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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BPTF-NSF

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BPTF-NSF
	FusionPDB ID: 10094
	FusionGDB2.0 ID: 10094
		Hgene	Tgene
	Gene symbol	BPTF	NSF
	Gene ID	2186	4905
	Gene name	bromodomain PHD finger transcription factor	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
	Synonyms	FAC1\|FALZ\|NEDDFL\|NURF301	SEC18\|SKD2
	Cytomap	17q24.2	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	nucleosome-remodeling factor subunit BPTFbromodomain and PHD domain transcription factorbromodomain and PHD finger-containing transcription factorfetal Alz-50 clone 1 proteinfetal Alz-50 reactive clone 1fetal Alzheimer antigennucleosome remodeling f	vesicle-fusing ATPaseN-ethylmaleimide-sensitive factor-like proteinN-ethylmaleimide-sensitive fusion proteinNEM-sensitive fusion proteinepididymis secretory sperm binding proteinvesicular-fusion protein NSF
	Modification date	20200313	20200313
	UniProtAcc	Q12830	NSFL1C
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000306378, ENST00000321892, ENST00000335221, ENST00000424123, ENST00000577770,	ENST00000225282, ENST00000398238, ENST00000575068,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 21 X 13=7371	11 X 8 X 6=528
	# samples	42	12
	** MAII score	log2(42/7371*10)=-4.1333991254172 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BPTF [Title/Abstract] AND NSF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BPTF(65822453)-NSF(44751779), # samples:1
Anticipated loss of major functional domain due to fusion event.	BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BPTF-NSF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BPTF	GO:0000122	negative regulation of transcription by RNA polymerase II	10727212
Hgene	BPTF	GO:0006338	chromatin remodeling	14609955
Tgene	NSF	GO:0001921	positive regulation of receptor recycling	15613468

Fusion gene breakpoints across BPTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NSF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A0TV	BPTF	chr17	65822453	+	NSF	chr17	44751779	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000335221	BPTF	chr17	65822453	+	ENST00000398238	NSF	chr17	44751779	+	3805	674	61	2163	700
ENST00000335221	BPTF	chr17	65822453	+	ENST00000225282	NSF	chr17	44751779	+	2665	674	61	2145	694
ENST00000335221	BPTF	chr17	65822453	+	ENST00000575068	NSF	chr17	44751779	+	2400	674	61	2163	700
ENST00000321892	BPTF	chr17	65822453	+	ENST00000398238	NSF	chr17	44751779	+	3805	674	61	2163	700
ENST00000321892	BPTF	chr17	65822453	+	ENST00000225282	NSF	chr17	44751779	+	2665	674	61	2145	694
ENST00000321892	BPTF	chr17	65822453	+	ENST00000575068	NSF	chr17	44751779	+	2400	674	61	2163	700
ENST00000306378	BPTF	chr17	65822453	+	ENST00000398238	NSF	chr17	44751779	+	3804	673	60	2162	700
ENST00000306378	BPTF	chr17	65822453	+	ENST00000225282	NSF	chr17	44751779	+	2664	673	60	2144	694
ENST00000306378	BPTF	chr17	65822453	+	ENST00000575068	NSF	chr17	44751779	+	2399	673	60	2162	700
ENST00000424123	BPTF	chr17	65822453	+	ENST00000398238	NSF	chr17	44751779	+	3327	196	0	1685	561
ENST00000424123	BPTF	chr17	65822453	+	ENST00000225282	NSF	chr17	44751779	+	2187	196	0	1667	555
ENST00000424123	BPTF	chr17	65822453	+	ENST00000575068	NSF	chr17	44751779	+	1922	196	0	1685	561

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000335221	ENST00000398238	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.001080245	0.9989197
ENST00000335221	ENST00000225282	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.00371771	0.9962823
ENST00000335221	ENST00000575068	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.00435703	0.995643
ENST00000321892	ENST00000398238	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.001080245	0.9989197
ENST00000321892	ENST00000225282	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.00371771	0.9962823
ENST00000321892	ENST00000575068	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.00435703	0.995643
ENST00000306378	ENST00000398238	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.001081031	0.998919
ENST00000306378	ENST00000225282	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.003725806	0.99627423
ENST00000306378	ENST00000575068	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.004361295	0.9956388
ENST00000424123	ENST00000398238	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.000506306	0.9994937
ENST00000424123	ENST00000225282	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.001442657	0.9985574
ENST00000424123	ENST00000575068	BPTF	chr17	65822453	+	NSF	chr17	44751779	+	0.001661111	0.9983388

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10094_10094_1_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_2_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_3_BPTF-NSF_BPTF_chr17_65822453_ENST00000306378_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_4_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_5_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_6_BPTF-NSF_BPTF_chr17_65822453_ENST00000321892_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_7_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000225282_length(amino acids)=694AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_8_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000398238_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_9_BPTF-NSF_BPTF_chr17_65822453_ENST00000335221_NSF_chr17_44751779_ENST00000575068_length(amino acids)=700AA_BP=204
MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHRGSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAP
GRGGRGGGGGRTGGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEME
DDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQR
RLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRL
QILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGT
NQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQA
MKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE

--------------------------------------------------------------

>10094_10094_10_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000225282_length(amino acids)=555AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE

--------------------------------------------------------------

>10094_10094_11_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000398238_length(amino acids)=561AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE

--------------------------------------------------------------

>10094_10094_12_BPTF-NSF_BPTF_chr17_65822453_ENST00000424123_NSF_chr17_44751779_ENST00000575068_length(amino acids)=561AA_BP=65
MVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGCKHVKGILLYGPPGCGKTLLARQI
GKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQ
LNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAM
NRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEG
PPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKA
PPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPE

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:65822453/chr17:44751779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BPTF Q12830	NSF NSFL1C
FUNCTION: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.	370

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

143_180

204.33333333333334

2921.0

Compositional bias

Note=Glu-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

149_185

204.33333333333334

2921.0

Compositional bias

Note=Asp-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

143_180

204.33333333333334

3047.0

Compositional bias

Note=Glu-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

149_185

204.33333333333334

3047.0

Compositional bias

Note=Asp-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

143_180

204.33333333333334

2904.0

Compositional bias

Note=Glu-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

149_185

204.33333333333334

2904.0

Compositional bias

Note=Asp-rich

Tgene

NSF

chr17:65822453

chr17:44751779

ENST00000398238

505_510

248.33333333333334

745.0

Nucleotide binding

ATP

Tgene

NSF

chr17:65822453

chr17:44751779

ENST00000398238

545_552

248.33333333333334

745.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2022_2050

204.33333333333334

2921.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2706_2732

204.33333333333334

2921.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

574_604

204.33333333333334

2921.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

978_1007

204.33333333333334

2921.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2022_2050

204.33333333333334

3047.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2706_2732

204.33333333333334

3047.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

574_604

204.33333333333334

3047.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

978_1007

204.33333333333334

3047.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2022_2050

204.33333333333334

2904.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2706_2732

204.33333333333334

2904.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

574_604

204.33333333333334

2904.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

978_1007

204.33333333333334

2904.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

1709_1803

204.33333333333334

2921.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2338_2361

204.33333333333334

2921.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2795_2817

204.33333333333334

2921.0

Compositional bias

Note=Pro-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2848_2853

204.33333333333334

2921.0

Compositional bias

Note=Poly-Lys

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

1709_1803

204.33333333333334

3047.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2338_2361

204.33333333333334

3047.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2795_2817

204.33333333333334

3047.0

Compositional bias

Note=Pro-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2848_2853

204.33333333333334

3047.0

Compositional bias

Note=Poly-Lys

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

1709_1803

204.33333333333334

2904.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2338_2361

204.33333333333334

2904.0

Compositional bias

Note=Thr-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2795_2817

204.33333333333334

2904.0

Compositional bias

Note=Pro-rich

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2848_2853

204.33333333333334

2904.0

Compositional bias

Note=Poly-Lys

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

240_300

204.33333333333334

2921.0

Domain

DDT

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2944_3014

204.33333333333334

2921.0

Domain

Bromo

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

240_300

204.33333333333334

3047.0

Domain

DDT

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2944_3014

204.33333333333334

3047.0

Domain

Bromo

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

240_300

204.33333333333334

2904.0

Domain

DDT

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2944_3014

204.33333333333334

2904.0

Domain

Bromo

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

2867_2918

204.33333333333334

2921.0

Zinc finger

PHD-type 2

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000306378

390_437

204.33333333333334

2921.0

Zinc finger

PHD-type 1

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

2867_2918

204.33333333333334

3047.0

Zinc finger

PHD-type 2

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000321892

390_437

204.33333333333334

3047.0

Zinc finger

PHD-type 1

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

2867_2918

204.33333333333334

2904.0

Zinc finger

PHD-type 2

Hgene

BPTF

chr17:65822453

chr17:44751779

ENST00000335221

390_437

204.33333333333334

2904.0

Zinc finger

PHD-type 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BPTF
NSF

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000306378	+	1	28	640_749	204.33333333333334	2921.0	KEAP1
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000321892	+	1	30	640_749	204.33333333333334	3047.0	KEAP1
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000335221	+	1	30	640_749	204.33333333333334	2904.0	KEAP1
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000306378	+	1	28	839_921	204.33333333333334	2921.0	MAZ
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000321892	+	1	30	839_921	204.33333333333334	3047.0	MAZ
Hgene	BPTF	chr17:65822453	chr17:44751779	ENST00000335221	+	1	30	839_921	204.33333333333334	2904.0	MAZ

Top

Related Drugs to BPTF-NSF

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to BPTF-NSF

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source