UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:TP63-LEPREL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TP63-LEPREL1
FusionPDB ID: 93248
FusionGDB2.0 ID: 93250
HgeneTgene
Gene symbol

TP63

LEPREL1

Gene ID

8626

55214

Gene nametumor protein p63prolyl 3-hydroxylase 2
SynonymsAIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73LLEPREL1|MCVD|MLAT4
Cytomap

3q28

3q28

Type of geneprotein-codingprotein-coding
Descriptiontumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing proteinprolyl 3-hydroxylase 2leprecan-like 1myxoid liposarcoma-associated protein 4procollagen-proline 3-dioxygenase 2prolyl 3-hydroxylase 3
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000264731, ENST00000320472, 
ENST00000354600, ENST00000392460, 
ENST00000392461, ENST00000392463, 
ENST00000418709, ENST00000437221, 
ENST00000440651, ENST00000456148, 
ENST00000449992, ENST00000382063, 
ENST00000427335, ENST00000319332, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=1445 X 3 X 5=75
# samples 96
** MAII scorelog2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TP63 [Title/Abstract] AND LEPREL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LEPREL1(189838041)-TP63(189526061), # samples:1
TP63(189526315)-LEPREL1(189713231), # samples:2
Anticipated loss of major functional domain due to fusion event.LEPREL1-TP63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LEPREL1-TP63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TP63-LEPREL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

HgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

HgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

HgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

HgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969

TgeneLEPREL1

GO:0008285

negative regulation of cell proliferation

19436308

TgeneLEPREL1

GO:0019511

peptidyl-proline hydroxylation

18487197

TgeneLEPREL1

GO:0032963

collagen metabolic process

18487197


check buttonFusion gene breakpoints across TP63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LEPREL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-A49A-01ATP63chr3

189526315

-LEPREL1chr3

189713231

-
ChimerDB4HNSCTCGA-CN-A49ATP63chr3

189526315

+LEPREL1chr3

189713231

-
ChimerDB4LUSCTCGA-39-5028TP63chr3

189507631

+LEPREL1chr3

189705458

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264731TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3499668802314744
ENST00000418709TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3438607192253744
ENST00000320472TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3438607192253744
ENST00000392460TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-341057902225741
ENST00000440651TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-341057902225741
ENST00000354600TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-3269438932084663
ENST00000437221TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000392463TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000392461TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647
ENST00000456148TP63chr3189526315+ENST00000319332LEPREL1chr3189713231-312829701943647

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264731ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0010822270.9989178
ENST00000418709ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013358650.99866414
ENST00000320472ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013358650.99866414
ENST00000392460ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013649970.998635
ENST00000440651ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0013649970.998635
ENST00000354600ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.0010080140.998992
ENST00000437221ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000392463ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000392461ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225
ENST00000456148ENST00000319332TP63chr3189526315+LEPREL1chr3189713231-0.00110780.99889225

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93248_93248_1_TP63-LEPREL1_TP63_chr3_189526315_ENST00000264731_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=744AA_BP=196
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------

>93248_93248_2_TP63-LEPREL1_TP63_chr3_189526315_ENST00000320472_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=744AA_BP=196
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------

>93248_93248_3_TP63-LEPREL1_TP63_chr3_189526315_ENST00000354600_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=663AA_BP=115
MEPEERTAALINLTANMLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSN
TDYPGPHSFDVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADD
FEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFA
YYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGR
QDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRG
KTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCL
LDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLY

--------------------------------------------------------------

>93248_93248_4_TP63-LEPREL1_TP63_chr3_189526315_ENST00000392460_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=741AA_BP=193
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQAL
REYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALE
CAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNV
EGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFE
GATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEP
PAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVI

--------------------------------------------------------------

>93248_93248_5_TP63-LEPREL1_TP63_chr3_189526315_ENST00000392461_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=647AA_BP=99
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------

>93248_93248_6_TP63-LEPREL1_TP63_chr3_189526315_ENST00000392463_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=647AA_BP=99
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------

>93248_93248_7_TP63-LEPREL1_TP63_chr3_189526315_ENST00000418709_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=744AA_BP=196
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD

--------------------------------------------------------------

>93248_93248_8_TP63-LEPREL1_TP63_chr3_189526315_ENST00000437221_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=647AA_BP=99
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------

>93248_93248_9_TP63-LEPREL1_TP63_chr3_189526315_ENST00000440651_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=741AA_BP=193
MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATNKIE
ISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
FQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQAL
REYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALE
CAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNV
EGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFE
GATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEP
PAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVI

--------------------------------------------------------------

>93248_93248_10_TP63-LEPREL1_TP63_chr3_189526315_ENST00000456148_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=647AA_BP=99
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQS
STAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYF
VEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKA
YLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAE
VHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATV
LKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYT
FRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILD

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:189838041/chr3:189526061)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+4141_107193.0681.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+4121_107193.0511.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+4131_107193.0556.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+4111_107193.0488.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+4141_107193.0677.0RegionNote=Transcription activation
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015557_671160.0709.0DomainFe2OG dioxygenase
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015705_708160.0709.0MotifPrevents secretion from ER
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015210_243160.0709.0RepeatNote=TPR 3
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015306_339160.0709.0RepeatNote=TPR 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414437_444193.0681.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412437_444193.0511.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212437_44499.0587.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113437_4440596.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413437_444193.0556.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210437_44499.0417.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211437_44499.0462.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411437_444193.0488.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29437_44499.0394.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414437_444193.0677.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111437_4440.0502.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212437_44499.0583.0Compositional biasNote=Poly-Gln
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414170_362193.0681.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412170_362193.0511.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212170_36299.0587.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113170_3620596.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413170_362193.0556.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210170_36299.0417.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211170_36299.0462.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411170_362193.0488.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29170_36299.0394.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414170_362193.0677.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111170_3620.0502.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212170_36299.0583.0DNA binding.
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414541_607193.0681.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412541_607193.0511.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212541_60799.0587.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113541_6070596.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413541_607193.0556.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210541_60799.0417.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211541_60799.0462.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411541_607193.0488.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29541_60799.0394.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414541_607193.0677.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111541_6070.0502.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212541_60799.0583.0DomainNote=SAM
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414394_443193.0681.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414610_680193.0681.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412394_443193.0511.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412610_680193.0511.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+2121_10799.0587.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212394_44399.0587.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212610_68099.0587.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+1131_1070596.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113394_4430596.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113610_6800596.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413394_443193.0556.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413610_680193.0556.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+2101_10799.0417.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210394_44399.0417.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210610_68099.0417.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+2111_10799.0462.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211394_44399.0462.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211610_68099.0462.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411394_443193.0488.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411610_680193.0488.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+291_10799.0394.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29394_44399.0394.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29610_68099.0394.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414394_443193.0677.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414610_680193.0677.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+1111_1070.0502.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111394_4430.0502.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111610_6800.0502.0RegionNote=Transactivation inhibition
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+2121_10799.0583.0RegionNote=Transcription activation
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212394_44399.0583.0RegionNote=Oligomerization
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212610_68099.0583.0RegionNote=Transactivation inhibition
TgeneLEPREL1chr3:189526315chr3:189713231ENST0000031933201593_99160.0709.0Compositional biasNote=Poly-Pro
TgeneLEPREL1chr3:189526315chr3:189713231ENST00000319332015148_181160.0709.0RepeatNote=TPR 2
TgeneLEPREL1chr3:189526315chr3:189713231ENST0000031933201544_77160.0709.0RepeatNote=TPR 1


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1502_TP63_189526315_LEPREL1_189713231_ranked_0.pdbTP63189526315189526315ENST00000319332LEPREL1chr3189713231-
MKEMNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSEDGATN
KIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSF
DVSFQQSSTAKSATWTLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFE
QALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVK
ALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSG
VNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNE
KFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECW
KEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQAD
744


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TP63_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TP63
LEPREL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP63chr3:189526315chr3:189713231ENST00000264731+414352_388193.0681.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000320472+412352_388193.0511.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000354600+212352_38899.0587.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000382063+113352_3880596.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392460+413352_388193.0556.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392461+210352_38899.0417.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000392463+211352_38899.0462.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000418709+411352_388193.0488.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000437221+29352_38899.0394.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000440651+414352_388193.0677.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000449992+111352_3880.0502.0HIPK2
HgeneTP63chr3:189526315chr3:189713231ENST00000456148+212352_38899.0583.0HIPK2


Top

Related Drugs to TP63-LEPREL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to TP63-LEPREL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource