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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TRIO-TERT

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TRIO-TERT
FusionPDB ID: 94220
FusionGDB2.0 ID: 94220
HgeneTgene
Gene symbol

TRIO

TERT

Gene ID

7204

7015

Gene nametrio Rho guanine nucleotide exchange factortelomerase reverse transcriptase
SynonymsARHGEF23|MEBAS|MRD44|tgatCMM9|DKCA2|DKCB4|EST2|PFBMFT1|TCS1|TP2|TRT|hEST2|hTRT
Cytomap

5p15.2

5p15.33

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)telomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
Modification date2020031320200329
UniProtAcc

TPI1

.
Ensembl transtripts involved in fusion geneENST idsENST00000344204, ENST00000537187, 
ENST00000344135, ENST00000509967, 
ENST00000515710, 		ENST00000522877, 
ENST00000296820, ENST00000310581, 
ENST00000334602, ENST00000508104, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score34 X 28 X 12=1142422 X 7 X 15=2310
# samples 3531
** MAII scorelog2(35/11424*10)=-5.02856915219677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/2310*10)=-2.89755273102918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TRIO [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TRIO(14420130)-TERT(1282739), # samples:7
Anticipated loss of major functional domain due to fusion event.TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRIO-TERT seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TRIO-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTERT

GO:0001172

transcription, RNA-templated

19701182

TgeneTERT

GO:0006278

RNA-dependent DNA biosynthetic process

9398860

TgeneTERT

GO:0007004

telomere maintenance via telomerase

9443919|16043710|17940095|19701182|21531765|29695869

TgeneTERT

GO:0007005

mitochondrion organization

21937513

TgeneTERT

GO:0010629

negative regulation of gene expression

11927518

TgeneTERT

GO:0022616

DNA strand elongation

16043710

TgeneTERT

GO:0030422

production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:0031647

regulation of protein stability

24415760|26194824

TgeneTERT

GO:0032092

positive regulation of protein binding

24415760

TgeneTERT

GO:0051000

positive regulation of nitric-oxide synthase activity

11927518

TgeneTERT

GO:0070200

establishment of protein localization to telomere

25589350

TgeneTERT

GO:0071897

DNA biosynthetic process

9398860|19701182

TgeneTERT

GO:1903704

negative regulation of production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:1904751

positive regulation of protein localization to nucleolus

24415760

TgeneTERT

GO:2000773

negative regulation of cellular senescence

11927518


check buttonFusion gene breakpoints across TRIO (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L3-01ATRIOchr5

14420129

+TERTchr5

1282738

-
ChimerDB4SARCTCGA-DX-A1L3-01ATRIOchr5

14420130

-TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A1L3-01ATRIOchr5

14420130

+TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A1L3TRIOchr5

14420130

+TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A2J0-01ATRIOchr5

14406781

+TERTchr5

1268748

-
ChimerDB4SARCTCGA-DX-A2J0-01ATRIOchr5

14406781

-TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A2J0-01ATRIOchr5

14406781

+TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A7EF-01ATRIOchr5

14420130

-TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A7EF-01ATRIOchr5

14420130

+TERTchr5

1282739

-
ChimerDB4SARCTCGA-DX-A7EFTRIOchr5

14420130

+TERTchr5

1282739

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344204TRIOchr514420130+ENST00000310581TERTchr51282739-761452272470522342
ENST00000344204TRIOchr514420130+ENST00000334602TERTchr51282739-686452272468632279
ENST00000344204TRIOchr514420130+ENST00000508104TERTchr51282739-614052272460772017
ENST00000537187TRIOchr514420130+ENST00000310581TERTchr51282739-75965209670342342
ENST00000537187TRIOchr514420130+ENST00000334602TERTchr51282739-68465209668452279
ENST00000537187TRIOchr514420130+ENST00000508104TERTchr51282739-61225209660592017
ENST00000344204TRIOchr514406781+ENST00000296820TERTchr51282739-718149832450541676
ENST00000537187TRIOchr514406781+ENST00000296820TERTchr51282739-71634965650361676
ENST00000344204TRIOchr514406781+ENST00000296820TERTchr51268748-646849832451201698
ENST00000344204TRIOchr514406781+ENST00000508104TERTchr51268748-518349832451201698
ENST00000537187TRIOchr514406781+ENST00000296820TERTchr51268748-64504965651021698
ENST00000537187TRIOchr514406781+ENST00000508104TERTchr51268748-51654965651021698
ENST00000344204TRIOchr514420129+ENST00000310581TERTchr51282738-761452272470522342
ENST00000344204TRIOchr514420129+ENST00000334602TERTchr51282738-686452272468632279
ENST00000344204TRIOchr514420129+ENST00000508104TERTchr51282738-614052272460772017
ENST00000537187TRIOchr514420129+ENST00000310581TERTchr51282738-75965209670342342
ENST00000537187TRIOchr514420129+ENST00000334602TERTchr51282738-68465209668452279
ENST00000537187TRIOchr514420129+ENST00000508104TERTchr51282738-61225209660592017

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344204ENST00000310581TRIOchr514420130+TERTchr51282739-0.005770970.9942291
ENST00000344204ENST00000334602TRIOchr514420130+TERTchr51282739-0.0054410810.9945589
ENST00000344204ENST00000508104TRIOchr514420130+TERTchr51282739-0.0061011580.99389887
ENST00000537187ENST00000310581TRIOchr514420130+TERTchr51282739-0.0056718780.9943281
ENST00000537187ENST00000334602TRIOchr514420130+TERTchr51282739-0.0053881460.99461186
ENST00000537187ENST00000508104TRIOchr514420130+TERTchr51282739-0.0060415920.99395835
ENST00000344204ENST00000296820TRIOchr514406781+TERTchr51282739-0.0054100520.9945899
ENST00000537187ENST00000296820TRIOchr514406781+TERTchr51282739-0.0053290470.9946709
ENST00000344204ENST00000296820TRIOchr514406781+TERTchr51268748-0.0057429910.99425703
ENST00000344204ENST00000508104TRIOchr514406781+TERTchr51268748-0.0074400820.9925599
ENST00000537187ENST00000296820TRIOchr514406781+TERTchr51268748-0.0056804770.99431944
ENST00000537187ENST00000508104TRIOchr514406781+TERTchr51268748-0.0074131330.9925869
ENST00000344204ENST00000310581TRIOchr514420129+TERTchr51282738-0.005770970.9942291
ENST00000344204ENST00000334602TRIOchr514420129+TERTchr51282738-0.0054410810.9945589
ENST00000344204ENST00000508104TRIOchr514420129+TERTchr51282738-0.0061011580.99389887
ENST00000537187ENST00000310581TRIOchr514420129+TERTchr51282738-0.0056718780.9943281
ENST00000537187ENST00000334602TRIOchr514420129+TERTchr51282738-0.0053881460.99461186
ENST00000537187ENST00000508104TRIOchr514420129+TERTchr51282738-0.0060415920.99395835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>94220_94220_1_TRIO-TERT_TRIO_chr5_14406781_ENST00000344204_TERT_chr5_1268748_ENST00000296820_length(amino acids)=1698AA_BP=1653
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_2_TRIO-TERT_TRIO_chr5_14406781_ENST00000344204_TERT_chr5_1268748_ENST00000508104_length(amino acids)=1698AA_BP=1653
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_3_TRIO-TERT_TRIO_chr5_14406781_ENST00000344204_TERT_chr5_1282739_ENST00000296820_length(amino acids)=1676AA_BP=1650
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_4_TRIO-TERT_TRIO_chr5_14406781_ENST00000537187_TERT_chr5_1268748_ENST00000296820_length(amino acids)=1698AA_BP=1653
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_5_TRIO-TERT_TRIO_chr5_14406781_ENST00000537187_TERT_chr5_1268748_ENST00000508104_length(amino acids)=1698AA_BP=1653
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_6_TRIO-TERT_TRIO_chr5_14406781_ENST00000537187_TERT_chr5_1282739_ENST00000296820_length(amino acids)=1676AA_BP=1650
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR

--------------------------------------------------------------

>94220_94220_7_TRIO-TERT_TRIO_chr5_14420129_ENST00000344204_TERT_chr5_1282738_ENST00000310581_length(amino acids)=2342AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYA
RTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTA
SLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTI

--------------------------------------------------------------

>94220_94220_8_TRIO-TERT_TRIO_chr5_14420129_ENST00000344204_TERT_chr5_1282738_ENST00000334602_length(amino acids)=2279AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFH
ACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQL

--------------------------------------------------------------

>94220_94220_9_TRIO-TERT_TRIO_chr5_14420129_ENST00000344204_TERT_chr5_1282738_ENST00000508104_length(amino acids)=2017AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGD

--------------------------------------------------------------

>94220_94220_10_TRIO-TERT_TRIO_chr5_14420129_ENST00000537187_TERT_chr5_1282738_ENST00000310581_length(amino acids)=2342AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYA
RTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTA
SLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTI

--------------------------------------------------------------

>94220_94220_11_TRIO-TERT_TRIO_chr5_14420129_ENST00000537187_TERT_chr5_1282738_ENST00000334602_length(amino acids)=2279AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFH
ACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQL

--------------------------------------------------------------

>94220_94220_12_TRIO-TERT_TRIO_chr5_14420129_ENST00000537187_TERT_chr5_1282738_ENST00000508104_length(amino acids)=2017AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGD

--------------------------------------------------------------

>94220_94220_13_TRIO-TERT_TRIO_chr5_14420130_ENST00000344204_TERT_chr5_1282739_ENST00000310581_length(amino acids)=2342AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYA
RTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTA
SLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTI

--------------------------------------------------------------

>94220_94220_14_TRIO-TERT_TRIO_chr5_14420130_ENST00000344204_TERT_chr5_1282739_ENST00000334602_length(amino acids)=2279AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFH
ACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQL

--------------------------------------------------------------

>94220_94220_15_TRIO-TERT_TRIO_chr5_14420130_ENST00000344204_TERT_chr5_1282739_ENST00000508104_length(amino acids)=2017AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGD

--------------------------------------------------------------

>94220_94220_16_TRIO-TERT_TRIO_chr5_14420130_ENST00000537187_TERT_chr5_1282739_ENST00000310581_length(amino acids)=2342AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYA
RTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTA
SLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTI

--------------------------------------------------------------

>94220_94220_17_TRIO-TERT_TRIO_chr5_14420130_ENST00000537187_TERT_chr5_1282739_ENST00000334602_length(amino acids)=2279AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ
PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRD
GLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFH
ACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQL

--------------------------------------------------------------

>94220_94220_18_TRIO-TERT_TRIO_chr5_14420130_ENST00000537187_TERT_chr5_1282739_ENST00000508104_length(amino acids)=2017AA_BP=1734
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTF
PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKA
PIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIF
HQKAEKYMSNVDSWCKACGEVDLPSELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISDLESWNDELS
QQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIRDCAE
KVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGS
SIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEF
HNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSK
YLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL
VPCGSLCIAHSRSSMEMEGIFNHKGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIR
QHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASV
LGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:14420130/chr5:1282739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

TPI1

.
249FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+3357715_7181653.03098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+3358715_7181653.02922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+3357715_7181653.03098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+3358715_7181653.02922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+3457715_7181734.33333333333333098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+3458715_7181734.33333333333332922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+3457715_7181734.33333333333333098.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+3458715_7181734.33333333333332922.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571292_14671653.03098.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571480_15911653.03098.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+335765_2101653.03098.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581292_14671653.02922.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581480_15911653.02922.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+335865_2101653.02922.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571292_14671653.03098.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571480_15911653.03098.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+335765_2101653.03098.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581292_14671653.02922.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581480_15911653.02922.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+335865_2101653.02922.0DomainCRAL-TRIO
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571292_14671734.33333333333333098.0DomainDH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571480_15911734.33333333333333098.0DomainPH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571656_17211734.33333333333333098.0DomainSH3 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+345765_2101734.33333333333333098.0DomainCRAL-TRIO
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581292_14671734.33333333333332922.0DomainDH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581480_15911734.33333333333332922.0DomainPH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581656_17211734.33333333333332922.0DomainSH3 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+345865_2101734.33333333333332922.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571292_14671734.33333333333333098.0DomainDH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571480_15911734.33333333333333098.0DomainPH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571656_17211734.33333333333333098.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+345765_2101734.33333333333333098.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581292_14671734.33333333333332922.0DomainDH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581480_15911734.33333333333332922.0DomainPH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581656_17211734.33333333333332922.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+345865_2101734.33333333333332922.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571109_12161653.03098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+3357311_4181653.03098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+3357538_6441653.03098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+3357878_9841653.03098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581109_12161653.02922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+3358311_4181653.02922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+3358538_6441653.02922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+3358878_9841653.02922.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571109_12161653.03098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+3357311_4181653.03098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+3357538_6441653.03098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+3357878_9841653.03098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581109_12161653.02922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+3358311_4181653.02922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+3358538_6441653.02922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+3358878_9841653.02922.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571109_12161734.33333333333333098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+3457311_4181734.33333333333333098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+3457538_6441734.33333333333333098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+3457878_9841734.33333333333333098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581109_12161734.33333333333332922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+3458311_4181734.33333333333332922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+3458538_6441734.33333333333332922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+3458878_9841734.33333333333332922.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571109_12161734.33333333333333098.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+3457311_4181734.33333333333333098.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+3457538_6441734.33333333333333098.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+3457878_9841734.33333333333333098.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581109_12161734.33333333333332922.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+3458311_4181734.33333333333332922.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+3458538_6441734.33333333333332922.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+3458878_9841734.33333333333332922.0RepeatNote=Spectrin 3
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114605_935524.3333333333334445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116605_935524.33333333333341133.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115605_935524.33333333333341070.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418605_935524.3333333333334808.0DomainReverse transcriptase
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114605_935524.3333333333334445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116605_935524.33333333333341133.0DomainReverse transcriptase
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115605_935524.33333333333341070.0DomainReverse transcriptase
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418605_935524.3333333333334808.0DomainReverse transcriptase
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114605_935524.3333333333334445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116605_935524.33333333333341133.0DomainReverse transcriptase
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115605_935524.33333333333341070.0DomainReverse transcriptase
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418605_935524.3333333333334808.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514914_928762.0445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514936_1132762.0445.6666666666667RegionNote=CTE
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716914_928822.66666666666661133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716936_1132822.66666666666661133.0RegionNote=CTE
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715914_928822.66666666666661070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715936_1132822.66666666666661070.0RegionNote=CTE
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458914_928762.0808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458936_1132762.0808.0RegionNote=CTE
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114914_928524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114936_1132524.3333333333334445.6666666666667RegionNote=CTE
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116914_928524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116936_1132524.33333333333341133.0RegionNote=CTE
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115914_928524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115936_1132524.33333333333341070.0RegionNote=CTE
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418914_928524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418936_1132524.3333333333334808.0RegionNote=CTE
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114914_928524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114936_1132524.3333333333334445.6666666666667RegionNote=CTE
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116914_928524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116936_1132524.33333333333341133.0RegionNote=CTE
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115914_928524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115936_1132524.33333333333341070.0RegionNote=CTE
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418914_928524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418936_1132524.3333333333334808.0RegionNote=CTE
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114914_928524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114936_1132524.3333333333334445.6666666666667RegionNote=CTE
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116914_928524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116936_1132524.33333333333341133.0RegionNote=CTE
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115914_928524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115936_1132524.33333333333341070.0RegionNote=CTE
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418914_928524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418936_1132524.3333333333334808.0RegionNote=CTE

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571845_18501653.03098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572292_23121653.03098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572545_25511653.03098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581845_18501653.02922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582292_23121653.02922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582545_25511653.02922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571845_18501653.03098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572292_23121653.03098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572545_25511653.03098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581845_18501653.02922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582292_23121653.02922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582545_25511653.02922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571845_18501734.33333333333333098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572292_23121734.33333333333333098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572545_25511734.33333333333333098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581845_18501734.33333333333332922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582292_23121734.33333333333332922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582545_25511734.33333333333332922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101845_18500597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102292_23120597.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102545_25510597.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+110715_7180597.0Compositional biasNote=Poly-Gln
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571845_18501734.33333333333333098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572292_23121734.33333333333333098.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572545_25511734.33333333333333098.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581845_18501734.33333333333332922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582292_23121734.33333333333332922.0Compositional biasNote=Poly-Gly
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582545_25511734.33333333333332922.0Compositional biasNote=Poly-Ser
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571656_17211653.03098.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33571969_21451653.03098.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572157_22711653.03098.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572551_26161653.03098.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572685_27751653.03098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572796_30521653.03098.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581656_17211653.02922.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33581969_21451653.02922.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582157_22711653.02922.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582551_26161653.02922.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582685_27751653.02922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582796_30521653.02922.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571656_17211653.03098.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33571969_21451653.03098.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572157_22711653.03098.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572551_26161653.03098.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572685_27751653.03098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572796_30521653.03098.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581656_17211653.02922.0DomainSH3 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33581969_21451653.02922.0DomainDH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582157_22711653.02922.0DomainPH 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582551_26161653.02922.0DomainSH3 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582685_27751653.02922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582796_30521653.02922.0DomainProtein kinase
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34571969_21451734.33333333333333098.0DomainDH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572157_22711734.33333333333333098.0DomainPH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572551_26161734.33333333333333098.0DomainSH3 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572685_27751734.33333333333333098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572796_30521734.33333333333333098.0DomainProtein kinase
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34581969_21451734.33333333333332922.0DomainDH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582157_22711734.33333333333332922.0DomainPH 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582551_26161734.33333333333332922.0DomainSH3 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582685_27751734.33333333333332922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582796_30521734.33333333333332922.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101292_14670597.0DomainDH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101480_15910597.0DomainPH 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101656_17210597.0DomainSH3 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101969_21450597.0DomainDH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102157_22710597.0DomainPH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102551_26160597.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102685_27750597.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102796_30520597.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+11065_2100597.0DomainCRAL-TRIO
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34571969_21451734.33333333333333098.0DomainDH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572157_22711734.33333333333333098.0DomainPH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572551_26161734.33333333333333098.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572685_27751734.33333333333333098.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572796_30521734.33333333333333098.0DomainProtein kinase
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34581969_21451734.33333333333332922.0DomainDH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582157_22711734.33333333333332922.0DomainPH 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582551_26161734.33333333333332922.0DomainSH3 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582685_27751734.33333333333332922.0DomainNote=Ig-like C2-type
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582796_30521734.33333333333332922.0DomainProtein kinase
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1268748ENST00000344204+33572802_28101653.03098.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1268748ENST00000537187+33582802_28101653.02922.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1282739ENST00000344204+33572802_28101653.03098.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1282739ENST00000537187+33582802_28101653.02922.0Nucleotide bindingATP
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14420129chr5:1282738ENST00000344204+34572802_28101734.33333333333333098.0Nucleotide bindingATP
HgeneTRIOchr5:14420129chr5:1282738ENST00000537187+34582802_28101734.33333333333332922.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1102802_28100597.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:1282739ENST00000344204+34572802_28101734.33333333333333098.0Nucleotide bindingATP
HgeneTRIOchr5:14420130chr5:1282739ENST00000537187+34582802_28101734.33333333333332922.0Nucleotide bindingATP
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1268748ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14406781chr5:1282739ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420129chr5:1282738ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+1101109_12160597.0RepeatNote=Spectrin 4
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+110311_4180597.0RepeatNote=Spectrin 1
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+110538_6440597.0RepeatNote=Spectrin 2
HgeneTRIOchr5:14420130chr5:1282739ENST00000344135+110878_9840597.0RepeatNote=Spectrin 3
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514605_935762.0445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716605_935822.66666666666661133.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715605_935822.66666666666661070.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458605_935762.0808.0DomainReverse transcriptase
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514222_240762.0445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514328_333762.0445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716222_240822.66666666666661133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716328_333822.66666666666661133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715222_240822.66666666666661070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715328_333822.66666666666661070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458222_240762.0808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458328_333762.0808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114222_240524.3333333333334445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114328_333524.3333333333334445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116222_240524.33333333333341133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116328_333524.33333333333341133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115222_240524.33333333333341070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115328_333524.33333333333341070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418222_240524.3333333333334808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418328_333524.3333333333334808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114222_240524.3333333333334445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114328_333524.3333333333334445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116222_240524.33333333333341133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116328_333524.33333333333341133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115222_240524.33333333333341070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115328_333524.33333333333341070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418222_240524.3333333333334808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418328_333524.3333333333334808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114222_240524.3333333333334445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114328_333524.3333333333334445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116222_240524.33333333333341133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116328_333524.33333333333341133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115222_240524.33333333333341070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115328_333524.33333333333341070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418222_240524.3333333333334808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418328_333524.3333333333334808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:14406781chr5:1268748ENST000002968205141_230762.0445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514231_324762.0445.6666666666667RegionNote=Linker
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514301_538762.0445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514325_550762.0445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514376_521762.0445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1268748ENST00000296820514397_417762.0445.6666666666667RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1268748ENST0000029682051458_197762.0445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1268748ENST000003105817161_230822.66666666666661133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716231_324822.66666666666661133.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716301_538822.66666666666661133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716325_550822.66666666666661133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716376_521822.66666666666661133.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1268748ENST00000310581716397_417822.66666666666661133.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1268748ENST0000031058171658_197822.66666666666661133.0RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1268748ENST000003346027151_230822.66666666666661070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715231_324822.66666666666661070.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715301_538822.66666666666661070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715325_550822.66666666666661070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715376_521822.66666666666661070.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1268748ENST00000334602715397_417822.66666666666661070.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1268748ENST0000033460271558_197822.66666666666661070.0RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1268748ENST00000508104581_230762.0808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458231_324762.0808.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458301_538762.0808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458325_550762.0808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458376_521762.0808.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1268748ENST0000050810458397_417762.0808.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1268748ENST000005081045858_197762.0808.0RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1282739ENST000002968201141_230524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114231_324524.3333333333334445.6666666666667RegionNote=Linker
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114301_538524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114325_550524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114376_521524.3333333333334445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1282739ENST00000296820114397_417524.3333333333334445.6666666666667RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1282739ENST0000029682011458_197524.3333333333334445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1282739ENST000003105811161_230524.33333333333341133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116231_324524.33333333333341133.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116301_538524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116325_550524.33333333333341133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116376_521524.33333333333341133.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1282739ENST00000310581116397_417524.33333333333341133.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1282739ENST0000031058111658_197524.33333333333341133.0RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1282739ENST000003346021151_230524.33333333333341070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115231_324524.33333333333341070.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115301_538524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115325_550524.33333333333341070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115376_521524.33333333333341070.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1282739ENST00000334602115397_417524.33333333333341070.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1282739ENST0000033460211558_197524.33333333333341070.0RegionNote=GQ motif
TgeneTERTchr5:14406781chr5:1282739ENST00000508104181_230524.3333333333334808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418231_324524.3333333333334808.0RegionNote=Linker
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418301_538524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418325_550524.3333333333334808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418376_521524.3333333333334808.0RegionNote=QFP motif
TgeneTERTchr5:14406781chr5:1282739ENST0000050810418397_417524.3333333333334808.0RegionNote=CP motif
TgeneTERTchr5:14406781chr5:1282739ENST000005081041858_197524.3333333333334808.0RegionNote=GQ motif
TgeneTERTchr5:14420129chr5:1282738ENST000002968201141_230524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114231_324524.3333333333334445.6666666666667RegionNote=Linker
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114301_538524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114325_550524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114376_521524.3333333333334445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:14420129chr5:1282738ENST00000296820114397_417524.3333333333334445.6666666666667RegionNote=CP motif
TgeneTERTchr5:14420129chr5:1282738ENST0000029682011458_197524.3333333333334445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:14420129chr5:1282738ENST000003105811161_230524.33333333333341133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116231_324524.33333333333341133.0RegionNote=Linker
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116301_538524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116325_550524.33333333333341133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116376_521524.33333333333341133.0RegionNote=QFP motif
TgeneTERTchr5:14420129chr5:1282738ENST00000310581116397_417524.33333333333341133.0RegionNote=CP motif
TgeneTERTchr5:14420129chr5:1282738ENST0000031058111658_197524.33333333333341133.0RegionNote=GQ motif
TgeneTERTchr5:14420129chr5:1282738ENST000003346021151_230524.33333333333341070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115231_324524.33333333333341070.0RegionNote=Linker
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115301_538524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115325_550524.33333333333341070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115376_521524.33333333333341070.0RegionNote=QFP motif
TgeneTERTchr5:14420129chr5:1282738ENST00000334602115397_417524.33333333333341070.0RegionNote=CP motif
TgeneTERTchr5:14420129chr5:1282738ENST0000033460211558_197524.33333333333341070.0RegionNote=GQ motif
TgeneTERTchr5:14420129chr5:1282738ENST00000508104181_230524.3333333333334808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418231_324524.3333333333334808.0RegionNote=Linker
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418301_538524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418325_550524.3333333333334808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418376_521524.3333333333334808.0RegionNote=QFP motif
TgeneTERTchr5:14420129chr5:1282738ENST0000050810418397_417524.3333333333334808.0RegionNote=CP motif
TgeneTERTchr5:14420129chr5:1282738ENST000005081041858_197524.3333333333334808.0RegionNote=GQ motif
TgeneTERTchr5:14420130chr5:1282739ENST000002968201141_230524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114231_324524.3333333333334445.6666666666667RegionNote=Linker
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114301_538524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114325_550524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114376_521524.3333333333334445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:14420130chr5:1282739ENST00000296820114397_417524.3333333333334445.6666666666667RegionNote=CP motif
TgeneTERTchr5:14420130chr5:1282739ENST0000029682011458_197524.3333333333334445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:14420130chr5:1282739ENST000003105811161_230524.33333333333341133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116231_324524.33333333333341133.0RegionNote=Linker
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116301_538524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116325_550524.33333333333341133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116376_521524.33333333333341133.0RegionNote=QFP motif
TgeneTERTchr5:14420130chr5:1282739ENST00000310581116397_417524.33333333333341133.0RegionNote=CP motif
TgeneTERTchr5:14420130chr5:1282739ENST0000031058111658_197524.33333333333341133.0RegionNote=GQ motif
TgeneTERTchr5:14420130chr5:1282739ENST000003346021151_230524.33333333333341070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115231_324524.33333333333341070.0RegionNote=Linker
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115301_538524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115325_550524.33333333333341070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115376_521524.33333333333341070.0RegionNote=QFP motif
TgeneTERTchr5:14420130chr5:1282739ENST00000334602115397_417524.33333333333341070.0RegionNote=CP motif
TgeneTERTchr5:14420130chr5:1282739ENST0000033460211558_197524.33333333333341070.0RegionNote=GQ motif
TgeneTERTchr5:14420130chr5:1282739ENST00000508104181_230524.3333333333334808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418231_324524.3333333333334808.0RegionNote=Linker
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418301_538524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418325_550524.3333333333334808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418376_521524.3333333333334808.0RegionNote=QFP motif
TgeneTERTchr5:14420130chr5:1282739ENST0000050810418397_417524.3333333333334808.0RegionNote=CP motif
TgeneTERTchr5:14420130chr5:1282739ENST000005081041858_197524.3333333333334808.0RegionNote=GQ motif


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TRIO_pLDDT.png
all structure
all structure
TERT_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TRIO
TERT


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TRIO-TERT


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TRIO-TERT


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource