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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BPTF-NOL11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BPTF-NOL11
FusionPDB ID: 10092
FusionGDB2.0 ID: 10092
HgeneTgene
Gene symbol

BPTF

NOL11

Gene ID

2186

25926

Gene namebromodomain PHD finger transcription factornucleolar protein 11
SynonymsFAC1|FALZ|NEDDFL|NURF301-
Cytomap

17q24.2

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionnucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling fnucleolar protein 11
Modification date2020031320200313
UniProtAcc

Q12830

Q9H8H0

Ensembl transtripts involved in fusion geneENST idsENST00000306378, ENST00000321892, 
ENST00000335221, ENST00000424123, 
ENST00000577770, 		ENST00000581966, 
ENST00000535137, ENST00000253247, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 21 X 13=73713 X 9 X 6=162
# samples 429
** MAII scorelog2(42/7371*10)=-4.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BPTF [Title/Abstract] AND NOL11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BPTF(65944422)-NOL11(65715790), # samples:3
BPTF(65862803)-NOL11(65739859), # samples:3
Anticipated loss of major functional domain due to fusion event.BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BPTF-NOL11 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
BPTF-NOL11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBPTF

GO:0000122

negative regulation of transcription by RNA polymerase II

10727212

HgeneBPTF

GO:0006338

chromatin remodeling

14609955


check buttonFusion gene breakpoints across BPTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOL11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A8OQ-01ABPTFchr17

65928135

+NOL11chr17

65735632

+
ChimerDB4SKCMTCGA-ER-A19W-06ABPTFchr17

65822453

-NOL11chr17

65739595

+
ChimerDB4TGCTTCGA-2G-AAKL-01ABPTFchr17

65944422

-NOL11chr17

65715790

+
ChimerDB4TGCTTCGA-2G-AAKL-01ABPTFchr17

65944422

+NOL11chr17

65715790

+
ChimerDB4TGCTTCGA-2G-AAKLBPTFchr17

65944422

+NOL11chr17

65715790

+
ChimerDB4UCECTCGA-D1-A2G7-01ABPTFchr17

65822453

+NOL11chr17

65730479

+
ChimerDB4UCECTCGA-D1-A2G7BPTFchr17

65822453

+NOL11chr17

65730478

+
ChimerDB4UCSTCGA-N8-A56S-01ABPTFchr17

65862803

-NOL11chr17

65739859

+
ChimerDB4UCSTCGA-N8-A56S-01ABPTFchr17

65862803

+NOL11chr17

65739859

+
ChimerDB4UCSTCGA-N8-A56SBPTFchr17

65862803

+NOL11chr17

65739858

+
ChimerDB4UCSTCGA-N8-A56SBPTFchr17

65862803

+NOL11chr17

65739859

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335221BPTFchr1765944422+ENST00000253247NOL11chr1765715790+1062779366199543297
ENST00000321892BPTFchr1765944422+ENST00000253247NOL11chr1765715790+11056836561103833440
ENST00000306378BPTFchr1765944422+ENST00000253247NOL11chr1765715790+10677798660100043314
ENST00000424123BPTFchr1765944422+ENST00000253247NOL11chr1765715790+101497458094763158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335221ENST00000253247BPTFchr1765944422+NOL11chr1765715790+0.0005258240.9994742
ENST00000321892ENST00000253247BPTFchr1765944422+NOL11chr1765715790+0.0003845070.99961543
ENST00000306378ENST00000253247BPTFchr1765944422+NOL11chr1765715790+0.0003554670.9996445
ENST00000424123ENST00000253247BPTFchr1765944422+NOL11chr1765715790+0.0004959410.9995041

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10092_10092_1_BPTF-NOL11_BPTF_chr17_65944422_ENST00000306378_NOL11_chr17_65715790_ENST00000253247_length(amino acids)=3314AA_BP=2642
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEVGDFKSEKS
NGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEG
KYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKA
VQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEY
RVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISK
ITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLE
KIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDV
SIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKS
TNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLP
VKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKV
NNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQ
VEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENC
AKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRK
FVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKA
PPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEE
ELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQ
NKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQ
STLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHG
GNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVH
QDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSP
VRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQP
QVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIE
IKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATK
LSALLFKHKEQLRAEILKKRALLDKDLQIEVQVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATL
SAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLL
LGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKE
CLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNS
EQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVL
SYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEED
KCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQ

--------------------------------------------------------------

>10092_10092_2_BPTF-NOL11_BPTF_chr17_65944422_ENST00000321892_NOL11_chr17_65715790_ENST00000253247_length(amino acids)=3440AA_BP=2768
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKG
NSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQ
SESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGK
EVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKV
LTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVK
KKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKC
SRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEG
FHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPE
DLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASAD
DIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNES
ISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTST
FQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTV
ITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVT
SMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFG
ITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKET
PTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTIS
PAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT
IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSA
TSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPL
ATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTT
VSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
PQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSAVQTH
QIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQV
MKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQVSDQKPLGSWSVKQGQIITCPA
VCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFF
VVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSL
LLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLA
GALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDF
HTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQET
DVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIP
AQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQ

--------------------------------------------------------------

>10092_10092_3_BPTF-NOL11_BPTF_chr17_65944422_ENST00000335221_NOL11_chr17_65715790_ENST00000253247_length(amino acids)=3297AA_BP=2625
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDF
CAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENK
IKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNK
ARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKG
NSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQ
SESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGK
EVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKV
LTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVK
KKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKTHVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKC
SRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEG
FHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPE
DLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASAD
DIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNES
ISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTST
FQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTV
ITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVT
SMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFG
ITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKET
PTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTIS
PAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT
IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSA
TSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPL
ATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTT
VSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQ
PQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEIL
KKRALLDKDLQIEVQVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVVHDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLV
LFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFITEKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVD
RKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARNGVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKE
LPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDPGTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQ
PEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLLERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKD
VQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSINSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDET
KESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLYFLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVV

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>10092_10092_4_BPTF-NOL11_BPTF_chr17_65944422_ENST00000424123_NOL11_chr17_65715790_ENST00000253247_length(amino acids)=3158AA_BP=2486
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEEKDIPPLEF
PKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLY
FIDGMTWPEVLRVYCESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCS
AVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQ
LAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKD
AEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASEL
PQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSSQSESAKAADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKG
ASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNS
FALNKHQHREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALA
LAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISK
THVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELL
DSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGK
TSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQN
SIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPLSRAM
DFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQ
QKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKIIPENDIK
SLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKK
VTSSPITSEEESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVT
KLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVL
PNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSE
TEITTTEIIKRRDVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAFAER
VEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVK
QGQSNSGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVM
VQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQG
QTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSV
GPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVSSHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRP
STPSQLSPGQQSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEE
KQAAKKRKREESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQVSDQKPLGSWSVKQGQIITCPAVCNFQTGEYVVV
HDNKVLRIWNNEDVNLDKVFKATLSAEVYRILSVQGTEPLVLFKEGAVRGLEALLADPQQKIETVISDEEVIKWTKFFVVFRHPVLIFIT
EKHGNYFAYVQMFNSRILTKYTLLLGQDENSVIKSFTASVDRKFISLMSLSSDGCIYETLIPIRPADPEKNQSLVKSLLLKAVVSGNARN
GVALTALDQDHVAVLGSPLAASKECLSVWNIKFQTLQTSKELPQGTSGQLWYYGEHLFMLHGKSLTVIPYKCEVSSLAGALGKLKHSQDP
GTHVVSHFVNWETPQGCGLGFQNSEQSRRILRRRKIEVSLQPEVPPSKQLLSTIMKDSEKHIEVEVRKFLALKQTPDFHTVIGDTVTGLL
ERCKAEPSFYPRNCLMQLIQTHVLSYSLCPDLMEIALKKKDVQLLQLCLQQFPDIPESVTCACLKIFLSIGDDSLQETDVNMESVFDYSI
NSVHDEKMEEQTEILQNGFNPEEDKCNNCDQELNKKPQDETKESTSCPVVQKRAALLNAILHSAYSETFLLPHLKDIPAQHITLFLKYLY
FLYLKCSENATMTLPGIHPPTLNQIMDWICLLLDANFTVVVMMPEAKRLLINLYKLVKSQISVYSELNKIEVSFRELQKLNQEKNNRGLY

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65944422/chr17:65715790)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BPTF

Q12830

NOL11

Q9H8H0

FUNCTION: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.FUNCTION: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000269|PubMed:22916032}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282022_20502642.02921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328574_6042642.02921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328978_10072642.02921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302022_20502768.03047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302706_27322768.03047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530574_6042768.03047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530978_10072768.03047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302022_20502625.02904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530574_6042625.02904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530978_10072625.02904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128143_180204.333333333333342921.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128149_185204.333333333333342921.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130143_180204.333333333333343047.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130149_185204.333333333333343047.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130143_180204.333333333333342904.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130149_185204.333333333333342904.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128143_180204.333333333333342921.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128149_185204.333333333333342921.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130143_180204.333333333333343047.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130149_185204.333333333333343047.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130143_180204.333333333333342904.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130149_185204.333333333333342904.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328143_1802642.02921.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328149_1852642.02921.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23281709_18032642.02921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282338_23612642.02921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530143_1802768.03047.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530149_1852768.03047.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25301709_18032768.03047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302338_23612768.03047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530143_1802625.02904.0Compositional biasNote=Glu-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530149_1852625.02904.0Compositional biasNote=Asp-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25301709_18032625.02904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302338_23612625.02904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328240_3002642.02921.0DomainDDT
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530240_3002768.03047.0DomainDDT
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530240_3002625.02904.0DomainDDT
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+2328390_4372642.02921.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+2530390_4372768.03047.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+2530390_4372625.02904.0Zinc fingerPHD-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282022_2050204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282706_2732204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128574_604204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128978_1007204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302022_2050204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302706_2732204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130574_604204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130978_1007204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302022_2050204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302706_2732204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130574_604204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130978_1007204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282022_2050204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282706_2732204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128574_604204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128978_1007204.333333333333342921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302022_2050204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302706_2732204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130574_604204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130978_1007204.333333333333343047.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302022_2050204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302706_2732204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130574_604204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130978_1007204.333333333333342904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282706_27322642.02921.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302706_27322625.02904.0Coiled coilOntology_term=ECO:0000255
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1281709_1803204.333333333333342921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282338_2361204.333333333333342921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282795_2817204.333333333333342921.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282848_2853204.333333333333342921.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1301709_1803204.333333333333343047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302338_2361204.333333333333343047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302795_2817204.333333333333343047.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302848_2853204.333333333333343047.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1301709_1803204.333333333333342904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302338_2361204.333333333333342904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302795_2817204.333333333333342904.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302848_2853204.333333333333342904.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1281709_1803204.333333333333342921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282338_2361204.333333333333342921.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282795_2817204.333333333333342921.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282848_2853204.333333333333342921.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1301709_1803204.333333333333343047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302338_2361204.333333333333343047.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302795_2817204.333333333333343047.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302848_2853204.333333333333343047.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1301709_1803204.333333333333342904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302338_2361204.333333333333342904.0Compositional biasNote=Thr-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302795_2817204.333333333333342904.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302848_2853204.333333333333342904.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282795_28172642.02921.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282848_28532642.02921.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302795_28172768.03047.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302848_28532768.03047.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302795_28172625.02904.0Compositional biasNote=Pro-rich
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302848_28532625.02904.0Compositional biasNote=Poly-Lys
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128240_300204.333333333333342921.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282944_3014204.333333333333342921.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130240_300204.333333333333343047.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302944_3014204.333333333333343047.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130240_300204.333333333333342904.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302944_3014204.333333333333342904.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128240_300204.333333333333342921.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282944_3014204.333333333333342921.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130240_300204.333333333333343047.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302944_3014204.333333333333343047.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130240_300204.333333333333342904.0DomainDDT
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302944_3014204.333333333333342904.0DomainBromo
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282944_30142642.02921.0DomainBromo
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302944_30142768.03047.0DomainBromo
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302944_30142625.02904.0DomainBromo
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+1282867_2918204.333333333333342921.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128390_437204.333333333333342921.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+1302867_2918204.333333333333343047.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130390_437204.333333333333343047.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+1302867_2918204.333333333333342904.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130390_437204.333333333333342904.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+1282867_2918204.333333333333342921.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128390_437204.333333333333342921.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+1302867_2918204.333333333333343047.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130390_437204.333333333333343047.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+1302867_2918204.333333333333342904.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130390_437204.333333333333342904.0Zinc fingerPHD-type 1
HgeneBPTFchr17:65944422chr17:65715790ENST00000306378+23282867_29182642.02921.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65944422chr17:65715790ENST00000321892+25302867_29182768.03047.0Zinc fingerPHD-type 2
HgeneBPTFchr17:65944422chr17:65715790ENST00000335221+25302867_29182625.02904.0Zinc fingerPHD-type 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BPTF
NOL11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128640_749204.333333333333342921.0KEAP1
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130640_749204.333333333333343047.0KEAP1
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130640_749204.333333333333342904.0KEAP1
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128640_749204.333333333333342921.0KEAP1
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130640_749204.333333333333343047.0KEAP1
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130640_749204.333333333333342904.0KEAP1
HgeneBPTFchr17:65822453chr17:65730478ENST00000306378+128839_921204.333333333333342921.0MAZ
HgeneBPTFchr17:65822453chr17:65730478ENST00000321892+130839_921204.333333333333343047.0MAZ
HgeneBPTFchr17:65822453chr17:65730478ENST00000335221+130839_921204.333333333333342904.0MAZ
HgeneBPTFchr17:65822453chr17:65730479ENST00000306378+128839_921204.333333333333342921.0MAZ
HgeneBPTFchr17:65822453chr17:65730479ENST00000321892+130839_921204.333333333333343047.0MAZ
HgeneBPTFchr17:65822453chr17:65730479ENST00000335221+130839_921204.333333333333342904.0MAZ


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Related Drugs to BPTF-NOL11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BPTF-NOL11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource