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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIM33-CSMD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIM33-CSMD2
FusionPDB ID: 94076
FusionGDB2.0 ID: 94076
HgeneTgene
Gene symbol

TRIM33

CSMD2

Gene ID

51592

114784

Gene nametripartite motif containing 33CUB and Sushi multiple domains 2
SynonymsECTO|PTC7|RFG7|TF1G|TIF1G|TIF1GAMMA|TIFGAMMAdJ1007G16.1|dJ1007G16.2|dJ947L8.1
Cytomap

1p13.2

1p35.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM33RET-fused gene 7 proteinRING-type E3 ubiquitin transferase TRIM33TIF1-gammaectodermin homologprotein Rfg7transcriptional intermediary factor 1 gammaCUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2
Modification date2020031320200313
UniProtAcc

Q9UPN9

Q7Z408

Ensembl transtripts involved in fusion geneENST idsENST00000358465, ENST00000369543, 
ENST00000450349, ENST00000476908, 
ENST00000373388, ENST00000338325, 
ENST00000373377, ENST00000489419, 
ENST00000373380, ENST00000373381, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 18 X 10=306013 X 12 X 7=1092
# samples 2114
** MAII scorelog2(21/3060*10)=-3.86507041991389
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIM33 [Title/Abstract] AND CSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIM33(114948032)-CSMD2(34128692), # samples:3
Anticipated loss of major functional domain due to fusion event.TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIM33-CSMD2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRIM33

GO:0016567

protein ubiquitination

19135894

HgeneTRIM33

GO:0017015

regulation of transforming growth factor beta receptor signaling pathway

19135894

HgeneTRIM33

GO:0030514

negative regulation of BMP signaling pathway

19135894


check buttonFusion gene breakpoints across TRIM33 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CSMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-52-7809-01ATRIM33chr1

114948032

-CSMD2chr1

34128692

-
ChimerDB4LUSCTCGA-52-7809TRIM33chr1

114948032

-CSMD2chr1

34128692

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358465TRIM33chr1114948032-ENST00000373381CSMD2chr134128692-123072852096953231
ENST00000358465TRIM33chr1114948032-ENST00000373380CSMD2chr134128692-63392852056841894
ENST00000369543TRIM33chr1114948032-ENST00000373381CSMD2chr134128692-123072852096953231
ENST00000369543TRIM33chr1114948032-ENST00000373380CSMD2chr134128692-63392852056841894

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358465ENST00000373381TRIM33chr1114948032-CSMD2chr134128692-0.0012789160.99872106
ENST00000358465ENST00000373380TRIM33chr1114948032-CSMD2chr134128692-0.0017647760.9982352
ENST00000369543ENST00000373381TRIM33chr1114948032-CSMD2chr134128692-0.0012789160.99872106
ENST00000369543ENST00000373380TRIM33chr1114948032-CSMD2chr134128692-0.0017647760.9982352

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94076_94076_1_TRIM33-CSMD2_TRIM33_chr1_114948032_ENST00000358465_CSMD2_chr1_34128692_ENST00000373380_length(amino acids)=1894AA_BP=1089
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPRLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKD
LHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPT
CIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS
LFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG
GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFS
AKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNL
TERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDI
SVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVIL
SPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFK
LEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPY
SSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSGHLAA

--------------------------------------------------------------

>94076_94076_2_TRIM33-CSMD2_TRIM33_chr1_114948032_ENST00000358465_CSMD2_chr1_34128692_ENST00000373381_length(amino acids)=3231AA_BP=1267
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPRLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKD
LHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPT
CIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS
LFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG
GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFS
AKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNL
TERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDI
SVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVIL
SPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFK
LEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPY
SSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLT
KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQT
CSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR
APLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYH
LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPT
CRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQTKLHSIFYKLLFDVLSSPSLTKAGHCG
TPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAE
GAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGH
PGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHV
LRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPG
IPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSL
PAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGV
PQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGG
SEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGV
ELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFAS

--------------------------------------------------------------

>94076_94076_3_TRIM33-CSMD2_TRIM33_chr1_114948032_ENST00000369543_CSMD2_chr1_34128692_ENST00000373380_length(amino acids)=1894AA_BP=1089
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPRLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKD
LHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPT
CIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS
LFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG
GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFS
AKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNL
TERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDI
SVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVIL
SPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFK
LEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPY
SSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSGHLAA

--------------------------------------------------------------

>94076_94076_4_TRIM33-CSMD2_TRIM33_chr1_114948032_ENST00000369543_CSMD2_chr1_34128692_ENST00000373381_length(amino acids)=3231AA_BP=1267
LRLGLGAAAAATRAAGGAGRSGGFKEENMAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGP
DDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLR
CLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCI
EAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLE
KKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIAS
GSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLA
QLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGI
PRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAG
SSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTE
DEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSA
RIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPRLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPKD
LHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPT
CIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS
LFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTAPCG
GQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFS
AKGLAPARGFHFVYQAVPRTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGGNL
TERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDI
SVSAAGFHLEYKTVGLSSCPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTVEEMEGVIL
SPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFK
LEYQAYELQECPDPEPFANGIVRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPY
SSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLT
KCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQT
CSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPR
APLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYH
LQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPT
CRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLATQTKLHSIFYKLLFDVLSSPSLTKAGHCG
TPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAE
GAARSQCLASGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVLSCQGDGTWDRPRPQCLLVSCGH
PGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHV
LRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPG
IPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSL
PAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGV
PQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGG
SEHRTCKADGSWTGKPPICLEVRPSGRPINTAREPPLTQALIPGDVFAKNSLWKGAYEYQGKKQPAMLRVTGFQVANSKVNATMIDHSGV
ELHLAGTYKKEDFHLLLQVYQITGPVEIFMNKFKDDHWALDGHVSSESSGATFIYQGSVKGQGFGQFGFQRLDLRLLESDPESIGRHFAS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114948032/chr1:34128692)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIM33

Q9UPN9

CSMD2

Q7Z408

FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). {ECO:0000250, ECO:0000269|PubMed:10022127, ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520299_401922.66666666666661128.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519299_401922.66666666666661111.0Coiled coilOntology_term=ECO:0000255
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-152013_18922.66666666666661128.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-152044_49922.66666666666661128.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520545_550922.66666666666661128.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-151913_18922.66666666666661111.0Compositional biasNote=Poly-Gly
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-151944_49922.66666666666661111.0Compositional biasNote=Poly-Glu
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519545_550922.66666666666661111.0Compositional biasNote=Poly-Thr
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-15201_147922.66666666666661128.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-15191_147922.66666666666661111.0RegionNote=Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repression
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520125_154922.66666666666661128.0Zinc fingerRING-type
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520212_259922.66666666666661128.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520271_312922.66666666666661128.0Zinc fingerB box-type 2
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519125_154922.66666666666661111.0Zinc fingerRING-type
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519212_259922.66666666666661111.0Zinc fingerB box-type 1
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519271_312922.66666666666661111.0Zinc fingerB box-type 2
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241037_1096223.666666666666661168.0DomainSushi 6
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241098_1206223.666666666666661168.0DomainCUB 7
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241209_1269223.666666666666661168.0DomainSushi 7
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241271_1380223.666666666666661168.0DomainCUB 8
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241383_1443223.666666666666661168.0DomainSushi 8
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241445_1553223.666666666666661168.0DomainCUB 9
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241556_1617223.666666666666661168.0DomainSushi 9
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241619_1727223.666666666666661168.0DomainCUB 10
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241733_1794223.666666666666661168.0DomainSushi 10
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241796_1904223.666666666666661168.0DomainCUB 11
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241907_1966223.666666666666661168.0DomainSushi 11
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241968_2076223.666666666666661168.0DomainCUB 12
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242121_2180223.666666666666661168.0DomainSushi 12
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242182_2293223.666666666666661168.0DomainCUB 13
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242292_2353223.666666666666661168.0DomainSushi 13
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242355_2466223.666666666666661168.0DomainCUB 14
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242466_2528223.666666666666661168.0DomainSushi 14
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242529_2590223.666666666666661168.0DomainSushi 15
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242591_2655223.666666666666661168.0DomainSushi 16
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242656_2713223.666666666666661168.0DomainSushi 17
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242714_2771223.666666666666661168.0DomainSushi 18
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242772_2829223.666666666666661168.0DomainSushi 19
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242833_2890223.666666666666661168.0DomainSushi 20
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242891_2949223.666666666666661168.0DomainSushi 21
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803242950_3009223.666666666666661168.0DomainSushi 22
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243010_3067223.666666666666661168.0DomainSushi 23
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243068_3125223.666666666666661168.0DomainSushi 24
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243129_3187223.666666666666661168.0DomainSushi 25
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243188_3247223.666666666666661168.0DomainSushi 26
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324341_402223.666666666666661168.0DomainSushi 2
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324405_516223.666666666666661168.0DomainCUB 3
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324519_576223.666666666666661168.0DomainSushi 3
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324578_686223.666666666666661168.0DomainCUB 4
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324689_750223.666666666666661168.0DomainSushi 4
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324752_860223.666666666666661168.0DomainCUB 5
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324865_922223.666666666666661168.0DomainSushi 5
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324924_1034223.666666666666661168.0DomainCUB 6
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243430_3487223.666666666666661168.0Topological domainCytoplasmic
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803243409_3429223.666666666666661168.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520974_1046922.66666666666661128.0DomainBromo
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519974_1046922.66666666666661111.0DomainBromo
HgeneTRIM33chr1:114948032chr1:34128692ENST00000358465-1520887_934922.66666666666661128.0Zinc fingerPHD-type
HgeneTRIM33chr1:114948032chr1:34128692ENST00000369543-1519887_934922.66666666666661111.0Zinc fingerPHD-type
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324137_198223.666666666666661168.0DomainSushi 1
TgeneCSMD2chr1:114948032chr1:34128692ENST00000373380324202_306223.666666666666661168.0DomainCUB 2
TgeneCSMD2chr1:114948032chr1:34128692ENST0000037338032426_134223.666666666666661168.0DomainCUB 1
TgeneCSMD2chr1:114948032chr1:34128692ENST000003733803241_3408223.666666666666661168.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIM33_pLDDT.png
all structure
all structure
CSMD2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TRIM33NCOR1, TRIM33, TRIM24, SMAD2, SMAD3, TAL1, TCF12, TCF3, LDB1, RUNX1T1, CBFA2T3, SSBP2, SSBP3, SSBP4, LYL1, TCF4, RUNX1, SUPT16H, SSRP1, CDK9, SMAD4, HIST1H3A, ELAVL1, CUL3, Trim24, Nfe2l2, UBE2D3, ANAPC1, CDC27, ANAPC4, ANAPC5, CDC16, ANAPC7, CDC23, CDC20, BUB1B, CCNA2, EPAS1, SOX2, UBE2I, CRYAB, SHFM1, ZBTB1, CHD1L, SKIL, DHX33, UBE2N, UBE2E1, FZR1, KLHL20, PSME3, QPRT, RABGGTB, DCAF15, LHX6, MTA1, RFC4, NTRK1, EWSR1, XPO1, FGA, RRM1, SSB, VDAC2, C17orf53, JUN, FOXI1, CTNNB1, NANOG, NLGN3, WDYHV1, ACY1, LMO2, ZNF324B, ZIM2, CNKSR1, HAO2, ERG, FOXA1, TRIM25, MAPK6, TRIM28, UBE2D2, ESR2, EZH2, CYLD, TP53BP1, BRCA1, MDC1, KIAA1429, MYC, RPS6KA6, PLEKHA4, ESR1, IMMP1L, THOC1, BRD1, SP100, VCP, PNMA2, NID2, ERC1, KPNA6, BCKDHB, BCKDHA, KPNA1, SKIV2L, KIAA1551, CALU, TTC37, DBT, PNMA1, RCN1, GNB2L1, RCN2, FBN2, NIN, PEX5, DNAJC10, ANGEL1, DCAF7, ASS1, AOX1, TRAF2, ADCK3, UNC80, CHAMP1, GCDH, FAM53C, NT5DC2, SKI, FHL3, MLKL, LRP2, PELO, BAG2, TMX3, EDEM3, HDAC6, UACA, GPX1, NELL2, BTBD18, SDF4, CAV1, ZNF43, TRIM4, GFOD1, POLR2C, KDM5C, SLFN11, PJA2, SCO2, ZFP82, CHEK1, PER1, SAT1, DGKE, TIMM50, POGZ, ANKRD28, TUBG1, RNF31, GGCX, EGFR, BRD4, CEP78, SUMO2, PDIA4, SOD1, DPP7, CALM1, TPM3, LCE3D, TRIM37, ASF1A, CBX3, NUP50, TERF2IP, Pias1, THRSP, ZNF484, TRIM52, HSPB2, ZNF776, KRT37, PYCRL, ZNF418, TGM7, CCT8L2, KRT39, MAGEA9, NUP62, MAD2L1, ZNF460, CRYAA, SHARPIN, KRT38, SSSCA1, FOXF2, ZNF333, ZNF747, SOHLH1, HSPA8, ZNF44, LOXL4, KCTD17, ZNF764, C12orf74, ELF4, ELF5, FOS, HNF4A, KLF8, LHX4, MYOD1, SOX17, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIM33all structure
CSMD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRIM33-CSMD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIM33-CSMD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIM33C0238463Papillary thyroid carcinoma2ORPHANET