protein kinase	protein CREG2
	Modification date	20200329	20200313
	UniProtAcc	.	Q8IUH2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000360843, ENST00000431350, ENST00000434911, ENST00000442919, ENST00000521943, ENST00000486857,	ENST00000495455, ENST00000324768,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 15 X 6=1170	3 X 2 X 4=24
	# samples	18	5
	** MAII score	log2(18/1170*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TLK1 [Title/Abstract] AND CREG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TLK1(171902684)-CREG2(101971828), # samples:3
Anticipated loss of major functional domain due to fusion event.	TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TLK1-CREG2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. TLK1-CREG2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TLK1	GO:0001672	regulation of chromatin assembly or disassembly	12660173
Hgene	TLK1	GO:0006468	protein phosphorylation	12660173
Hgene	TLK1	GO:0006886	intracellular protein transport	10588641
Hgene	TLK1	GO:0035556	intracellular signal transduction	12660173

Fusion gene breakpoints across TLK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-46-6025-01A	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-
ChimerDB4	LUSC	TCGA-46-6025	TLK1	chr2	171902683	-	CREG2	chr2	101971828	-
ChimerDB4	LUSC	TCGA-46-6025	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360843	TLK1	chr2	171902684	-	ENST00000324768	CREG2	chr2	101971828	-	7271	1637	402	1898	498
ENST00000431350	TLK1	chr2	171902684	-	ENST00000324768	CREG2	chr2	101971828	-	7208	1574	402	1835	477
ENST00000442919	TLK1	chr2	171902684	-	ENST00000324768	CREG2	chr2	101971828	-	7275	1641	469	1902	477
ENST00000434911	TLK1	chr2	171902684	-	ENST00000324768	CREG2	chr2	101971828	-	6605	971	90	1232	380
ENST00000360843	TLK1	chr2	171902683	-	ENST00000324768	CREG2	chr2	101971828	-	7271	1637	402	1898	498
ENST00000431350	TLK1	chr2	171902683	-	ENST00000324768	CREG2	chr2	101971828	-	7208	1574	402	1835	477
ENST00000442919	TLK1	chr2	171902683	-	ENST00000324768	CREG2	chr2	101971828	-	7275	1641	469	1902	477
ENST00000434911	TLK1	chr2	171902683	-	ENST00000324768	CREG2	chr2	101971828	-	6605	971	90	1232	380

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360843	ENST00000324768	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-	0.000787864	0.99921215
ENST00000431350	ENST00000324768	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-	0.000985392	0.9990146
ENST00000442919	ENST00000324768	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-	0.001017246	0.9989827
ENST00000434911	ENST00000324768	TLK1	chr2	171902684	-	CREG2	chr2	101971828	-	0.00064855	0.99935144
ENST00000360843	ENST00000324768	TLK1	chr2	171902683	-	CREG2	chr2	101971828	-	0.000787864	0.99921215
ENST00000431350	ENST00000324768	TLK1	chr2	171902683	-	CREG2	chr2	101971828	-	0.000985392	0.9990146
ENST00000442919	ENST00000324768	TLK1	chr2	171902683	-	CREG2	chr2	101971828	-	0.001017246	0.9989827
ENST00000434911	ENST00000324768	TLK1	chr2	171902683	-	CREG2	chr2	101971828	-	0.00064855	0.99935144

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91139_91139_1_TLK1-CREG2_TLK1_chr2_171902683_ENST00000360843_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=498AA_BP=412
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGFPNLPVFQSLAYWEMGRTAGGKSIGGRGHKISDYFEYQGGNGS
SPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCD
LRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQRED
IERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSR

--------------------------------------------------------------

>91139_91139_2_TLK1-CREG2_TLK1_chr2_171902683_ENST00000431350_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=477AA_BP=391
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHST
PSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNK
CISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQA
PSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIE

--------------------------------------------------------------

>91139_91139_3_TLK1-CREG2_TLK1_chr2_171902683_ENST00000434911_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=380AA_BP=294
MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRP
NSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK
LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEP
KQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIEHIWLQKW

--------------------------------------------------------------

>91139_91139_4_TLK1-CREG2_TLK1_chr2_171902683_ENST00000442919_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=477AA_BP=391
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHST
PSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNK
CISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQA
PSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIE

--------------------------------------------------------------

>91139_91139_5_TLK1-CREG2_TLK1_chr2_171902684_ENST00000360843_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=498AA_BP=412
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGFPNLPVFQSLAYWEMGRTAGGKSIGGRGHKISDYFEYQGGNGS
SPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCD
LRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQRED
IERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSR

--------------------------------------------------------------

>91139_91139_6_TLK1-CREG2_TLK1_chr2_171902684_ENST00000431350_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=477AA_BP=391
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHST
PSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNK
CISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQA
PSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIE

--------------------------------------------------------------

>91139_91139_7_TLK1-CREG2_TLK1_chr2_171902684_ENST00000434911_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=380AA_BP=294
MAVLFLYDLKTTGKTPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRP
NSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKK
LLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEP
KQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIEHIWLQKW

--------------------------------------------------------------

>91139_91139_8_TLK1-CREG2_TLK1_chr2_171902684_ENST00000442919_CREG2_chr2_101971828_ENST00000324768_length(amino acids)=477AA_BP=391
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHST
PSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNK
CISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQA
PSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:171902684/chr2:101971828)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CREG2 Q8IUH2
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000360843

230_281

410.6666666666667

788.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000431350

230_281

389.6666666666667

767.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000434911

230_281

293.6666666666667

671.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000442919

230_281

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000521943

230_281

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000360843

230_281

410.6666666666667

788.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000431350

230_281

389.6666666666667

767.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000434911

230_281

293.6666666666667

671.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000442919

230_281

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000521943

230_281

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000360843

397_445

410.6666666666667

788.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000431350

397_445

389.6666666666667

767.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000434911

397_445

293.6666666666667

671.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000442919

397_445

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000521943

397_445

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000360843

397_445

410.6666666666667

788.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000431350

397_445

389.6666666666667

767.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000434911

397_445

293.6666666666667

671.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000442919

397_445

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000521943

397_445

341.6666666666667

719.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000360843

456_734

410.6666666666667

788.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000431350

456_734

389.6666666666667

767.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000434911

456_734

293.6666666666667

671.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000442919

456_734

341.6666666666667

719.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000521943

456_734

341.6666666666667

719.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000360843

456_734

410.6666666666667

788.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000431350

456_734

389.6666666666667

767.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000434911

456_734

293.6666666666667

671.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000442919

456_734

341.6666666666667

719.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000521943

456_734

341.6666666666667

719.0

Domain

Protein kinase

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000360843

462_470

410.6666666666667

788.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000431350

462_470

389.6666666666667

767.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000434911

462_470

293.6666666666667

671.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000442919

462_470

341.6666666666667

719.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902683

chr2:101971828

ENST00000521943

462_470

341.6666666666667

719.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000360843

462_470

410.6666666666667

788.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000431350

462_470

389.6666666666667

767.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000434911

462_470

293.6666666666667

671.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000442919

462_470

341.6666666666667

719.0

Nucleotide binding

ATP

Hgene

TLK1

chr2:171902684

chr2:101971828

ENST00000521943

462_470

341.6666666666667

719.0

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1060_TLK1_171902684_CREG2_101971828_1060_TLK1_171902684_CREG2_101971828_ranked_0.pdb	TLK1	171902683	171902684	ENST00000324768	CREG2	chr2	101971828	-	MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST NNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGFPNLPVFQSLAYWEMGRTAGGKSIGGRGHKISDYFEYQGGNGS SPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCD LRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQRED IERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLKNIVDPEDPRCVQLTLTGQMIAVSPEEVEFAKQAMFSR	498

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TLK1_pLDDT.png

CREG2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TLK1
CREG2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TLK1-CREG2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TLK1-CREG2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source