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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZBTB20-CLDN11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZBTB20-CLDN11
FusionPDB ID: 100347
FusionGDB2.0 ID: 100347
HgeneTgene
Gene symbol

ZBTB20

CLDN11

Gene ID

26137

5010

Gene namezinc finger and BTB domain containing 20claudin 11
SynonymsDPZF|HOF|ODA-8S|PRIMS|ZNF288OSP|OTM
Cytomap

3q13.31

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288claudin-11oligodendrocyte transmembrane proteinoligodendrocyte-specific protein
Modification date2020031320200313
UniProtAcc.

O75508

Ensembl transtripts involved in fusion geneENST idsENST00000357258, ENST00000393785, 
ENST00000462705, ENST00000464560, 
ENST00000471418, ENST00000474710, 
ENST00000481632, ENST00000488663, 
ENST00000489485, ENST00000064724, 
ENST00000451576, ENST00000486975, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score49 X 36 X 18=3175210 X 9 X 9=810
# samples 6410
** MAII scorelog2(64/31752*10)=-5.63263175211247
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/810*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZBTB20 [Title/Abstract] AND CLDN11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZBTB20(114069121)-CLDN11(170140951), # samples:3
Anticipated loss of major functional domain due to fusion event.ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZBTB20-CLDN11 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLDN11

GO:0120192

tight junction assembly

30734065


check buttonFusion gene breakpoints across ZBTB20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLDN11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7211-01AZBTB20chr3

114069121

-CLDN11chr3

170140951

+
ChimerDB4PRADTCGA-HC-7211ZBTB20chr3

114069120

-CLDN11chr3

170140950

+
ChimerDB4PRADTCGA-HC-7211ZBTB20chr3

114069121

-CLDN11chr3

170140951

+
ChimerDB4PRADTCGA-HC-7211ZBTB20chr3

114099064

-CLDN11chr3

170140951

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462705ZBTB20chr3114069121-ENST00000486975CLDN11chr3170140951+312124075972678693
ENST00000462705ZBTB20chr3114069121-ENST00000451576CLDN11chr3170140951+267924075972678693
ENST00000462705ZBTB20chr3114069121-ENST00000064724CLDN11chr3170140951+414824075972804735
ENST00000481632ZBTB20chr3114069121-ENST00000486975CLDN11chr3170140951+273920252152296693
ENST00000481632ZBTB20chr3114069121-ENST00000451576CLDN11chr3170140951+229720252152296694
ENST00000481632ZBTB20chr3114069121-ENST00000064724CLDN11chr3170140951+376620252152422735
ENST00000357258ZBTB20chr3114069121-ENST00000486975CLDN11chr3170140951+291321993892470693
ENST00000357258ZBTB20chr3114069121-ENST00000451576CLDN11chr3170140951+247121993892470694
ENST00000357258ZBTB20chr3114069121-ENST00000064724CLDN11chr3170140951+394021993892596735
ENST00000462705ZBTB20chr3114069120-ENST00000486975CLDN11chr3170140950+312124075972678693
ENST00000462705ZBTB20chr3114069120-ENST00000451576CLDN11chr3170140950+267924075972678693
ENST00000462705ZBTB20chr3114069120-ENST00000064724CLDN11chr3170140950+414824075972804735
ENST00000481632ZBTB20chr3114069120-ENST00000486975CLDN11chr3170140950+273920252152296693
ENST00000481632ZBTB20chr3114069120-ENST00000451576CLDN11chr3170140950+229720252152296694
ENST00000481632ZBTB20chr3114069120-ENST00000064724CLDN11chr3170140950+376620252152422735
ENST00000357258ZBTB20chr3114069120-ENST00000486975CLDN11chr3170140950+291321993892470693
ENST00000357258ZBTB20chr3114069120-ENST00000451576CLDN11chr3170140950+247121993892470694
ENST00000357258ZBTB20chr3114069120-ENST00000064724CLDN11chr3170140950+394021993892596735

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462705ENST00000486975ZBTB20chr3114069121-CLDN11chr3170140951+0.016524010.98347604
ENST00000462705ENST00000451576ZBTB20chr3114069121-CLDN11chr3170140951+0.0236609780.976339
ENST00000462705ENST00000064724ZBTB20chr3114069121-CLDN11chr3170140951+0.0055500860.99445
ENST00000481632ENST00000486975ZBTB20chr3114069121-CLDN11chr3170140951+0.0212470350.978753
ENST00000481632ENST00000451576ZBTB20chr3114069121-CLDN11chr3170140951+0.034011720.9659882
ENST00000481632ENST00000064724ZBTB20chr3114069121-CLDN11chr3170140951+0.0060644620.9939355
ENST00000357258ENST00000486975ZBTB20chr3114069121-CLDN11chr3170140951+0.0170181840.98298186
ENST00000357258ENST00000451576ZBTB20chr3114069121-CLDN11chr3170140951+0.0254469890.974553
ENST00000357258ENST00000064724ZBTB20chr3114069121-CLDN11chr3170140951+0.0056235820.9943764
ENST00000462705ENST00000486975ZBTB20chr3114069120-CLDN11chr3170140950+0.016524010.98347604
ENST00000462705ENST00000451576ZBTB20chr3114069120-CLDN11chr3170140950+0.0236609780.976339
ENST00000462705ENST00000064724ZBTB20chr3114069120-CLDN11chr3170140950+0.0055500860.99445
ENST00000481632ENST00000486975ZBTB20chr3114069120-CLDN11chr3170140950+0.0212470350.978753
ENST00000481632ENST00000451576ZBTB20chr3114069120-CLDN11chr3170140950+0.034011720.9659882
ENST00000481632ENST00000064724ZBTB20chr3114069120-CLDN11chr3170140950+0.0060644620.9939355
ENST00000357258ENST00000486975ZBTB20chr3114069120-CLDN11chr3170140950+0.0170181840.98298186
ENST00000357258ENST00000451576ZBTB20chr3114069120-CLDN11chr3170140950+0.0254469890.974553
ENST00000357258ENST00000064724ZBTB20chr3114069120-CLDN11chr3170140950+0.0056235820.9943764

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100347_100347_1_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000357258_CLDN11_chr3_170140950_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_2_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000357258_CLDN11_chr3_170140950_ENST00000451576_length(amino acids)=694AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_3_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000357258_CLDN11_chr3_170140950_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_4_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000462705_CLDN11_chr3_170140950_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_5_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000462705_CLDN11_chr3_170140950_ENST00000451576_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_6_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000462705_CLDN11_chr3_170140950_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_7_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000481632_CLDN11_chr3_170140950_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_8_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000481632_CLDN11_chr3_170140950_ENST00000451576_length(amino acids)=694AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_9_ZBTB20-CLDN11_ZBTB20_chr3_114069120_ENST00000481632_CLDN11_chr3_170140950_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_10_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000357258_CLDN11_chr3_170140951_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_11_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000357258_CLDN11_chr3_170140951_ENST00000451576_length(amino acids)=694AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_12_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000357258_CLDN11_chr3_170140951_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_13_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000462705_CLDN11_chr3_170140951_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_14_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000462705_CLDN11_chr3_170140951_ENST00000451576_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_15_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000462705_CLDN11_chr3_170140951_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_16_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000481632_CLDN11_chr3_170140951_ENST00000064724_length(amino acids)=735AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV
LPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYY

--------------------------------------------------------------

>100347_100347_17_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000481632_CLDN11_chr3_170140951_ENST00000451576_length(amino acids)=694AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

>100347_100347_18_ZBTB20-CLDN11_ZBTB20_chr3_114069121_ENST00000481632_CLDN11_chr3_170140951_ENST00000486975_length(amino acids)=693AA_BP=603
MILKLLKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSN
SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAAS
ILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVS
HHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTE
DTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITV
SNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQ
FVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGYVQACRALMIAASVLGLPAILLLLTV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:114069121/chr3:170140951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLDN11

O75508

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45104_167601.3333333333334742.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45104_167601.3333333333334742.0DomainBTB
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56104_167528.3333333333334669.0DomainBTB
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45578_600601.3333333333334742.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45578_600601.3333333333334742.0Zinc fingerC2H2-type 1
TgeneCLDN11chr3:114069120chr3:170140950ENST0000006472403104_12275.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069120chr3:170140950ENST0000006472403144_15775.33333333333333208.0Topological domainExtracellular
TgeneCLDN11chr3:114069120chr3:170140950ENST0000006472403179_20775.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069121chr3:170140951ENST0000006472403104_12275.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069121chr3:170140951ENST0000006472403144_15775.33333333333333208.0Topological domainExtracellular
TgeneCLDN11chr3:114069121chr3:170140951ENST0000006472403179_20775.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069120chr3:170140950ENST0000006472403123_14375.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069120chr3:170140950ENST0000006472403158_17875.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069120chr3:170140950ENST000000647240383_10375.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069121chr3:170140951ENST0000006472403123_14375.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069121chr3:170140951ENST0000006472403158_17875.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069121chr3:170140951ENST000000647240383_10375.33333333333333208.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000357258-910715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000393785-56715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000462705-1112715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000464560-78715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000471418-67715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45606_628601.3333333333334742.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45634_656601.3333333333334742.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45662_684601.3333333333334742.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000474710-45715_737601.3333333333334742.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069120chr3:170140950ENST00000481632-56715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000357258-910715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000393785-56715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000462705-1112715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000464560-78715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000471418-67715_737528.3333333333334669.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45606_628601.3333333333334742.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45634_656601.3333333333334742.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45662_684601.3333333333334742.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000474710-45715_737601.3333333333334742.0Zinc fingerC2H2-type 5
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56578_600528.3333333333334669.0Zinc fingerC2H2-type 1
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56606_628528.3333333333334669.0Zinc fingerC2H2-type 2
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56634_656528.3333333333334669.0Zinc fingerC2H2-type 3
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56662_684528.3333333333334669.0Zinc fingerC2H2-type 4
HgeneZBTB20chr3:114069121chr3:170140951ENST00000481632-56715_737528.3333333333334669.0Zinc fingerC2H2-type 5
TgeneCLDN11chr3:114069120chr3:170140950ENST00000064724031_175.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069120chr3:170140950ENST000000647240323_8275.33333333333333208.0Topological domainExtracellular
TgeneCLDN11chr3:114069121chr3:170140951ENST00000064724031_175.33333333333333208.0Topological domainCytoplasmic
TgeneCLDN11chr3:114069121chr3:170140951ENST000000647240323_8275.33333333333333208.0Topological domainExtracellular
TgeneCLDN11chr3:114069120chr3:170140950ENST00000064724032_2275.33333333333333208.0TransmembraneHelical
TgeneCLDN11chr3:114069121chr3:170140951ENST00000064724032_2275.33333333333333208.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZBTB20_pLDDT.png
all structure
all structure
CLDN11_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZBTB20
CLDN11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZBTB20-CLDN11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZBTB20-CLDN11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource