UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:VAV2-FNBP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: VAV2-FNBP1
	FusionPDB ID: 97936
	FusionGDB2.0 ID: 97936
		Hgene	Tgene
	Gene symbol	VAV2	FNBP1
	Gene ID	7410	23048
	Gene name	vav guanine nucleotide exchange factor 2	formin binding protein 1
	Synonyms	VAV-2	FBP17
	Cytomap	9q34.2	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	guanine nucleotide exchange factor VAV2vav 2 oncogene	formin-binding protein 1formin-binding protein 17
	Modification date	20200313	20200313
	UniProtAcc	.	Q5T0N5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371850, ENST00000371851, ENST00000406606, ENST00000486113,	ENST00000443566, ENST00000478129, ENST00000355681, ENST00000420781, ENST00000446176,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 11 X 11=1573	24 X 24 X 8=4608
	# samples	19	26
	** MAII score	log2(19/1573*10)=-3.04944734708474 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/4608*10)=-4.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: VAV2 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	VAV2(136857197)-FNBP1(132757237), # samples:3
Anticipated loss of major functional domain due to fusion event.	VAV2-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VAV2-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VAV2-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VAV2-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across VAV2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FNBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	DLBC	TCGA-GS-A9TW-01A	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-
ChimerDB4	DLBC	TCGA-GS-A9TW	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000406606	VAV2	chr9	136857197	-	ENST00000446176	FNBP1	chr9	132757237	-	5389	207	3	2036	677
ENST00000406606	VAV2	chr9	136857197	-	ENST00000420781	FNBP1	chr9	132757237	-	5362	207	3	2009	668
ENST00000406606	VAV2	chr9	136857197	-	ENST00000355681	FNBP1	chr9	132757237	-	1968	207	3	1961	652
ENST00000371850	VAV2	chr9	136857197	-	ENST00000446176	FNBP1	chr9	132757237	-	5418	236	32	2065	677
ENST00000371850	VAV2	chr9	136857197	-	ENST00000420781	FNBP1	chr9	132757237	-	5391	236	32	2038	668
ENST00000371850	VAV2	chr9	136857197	-	ENST00000355681	FNBP1	chr9	132757237	-	1997	236	32	1990	652
ENST00000371851	VAV2	chr9	136857197	-	ENST00000446176	FNBP1	chr9	132757237	-	5712	530	203	2359	718
ENST00000371851	VAV2	chr9	136857197	-	ENST00000420781	FNBP1	chr9	132757237	-	5685	530	203	2332	709
ENST00000371851	VAV2	chr9	136857197	-	ENST00000355681	FNBP1	chr9	132757237	-	2291	530	203	2284	693

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000406606	ENST00000446176	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.002754668	0.9972453
ENST00000406606	ENST00000420781	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.002927012	0.99707294
ENST00000406606	ENST00000355681	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.011905399	0.9880946
ENST00000371850	ENST00000446176	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.002766975	0.9972331
ENST00000371850	ENST00000420781	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.002939528	0.9970605
ENST00000371850	ENST00000355681	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.010986877	0.9890132
ENST00000371851	ENST00000446176	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.003061661	0.99693835
ENST00000371851	ENST00000420781	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.00325789	0.9967422
ENST00000371851	ENST00000355681	VAV2	chr9	136857197	-	FNBP1	chr9	132757237	-	0.010177109	0.98982286

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97936_97936_1_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371850_FNBP1_chr9_132757237_ENST00000355681_length(amino acids)=652AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVD
ELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVN
NCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEG

--------------------------------------------------------------

>97936_97936_2_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371850_FNBP1_chr9_132757237_ENST00000420781_length(amino acids)=668AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGHSLTLQGATP
EDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPAR
SEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYV

--------------------------------------------------------------

>97936_97936_3_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371850_FNBP1_chr9_132757237_ENST00000446176_length(amino acids)=677AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRG
LSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA
EVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTIS

--------------------------------------------------------------

>97936_97936_4_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371851_FNBP1_chr9_132757237_ENST00000355681_length(amino acids)=693AA_BP=108
MGQPARSPAPALSPARARAGCPAAAALWLEHCPEPVGPAGAMEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHN
LSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNE
MNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADV
EKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI
DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKSPKQQKEPLSHRFNEFMTSK
PKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKL
RVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKAL

--------------------------------------------------------------

>97936_97936_5_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371851_FNBP1_chr9_132757237_ENST00000420781_length(amino acids)=709AA_BP=108
MGQPARSPAPALSPARARAGCPAAAALWLEHCPEPVGPAGAMEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHN
LSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNE
MNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADV
EKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI
DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKPPPPPPASASPSAVPNGPQS
PKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGHSLTLQGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQM
GDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATD

--------------------------------------------------------------

>97936_97936_6_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000371851_FNBP1_chr9_132757237_ENST00000446176_length(amino acids)=718AA_BP=108
MGQPARSPAPALSPARARAGCPAAAALWLEHCPEPVGPAGAMEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHN
LSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNE
MNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADV
EKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI
DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASAS
PSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMK
DVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQE

--------------------------------------------------------------

>97936_97936_7_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000406606_FNBP1_chr9_132757237_ENST00000355681_length(amino acids)=652AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVD
ELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVN
NCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEG

--------------------------------------------------------------

>97936_97936_8_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000406606_FNBP1_chr9_132757237_ENST00000420781_length(amino acids)=668AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGHSLTLQGATP
EDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPAR
SEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYV

--------------------------------------------------------------

>97936_97936_9_VAV2-FNBP1_VAV2_chr9_136857197_ENST00000406606_FNBP1_chr9_132757237_ENST00000446176_length(amino acids)=677AA_BP=67
MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIK
FVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIP
NIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRG
LSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA
EVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTIS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:136857197/chr9:132757237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FNBP1 Q5T0N5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269\|PubMed:15260990, ECO:0000269\|PubMed:16326391, ECO:0000269\|PubMed:19342671}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

398_490

8.0

593.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

67_259

8.0

593.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

398_490

8.0

618.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

67_259

8.0

618.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

340_345

8.0

593.0

Compositional bias

Note=Poly-Pro

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

340_345

8.0

618.0

Compositional bias

Note=Poly-Pro

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

404_481

8.0

593.0

Domain

REM-1

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

550_611

8.0

593.0

Domain

SH3

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

404_481

8.0

618.0

Domain

REM-1

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

550_611

8.0

618.0

Domain

SH3

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

251_617

8.0

593.0

Region

Note=Required for self-association and induction of membrane tubulation

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

251_617

8.0

618.0

Region

Note=Required for self-association and induction of membrane tubulation

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

198_376

68.0

879.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

1_120

68.0

879.0

Domain

Calponin-homology (CH)

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

405_512

68.0

879.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

586_652

68.0

879.0

Domain

SH3 1

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

673_767

68.0

879.0

Domain

SH2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

816_877

68.0

879.0

Domain

SH3 2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

198_376

68.0

869.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

1_120

68.0

869.0

Domain

Calponin-homology (CH)

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

405_512

68.0

869.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

586_652

68.0

869.0

Domain

SH3 1

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

673_767

68.0

869.0

Domain

SH2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

816_877

68.0

869.0

Domain

SH3 2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

198_376

68.0

840.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

1_120

68.0

840.0

Domain

Calponin-homology (CH)

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

405_512

68.0

840.0

Domain

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

586_652

68.0

840.0

Domain

SH3 1

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

673_767

68.0

840.0

Domain

SH2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

816_877

68.0

840.0

Domain

SH3 2

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371850

523_572

68.0

879.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000371851

523_572

68.0

869.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

VAV2

chr9:136857197

chr9:132757237

ENST00000406606

523_572

68.0

840.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

1_264

8.0

593.0

Domain

F-BAR

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

1_264

8.0

618.0

Domain

F-BAR

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000355681

1_79

8.0

593.0

Region

Note=Required for self-association and induction of membrane tubulation

Tgene

FNBP1

chr9:136857197

chr9:132757237

ENST00000446176

1_79

8.0

618.0

Region

Note=Required for self-association and induction of membrane tubulation

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1462_VAV2_136857197_FNBP1_132757237_ranked_0.pdb	VAV2	136857197	136857197	ENST00000355681	FNBP1	chr9	132757237	-	MGQPARSPAPALSPARARAGCPAAAALWLEHCPEPVGPAGAMEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHN LSPGSIDLKDINFRPQMSQDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNE MNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADV EKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASAS PSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMK DVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQE	718

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

VAV2_pLDDT.png

FNBP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
VAV2
FNBP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	FNBP1	chr9:136857197	chr9:132757237	ENST00000355681		0	16	1_335	8.0	593.0	microtubules
Tgene	FNBP1	chr9:136857197	chr9:132757237	ENST00000446176		0	17	1_335	8.0	618.0	microtubules

Top

Related Drugs to VAV2-FNBP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to VAV2-FNBP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source