UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TRIM33-CSDE1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TRIM33-CSDE1
	FusionPDB ID: 94075
	FusionGDB2.0 ID: 94075
		Hgene	Tgene
	Gene symbol	TRIM33	CSDE1
	Gene ID	51592	7812
	Gene name	tripartite motif containing 33	cold shock domain containing E1
	Synonyms	ECTO\|PTC7\|RFG7\|TF1G\|TIF1G\|TIF1GAMMA\|TIFGAMMA	D1S155E\|UNR
	Cytomap	1p13.2	1p13.2
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gamma	cold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS
	Modification date	20200313	20200313
	UniProtAcc	Q9UPN9	O75534
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358465, ENST00000369543, ENST00000450349, ENST00000476908,	ENST00000369530, ENST00000530886, ENST00000483407, ENST00000534699, ENST00000261443, ENST00000339438, ENST00000358528, ENST00000438362,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 18 X 10=3060	18 X 14 X 7=1764
	# samples	21	19
	** MAII score	log2(21/3060*10)=-3.86507041991389 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1764*10)=-3.21477923722657 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TRIM33 [Title/Abstract] AND CSDE1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TRIM33(114945382)-CSDE1(115282511), # samples:4 CSDE1(115292442)-TRIM33(115007010), # samples:1
Anticipated loss of major functional domain due to fusion event.	TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. TRIM33-CSDE1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TRIM33	GO:0016567	protein ubiquitination	19135894
Hgene	TRIM33	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	19135894
Hgene	TRIM33	GO:0030514	negative regulation of BMP signaling pathway	19135894

Fusion gene breakpoints across TRIM33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CSDE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A0H0-01A	TRIM33	chr1	114970370	-	CSDE1	chr1	115280693	-
ChimerDB4	PRAD	TCGA-CH-5750-01A	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-
ChimerDB4	PRAD	TCGA-CH-5750	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-
ChimerDB4	PRAD	TCGA-CH-5750	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-
ChimerDB4	PRAD	TCGA-CH-5751-01A	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-
ChimerDB4	PRAD	TCGA-CH-5751	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-
ChimerDB4	PRAD	TCGA-CH-5751	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358465	TRIM33	chr1	114945381	-	ENST00000339438	CSDE1	chr1	115282511	-	6536	2976	0	5279	1759
ENST00000358465	TRIM33	chr1	114945381	-	ENST00000438362	CSDE1	chr1	115282511	-	6626	2976	0	5372	1790
ENST00000358465	TRIM33	chr1	114945381	-	ENST00000358528	CSDE1	chr1	115282511	-	6625	2976	0	5372	1790
ENST00000358465	TRIM33	chr1	114945381	-	ENST00000261443	CSDE1	chr1	115282511	-	6154	2976	0	5279	1759
ENST00000369543	TRIM33	chr1	114945381	-	ENST00000339438	CSDE1	chr1	115282511	-	6536	2976	0	5279	1759
ENST00000369543	TRIM33	chr1	114945381	-	ENST00000438362	CSDE1	chr1	115282511	-	6626	2976	0	5372	1790
ENST00000369543	TRIM33	chr1	114945381	-	ENST00000358528	CSDE1	chr1	115282511	-	6625	2976	0	5372	1790
ENST00000369543	TRIM33	chr1	114945381	-	ENST00000261443	CSDE1	chr1	115282511	-	6154	2976	0	5279	1759
ENST00000358465	TRIM33	chr1	114945382	-	ENST00000339438	CSDE1	chr1	115282511	-	6536	2976	0	5279	1759
ENST00000358465	TRIM33	chr1	114945382	-	ENST00000438362	CSDE1	chr1	115282511	-	6626	2976	0	5372	1790
ENST00000358465	TRIM33	chr1	114945382	-	ENST00000358528	CSDE1	chr1	115282511	-	6625	2976	0	5372	1790
ENST00000358465	TRIM33	chr1	114945382	-	ENST00000261443	CSDE1	chr1	115282511	-	6154	2976	0	5279	1759
ENST00000369543	TRIM33	chr1	114945382	-	ENST00000339438	CSDE1	chr1	115282511	-	6536	2976	0	5279	1759
ENST00000369543	TRIM33	chr1	114945382	-	ENST00000438362	CSDE1	chr1	115282511	-	6626	2976	0	5372	1790
ENST00000369543	TRIM33	chr1	114945382	-	ENST00000358528	CSDE1	chr1	115282511	-	6625	2976	0	5372	1790
ENST00000369543	TRIM33	chr1	114945382	-	ENST00000261443	CSDE1	chr1	115282511	-	6154	2976	0	5279	1759

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358465	ENST00000339438	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000206611	0.99979335
ENST00000358465	ENST00000438362	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000272983	0.99972695
ENST00000358465	ENST00000358528	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000271687	0.99972826
ENST00000358465	ENST00000261443	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000276906	0.99972314
ENST00000369543	ENST00000339438	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000206611	0.99979335
ENST00000369543	ENST00000438362	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000272983	0.99972695
ENST00000369543	ENST00000358528	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000271687	0.99972826
ENST00000369543	ENST00000261443	TRIM33	chr1	114945381	-	CSDE1	chr1	115282511	-	0.000276906	0.99972314
ENST00000358465	ENST00000339438	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000206611	0.99979335
ENST00000358465	ENST00000438362	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000272983	0.99972695
ENST00000358465	ENST00000358528	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000271687	0.99972826
ENST00000358465	ENST00000261443	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000276906	0.99972314
ENST00000369543	ENST00000339438	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000206611	0.99979335
ENST00000369543	ENST00000438362	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000272983	0.99972695
ENST00000369543	ENST00000358528	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000271687	0.99972826
ENST00000369543	ENST00000261443	TRIM33	chr1	114945382	-	CSDE1	chr1	115282511	-	0.000276906	0.99972314

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94075_94075_1_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000358465_CSDE1_chr1_115282511_ENST00000261443_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_2_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000358465_CSDE1_chr1_115282511_ENST00000339438_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_3_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000358465_CSDE1_chr1_115282511_ENST00000358528_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_4_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000358465_CSDE1_chr1_115282511_ENST00000438362_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_5_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000369543_CSDE1_chr1_115282511_ENST00000261443_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_6_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000369543_CSDE1_chr1_115282511_ENST00000339438_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_7_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000369543_CSDE1_chr1_115282511_ENST00000358528_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_8_TRIM33-CSDE1_TRIM33_chr1_114945381_ENST00000369543_CSDE1_chr1_115282511_ENST00000438362_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_9_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000358465_CSDE1_chr1_115282511_ENST00000261443_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_10_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000358465_CSDE1_chr1_115282511_ENST00000339438_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_11_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000358465_CSDE1_chr1_115282511_ENST00000358528_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_12_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000358465_CSDE1_chr1_115282511_ENST00000438362_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_13_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000369543_CSDE1_chr1_115282511_ENST00000261443_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_14_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000369543_CSDE1_chr1_115282511_ENST00000339438_length(amino acids)=1759AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEI
FFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPF
GDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIAD
EVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEG
STSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKG
KGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVL
GQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPR

--------------------------------------------------------------

>94075_94075_15_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000369543_CSDE1_chr1_115282511_ENST00000358528_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

>94075_94075_16_TRIM33-CSDE1_TRIM33_chr1_114945382_ENST00000369543_CSDE1_chr1_115282511_ENST00000438362_length(amino acids)=1790AA_BP=992
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVD
QRMSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLV
KIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIML
LKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVT
KVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRD
GFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNK
GKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANH
DKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEEGDMK
GEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114945382/chr1:115282511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TRIM33 Q9UPN9	CSDE1 O75534
FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269\|PubMed:10022127, ECO:0000269\|PubMed:15820681, ECO:0000269\|PubMed:16751102, ECO:0000269\|PubMed:19135894}.	FUNCTION: RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067). {ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:15314026, ECO:0000269\|PubMed:29395067}.; FUNCTION: (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA. {ECO:0000269\|PubMed:10049359}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

299_401

964.0

1128.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

299_401

964.0

1111.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

299_401

964.0

1128.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

299_401

964.0

1111.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

13_18

964.0

1128.0

Compositional bias

Note=Poly-Gly

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

44_49

964.0

1128.0

Compositional bias

Note=Poly-Glu

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

545_550

964.0

1128.0

Compositional bias

Note=Poly-Thr

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

13_18

964.0

1111.0

Compositional bias

Note=Poly-Gly

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

44_49

964.0

1111.0

Compositional bias

Note=Poly-Glu

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

545_550

964.0

1111.0

Compositional bias

Note=Poly-Thr

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

13_18

964.0

1128.0

Compositional bias

Note=Poly-Gly

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

44_49

964.0

1128.0

Compositional bias

Note=Poly-Glu

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

545_550

964.0

1128.0

Compositional bias

Note=Poly-Thr

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

13_18

964.0

1111.0

Compositional bias

Note=Poly-Gly

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

44_49

964.0

1111.0

Compositional bias

Note=Poly-Glu

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

545_550

964.0

1111.0

Compositional bias

Note=Poly-Thr

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

1_147

964.0

1128.0

Region

Note=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

1_147

964.0

1111.0

Region

Note=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

1_147

964.0

1128.0

Region

Note=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

1_147

964.0

1111.0

Region

Note=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

125_154

964.0

1128.0

Zinc finger

RING-type

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

212_259

964.0

1128.0

Zinc finger

B box-type 1

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

271_312

964.0

1128.0

Zinc finger

B box-type 2

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

887_934

964.0

1128.0

Zinc finger

PHD-type

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

125_154

964.0

1111.0

Zinc finger

RING-type

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

212_259

964.0

1111.0

Zinc finger

B box-type 1

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

271_312

964.0

1111.0

Zinc finger

B box-type 2

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

887_934

964.0

1111.0

Zinc finger

PHD-type

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

125_154

964.0

1128.0

Zinc finger

RING-type

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

212_259

964.0

1128.0

Zinc finger

B box-type 1

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

271_312

964.0

1128.0

Zinc finger

B box-type 2

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

887_934

964.0

1128.0

Zinc finger

PHD-type

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

125_154

964.0

1111.0

Zinc finger

RING-type

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

212_259

964.0

1111.0

Zinc finger

B box-type 1

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

271_312

964.0

1111.0

Zinc finger

B box-type 2

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

887_934

964.0

1111.0

Zinc finger

PHD-type

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

136_179

0.0

768.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

186_245

0.0

768.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

26_87

0.0

768.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

297_337

0.0

768.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

349_410

0.0

768.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

447_507

0.0

768.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

519_579

0.0

768.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

610_670

0.0

768.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

674_735

0.0

768.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000261443

748_789

0.0

768.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

136_179

0.0

768.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

186_245

0.0

768.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

26_87

0.0

768.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

297_337

0.0

768.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

349_410

0.0

768.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

447_507

0.0

768.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

519_579

0.0

768.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

610_670

0.0

768.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

674_735

0.0

768.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000339438

748_789

0.0

768.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

136_179

0.0

799.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

186_245

0.0

799.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

26_87

0.0

799.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

297_337

0.0

799.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

349_410

0.0

799.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

447_507

0.0

799.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

519_579

0.0

799.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

610_670

0.0

799.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

674_735

0.0

799.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000358528

748_789

0.0

799.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

136_179

46.0

814.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

186_245

46.0

814.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

297_337

46.0

814.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

349_410

46.0

814.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

447_507

46.0

814.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

519_579

46.0

814.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

610_670

46.0

814.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

674_735

46.0

814.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

748_789

46.0

814.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

136_179

0.0

799.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

186_245

0.0

799.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

26_87

0.0

799.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

297_337

0.0

799.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

349_410

0.0

799.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

447_507

0.0

799.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

519_579

0.0

799.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

610_670

0.0

799.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

674_735

0.0

799.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000534699

748_789

0.0

799.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

136_179

0.0

768.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

186_245

0.0

768.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

26_87

0.0

768.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

297_337

0.0

768.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

349_410

0.0

768.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

447_507

0.0

768.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

519_579

0.0

768.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

610_670

0.0

768.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

674_735

0.0

768.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000261443

748_789

0.0

768.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

136_179

0.0

768.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

186_245

0.0

768.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

26_87

0.0

768.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

297_337

0.0

768.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

349_410

0.0

768.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

447_507

0.0

768.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

519_579

0.0

768.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

610_670

0.0

768.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

674_735

0.0

768.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000339438

748_789

0.0

768.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

136_179

0.0

799.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

186_245

0.0

799.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

26_87

0.0

799.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

297_337

0.0

799.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

349_410

0.0

799.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

447_507

0.0

799.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

519_579

0.0

799.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

610_670

0.0

799.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

674_735

0.0

799.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000358528

748_789

0.0

799.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

136_179

46.0

814.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

186_245

46.0

814.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

297_337

46.0

814.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

349_410

46.0

814.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

447_507

46.0

814.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

519_579

46.0

814.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

610_670

46.0

814.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

674_735

46.0

814.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

748_789

46.0

814.0

Domain

SUZ-C

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

136_179

0.0

799.0

Domain

Note=CSD 2%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

186_245

0.0

799.0

Domain

Note=CSD 3

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

26_87

0.0

799.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

297_337

0.0

799.0

Domain

Note=CSD 4%3B truncated

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

349_410

0.0

799.0

Domain

Note=CSD 5

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

447_507

0.0

799.0

Domain

Note=CSD 6

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

519_579

0.0

799.0

Domain

Note=CSD 7

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

610_670

0.0

799.0

Domain

Note=CSD 8

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

674_735

0.0

799.0

Domain

Note=CSD 9

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000534699

748_789

0.0

799.0

Domain

SUZ-C

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000358465

974_1046

964.0

1128.0

Domain

Bromo

Hgene

TRIM33

chr1:114945381

chr1:115282511

ENST00000369543

974_1046

964.0

1111.0

Domain

Bromo

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000358465

974_1046

964.0

1128.0

Domain

Bromo

Hgene

TRIM33

chr1:114945382

chr1:115282511

ENST00000369543

974_1046

964.0

1111.0

Domain

Bromo

Tgene

CSDE1

chr1:114945381

chr1:115282511

ENST00000369530

26_87

46.0

814.0

Domain

Note=CSD 1

Tgene

CSDE1

chr1:114945382

chr1:115282511

ENST00000369530

26_87

46.0

814.0

Domain

Note=CSD 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TRIM33_pLDDT.png

CSDE1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

TRIM33

NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, Trim24, Nfe2l2, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25, MAPK6, TRIM28, UBE2D2, ESR2, EZH2, CYLD, TP53BP1, BRCA1, MDC1, KIAA1429, MYC, RPS6KA6, PLEKHA4, ESR1, IMMP1L, THOC1, BRD1, SP100, VCP, PNMA2, NID2, ERC1, KPNA6, BCKDHB, BCKDHA, KPNA1, SKIV2L, KIAA1551, CALU, TTC37, DBT, PNMA1, RCN1, GNB2L1, RCN2, FBN2, NIN, PEX5, DNAJC10, ANGEL1, DCAF7, ASS1, AOX1, TRAF2, ADCK3, UNC80, CHAMP1, GCDH, FAM53C, NT5DC2, SKI, FHL3, MLKL, LRP2, PELO, BAG2, TMX3, EDEM3, HDAC6, UACA, GPX1, NELL2, BTBD18, SDF4, CAV1, ZNF43, TRIM4, GFOD1, POLR2C, KDM5C, SLFN11, PJA2, SCO2, ZFP82, CHEK1, PER1, SAT1, DGKE, TIMM50, POGZ, ANKRD28, TUBG1, RNF31, GGCX, EGFR, BRD4, CEP78, SUMO2, PDIA4, SOD1, DPP7, CALM1, TPM3, LCE3D, TRIM37, ASF1A, CBX3, NUP50, TERF2IP, Pias1, THRSP, ZNF484, TRIM52, HSPB2, ZNF776, KRT37, PYCRL, ZNF418, TGM7, CCT8L2, KRT39, MAGEA9, NUP62, MAD2L1, ZNF460, CRYAA, SHARPIN, KRT38, SSSCA1, FOXF2, ZNF333, ZNF747, SOHLH1, HSPA8, ZNF44, LOXL4, KCTD17, ZNF764, C12orf74, ELF4, ELF5, FOS, HNF4A, KLF8, LHX4, MYOD1, SOX17, SP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TRIM33
CSDE1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TRIM33-CSDE1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TRIM33-CSDE1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TRIM33	C0238463	Papillary thyroid carcinoma	2	ORPHANET