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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TLK2-CEP112

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TLK2-CEP112
FusionPDB ID: 91152
FusionGDB2.0 ID: 91152
HgeneTgene
Gene symbol

TLK2

CEP112

Gene ID

11011

201134

Gene nametousled like kinase 2centrosomal protein 112
SynonymsHsHPK|MRD57|PKU-ALPHACCDC46|MACOCO
Cytomap

17q23.2

17q24.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 2centrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46
Modification date2020031320200313
UniProtAcc.

Q8N8E3

Ensembl transtripts involved in fusion geneENST idsENST00000326270, ENST00000343388, 
ENST00000346027, ENST00000542523, 
ENST00000582809, ENST00000577616, 
ENST00000580482, ENST00000317442, 
ENST00000392769, ENST00000535342, 
ENST00000537949, ENST00000541355, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 11 X 9=178222 X 17 X 10=3740
# samples 2421
** MAII scorelog2(24/1782*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/3740*10)=-4.15457703710888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TLK2 [Title/Abstract] AND CEP112 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TLK2(60685509)-CEP112(63685336), # samples:3
Anticipated loss of major functional domain due to fusion event.TLK2-CEP112 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-CEP112 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK2

GO:0006468

protein phosphorylation

12660173

HgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

HgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

HgeneTLK2

GO:0035556

intracellular signal transduction

12660173

HgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173


check buttonFusion gene breakpoints across TLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP112 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JS-01ATLK2chr17

60685509

+CEP112chr17

63685336

-
ChimerDB4ACCTCGA-OR-A5JSTLK2chr17

60685509

+CEP112chr17

63685336

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000582809TLK2chr1760685509+ENST00000535342CEP112chr1763685336-302923353702595741
ENST00000582809TLK2chr1760685509+ENST00000392769CEP112chr1763685336-302623353702595741
ENST00000582809TLK2chr1760685509+ENST00000541355CEP112chr1763685336-274623353702595741
ENST00000582809TLK2chr1760685509+ENST00000537949CEP112chr1763685336-265423353702595741
ENST00000582809TLK2chr1760685509+ENST00000317442CEP112chr1763685336-275123353702595741
ENST00000326270TLK2chr1760685509+ENST00000535342CEP112chr1763685336-310724131212673850
ENST00000326270TLK2chr1760685509+ENST00000392769CEP112chr1763685336-310424131212673850
ENST00000326270TLK2chr1760685509+ENST00000541355CEP112chr1763685336-282424131212673850
ENST00000326270TLK2chr1760685509+ENST00000537949CEP112chr1763685336-273224131212673850
ENST00000326270TLK2chr1760685509+ENST00000317442CEP112chr1763685336-282924131212673850
ENST00000346027TLK2chr1760685509+ENST00000535342CEP112chr1763685336-304423501212610829
ENST00000346027TLK2chr1760685509+ENST00000392769CEP112chr1763685336-304123501212610829
ENST00000346027TLK2chr1760685509+ENST00000541355CEP112chr1763685336-276123501212610829
ENST00000346027TLK2chr1760685509+ENST00000537949CEP112chr1763685336-266923501212610829
ENST00000346027TLK2chr1760685509+ENST00000317442CEP112chr1763685336-276623501212610829
ENST00000343388TLK2chr1760685509+ENST00000535342CEP112chr1763685336-28232129502389779
ENST00000343388TLK2chr1760685509+ENST00000392769CEP112chr1763685336-28202129502389779
ENST00000343388TLK2chr1760685509+ENST00000541355CEP112chr1763685336-25402129502389779
ENST00000343388TLK2chr1760685509+ENST00000537949CEP112chr1763685336-24482129502389779
ENST00000343388TLK2chr1760685509+ENST00000317442CEP112chr1763685336-25452129502389779
ENST00000542523TLK2chr1760685509+ENST00000535342CEP112chr1763685336-27022008252268747
ENST00000542523TLK2chr1760685509+ENST00000392769CEP112chr1763685336-26992008252268747
ENST00000542523TLK2chr1760685509+ENST00000541355CEP112chr1763685336-24192008252268747
ENST00000542523TLK2chr1760685509+ENST00000537949CEP112chr1763685336-23272008252268747
ENST00000542523TLK2chr1760685509+ENST00000317442CEP112chr1763685336-24242008252268747

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582809ENST00000535342TLK2chr1760685509+CEP112chr1763685336-0.0014617580.99853826
ENST00000582809ENST00000392769TLK2chr1760685509+CEP112chr1763685336-0.0014792890.9985207
ENST00000582809ENST00000541355TLK2chr1760685509+CEP112chr1763685336-0.0027506440.9972493
ENST00000582809ENST00000537949TLK2chr1760685509+CEP112chr1763685336-0.0029729920.997027
ENST00000582809ENST00000317442TLK2chr1760685509+CEP112chr1763685336-0.0027417290.9972582
ENST00000326270ENST00000535342TLK2chr1760685509+CEP112chr1763685336-0.000211850.9997881
ENST00000326270ENST00000392769TLK2chr1760685509+CEP112chr1763685336-0.0002162210.9997838
ENST00000326270ENST00000541355TLK2chr1760685509+CEP112chr1763685336-0.000360920.99963903
ENST00000326270ENST00000537949TLK2chr1760685509+CEP112chr1763685336-0.0003808330.9996191
ENST00000326270ENST00000317442TLK2chr1760685509+CEP112chr1763685336-0.0003613310.9996387
ENST00000346027ENST00000535342TLK2chr1760685509+CEP112chr1763685336-0.0002619580.99973804
ENST00000346027ENST00000392769TLK2chr1760685509+CEP112chr1763685336-0.0002673440.9997327
ENST00000346027ENST00000541355TLK2chr1760685509+CEP112chr1763685336-0.0004465970.9995534
ENST00000346027ENST00000537949TLK2chr1760685509+CEP112chr1763685336-0.0004715850.9995284
ENST00000346027ENST00000317442TLK2chr1760685509+CEP112chr1763685336-0.0004461930.99955374
ENST00000343388ENST00000535342TLK2chr1760685509+CEP112chr1763685336-0.0003974310.9996026
ENST00000343388ENST00000392769TLK2chr1760685509+CEP112chr1763685336-0.0004036840.9995963
ENST00000343388ENST00000541355TLK2chr1760685509+CEP112chr1763685336-0.0007207010.9992793
ENST00000343388ENST00000537949TLK2chr1760685509+CEP112chr1763685336-0.0007767360.99922323
ENST00000343388ENST00000317442TLK2chr1760685509+CEP112chr1763685336-0.0007227810.9992772
ENST00000542523ENST00000535342TLK2chr1760685509+CEP112chr1763685336-0.0004040610.99959594
ENST00000542523ENST00000392769TLK2chr1760685509+CEP112chr1763685336-0.0004106690.9995894
ENST00000542523ENST00000541355TLK2chr1760685509+CEP112chr1763685336-0.0007682980.9992317
ENST00000542523ENST00000537949TLK2chr1760685509+CEP112chr1763685336-0.0008362270.99916375
ENST00000542523ENST00000317442TLK2chr1760685509+CEP112chr1763685336-0.0007688720.9992311

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91152_91152_1_TLK2-CEP112_TLK2_chr17_60685509_ENST00000326270_CEP112_chr17_63685336_ENST00000317442_length(amino acids)=850AA_BP=764
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM

--------------------------------------------------------------

>91152_91152_2_TLK2-CEP112_TLK2_chr17_60685509_ENST00000326270_CEP112_chr17_63685336_ENST00000392769_length(amino acids)=850AA_BP=764
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM

--------------------------------------------------------------

>91152_91152_3_TLK2-CEP112_TLK2_chr17_60685509_ENST00000326270_CEP112_chr17_63685336_ENST00000535342_length(amino acids)=850AA_BP=764
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM

--------------------------------------------------------------

>91152_91152_4_TLK2-CEP112_TLK2_chr17_60685509_ENST00000326270_CEP112_chr17_63685336_ENST00000537949_length(amino acids)=850AA_BP=764
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM

--------------------------------------------------------------

>91152_91152_5_TLK2-CEP112_TLK2_chr17_60685509_ENST00000326270_CEP112_chr17_63685336_ENST00000541355_length(amino acids)=850AA_BP=764
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM

--------------------------------------------------------------

>91152_91152_6_TLK2-CEP112_TLK2_chr17_60685509_ENST00000343388_CEP112_chr17_63685336_ENST00000317442_length(amino acids)=779AA_BP=693
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELES

--------------------------------------------------------------

>91152_91152_7_TLK2-CEP112_TLK2_chr17_60685509_ENST00000343388_CEP112_chr17_63685336_ENST00000392769_length(amino acids)=779AA_BP=693
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELES

--------------------------------------------------------------

>91152_91152_8_TLK2-CEP112_TLK2_chr17_60685509_ENST00000343388_CEP112_chr17_63685336_ENST00000535342_length(amino acids)=779AA_BP=693
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELES

--------------------------------------------------------------

>91152_91152_9_TLK2-CEP112_TLK2_chr17_60685509_ENST00000343388_CEP112_chr17_63685336_ENST00000537949_length(amino acids)=779AA_BP=693
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELES

--------------------------------------------------------------

>91152_91152_10_TLK2-CEP112_TLK2_chr17_60685509_ENST00000343388_CEP112_chr17_63685336_ENST00000541355_length(amino acids)=779AA_BP=693
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG
KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELES

--------------------------------------------------------------

>91152_91152_11_TLK2-CEP112_TLK2_chr17_60685509_ENST00000346027_CEP112_chr17_63685336_ENST00000317442_length(amino acids)=829AA_BP=743
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ
ENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNF

--------------------------------------------------------------

>91152_91152_12_TLK2-CEP112_TLK2_chr17_60685509_ENST00000346027_CEP112_chr17_63685336_ENST00000392769_length(amino acids)=829AA_BP=743
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ
ENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNF

--------------------------------------------------------------

>91152_91152_13_TLK2-CEP112_TLK2_chr17_60685509_ENST00000346027_CEP112_chr17_63685336_ENST00000535342_length(amino acids)=829AA_BP=743
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ
ENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNF

--------------------------------------------------------------

>91152_91152_14_TLK2-CEP112_TLK2_chr17_60685509_ENST00000346027_CEP112_chr17_63685336_ENST00000537949_length(amino acids)=829AA_BP=743
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ
ENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNF

--------------------------------------------------------------

>91152_91152_15_TLK2-CEP112_TLK2_chr17_60685509_ENST00000346027_CEP112_chr17_63685336_ENST00000541355_length(amino acids)=829AA_BP=743
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQ
ENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQVNF

--------------------------------------------------------------

>91152_91152_16_TLK2-CEP112_TLK2_chr17_60685509_ENST00000542523_CEP112_chr17_63685336_ENST00000317442_length(amino acids)=747AA_BP=661
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN
QSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS

--------------------------------------------------------------

>91152_91152_17_TLK2-CEP112_TLK2_chr17_60685509_ENST00000542523_CEP112_chr17_63685336_ENST00000392769_length(amino acids)=747AA_BP=661
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN
QSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS

--------------------------------------------------------------

>91152_91152_18_TLK2-CEP112_TLK2_chr17_60685509_ENST00000542523_CEP112_chr17_63685336_ENST00000535342_length(amino acids)=747AA_BP=661
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN
QSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS

--------------------------------------------------------------

>91152_91152_19_TLK2-CEP112_TLK2_chr17_60685509_ENST00000542523_CEP112_chr17_63685336_ENST00000537949_length(amino acids)=747AA_BP=661
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN
QSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS

--------------------------------------------------------------

>91152_91152_20_TLK2-CEP112_TLK2_chr17_60685509_ENST00000542523_CEP112_chr17_63685336_ENST00000541355_length(amino acids)=747AA_BP=661
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN
QSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTIS

--------------------------------------------------------------

>91152_91152_21_TLK2-CEP112_TLK2_chr17_60685509_ENST00000582809_CEP112_chr17_63685336_ENST00000317442_length(amino acids)=741AA_BP=655
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI
LQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV

--------------------------------------------------------------

>91152_91152_22_TLK2-CEP112_TLK2_chr17_60685509_ENST00000582809_CEP112_chr17_63685336_ENST00000392769_length(amino acids)=741AA_BP=655
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI
LQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV

--------------------------------------------------------------

>91152_91152_23_TLK2-CEP112_TLK2_chr17_60685509_ENST00000582809_CEP112_chr17_63685336_ENST00000535342_length(amino acids)=741AA_BP=655
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI
LQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV

--------------------------------------------------------------

>91152_91152_24_TLK2-CEP112_TLK2_chr17_60685509_ENST00000582809_CEP112_chr17_63685336_ENST00000537949_length(amino acids)=741AA_BP=655
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI
LQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV

--------------------------------------------------------------

>91152_91152_25_TLK2-CEP112_TLK2_chr17_60685509_ENST00000582809_CEP112_chr17_63685336_ENST00000541355_length(amino acids)=741AA_BP=655
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDI
LQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLMPASLRQELEDTISSLKSQV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:60685509/chr17:63685336)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP112

Q8N8E3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK2chr17:60685509chr17:63685336ENST00000326270+2223225_276715.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000326270+2223317_347715.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000326270+2223403_451715.0773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000343388+2021225_276661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000343388+2021317_347661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000343388+2021403_451661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000346027+2122225_276693.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000346027+2122317_347693.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000346027+2122403_451693.0751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000542523+2021225_276661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000542523+2021317_347661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000542523+2021403_451661.0719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60685509chr17:63685336ENST00000326270+2223468_476715.0773.0Nucleotide bindingATP
HgeneTLK2chr17:60685509chr17:63685336ENST00000343388+2021468_476661.0719.0Nucleotide bindingATP
HgeneTLK2chr17:60685509chr17:63685336ENST00000346027+2122468_476693.0751.0Nucleotide bindingATP
HgeneTLK2chr17:60685509chr17:63685336ENST00000542523+2021468_476661.0719.0Nucleotide bindingATP
TgeneCEP112chr17:60685509chr17:63685336ENST0000031744227277_954125.0212.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK2chr17:60685509chr17:63685336ENST00000326270+2223462_741715.0773.0DomainProtein kinase
HgeneTLK2chr17:60685509chr17:63685336ENST00000343388+2021462_741661.0719.0DomainProtein kinase
HgeneTLK2chr17:60685509chr17:63685336ENST00000346027+2122462_741693.0751.0DomainProtein kinase
HgeneTLK2chr17:60685509chr17:63685336ENST00000542523+2021462_741661.0719.0DomainProtein kinase
TgeneCEP112chr17:60685509chr17:63685336ENST000003927692227277_954869.0956.0Coiled coilOntology_term=ECO:0000255
TgeneCEP112chr17:60685509chr17:63685336ENST000005353422227277_954869.0956.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1632_TLK2_60685509_CEP112_63685336_ranked_0.pdbTLK26068550960685509ENST00000317442CEP112chr1763685336-
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIF
YQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETKLKGLM
850


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TLK2_pLDDT.png
all structure
all structure
CEP112_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TLK2
CEP112


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TLK2-CEP112


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TLK2-CEP112


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource