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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TOP2A-IKZF3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TOP2A-IKZF3
FusionPDB ID: 93084
FusionGDB2.0 ID: 93084
HgeneTgene
Gene symbol

TOP2A

IKZF3

Gene ID

7153

22806

Gene nameDNA topoisomerase II alphaIKAROS family zinc finger 3
SynonymsTOP2|TP2AAIO|AIOLOS|ZNFN1A3
Cytomap

17q21.2

17q12-q21.1

Type of geneprotein-codingprotein-coding
DescriptionDNA topoisomerase 2-alphaDNA gyraseDNA topoisomerase (ATP-hydrolyzing)DNA topoisomerase II, 170 kDDNA topoisomerase II, alpha isozymetopoisomerase (DNA) II alpha 170kDazinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2020032220200327
UniProtAcc.

Q9UKT9

Ensembl transtripts involved in fusion geneENST idsENST00000423485, ENST00000346872, 
ENST00000377944, ENST00000377945, 
ENST00000377952, ENST00000377958, 
ENST00000394189, ENST00000439016, 
ENST00000439167, ENST00000535189, 
ENST00000583368, ENST00000346243, 
ENST00000350532, ENST00000351680, 
ENST00000467757, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 12 X 7=67234 X 12 X 14=5712
# samples 1349
** MAII scorelog2(13/672*10)=-2.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(49/5712*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TOP2A [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TOP2A(38567361)-IKZF3(37922746), # samples:2
TOP2A(38567360)-IKZF3(37922746), # samples:2
TOP2A(38567605)-IKZF3(37922746), # samples:2
Anticipated loss of major functional domain due to fusion event.TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
TOP2A-IKZF3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTOP2A

GO:0006265

DNA topological change

22323612

HgeneTOP2A

GO:0006266

DNA ligation

15491148

HgeneTOP2A

GO:0006974

cellular response to DNA damage stimulus

16611985

HgeneTOP2A

GO:0030263

apoptotic chromosome condensation

10959840

HgeneTOP2A

GO:0043065

positive regulation of apoptotic process

16611985


check buttonFusion gene breakpoints across TOP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IKZF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AF-A56L-01ATOP2Achr17

38567361

-IKZF3chr17

37922746

-
ChimerDB4READTCGA-AF-A56LTOP2Achr17

38567360

-IKZF3chr17

37922746

-
ChimerDB4READTCGA-AF-A56LTOP2Achr17

38567361

-IKZF3chr17

37922746

-
ChimerDB4READTCGA-AF-A56LTOP2Achr17

38567605

-IKZF3chr17

37922746

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423485TOP2Achr1738567361-ENST00000346243IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567361-ENST00000350532IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567361-ENST00000351680IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567361-ENST00000467757IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567360-ENST00000346243IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567360-ENST00000350532IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567360-ENST00000351680IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567360-ENST00000467757IKZF3chr1737922746-206613621351445436
ENST00000423485TOP2Achr1738567605-ENST00000346243IKZF3chr1737922746-192812241351307390
ENST00000423485TOP2Achr1738567605-ENST00000350532IKZF3chr1737922746-192812241351307390
ENST00000423485TOP2Achr1738567605-ENST00000351680IKZF3chr1737922746-192812241351307390
ENST00000423485TOP2Achr1738567605-ENST00000467757IKZF3chr1737922746-192812241351307390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423485ENST00000346243TOP2Achr1738567361-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000350532TOP2Achr1738567361-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000351680TOP2Achr1738567361-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000467757TOP2Achr1738567361-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000346243TOP2Achr1738567360-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000350532TOP2Achr1738567360-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000351680TOP2Achr1738567360-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000467757TOP2Achr1738567360-IKZF3chr1737922746-0.000666520.99933344
ENST00000423485ENST00000346243TOP2Achr1738567605-IKZF3chr1737922746-0.0005191530.9994809
ENST00000423485ENST00000350532TOP2Achr1738567605-IKZF3chr1737922746-0.0005191530.9994809
ENST00000423485ENST00000351680TOP2Achr1738567605-IKZF3chr1737922746-0.0005191530.9994809
ENST00000423485ENST00000467757TOP2Achr1738567605-IKZF3chr1737922746-0.0005191530.9994809

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93084_93084_1_TOP2A-IKZF3_TOP2A_chr17_38567360_ENST00000423485_IKZF3_chr17_37922746_ENST00000346243_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_2_TOP2A-IKZF3_TOP2A_chr17_38567360_ENST00000423485_IKZF3_chr17_37922746_ENST00000350532_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_3_TOP2A-IKZF3_TOP2A_chr17_38567360_ENST00000423485_IKZF3_chr17_37922746_ENST00000351680_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_4_TOP2A-IKZF3_TOP2A_chr17_38567360_ENST00000423485_IKZF3_chr17_37922746_ENST00000467757_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_5_TOP2A-IKZF3_TOP2A_chr17_38567361_ENST00000423485_IKZF3_chr17_37922746_ENST00000346243_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_6_TOP2A-IKZF3_TOP2A_chr17_38567361_ENST00000423485_IKZF3_chr17_37922746_ENST00000350532_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_7_TOP2A-IKZF3_TOP2A_chr17_38567361_ENST00000423485_IKZF3_chr17_37922746_ENST00000351680_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_8_TOP2A-IKZF3_TOP2A_chr17_38567361_ENST00000423485_IKZF3_chr17_37922746_ENST00000467757_length(amino acids)=436AA_BP=409
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_9_TOP2A-IKZF3_TOP2A_chr17_38567605_ENST00000423485_IKZF3_chr17_37922746_ENST00000346243_length(amino acids)=390AA_BP=362
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_10_TOP2A-IKZF3_TOP2A_chr17_38567605_ENST00000423485_IKZF3_chr17_37922746_ENST00000350532_length(amino acids)=390AA_BP=362
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_11_TOP2A-IKZF3_TOP2A_chr17_38567605_ENST00000423485_IKZF3_chr17_37922746_ENST00000351680_length(amino acids)=390AA_BP=362
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

>93084_93084_12_TOP2A-IKZF3_TOP2A_chr17_38567605_ENST00000423485_IKZF3_chr17_37922746_ENST00000467757_length(amino acids)=390AA_BP=362
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38567361/chr17:37922746)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IKZF3

Q9UKT9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-1035148_150401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-1035161_168401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-1035376_378401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-1035148_150401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-1035161_168401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-1035376_378401.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-935148_150355.01532.0Nucleotide bindingATP
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-935161_168355.01532.0Nucleotide bindingATP
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346202_224197.33333333333334432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346452_474197.33333333333334432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346480_504197.33333333333334432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268452_474275.3333333333333510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268480_504275.3333333333333510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446146_168132.33333333333334367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446174_196132.33333333333334367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446202_224132.33333333333334367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446452_474132.33333333333334367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446480_504132.33333333333334367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535146_168141.33333333333334376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535174_196141.33333333333334376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535202_224141.33333333333334376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535452_474141.33333333333334376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535480_504141.33333333333334376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224118_14054.333333333333336289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224146_16854.333333333333336289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224174_19654.333333333333336289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224452_47454.333333333333336289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795224480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857202_224188.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857452_474188.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857480_504188.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935118_14093.33333333333333328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935146_16893.33333333333333328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935174_19693.33333333333333328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935202_22493.33333333333333328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935452_47493.33333333333333328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000039418935480_50493.33333333333333328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646202_224180.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646452_474180.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646480_504180.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746202_224202.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746452_474202.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746480_504202.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757452_474219.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757480_504219.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957452_474241.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957480_504241.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346202_224197.33333333333334432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346452_474197.33333333333334432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346480_504197.33333333333334432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268452_474275.3333333333333510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268480_504275.3333333333333510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446146_168132.33333333333334367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446174_196132.33333333333334367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446202_224132.33333333333334367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446452_474132.33333333333334367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446480_504132.33333333333334367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535146_168141.33333333333334376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535174_196141.33333333333334376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535202_224141.33333333333334376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535452_474141.33333333333334376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535480_504141.33333333333334376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224118_14054.333333333333336289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224146_16854.333333333333336289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224174_19654.333333333333336289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224452_47454.333333333333336289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795224480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857202_224188.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857452_474188.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857480_504188.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935118_14093.33333333333333328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935146_16893.33333333333333328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935174_19693.33333333333333328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935202_22493.33333333333333328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935452_47493.33333333333333328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000039418935480_50493.33333333333333328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646202_224180.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646452_474180.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646480_504180.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746202_224202.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746452_474202.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746480_504202.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757452_474219.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757480_504219.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957452_474241.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957480_504241.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346202_224197.33333333333334432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346452_474197.33333333333334432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346480_504197.33333333333334432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268452_474275.3333333333333510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268480_504275.3333333333333510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057452_474236.33333333333334471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057480_504236.33333333333334471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446146_168132.33333333333334367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446174_196132.33333333333334367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446202_224132.33333333333334367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446452_474132.33333333333334367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446480_504132.33333333333334367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535146_168141.33333333333334376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535174_196141.33333333333334376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535202_224141.33333333333334376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535452_474141.33333333333334376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535480_504141.33333333333334376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224118_14054.333333333333336289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224146_16854.333333333333336289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224174_19654.333333333333336289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224202_22454.333333333333336289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224452_47454.333333333333336289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795224480_50454.333333333333336289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857202_224188.33333333333334423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857452_474188.33333333333334423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857480_504188.33333333333334423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935118_14093.33333333333333328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935146_16893.33333333333333328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935174_19693.33333333333333328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935202_22493.33333333333333328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935452_47493.33333333333333328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000039418935480_50493.33333333333333328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646202_224180.33333333333334415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646452_474180.33333333333334415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646480_504180.33333333333334415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746202_224202.33333333333334437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746452_474202.33333333333334437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746480_504202.33333333333334437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757452_474219.33333333333334454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757480_504219.33333333333334454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957452_474241.33333333333334476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957480_504241.33333333333334476.0Zinc fingerC2H2-type 6%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-1035455_572401.01532.0DomainToprim
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-1035455_572401.01532.0DomainToprim
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-935455_572355.01532.0DomainToprim
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-10351018_1028401.01532.0MotifNote=Nuclear export signal
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-10351018_1028401.01532.0MotifNote=Nuclear export signal
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-9351018_1028355.01532.0MotifNote=Nuclear export signal
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-935376_378355.01532.0Nucleotide bindingATP
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346118_140197.33333333333334432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346146_168197.33333333333334432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034624346174_196197.33333333333334432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268118_140275.3333333333333510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268146_168275.3333333333333510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268174_196275.3333333333333510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000034687268202_224275.3333333333333510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035053257202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000035168057202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794446118_140132.33333333333334367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037794535118_140141.33333333333334376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857118_140188.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857146_168188.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000037795857174_196188.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646118_140180.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646146_168180.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043901646174_196180.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746118_140202.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746146_168202.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000043916746174_196202.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757118_140219.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757146_168219.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757174_196219.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000046775757202_224219.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957118_140241.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957146_168241.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957174_196241.33333333333334476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567360chr17:37922746ENST0000053518957202_224241.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346118_140197.33333333333334432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346146_168197.33333333333334432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034624346174_196197.33333333333334432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268118_140275.3333333333333510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268146_168275.3333333333333510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268174_196275.3333333333333510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000034687268202_224275.3333333333333510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035053257202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000035168057202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794446118_140132.33333333333334367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037794535118_140141.33333333333334376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857118_140188.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857146_168188.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000037795857174_196188.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646118_140180.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646146_168180.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043901646174_196180.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746118_140202.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746146_168202.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000043916746174_196202.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757118_140219.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757146_168219.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757174_196219.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000046775757202_224219.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957118_140241.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957146_168241.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957174_196241.33333333333334476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567361chr17:37922746ENST0000053518957202_224241.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346118_140197.33333333333334432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346146_168197.33333333333334432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034624346174_196197.33333333333334432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268118_140275.3333333333333510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268146_168275.3333333333333510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268174_196275.3333333333333510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000034687268202_224275.3333333333333510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035053257202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057118_140236.33333333333334471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057146_168236.33333333333334471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057174_196236.33333333333334471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000035168057202_224236.33333333333334471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794446118_140132.33333333333334367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037794535118_140141.33333333333334376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857118_140188.33333333333334423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857146_168188.33333333333334423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000037795857174_196188.33333333333334423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646118_140180.33333333333334415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646146_168180.33333333333334415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043901646174_196180.33333333333334415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746118_140202.33333333333334437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746146_168202.33333333333334437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000043916746174_196202.33333333333334437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757118_140219.33333333333334454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757146_168219.33333333333334454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757174_196219.33333333333334454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000046775757202_224219.33333333333334454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957118_140241.33333333333334476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957146_168241.33333333333334476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957174_196241.33333333333334476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr17:38567605chr17:37922746ENST0000053518957202_224241.33333333333334476.0Zinc fingerC2H2-type 4%3B atypical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>912_TOP2A_38567361_IKZF3_37922746_912_TOP2A_38567361_IKZF3_37922746_ranked_0.pdbTOP2A3856760538567361ENST00000467757IKZF3chr1737922746-
MSPFTTVTMEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLY
KIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNI
FSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKL
PVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVK
436


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TOP2A_pLDDT.png
all structure
all structure
IKZF3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TOP2A
IKZF3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-1035990_999401.01532.0DNA
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-1035990_999401.01532.0DNA
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-935990_999355.01532.0DNA
HgeneTOP2Achr17:38567360chr17:37922746ENST00000423485-10351433_1439401.01532.0PLSCR1
HgeneTOP2Achr17:38567361chr17:37922746ENST00000423485-10351433_1439401.01532.0PLSCR1
HgeneTOP2Achr17:38567605chr17:37922746ENST00000423485-9351433_1439355.01532.0PLSCR1


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Related Drugs to TOP2A-IKZF3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TOP2A-IKZF3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource